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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Ethyl 3-(pyridin-2-ylamino)propanoate Manufacturer/High quality/Best price/In stock

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl N-pyridin-2-yl-beta-alaninate

Cas:103041-38-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% N-[2]Pyridyl-B-Alanin-Ethyl Ester 103041-38-9 Producer

Cas:103041-38-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

N-2-Pyridyl-Alanine Ethyl Ester

Cas:103041-38-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-2-Pyridinyl-β-alanine ethyl ester

Cas:103041-38-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good service Appearance:Powder Storage:Dry and cold condition Package:25KG, 500KG and1000KG, seaworthy and suitable for container transportation. Application:coatings, printing ink, rubber, glass, leather, cos

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/231.html Product Name Ethyl 3-(pyridin-2-ylamino)propanoate CAS No

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:1 Gram

FOB Price: $23.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Synonyms: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl ester;ethyl (2S)-2-[(pyridin-2-

103041-38-9 N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER

Cas:103041-38-9

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Ethyl 3- (pyridin-2-ylamino) Propanoate CAS 103041-38-9

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 103041-38-9 with best quality

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTERCAS103041-38-9

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: N-2-Pyridyl-B-Alanin-Ethyl Ester Synonyms: Ethyl 3-(pyridine-2-ylamino)propanoate CAS: 103041-38-9 MF: C10H14N2O2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Organi

N-2-Pyridyl-B-Alanin-Ethyl Ester

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry plac

3-(pyridin-2-ylamino)propanoate/CAS 103041-38-9

Cas:103041-38-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl 3-(pyridin-2-ylamino)propanoate 103041-38-9

Cas:103041-38-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

anticoagulant, N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER CAS:103041-38-9

Cas:103041-38-9

Min.Order:1 Kilogram

FOB Price: $24.6 / 27.3

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail

N-2- pyridyl-alanine ethyl ester; CAS:103041-38-9; Dabigatran etexilate intermediate 7

Cas:103041-38-9

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Synonyms: Ethyl-3-(pyridine-2-ylamino)propanoate;N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl es

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Manufactory best quality

Cas:103041-38-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

N-[2]Pyridyl-B-Alanin-Ethyl Ester

Cas:103041-38-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 103041-38-9 N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER

Cas:103041-38-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 3-(PYRIDIN-2-YLAMINO) PROPANOATE

Cas:103041-38-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER

Cas:103041-38-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER/High quality/Best price

Cas:103041-38-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(pyridin-2-ylamino)propanoate

Cas:103041-38-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

2-aminopyridine
504-29-0

2-aminopyridine

ethyl acrylate
140-88-5

ethyl acrylate

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In ethanol at 120℃; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Green chemistry; chemoselective reaction;94%
With acetic acid In acetic acid at 88℃; Product distribution / selectivity;86.7%
In acetic acid at 88℃; Product distribution / selectivity;86.7%
ethanol
64-17-5

ethanol

3-[(pyridin-2-yl)amino]propanoic acid
104961-64-0

3-[(pyridin-2-yl)amino]propanoic acid

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

Conditions
ConditionsYield
With thionyl chloride at 0 - 70℃; for 12h;69.2%
2-aminopyridine
504-29-0

2-aminopyridine

4-tert-Butylcatechol
98-29-3

4-tert-Butylcatechol

ethyl acrylate
140-88-5

ethyl acrylate

A

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

B

3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one
5439-14-5

3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one

2-aminopyridine
504-29-0

2-aminopyridine

ethyl acrylate
140-88-5

ethyl acrylate

A

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

B

3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one
5439-14-5

3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

2-(chloromethyl)-1-methyl-1H-benzimidazole-6-carboxylic acid

2-(chloromethyl)-1-methyl-1H-benzimidazole-6-carboxylic acid

ethyl 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzimidazole-6-carboxamido)propanate

ethyl 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzimidazole-6-carboxamido)propanate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at -10℃; Reagent/catalyst; Temperature; Solvent;97.7%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

3-Bromo-4-ethylbenzoic acid
99548-53-5

3-Bromo-4-ethylbenzoic acid

C18H20BrN3O3

C18H20BrN3O3

Conditions
ConditionsYield
Stage #1: 3-Bromo-4-ethylbenzoic acid With thionyl chloride In tetrahydrofuran; N,N-dimethyl-formamide at -20 - 20℃; for 5h;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With pyridine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 6h; Solvent; Reagent/catalyst;
97%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride
1187067-68-0

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; Solvent; Reagent/catalyst;95.2%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-chloro-3-nitro-benzoyl chloride
38818-50-7

4-chloro-3-nitro-benzoyl chloride

3-[(4-chloro-3-nitrobenzoyl)pyridin-2-yl-amino]propionic acid ethyl ester
1620205-04-0

3-[(4-chloro-3-nitrobenzoyl)pyridin-2-yl-amino]propionic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h; Solvent; Reagent/catalyst;87%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 0℃; for 1h;
With triethylamine In dichloromethane at 20℃; for 1h; Solvent; Reagent/catalyst;16.3 g
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitrobenzoyl chloride hydrochloride

4-methylamino-3-nitrobenzoyl chloride hydrochloride

ethyl 3-[((4-methylamino-3-nitrobenzoyl)pyridin-2-yl)amino]propanoate

ethyl 3-[((4-methylamino-3-nitrobenzoyl)pyridin-2-yl)amino]propanoate

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitrobenzoyl chloride hydrochloride With triethylamine In toluene at 0 - 30℃; for 3h; Large scale;
Stage #2: In ethanol; toluene at 20 - 70℃; Large scale;
87%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

C10H8Cl2N2O

C10H8Cl2N2O

N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester
1307233-94-8

N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 1h;85%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-(methyl(pyridin-2-yl)amino)propanoate

ethyl 3-(methyl(pyridin-2-yl)amino)propanoate

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With formaldehyd; acetic acid In methanol; water at 30℃; for 2h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride In methanol; water at 0 - 30℃; Inert atmosphere;
84%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester

2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; for 7h;82.6%
methyl-3-methoxy-4-(methylamino)benzoate

methyl-3-methoxy-4-(methylamino)benzoate

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

C19H23N3O4

C19H23N3O4

Conditions
ConditionsYield
In ethyl acetate at 25℃; for 12h; Temperature; Concentration;80.7%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
ConditionsYield
With thionyl chloride; triethylamine In dichloromethane80%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid

2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
Stage #1: 2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid With thionyl chloride In tetrahydrofuran for 2h; Reflux;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 40℃; for 5h;
75.6%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate hydrochloride

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate hydrochloride

Conditions
ConditionsYield
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide for 0.75h; Reflux;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In tetrahydrofuran at 20 - 60℃;
Stage #3: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity;
47.2%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate hydrochloride

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate hydrochloride

Conditions
ConditionsYield
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide for 0.75h; Reflux;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In tetrahydrofuran at 20 - 60℃;
Stage #3: With hydrogenchloride In ethyl acetate Product distribution / selectivity;
47.2%
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;
Stage #1: 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In dichloromethane at 0 - 10℃;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate In dichloromethane at 0 - 30℃;
180 g
With triethylamine In dichloromethane at 20℃; for 12h;
With triethylamine In dichloromethane at 0 - 5℃; Inert atmosphere;
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride
1187067-68-0

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran at 30 - 40℃; for 2.25h;
Stage #2: With hydrogenchloride In diethyl ether; ethyl acetate
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

ethyl N-(4-methylamine-3-nitrobenzoyl)-N-(2-pyridyl)-3-aminopropionate hydrobromide

ethyl N-(4-methylamine-3-nitrobenzoyl)-N-(2-pyridyl)-3-aminopropionate hydrobromide

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran at 0 - 20℃;
Stage #2: With hydrogen bromide In tetrahydrofuran at 0 - 20℃; for 1.5h; Product distribution / selectivity;
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux
3.2: 10 h / Reflux
4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C
4.2: 10 - 20 °C
4.3: 0.75 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
1.2: 0 - 30 °C
2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr
3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C
3.2: 0.08 h / 0 - 5 °C
4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10
5.1: hydrogenchloride / ethanol / 35 - 42 °C
5.2: 0 - 32 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 12 h / 20 °C
2.1: palladium 10% on activated carbon / 20 h / 22801.5 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C
3.2: 20 °C
4.1: hydrogenchloride / ethanol / 12 h / 20 °C
4.2: 5 h / 20 °C
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux
3.2: 10 h / Reflux
4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C
4.2: 10 - 20 °C
4.3: 0.75 h / 50 °C
5.1: potassium carbonate / water; tetrahydrofuran / 0.25 h / 20 °C
5.2: 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C
1.2: 3 h / 20 - 30 °C
2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C
3.2: 24 h / 25 - 35 °C
3.3: 3 h / 0 - 10 °C
4.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C
4.2: 23.66 h / -35 - 30 °C
5.1: dichloromethane / 3 h / 15 - 25 °C
5.2: 8 h / 25 - 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
1.2: 0 - 30 °C
2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr
3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C
3.2: 0.08 h / 0 - 5 °C
4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10
5.1: hydrogenchloride / ethanol / 35 - 42 °C
5.2: 0 - 32 °C
6.1: potassium carbonate / water; acetonitrile / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: ammonium chloride / water / 80 - 90 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 20 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; potassium iodide; sodium carbonate / dichloromethane; water / 3 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: ammonium chloride / water / 80 - 90 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 20 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; potassium iodide; sodium hydrogencarbonate / water; ethyl acetate / 2 h / 40 °C
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-[[[-2-[[(4-cyanophenyl)amino]phenyl]-1-methyl-1H-benzoimidazol-5-yl]carbonyl]pyridine-2-ylamino]propionate oxalate
1223061-77-5

ethyl 3-[[[-2-[[(4-cyanophenyl)amino]phenyl]-1-methyl-1H-benzoimidazol-5-yl]carbonyl]pyridine-2-ylamino]propionate oxalate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux
3.2: 10 h / Reflux
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alanine ethyl ester methanesulfonate
872728-81-9

N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alanine ethyl ester methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux
3.2: 10 h / Reflux
4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C
4.2: 10 - 20 °C
4.3: 0.75 h / 50 °C
5.1: potassium carbonate / water; acetone / 0.5 h / 5 °C
5.2: 1 h / 50 °C
5.3: 1 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux
3.2: 10 h / Reflux
4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C
4.2: 10 - 20 °C
4.3: 0.75 h / 50 °C
5.1: potassium carbonate / water; tetrahydrofuran / 0.25 h / 20 °C
5.2: 1 h / 20 °C
6.1: ethyl acetate / 2 h / 20 - 45 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C
1.2: 3 h / 20 - 30 °C
2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C
3.2: 24 h / 25 - 35 °C
3.3: 3 h / 0 - 10 °C
4.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C
4.2: 23.66 h / -35 - 30 °C
5.1: dichloromethane / 3 h / 15 - 25 °C
5.2: 8 h / 25 - 50 °C
6.1: tetrahydrofuran / 5 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: ammonium chloride / water / 80 - 90 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 20 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; potassium iodide; sodium carbonate / dichloromethane; water / 3 h / 50 °C
5.1: acetone / 3 h / 0 - 35 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: ammonium chloride / water / 80 - 90 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 20 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; potassium iodide; sodium hydrogencarbonate / water; ethyl acetate / 2 h / 40 °C
5.1: acetone / 3 h / 0 - 35 °C
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux
1.2: 20 - 60 °C
2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride hemisulfate

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride hemisulfate

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran; dichloromethane at 40℃; for 2h;
Stage #2: With hydrogenchloride In chloroform
Stage #3: With sulfuric acid In dichloromethane
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
ConditionsYield
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide at 25 - 80℃; for 1.25h;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In ethyl acetate; N,N-dimethyl-formamide for 1h;
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide at 25 - 80℃; for 1.4h;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In ethyl acetate for 1h;
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 65 - 75℃; for 2h;
Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In toluene at 20 - 30℃; for 3h;
162 g
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
212322-56-0

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C
1.2: 3 h / 20 - 30 °C
2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
1.2: 0 - 30 °C
2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: ammonium chloride / water / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 12 h / 20 °C
2: palladium 10% on activated carbon / 20 h / 22801.5 Torr
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate mesylate

ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C
1.2: 3 h / 20 - 30 °C
2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C
3.2: 24 h / 25 - 35 °C
3.3: 3 h / 0 - 10 °C
View Scheme
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