Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiry1 Factory price 2 High quality 3 Good service Appearance:Powder Storage:Dry and cold condition Package:25KG, 500KG and1000KG, seaworthy and suitable for container transportation. Application:coatings, printing ink, rubber, glass, leather, cos
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/231.html Product Name Ethyl 3-(pyridin-2-ylamino)propanoate CAS No
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inquiryProduct Name: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Synonyms: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl ester;ethyl (2S)-2-[(pyridin-2-
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiryName: N-2-Pyridyl-B-Alanin-Ethyl Ester Synonyms: Ethyl 3-(pyridine-2-ylamino)propanoate CAS: 103041-38-9 MF: C10H14N2O2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Organi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Name: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Synonyms: Ethyl-3-(pyridine-2-ylamino)propanoate;N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl es
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiry2-aminopyridine
ethyl acrylate
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In ethanol at 120℃; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Green chemistry; chemoselective reaction; | 94% |
With acetic acid In acetic acid at 88℃; Product distribution / selectivity; | 86.7% |
In acetic acid at 88℃; Product distribution / selectivity; | 86.7% |
ethanol
3-[(pyridin-2-yl)amino]propanoic acid
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 70℃; for 12h; | 69.2% |
2-aminopyridine
4-tert-Butylcatechol
ethyl acrylate
A
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
B
3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one
2-aminopyridine
ethyl acrylate
A
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
B
3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at -10℃; Reagent/catalyst; Temperature; Solvent; | 97.7% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
3-Bromo-4-ethylbenzoic acid
Conditions | Yield |
---|---|
Stage #1: 3-Bromo-4-ethylbenzoic acid With thionyl chloride In tetrahydrofuran; N,N-dimethyl-formamide at -20 - 20℃; for 5h; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With pyridine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 6h; Solvent; Reagent/catalyst; | 97% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-(methylamino)-3-nitrobenzoic acid
ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; Solvent; Reagent/catalyst; | 95.2% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-chloro-3-nitro-benzoyl chloride
3-[(4-chloro-3-nitrobenzoyl)pyridin-2-yl-amino]propionic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1h; Solvent; Reagent/catalyst; | 87% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 0℃; for 1h; | |
With triethylamine In dichloromethane at 20℃; for 1h; Solvent; Reagent/catalyst; | 16.3 g |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitrobenzoyl chloride hydrochloride With triethylamine In toluene at 0 - 30℃; for 3h; Large scale; Stage #2: In ethanol; toluene at 20 - 70℃; Large scale; | 87% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 1h; | 85% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With formaldehyd; acetic acid In methanol; water at 30℃; for 2h; Inert atmosphere; Stage #2: With sodium cyanoborohydride In methanol; water at 0 - 30℃; Inert atmosphere; | 84% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
dabigatran etexilate
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; for 7h; | 82.6% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
In ethyl acetate at 25℃; for 12h; Temperature; Concentration; | 80.7% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
With thionyl chloride; triethylamine In dichloromethane | 80% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
dabigatran etexilate
Conditions | Yield |
---|---|
Stage #1: 2-[((4-[([(hexyloxy)carbonyl]amino)methanimidoyl]phenyl)amino)methyl]-1-methyl-1H-benzimidazole-5-carboxylic acid With thionyl chloride In tetrahydrofuran for 2h; Reflux; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 40℃; for 5h; | 75.6% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-(methylamino)-3-nitrobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide for 0.75h; Reflux; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In tetrahydrofuran at 20 - 60℃; Stage #3: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | 47.2% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-(methylamino)-3-nitrobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide for 0.75h; Reflux; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In tetrahydrofuran at 20 - 60℃; Stage #3: With hydrogenchloride In ethyl acetate Product distribution / selectivity; | 47.2% |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-methylamino-3-nitro-benzoic acid chloride
ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; | |
Stage #1: 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In dichloromethane at 0 - 10℃; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate In dichloromethane at 0 - 30℃; | 180 g |
With triethylamine In dichloromethane at 20℃; for 12h; | |
With triethylamine In dichloromethane at 0 - 5℃; Inert atmosphere; |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-methylamino-3-nitro-benzoic acid chloride
ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran at 30 - 40℃; for 2.25h; Stage #2: With hydrogenchloride In diethyl ether; ethyl acetate |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-methylamino-3-nitro-benzoic acid chloride
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran at 0 - 20℃; Stage #2: With hydrogen bromide In tetrahydrofuran at 0 - 20℃; for 1.5h; Product distribution / selectivity; |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux 4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 4.2: 10 - 20 °C 4.3: 0.75 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / 0 - 10 °C 1.2: 0 - 30 °C 2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr 3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C 3.2: 0.08 h / 0 - 5 °C 4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10 5.1: hydrogenchloride / ethanol / 35 - 42 °C 5.2: 0 - 32 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 12 h / 20 °C 2.1: palladium 10% on activated carbon / 20 h / 22801.5 Torr 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C 3.2: 20 °C 4.1: hydrogenchloride / ethanol / 12 h / 20 °C 4.2: 5 h / 20 °C View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
dabigatran etexilate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux 4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 4.2: 10 - 20 °C 4.3: 0.75 h / 50 °C 5.1: potassium carbonate / water; tetrahydrofuran / 0.25 h / 20 °C 5.2: 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C 1.2: 3 h / 20 - 30 °C 2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C 3.2: 24 h / 25 - 35 °C 3.3: 3 h / 0 - 10 °C 4.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C 4.2: 23.66 h / -35 - 30 °C 5.1: dichloromethane / 3 h / 15 - 25 °C 5.2: 8 h / 25 - 50 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane / 0 - 10 °C 1.2: 0 - 30 °C 2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr 3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C 3.2: 0.08 h / 0 - 5 °C 4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10 5.1: hydrogenchloride / ethanol / 35 - 42 °C 5.2: 0 - 32 °C 6.1: potassium carbonate / water; acetonitrile / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: ammonium chloride / water / 80 - 90 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux 3.2: 20 h / Inert atmosphere; Reflux 4.1: sodium hydroxide; potassium iodide; sodium carbonate / dichloromethane; water / 3 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: ammonium chloride / water / 80 - 90 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux 3.2: 20 h / Inert atmosphere; Reflux 4.1: sodium hydroxide; potassium iodide; sodium hydrogencarbonate / water; ethyl acetate / 2 h / 40 °C View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
ethyl 3-[[[-2-[[(4-cyanophenyl)amino]phenyl]-1-methyl-1H-benzoimidazol-5-yl]carbonyl]pyridine-2-ylamino]propionate oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alanine ethyl ester methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux 4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 4.2: 10 - 20 °C 4.3: 0.75 h / 50 °C 5.1: potassium carbonate / water; acetone / 0.5 h / 5 °C 5.2: 1 h / 50 °C 5.3: 1 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux 4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 4.2: 10 - 20 °C 4.3: 0.75 h / 50 °C 5.1: potassium carbonate / water; tetrahydrofuran / 0.25 h / 20 °C 5.2: 1 h / 20 °C 6.1: ethyl acetate / 2 h / 20 - 45 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C 1.2: 3 h / 20 - 30 °C 2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C 3.2: 24 h / 25 - 35 °C 3.3: 3 h / 0 - 10 °C 4.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C 4.2: 23.66 h / -35 - 30 °C 5.1: dichloromethane / 3 h / 15 - 25 °C 5.2: 8 h / 25 - 50 °C 6.1: tetrahydrofuran / 5 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: ammonium chloride / water / 80 - 90 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux 3.2: 20 h / Inert atmosphere; Reflux 4.1: sodium hydroxide; potassium iodide; sodium carbonate / dichloromethane; water / 3 h / 50 °C 5.1: acetone / 3 h / 0 - 35 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: ammonium chloride / water / 80 - 90 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux 3.2: 20 h / Inert atmosphere; Reflux 4.1: sodium hydroxide; potassium iodide; sodium hydrogencarbonate / water; ethyl acetate / 2 h / 40 °C 5.1: acetone / 3 h / 0 - 35 °C View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-methylamino-3-nitro-benzoic acid chloride
Conditions | Yield |
---|---|
Stage #1: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; 4-methylamino-3-nitro-benzoic acid chloride With triethylamine In tetrahydrofuran; dichloromethane at 40℃; for 2h; Stage #2: With hydrogenchloride In chloroform Stage #3: With sulfuric acid In dichloromethane |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
4-(methylamino)-3-nitrobenzoic acid
ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide at 25 - 80℃; for 1.25h; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In ethyl acetate; N,N-dimethyl-formamide for 1h; | |
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide at 25 - 80℃; for 1.4h; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In ethyl acetate for 1h; | |
Stage #1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 65 - 75℃; for 2h; Stage #2: 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate With triethylamine In toluene at 20 - 30℃; for 3h; | 162 g |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C 1.2: 3 h / 20 - 30 °C 2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0 - 10 °C 1.2: 0 - 30 °C 2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2: ammonium chloride / water / 80 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 12 h / 20 °C 2: palladium 10% on activated carbon / 20 h / 22801.5 Torr View Scheme |
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C 1.2: 3 h / 20 - 30 °C 2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C 3.2: 24 h / 25 - 35 °C 3.3: 3 h / 0 - 10 °C View Scheme |
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