The first asymmetric total syntheses of the antiviral natural products (+)-sattabacin and (+)-4-hydroxysattabacin are reported. Both total syntheses are remarkably concise and were completed without the use of protecting groups. These syntheses allowed the unambiguous assignment of the absolute ...

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were designed and synthesized through a structure-based molecular hybridization approach. The target compounds were evaluated for c-Met kinase inhibitory activities and cytotox...

Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D2 receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a ...

Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring was successfully carried out by constant current electrolysis using an undivided cell equipped with a platinum plate cathode and a magnesium rod anode in DMF in the presence of carbon ...

The oriental fruit fly, Bactrocera dorsalis, is one of the most destructive pests worldwide. The frequent use of chemical insecticides has led B. dorsalis to develop resistance to many insecticides in recent decades. New high-throughput-sequenced transcriptomes, as well as genomes, have revealed...

Mammalian spermatozoa gradually mature and acquire fertility during the transition from the testis to the caput and cauda epididymis, after which they are stored at the tail of the epididymis and the ampulla of vas deferens. During ejaculation, mixing of spermatozoa with the secretions of access...

In this study, we used a combined approach based on 2-dimensional electrophoresis (2-DE), difference in gel electrophoresis (DIGE), and mass spectrometry (MS) to identify the plasma protein composition in pregnant female dogs and compared it with non-pregnant female dogs. We used the plasma samp...

Publisher SummaryRecent technical advances in high throughput protein analysis by mass spectroscopy (MS) have been successfully applied to the analysis and characterization of the Drosophila melanogaster sperm proteome (DmSP). Likewise, MS, in conjunction with commensurate advances in genomics a...

Chaperonopathies are caused by qualitatively and/or quantitatively abnormal molecular chaperones. These are proteins, chaperoning system components along with co-chaperones, chaperone co-factors, receptors, and interactors. Any of them can be etiopathogenic in chaperonopathies. Chaperones can be...

In the last decade, and in particular since the development of in vitro fertilization techniques, the nuclear status of human sperm cells has shown to be a key parameter in the assessment of male fertility. The shape and condensed state of the mature sperm nucleus are determined by structural an...

The present study was undertaken to demonstrate the existence of mimicry between spermatozoa and bacteria. For this, the shared antigenic determinants between mouse spermatozoa and Streptococcus pyogenes against a common ligand, sperm immobilization factor (SIF), were isolated. The mimicry was e...

Expressed sequence tags (ESTs) were established from various tissues of the giant tiger shrimp (Penaeus monodon). To simultaneously examine expression patterns of a large number of transcripts in ovaries and testes of P. monodon, a cDNA microarray (ReproArrayGTS) containing 4992 features amplifi...

Chlorella vulgaris algae is comprised of a complex mixture of compounds such as carbohydrates, lipids, and proteins and is a suitable feedstock for biofuels. The aim of this study was to convert commercial and a low cost field cultivated algae, via pyrolysis, to produce bio-oil, synthesis gas, a...

Fuels produced from microalgae are a promising alternative for fuels from fossil resources. Algae biomass may be transformed by hydrothermal liquefaction (HTL) into biocrudes, which need upgrading by hydrotreatment to meet transportation fuel requirements.In this study, analyses of HTL biocrude ...

Pyrolysis and steam gasification of woody biomass chip (WBC) obtained from construction and demolition wastes, refuse-derived fuel (RDF), and refuse paper and plastic fuel (RPF) were performed at various temperatures using a lab-scale instrument. The gas, liquid, and solid products were examined...

The effect of heating rates ranging from 5 °C min−1 to 350 °C min−1 on the yields of pyrolysis products of wood and its main pseudo-components (cellulose, hemicellulose and lignin) have been investigated at a temperature of 800 °C in a horizontal fixed bed reactor. Results showed a successive...

This work primarily investigated the pyrolysis of post-consumer mixed plastic wastes during slow pyrolysis (non-isothermal) in a batch reactor to assess the effect of different heating rates on the product yield and its composition. The effect of residence time during fast pyrolysis (Isothermal)...

This study is to evaluate the potential of endophytic fungi of Salvadora persica for the production of bioactive compounds against pathogenic bacteria and fungi. Forty-two fungal isolates were obtained from 135 young and old stem and 125 root segments. Those 42 isolates representing ten fungi in...

In this work, Huadian oil shale from China was treated by hydrothermal pretreatment at 200 °C with 1.0–2.5 h in order to investigate the effect of hydrothermal pretreatment on pyrolysis product distribution and characteristics of oil. The differences in the elemental composition and thermal be...

This paper presents a preliminary study of the characterization of real waste from slaughterhouses as well as their rendering products (protein and fat) through different pyrolytic techniques: thermogravimetric analysis (TG), analytical pyrolysis in a pyroprobe equipment and hydrothermal liquefa...