An efficient method for the cross-coupling reactions of 1,3-dicarbonyl compounds with 2-oxo-1-pyrrolidine compounds 1 was developed. Cu(OTf)2 catalyzed C–C bond forming reactions using substrates 1 with 1,3-dicarbonyl compounds in chloroform, providing the corresponding compounds of 2-oxo-1-pyr...

An intermolecular Ugi reaction of 2-(1-(aminomethyl)cyclohexyl)acetic acid (gabapentin) with glyoxal and cyclohexyl isocyanide or aromatic aldehyde and tertbutyl isocyanide under mild conditions in ethanol have been developed to produce two novel class of N-cyclohexyl-3-(aryl)-3-oxo-2-(3-oxo-2-a...

Prediction of reservoir production using different technical scenarios and designs is essential for optimization of reservoir development plan. Due to the enormous scale of a reservoir, the simulators use simplified discretized equations to predict the production and other properties of the rese...

BackgroundAdvancements in the management of human immunodeficiency virus (HIV) now permit HIV-positive patients to have longer life spans, increasing their cumulative risk of developing an advanced degenerative joint disease, necessitating total hip arthroplasty (THA). The purpose of this study ...

Bottom-up proteomics characterizes proteins by analysis of peptides generated through proteolysis. Bottom-up analysis of a complex proteome inevitably generates tens of thousands of peptides, and the analysis of these peptides is a serious challenge. Capillary zone electrophoresis (CZE) generate...

Study objectivePrimary care (PC) follow-up for discharged emergency department (ED) patients provides patients with further medical attention. We conducted a pilot randomized controlled trial to determine whether using a freely-available physician appointment-booking website results in higher se...

Transparent electrodes (TEs) have attracted significant scientific, technological, and commercial interest in recent years due to the broad and growing use of such devices in electro-optics, consumer products (touch-screens for example), solar cells, and others. Currently, almost all commercial ...

One of the most challenging questions in fluid dynamics is whether the three-dimensional (3D) incompressible Navier-Stokes, 3D Euler and two-dimensional Quasi-Geostrophic (2D QG) equations can develop a finite-time singularity from smooth initial data. Recently, from a numerical point of view, L...

Froth flotation has been one of the most important and widely used methods to concentrate minerals since its introduction over a hundred years ago. Over the last few decades, in order to process more mineral while reducing capital costs, flotation equipment has become exponentially larger. The i...

ObjectivesTo assess subjective and objective outcomes in incontinent patients following “out-in” TOT, at >10-year follow-up; to evaluate effect on quality of life and other urinary symptoms, late adverse events and predictive factors for failure.

The existence of fictitious users of financial statements has been confirmed in previous research. Our study investigates how this powerful yet ‘made-up’ construct is deployed within the discourses of the main stakeholders including ‘real’ users themselves, as they shape regulatory debates i...

The coalescence and break-up of bubbles are important steps in many industrial processes. To date, most of the literature has been focussed on the coalescence process which has been studied using high speed cinematographic techniques. However, bubble break-up is equally important and requires fu...

A convenient new method was developed to prepare two types of vinyl cyclopropane derivatives through gold-catalyzed cyclization of 1-alkynyl cyclopropyl tert-butyl carbonates 2. Different from the previous reported 5-exo-dig route, the 6-endo-dig addition is the preferred pathway to provide six-...

A facile pyridinium chlorochromate (PCC) catalyzed (2 mol %) oxidation of alcohols to ketones and aldehydes using 1.05 equiv of H5IO6 in acetonitrile is described here.

An efficient, high yield and one-pot synthesis of phenyl cyclopropyl methanones by reaction of different aryl alcohols with 4′-fluoro-4-chloro-butyrophenone in THF/DMF in the presence of NaH/TBAB is reported. Most of the methanones were further reduced to respective alcohols or methylenes. All ...

The bacterial repair enzyme MutT hydrolyzes the damaged nucleotide OdGTP (the 5′-triphosphate derivative of 8-oxo-2′-deoxyguanosine; OdG), which is a known mutagen and has been linked to antibacterial action. Previous work has indicated important roles for the C8-oxygen, N7-hydrogen, and C2-ex...

The Cr(V) complexes, bis(2-ethyl-2-hydroxybutyrato)oxochromate(V) ([OCrV(ehba)2]−) and (2,2-bis(hydroxymethyl)-2-(bis(2-hydroxyethyl)amino)ethanolato)oxochromate(V) ([OCrV(BT)]2−), were reacted with a series of deoxyribonucleotide triphosphates. Oxidation of deoxyribose at C4′ was observed by m...

BRD4 is an attractive target for antitumor due to its important role in regulation of gene transcription. In this paper, we synthesized a series of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as potent BRD4 inhibitors and evaluated their BRD4 inhibitory activities in vitro and anti-proli...

A novel and efficient Ni-catalyzed aryl- and alkyl-selenation of imidazo[1,2-α]pyridines employing selenium powder has been developed for the first time. The significant advantages of this protocol are that it is an inexpensive nickel catalyst and exhibits broad functional-group compatibility a...

A simple and mild protocol towards the regioselective synthesis of 1-aryl/heteroaryl-1-(2-methylimidazo[1,2-a]pyridin-3-yl)methanones has been developed by one-pot condensation of 2-aminopyridine with 1,3-diketones involving the intermediacy of 2-bromo-1,3-diketones formed in situ from 1,3-diket...