Early Paleogene neodymium (Nd) isotopic reconstructions of ocean circulation in the Pacific suggest a bipolar mode of overturning circulation characterized by convection of deep-water masses from 70 to at least 40 Ma. This mode is fundamentally different from the “sluggish, diffusive” mode tha...

Soil washing, which is used to remove heavy metals from soil, is dependent on suitable washing agents. However, there is still a lack of economical, environmentally friendly washing agents with high removal efficiency. In this study, three washing agents, carboxyalkylthiosuccinic acid (CETSA), c...

Cryptorchidism, the failure of one or both testes to descend to an extra-abdominal location during mammalian development, is a common reproductive malady that often requires surgical intervention to remedy. Leydig cells are responsible for producing insulin-like peptide 3 (INSL3), a peptide horm...

This paper attempts to identify and classify the main uses of three compatibilizers used in polymer blends with extended applicability, such as PE-g-MA (Polyethylene-graft-maleic anhydride), PP-g-MA (Polypropylene-graft-maleic anhydride ) and SEBS-g-MA (Styrene-Ethylene / Butylene-Styrene-maleic...

1110 Ma Large Igneous Province (LIP) fragments in the Kalahari craton, southern Africa (Umkondo LIP); Dronning Maud Land, Antarctica; Bundelkhand portion of Indian craton (Mahoba dolerite dykes); Congo craton (Huila-Epembe dolerite dykes); and Amazonia (Rincon del Tigre-Huanchaca LIP) have been ...

The present paper establishes a new homotopy, called an LMA-homotopy, and further, an LMA-homotopy equivalence suitable for studying the homotopic properties of both Euclidean topology and M-topology. Indeed, the LMA-map (see Definition 12 of the present paper) is an advanced version of that of ...

U-Pb baddeleyite ages for key mafic dykes of the Amazonian Craton reveal four significant intraplate episodes that allow connections with global igneous activity through time and supercontinent cycles. The oldest dykes (Carajás-Rio Maria region) are diabases with ages of 1880.2 ± 1.5 Ma and 18...

BackgroundHigher tDCS current may putatively enhance efficacy, with tolerability the perceived limiting factor.

Indium extraction from synthetic indium-bearing zinc ferrite (IBZF) was investigated using sulfur dioxide as a reductant in sulfuric acid medium, and the recovery of indium and the full use of sulfur dioxide were achieved. The leaching kinetics of indium from synthetic IBZF were studied, and the...

Most caves owe their origin to carbonic acid generated in the soil. In contrast, sulfuric acid caves are produced by the oxidation of sulfides beneath the surface. Although sulfuric acid caves are relatively few, they include some large and well-known examples, such as Carlsbad Cavern, New Mexic...

To improve the sulfuric-acid leaching of germanium-bearing secondary zinc oxide, the occurrence states and sulfuric-acid leaching behavior of germanium in secondary zinc oxide were investigated experimentally via inductively coupled plasma optical emission spectrometry (ICP–OES), X-ray diffract...

Sulfonation process usually exhibit high reaction rate and low yield and selectivity of product in common reactors for its insufficient micromixing. This work employed a rotating packed bed (RPB) to intensify the micromixing of the phenol sulfonation process to improve the yield and selectivity ...

In Italy, especially along the Apennine Chain, numerous active and inactive sulfuric acid speleogenetic (SAS) caves have been documented in the last two decades. Here we present an overview of these peculiar hypogene systems, illustrating their main geomorphological and mineralogical features, a...

Sulfur stable isotopes from cave sulfates (mainly gypsum) have been used in a number of studies to trace the source of sulfur in caves formed by sulfuric acid, but only few studies apply combined use of sulfur and oxygen stable isotopes to further understand the processes operating in sulfuric a...

We used a nanofiltration (NF) membrane process to produce purified aqueous sulfuric acid from copper-refining sulfuric acid wastewater. Wastewater generated from a copper-refining process was used to explore the membrane performances and acid stabilities of six commercial NF membranes. A combina...

Summary1.A patient with history and physical findings of ingestion of Lysol was treated with oral procaine solution and ACTH.2.Marked dysphagia was overcome by procaine gargles and swallows before meals.3.The theoretical role of ACTH in preventing scarring and contracture in such a case is discu...

WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified radicicol (1) as an active compound, and synthesized several radicicol derivatives. Among them,...

BackgroundIntestinal injury is a key feature in sepsis. Inhibitors of heat shock protein 90 (Hsp90) have been shown to exert protective effects in models of inflammation. Herein, we hypothesized that Hsp90 might regulate intestinal inflammation and leakage in abdominal sepsis.

Radicicol is a natural antibiotic that specifically inhibits chaperone Hsp90 activity and binds to its active site with nanomolar affinity. Radicicol has been widely used as a lead compound to generate synthetic analogs with reduced toxicity and increased stability that could be employed clinica...

Radicicol and geldanamycin are potent inhibitors of the Hsp90 protein folding machinery, which is an emerging target for the development of cancer chemotherapeutics. However, radicicol is inactive in vivo and geldanamycin suffers from its redox-active behavior that produces toxicity unrelated to...