The neuropeptide substance P can induce degranulation of cardiac mast cells at high concentrations. Herein, we seek to further understand substance P activation of cardiac mast cells in the context of other neuropeptides as well as modulation by non-neuropeptides. This is important given the inc...

How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neur...

Stem cells have regenerative potentials that can be used for the treatment of critical and incurable diseases. Age-related macular degeneration (ARMD) and diabetic retinopathy are one of the most severe retinal disorders, which are mostly attributed to impairment of retinal pigmented epithelium ...

Regulation of vascular permeability plays a major role in the pathophysiology of visually threatening conditions such as retinal vein occlusion and diabetic retinopathy. Principally, several factors such as vascular endothelial growth factor (VEGF), are up-regulated or induced in response to hyp...

Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P ...

Substance P has recently received much attention as a mediator of adverse heart remodelling and cardiac inflammation by releasing proinflammatory cytokines and matrix metalloproteases from immune and cardiac mast cells. Based on animal models, Substance P is highly associated with the developmen...

Substance P (SP) is an undecapeptide encoding the tachykinin 1 (TAC1) gene and belongs to the tachykinin family. SP is widely distributed in the central nervous system and the peripheral nervous system. SP is also produced by nonneuronal cells, such as inflammatory cells and endothelial cells. T...

In this paper, the boosted methylene blue (MB) dye adsorption efficiency of polyaniline nanofibers doped with phytic acid (DPANI) is premeditated. DPANI was prepared by simple radical polymerization method using phytic acid (PA) solution. The synthesized doped nanofibers were characterized by di...

A thorough investigation on a set of organic diluents for water-lean solvent formulation has been carried in this work. The performance of aqueous monoethanolamine (MEA) 30 %w/w has been compared to that of mixtures between MEA 30 %w/w and methanol, acetone, monoethylene glycol (MEG), N-methyl-2...

A stable modified glassy carbon electrode with oracet blue (OB) has been fabricated and its electrochemical behavior was investigated by cyclic voltammetry. The properties of the electrodeposited films, during preparation under different conditions, and the stability of the deposited films were ...

An innovative method of a DNA electrochemical biosensor based on Oracet Blue (OB) as an electroactive label and gold electrode (AuE) for detection of Helicobacter pylori, was offered. A single–stranded DNA probe with a thiol modification was covalently immobilized on the surface of the AuE by f...

Correlations among atomic structure, chemical reactivity, charge transfer and electronic structure properties were investigated in nanoporous carbon at different mass densities. The model structures have been generated by a heat-quench procedure using Density Functional Theory calculations and f...

Mechanical milling is a classic and well-known technique for altering the morphology and microstructure and hence the physical and chemical properties of metallic and ceramic materials. Herein we demonstrate that by using zirconia jars and balls as the grinding media, an optimum milling duration...

This study examines the preparation of sustained-release lidocaine polyelectrolyte complex using reactive melt extrusion. Eudragit L100-55 was selected as the ionic polymer. The influence of drug forms (freebase vs. hydrochloride salt) on lidocaine–Eudragit L100-55 interactions, physical stabil...

The cadmium yellow paints used in several paintings of the early 1900s are undergoing a process of deterioration the reasons of which are still unclear. Structural defects in CdS, among other possible causes like photo-oxidative reactions, may play a role in the degradation process. Their presen...

ObjectivesYellow fever virus historically was a frequent threat to American and European coasts. Medical milestones such as the discovery of mosquitoes as vectors and subsequently an effective vaccine, significantly reduced its incidence, in spite of which, thousands of cases of this deathly dis...

The aim of this study was to evaluate the efficiency of Fe3O4 nanoparticles for Reactive Red 198 adsorption. The adsorbents were characterized by SEM and XRD. In this dataset, the influence of Reactive Red 198 dye concentration, solution pH, adsorbent dosage, and contact time on Reactive Red 198...

The present study is carried out to investigate the contribution of iron in the hematite phase in enhancing the reactivity of red mud. Compressive strength test was performed on the binder synthesized from both unpulverized and pulverized red mud. The results indicated an increase in strength of...

Irradiation with red light or near-infrared (NIR) lasers can bio-modulate cellular processes or revitalize injured tissues and therefore, widely been used for therapeutic interventions. Mechanistically, this cellular or biological process, referred as Photobiomodulation (PBM), is achieved by the...

In this study, the doped ZnO nanorods with silver (Ag) as photosensitive material are prepared by the solvothermal method. The structural and optical characterization is carried out by the scanning electron microscopy, X-ray diffraction, energy dispersive spectroscopy and UV–visible spectroscop...