Using (R)- or (S)-1-phenylethylamine as a resolving agent, (R)- and (S)-4-cyano-4-(4-nitrophenyl)hexanoic acids have been isolated. Cyclization of each enantiomer, followed by reduction of the nitro group, afforded (R)- and (S)-aminoglutethimide of high (>99% ee) enantiomeric purity, respectivel...

The standard (p∘ = 0.1 MPa) massic energies of combustion in oxygen of 1-ethylpiperidine and 2-ethylpiperidine, both in the liquid phase, were measured at T = 298.15 K by static bomb calorimetry. These values were used to derive the standard molar enthalpies of combustion and the standard molar...

An enantiospecific, eight-step synthesis of (3S,4R)-3-amino-4-ethylpiperidine 3 starting from readily available (S)-(−)-α-methyl-4-pyridinemethanol 6 has been achieved utilizing an Overman rearrangement of a chiral allylic trichloroacetimidate 13 as the key step. A diastereoselective hydrogenat...

An organism isolated from soil by enrichment on isonicotinic acid (INA) was characterized as Bacillus brevis. It used sugars more readily than amino acids as growth substrates. The organism also used isoniazid, 2-hydorxypyridine, and benzoic and p-hydroxybenzoic acids. This bacterium did not met...

Pyridine carboxylic acid salts or esters in water or water—acetonitrile mixtures were treated with elemental fluorine to give the corresponding 2-pyridones.

A method for the fluorometric determination of α-ketosuccinamic acid, the α-keto acid analog of asparagine, is described. The procedure involves the hydrolysis of α-ketosuccinamate to oxaloacetate by ω-amidase followed by NADH-dependent reduction of oxaloacetate to malate by malate dehydroge...

A novel β-(oxy)alkyl radical derived from trichloro methyl compound containing neither a suitably located C–C multiple bond nor a leaving group or a H-atom at the β-position of the radical in a reaction of 2,2,2-trichloro-1-phenyl-ethanone with 2 mol equiv each of CuCl and bpy in refluxing DC...

1,3-Dipolar cycloaddition of a chiral nitrone derived from (−)-menthone to (E)-1,4-dichlorobut-2-ene was the key step in a novel 5 step synthesis of (2S,3S,4R)-4-hydroxyisoleucine, obtained in 21% overall yield with high enantiopurity.

The reaction of (Z) or (E)-1,4-dichlorobut-2-ene (1,2), or 3,4-diclorobut-1-ene (3) with an excess of lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (5 mol %) in the presence of an electrophile [(CH2)4CO, ButCHO, Me3SiCl] in THF at O°C yields, after hydrolysis, the corresp...

Two new 2D coordination polymers, [Pb(NNO)2]n (1) and [Pb(NNO)(SCN)]n (2) (HNNO = nicotinic acid N-oxide), were synthesized and characterized by elemental analysis, FT-IR and 1H NMR spectroscopy, as well as single-crystal X-ray diffraction analysis. The thermal stability of the compounds was eva...

A series of metal carboxylates containing pyridine N-oxide are prepared via one pot synthesis and solid phase synthesis. The structural variations from metal to metal are observed. In the case of reactions of manganese(II) acetate with pyridine N-oxide in the presence of aromatic carboxylic acid...

The reactions of Ar2TeO (Ar = 4-MeO-C6H4) with 2-, 3- and 4-pyridine carboxylic acids (LH) afforded different organotelluroxane structural types depending on the stoichiometry of the reactants and the conditions of the reaction. Ar2Te(L)OH (1a–1c) are formed in a 1:1 reaction of Ar2TeO with LH ...

In the present study, nitrogen-doped reduced graphene oxide is synthesized using hydrothermal method for high-performance supercapacitor application. The N-doping level is found to be ∼7 at%, and nitrogen atoms remain in pyridinic, pyrrolic and quaternary form. Because of the multiple synergist...

The feed wastes and waste water treatment plants are the major sources for the entry of N-oxides into the soils then to aquatic life. The complexation of actinides with potentially stable anthropogenic ligands facilitate the transportation and migration of the actinides from the source confineme...

A novel 1D organic–inorganic hybrid compound [(C6H4NO2)Mo2O5OH] 1 has been synthesized hydrothermally and characterized by single crystal X-ray diffraction, IR, and thermogravimetric analysis. The structure of [(C6H4NO2)Mo2O5OH] consists of {MoO6}octahedra and pyridine-4-carboxylic ligands. {Mo...

The sequence of deprotonation of pyridine-6-phospho-4-carboxylic acid (PPCA) was investigated by employing quantum-chemical calculations performed at the B3LYP/6-311++G∗∗ level of theory. The shape of the potential functions for the proton transition within and between the functional groups of t...

We previously reported that 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivative 6 is an agonist of human peroxisome proliferator-activated receptor alpha (hPPARα). Here, we prepared a series of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives in order to examine the structure-acti...

The 32-membered stereoregular triphenyltin macrocycle: [Ph3Sn (OCOC5H4NO)]4·3(CH2Cl2) has been synthesized by the reaction of triphenyltin chloride with pyridine-4-carboxylic acid N-oxide. The complex was characterized by elemental analysis, FT-IR, NMR (1H, 119Sn) spectra and X-ray crystallogra...

Copper(II) carboxylate complexes [Cu2{CH3CH(C6H5)CH2COO}4]n (1) and [Cu2{CH3CH(C6H5)CH2COO}4(3-MePy)2] (2) were synthesized and characterized by FT-IR and single crystal X-ray analyses. Bridging bidentate binding modes of the carboxylate ligands were first suggested by FT-IR spectra and later on...

Amide hydrolysis of N-(6-methyl-2-pyridyl)acrylamide without the assistance of either acid or base produces the aminopyridinium carboxylate salt at low or room temperature. The carboxylate ion and the free amine functionalities are cooperatively involved in hydrogen bonding with lattice water to...