Novel fabrication techniques were developed to manufacture polycrystalline palladium, cobalt, and rhodium nanopillars with diameters of approximately 130 nm. These nanostructures have length-to-radius ratios in the range of 4 and 20. Using uniaxial nano-compression techniques, the buckling behav...

In an approach to optimize 2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (1a), a weak inhibitor of the cancer-related tyrosine kinase RET originating from a screening campaign, analogues with 3-thienyl substitution were prepared. Among the novel derivatives,...

A series of 5-vinyl-3-pyridinecarbonitriles were synthesized and evaluated as PKCθ inhibitors. The systematic optimization of 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-phenylvinyl]-3-pyridinecarbonitrile 3 resulted in the identification of compound 23e as a potent PKCθ inhibitor with good sel...

Novel pyrido[2,3-d]pyrimidines 4 have been synthesised starting from 2-amino-4-trifluoromethyl-6-substituted nicotinonitriles 1 via imine formation, selective amination followed by Dimroth rearrangement. Compound 4 were screened against Gram +ve and –ve bacteria in vitro. Compounds 4h and 4d sh...

In this communication, we report four component condensations of acetophenone, arylaldehydes, arylthiol, and malononitrile in the presence of Triton X-100 (5 mol%) aqueous micelles. This reaction led to the formation of 4,6-diaryl-2-(arylthio)nicotinonitrile new derivatives in good yields. The F...

The chapter is focused on the synthesis of 1,2,3-thiadiazoles including Hurd–Mori reaction, Wolff approach, and oxidative cyclization of hydrazones bearing thioamide group. It also contains data on the synthesis of fused 1,2,3-thiadiazoles and those linearly connected to other heterocycles. Mor...

The methyl and ethyl ester of 4-hydroxybutyric acid were prepared and evaluated as pro-drug models for the γ-lactone moiety occurring in several drugs such as pilocarpine. The esters were found to undergo a quantitative cyclization in neutral and alkaline aqueous solution at 37°C to γ-butyrol...

The in vivo clastogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) was examined in the micronucleus test using peripheral blood from three mouse strains (ICR, CD-1, and MS/Ae) and bone marrow from one rat strain (Sprague-Dawley). Doses up to the maximum tolerated were tested. The che...

Ten 5-nitro-2-furyl derivatives, with good to excellent in vitro anti-Trypanosoma cruzi activity, and nifurtimox were tested oral and intraperitoneally on healthy animals for its acute toxicity on murine models. According to animals' survival percentage, organ histological results, biochemi...

A series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesized from condensation of various hydrazides 2a–j with ketene dithioacetal. The synthesized compounds were screened for in vivo analgesic and anti-inflammatory activities using acetic acid writhing test in...

A novel 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-mediated formal cycloaddition of β,γ-alkenyl esters with p-tolylsulfonylazide (p-TsN3) for the synthesis of 3,5-disubstituted pyrazoles has been developed. The reaction proceeded through diazotization of β,γ-alkenyl esters sequential with ther...

Rhenium is a valuable metal in very low concentration and it is being increasingly used in industry due to its multiples properties, mainly in the aeronautics and oil industries. For this work, the PEG/CuSO4 aqueous two phase system (ATPS) was used for the partition of perrhenate anion. For the ...

Fluorescent sensor for the perrhenate/pertechnetate anions in aqueous media are rarely reported in literature as their large size and low charge density poses great challenge to their detection. Herein, we report the first fluorescent turn-on ratiometric sensor for perrhenate anion, exploiting i...

Aqueous solution was simulated by ammonium perrhenate and sodium sulfate in sulphuric acid system according to waste water from metallurgy process of copper and molybdenum. Molalities of perrhenate after extraction were measured at ionic strength from 0.2 to 2.0 mol kg−1 at temperature range 278...

A series of N-alkylammonium perrhenate salts [N(R1)3R2]+[ReO4]− with varying substituents R1 and R2 were synthesized and characterized and used as catalysts for the epoxidation of olefins. The effect of the substitution pattern on the catalytic activity was investigated.

Rhenium (Re) was recovered as high purity ammonium perrhenate (APR) from a scrub liquor produced by a pilot plant treating 2000 m3/h of a fume discharged from a molybdenite roaster. The hydrometallurgical process adopted incorporates first a neutralisation stage using lime to remove most of Mo, ...

The thermal expansion of NH4TcO4 and NH4ReO4 between 97 and 500 K has been established using variable temperature synchrotron X-ray diffraction. Both oxides display a tetragonal scheelite-type structure over the temperature range. The observed anomalous thermal expansion is associated with disor...

Photochromic oxygen-containing yttrium hydride (YHO) thin films with switchable optical properties have recently emerged as a promising material for the utilization in smart windows and sensor applications. In the present study, we have prepared YHO thin films with a lateral gradient of oxygen a...

The various shapes of flaw-free bulk yttrium hydrides could be fabricated and various mechanical properties were obtained. The lattice parameter decreased with the hydrogen content. The yttrium hydride had larger elastic moduli than the metal and the elastic moduli were dependent on the hydrogen...

Oxygen-containing yttrium hydride films (YHx:O) show interesting photochromic properties under ultraviolet irradiation. In this paper, oxygen-containing yttrium hydride films covered with tungsten oxide were prepared by a direct current magnetron sputtering method. This composite material showed...