Triostin A exists as two symmetrical conformers in weakly polar solvents like chloroform. Adenine and guanine derivatives were found to specifically interact with one of the two conformers, but uracil and cytosine derivatives did not. From the analysis of nmr and infrared spectra, it was conclud...

SummaryExcised thioesterase domains are versatile catalysts for macrocyclization. However, thioesterase-catalyzed cyclization is often precluded due to the occurrence of hydrolysis and product inhibition. To circumvent these obstacles, we devised an unprecedented strategy: coincubation with DNA ...

The binding kinetics of the intercalative binding of Triostin A to λ-DNA was investigated by measuring the force extension response of the DNA-ligand complexes with an optical tweezers system. These force response curves, containing the information about different binding properties, were analy...

Scatchard analysis of the binding of amphotericin B to sterols in egg phosphatidylcholine/sterol vesicles revealed that amphotericin B was bound to ergosterol by approximately one order of magnitude more tightly than to cholesterol. Amphotericin B methyl ester formed a tighter complex with each ...

A single-dose trial in mice (1.25 mg/kg SPA-S-753 or 1 mg/kg amphotericin B [AmB] by intravenous route) was performed to study the pharmacokinetics, tissue distribution, and urinary excretion of a new polyene, SPA-S-753 (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate), i...

SummaryA series of partricin A amides were synthesized using the active ester method by reaction with several amines on the carboxy group and then with some acids on the mycosamine group of partricin A. Most of the derivatives are more potent antifungals than the known reference standards, inclu...

Verticillin is one of the dimeric epipolythiodioxopiperazines (ETPs) which are toxic secondary metabolites produced only by fungi. ETPs have received substantial attention since its complex molecular architecture and a wide range of biological activities. Although biosynthesis of the monomeric g...

Verticillin A is a natural product isolated from fungal cultures and has displayed potent antibiotic, antiviral, nematocidal, and anticancer properties in vitro. While in vivo studies have been limited due to sparse supply, the in vivo efficacy data that does exist demonstrates potent anti-tumor...

The corrosion resistance of AISI 316 L borided and non-borided steels was evaluated during 10 days of immersion in a simulated body fluid (Hanks' solution). The FeB/Fe2B layer was developed using the powder-pack boriding process at 1223 K and 6 h of exposure. First, the electrochemical beha...

In this research, the self-propagating high-temperature synthesis characteristics of the 2WO3‒(1 + x)B2O3‒(9 + y)Mg system were studied using H3BO3 as the boron oxide source. The addition of extra B2O3 and Mg was considered as the main process parameter to obtain tungsten borides phases. XRD res...

Refining and purification is a significant way to obtain pure and high-quality magnesium alloy melts. This paper summarizes the flux refining methods and non-flux purification methods (blowing purification, filtration purification, electromagnetic purification and ultrasonic purification). It al...

A composite consisting of magnesium matrix reinforced with a network of TiC–Ti2AlC–TiB2 particulates has been fabricated using a practical in-situ reactive infiltration technique. The microstructural and phase composition of the magnesium matrix composite (R-Mg) was investigated using SEM/EDS ...

New results about the tribocorrosion resistance of borided ASTM F1537 alloy immersed in Hank's solution were obtained in this study. A CoB-Co2B layer, with around 30 μm of thickness, was obtained at the surface of the cobalt-based alloy using the powder-pack boriding process at 1273 K with...

Magnesium boride, a widely known superconductor, was converted from crystals to nanotubes whose diameter was approximately 5 nm by a hydrothermal reaction in an autoclave containing aqueous NaOH solution of 25 mol L−1. The reaction time and temperature were varied to determine the optimum condit...

The electrochemical oxidation of carbon represents a relevant limitation for the application of carbon-based materials at the electrodes of several electrochemical devices, like fuel cells, metal-air batteries, water electrolyzers or supercapacitors. Understanding the key influencing parameters ...

We report a facile synthesis route to a series of high-quality carbon nanotube/metal oxide (CNT/MO) nanocomposites including CNT/Co3O4, CNT/SnO2, CNT/Fe3O4, and CNT/NGP (nickel glycolate polymer) without functionalization of pristine CNT. Using pristine CNT, various metal salts, and sodium aceta...

In order to reveal the contribution of carbon support in metal oxide-based catalysts for the oxygen evolution reaction (OER), the active carbon is facilely functionalized with various active groups and composite with Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF). By systemically investigating the electrochem...

CNTs produced from chemical vapor deposition usually accompany with various impurities such as carbonaceous species and metal residues. In this work, the influence of graphitization and oxidation on the catalytic activity of the CNTs is investigated by using of acrolein oxidation reaction (ACR) ...

Different carbon structures (activated carbon, carbon nanotubes, graphene and graphite) were investigated for the replacement of heteropoly catalysts for the oxidation of methacrolein to methacrylic acid. Activated carbon showed the best catalytic performance with higher catalytic activity than ...

MoSi2-based oxidation protective coating was fabricated on carbon/carbon (C/C) composites by combining pack cementation and supersonic atmospheric plasma spraying techniques. This work firstly studied the effect of spraying power on the phase composition of MoSi2 coating. Proper power at 50–55 ...