The aim of this work was to compare encapsulation of stearidonic acid soybean oil (SDASO) by complex coacervation in the classical gelatin (GE)-gum arabic (GA) system with that of a Maillard reaction product (MRP). A portion of the control (microcapsules based on the GE-GA system) was cross-link...

The simultaneous synthesis of a phytosteryl ester and enrichment of stearidonic acid (SDA) were performed via a one-step lipase-catalyzed esterification of fatty acids from Ahiflower™ seed oil with phytosterol. A commercial lipase (Lipase OF) from Candida rugosa was employed as a biocatalyst. Th...

The antioxidant capacity of Maillard reaction (MR)–modified gelatin (GE)–gum arabic (GA) coacervates was optimized to produce microcapsules with superior oxidative stability compared to the unmodified control. MR was used to crosslink GE and GA, with or without maltodextrin (MD), to produce an...

Lymphoma is the most common hematopoietic tumor in dogs and humans, with similar pathogenesis and therapeutic responses. Anticancer drugs like vincristine (VCR) and doxorubicin (DOX) are often used in treating lymphoma. However, the cure rate is generally poor due to chemoresistance. Here, we so...

BackgroundConsumption of soybean oil enriched with stearidonic acid was previously shown to increase eicosapentaenoic acid (EPA) in red blood cells (RBC).

Increasing concentration of histidine significantly increased stearidonic acid production and cell growth in oleaginous Saccharomyces cerevisiae that has been genetically modified by Δsnf2 disruption, DGA1 and Δ6 desaturase gene overexpression, and LEU2 expression. High concentration of histid...

The aim of this study was to synthesize stearidonic acid (SDA)-rich triacylglycerol (TAG) via a two-step lipase-catalyzed esterification under vacuum. SDA-rich fatty acid, which was prepared from echium oil via Candida rugosa lipase-catalyzed selective esterification, was used as the substrate. ...

The aim of this study is to research whether stearidonic acid (SDA) has insulinotropic effect and the mechanisms. MIN6 pancreatic β-cells were treated with SDA and effects were analyzed. Protein and mRNA expressions of G protein-coupled receptor 40 (GPR40) increased after 24-h SDA treatment, wh...

This study explored the co-production of fucoxanthin and stearidonic acid from Isochrysis zhangjiangensis by investigating its carbon metabolism under different light intensities. Results showed high light inhibited the synthesis of fucoxanthin and stearidonic acid, while promoted cell growth an...

The red imported fire ant, Solenopsis invicta Buren, is a serious invasive pest of quarantine significance. Potential establishment of this ant is of great concern in S. invicta free countries such as South Korea, where there have been multiple recent interceptions. The majority of those detecti...

Anti-microbial effect is produced when the ligand (L) S-ethyl-l-cysteine sulfoxide (Ethiin) makes coordination complex with metal ‘M’ (M = Cu, Co, Ni), while, ethiin did not show any antimicrobial effect. The synthesized complexes have 1:2 metal to ligand ratio (ML2). The spectro-chemical anal...

Low permeability of microbial cells and mass transfer limitations are major problems for efficient whole-cell biocatalysis. In this work, a method for enhanced enantioselective synthesis of S-EHPP, an intermediate for antidepressant drug fluoxetine via Kluyveromyces lactis whole-cell-catalyzed r...

Publisher SummaryPetroleum industry refines crude petroleum and processes natural gas into a multitude of products. It is also involved in the distribution and marketing of petroleum-derived products. The primary family of pollutants emitted from those activities is volatile organic compounds ar...

The direct polymerization of aromatic diacid dimethyl esters with aromatic diamines using phosphorus activating agents and tertiary amines was conducted at room temperature. The reaction mechanism was investigated with model compounds. The diacid dimethyl ester of pyromellitic dianhydride was re...

We report synthesis and optimization of a series of (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1′, P2′ and P3 portions led to a promising 3,5-disubstituted piperidine 32o showing high renin inhibitory activity a...

Chiral 2,3-trans-substituted piperidines were readily prepared in three steps from β-amino-α-methylene esters, which were prepared by the Michael/Mannich domino reaction of chiral sulfinimines. Hydrogenation of the N-tosyl-2-aryl-1,2,5,6-tetrahydropyridine intermediates took place smoothly in ...

A series of new ceritinib analogs by extensive functionalization of the tail piperidine ring with various phosphamides and carbamates have been synthesized. All the ceritinib derivatives were evaluated for their cytotoxic activities against H2228 cell line. From the activity profile obtained, th...

A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using cerium(IV) triflate as a catalyst is described. In most cases, the piperidine precipitates out of the...

The targeting of protein kinases and phosphatases is fundamental to their roles as cellular regulators. The type one serine/threonine protein phosphatase (PP1) is enriched in the nucleus, yet few nuclear PP1 targeting subunits have been described and characterized. Here we show that the human pr...

SummaryCircular RNAs (circRNAs) generated via back-splicing are enhanced by flanking complementary sequences. Expression levels of circRNAs vary under different conditions, suggesting participation of protein factors in their biogenesis. Using genome-wide siRNA screening that targets all human u...