Arylnickel(II) phosphine complexes containing substituted N-O bidentate ligands, of the type [NiR(N-O)L][N-O = 4-nitropyridine-2-carboxylate (4-NO2-pyca), R = o-tolyl, L = PPh3; N-O = 2-pyrazinecarboxylate (pyzca), R = o-tolyl, L = PPh3; and N-O = 4-methoxypyridine-2-carboxylate (4-MeO-pyca), R ...

Transition metal catalysed reactions of CO and ethene can lead to a variety of products ranging from small molecules to perfectly alternating long chain polyketones. In this review, we discuss the formation of small molecules with chain lengths up to 12 C atoms. Palladium based complexes of mono...

The preparation and the characterization of palladium(II) neutral dichloro complexes [PdCl2(P^P′)] 1a–d and cationic disolvento complexes [Pd(P^P′)(H2O)2](OTf)2 3a–d containing non-symmetrical Cs-symmetrical diphosphines are reported.Terpolymerization of ethene, propene and carbon monoxide w...

The alternating copolymerization of carbon monoxide and olefins is a reaction that transition metal complexes, generally containing palladium, catalyze in different phase variation systems. The polyketone products are not only low cost thermal plastics that can be made but also polymeric materia...

[PdCl2(dppb)] is highly active in the catalytic CO-ethene copolymerization in H2O–H(CH2)nCOOH (n = 0, 1 or 2). The influence on the productivity, the limiting viscosity number and the average viscosity molecular weight MW¯v of the following reaction conditions is investigated: (i) solvent comp...

Stereoselective alternating copolymerization of carbon monoxide with various alkenes is reviewed. Using Pd(II) complexes of chiral ligands, completely alternating, isotactic, and enantioselective copolymerizations have been achieved from aliphatic 1-alkenes and from vinylarenes. Alternating copo...

The [PdCl2(dppf)] complex efficiently catalyzes the terpolymerization of propene and ethene with carbon monoxide in HCOOH–H2O as a solvent, when H2O concentration ranges between 50 and 65 molar %. The productivity, the melting temperature and the viscosity average molecular weight of the terpol...

The title complex is highly active and selective for the alternating copolymerisation of carbon monoxide and ethene in CH3COOH–H2O as a solvent. Under typical reaction conditions, 90 °C, 4.5 MPa, CO/ethene = 1/1, the productivity passes through a maximum of 15,500 gPK (gPd h)−1 when the concen...

The copolymerization of ethene with carbon monoxide catalyzed by [Pd(OAc)2(dppp)] in an aprotic solvent such as 1,4-dioxane or nitromethane is efficiently promoted both by H2O and HCOOH and yields a perfectly alternating polyketone (PK). The influence of the concentration of the promoters, press...

The alternating copolymerization of carbon monoxide with ethene is efficiently accomplished using [PdCl2(dppf)] as catalyst precursor in H2O–HCOOH as a solvent. At 90 °C, under 4.5 MPa of total pressure with the monomers in the ratio 1/1, the productivity passes through a maximum of 18,100 gPK...

Acenaphthylene units work as a useful platform for the synthesis of polycyclic aromatic hydrocarbons (PAH). Three 1,2-diarylacenaphthylene derivatives (9-phenanthryl, 7-t-butyl-2-pyrenyl and 2-naphthyl) were prepared by Suzuki-Miyaura coupling of 1,2-dibromoacenaphthylene with the corresponding ...

The tumor-initiating activities of benzo[a]fluoranthene (BaF), benzo[b]fluoranthene (BbF), naphtho[1,2-b]fluoranthene (NbF) and naphtho[2,1-a]fluoranthene (NaF) were evaluated on the skin of female CD-1 mice. Each of these polycyclic aromatic hydrocarbons was assayed at total initiation doses of...

The Sonogashira coupling of 2-ethynyl, 4-ethynyl and 2,7-diethynyl derivatives of 1,8-bis(dimethylamino)naphthalene (proton sponge) with 1-iodo- and 1,8-diiodonaphthalenes has been studied. The reaction of the above alkynes with 1-iodonaphthalene gave the expected naphthylethynyl derivatives of ...

An efficient method for incorporation of the cyanomethyl fragment into the benzene ring of bi- and tricyclic fluoroquinolones through the nucleophilic substitution of a fluorine atom with carbanions derived from CH-active cyanoacetates, followed by an acidic hydrolysis of the reaction intermedia...

The endothelin axis and in particular the two receptor subtypes, ETA and ETB, are under investigation for the treatment of various diseases such as pulmonary arterial hypertension, fibrosis, renal failure and cancer. Previous work in our lab has shown that 1,3,6-trisubstituted-4-oxo-1,4-dihydroq...

Acetylcholinesterase (AChE) is the key enzyme targeted in Alzheimer's disease (AD) therapy, nevertheless butyrylcholinesterase (BuChE) has been drawing attention due to its role in the disease progression. Thus, we aimed to synthesize novel cholinesterases inhibitors considering structural ...

The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promisi...

Lithiation of N-(benzotriazol-1-ylmethyl)benzamide or N-(benzotriazol-1-ylmethyl)-2,2-dimethylbutyramide, readily prepared from the corresponding amides, formaldehyde and benzotriazole, followed by quenching with various electrophiles, such as alkyl halides, ketones or ester, gives the correspon...

A total of 48 methamphetamine hydrochloride samples from eight seizures were analyzed using gas chromatography–mass spectrometry (GC–MS) and gas chromatography with a flame ionization detector (GC–FID).Major impurities detected include 1,2-dimethyl-3-phenylaziridine, ephedrine/pseudoephedrine...

Enteric methane constitutes an energy loss for the animal and contributes to global warming and climate change. Stearidonic acid (SDA; C18:4n-3), a highly polyunsaturated n-3 fatty acid, could have potential to reduce methane production. Effects of increasing levels of SDA on methane production ...