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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Manufacturer/High quality/Best price/In stock

Cas:119193-19-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

(3R,4R)-3,4-DiMethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (S)-Triphenylmethoxymethyloxirane

Cas:119193-19-0

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

(+)-(3R, 4R) -3, 4-Dimethyl-4- (3-Hydroxyphenyl) Piperidine

Cas:119193-19-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-[(3R,4R)-3,4-Dimethyl-4-piperidinyl]-phenol

Cas:119193-19-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Manufacturer/High quality/Best price/In stock

Cas:119193-19-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 119193-19-0 with best quality

Cas:119193-19-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Names Top quality (3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine CAS No 119193-19-0 MF C13H19NO

Alvimopan Intermediates CAS: 119193-19-0

Cas:119193-19-0

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidineCAS NO.: 119193-19-0

Cas:119193-19-0

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine 119193-19-0

Cas:119193-19-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE CAS:119193-19-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specia

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE CAS:119193-19-0

Cas:119193-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine CAS NO.119193-19-0

Cas:119193-19-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(S)-Triphenylmethoxymethyloxirane

Cas:119193-19-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name (3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Molecular Structure Molecular Formula C13H19NO Molec

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Price(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:0

Negotiable

Type:Trading Company

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYP

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(3R,4R)-3-(3,4-Dimethyl-4-piperidinyl)phenol

Cas:119193-19-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine

Cas:119193-19-0

Min.Order:0

Negotiable

Type:Other

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE

Cas:119193-19-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Synthetic route

(3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester
145678-86-0

(3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
With hydrogen bromide In acetic acid Reflux;88%
With sodium hydroxide; hydrogen bromide; acetic acid 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h; Yield given. Multistep reaction;
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine
149655-33-4

(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
With hydrogen bromide In acetic acid for 18h; Heating; Yield given;
With hydrogen bromide; acetic acid Heating;
C9H16NO3SBr
951240-63-4

C9H16NO3SBr

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C
2.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
3.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
4.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
5.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
6.1: n-butyllithium / tetrahydrofuran / -15 °C
6.2: tetrahydrofuran / -50 °C
7.1: sodium borohydride / methanol
8.1: phenyl chloroformate / toluene
9.1: hydrogen bromide; acetic acid / Heating
View Scheme
C13H25NO6SBrP
951240-64-5

C13H25NO6SBrP

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
2.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
3.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
4.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
5.1: n-butyllithium / tetrahydrofuran / -15 °C
5.2: tetrahydrofuran / -50 °C
6.1: sodium borohydride / methanol
7.1: phenyl chloroformate / toluene
8.1: hydrogen bromide; acetic acid / Heating
View Scheme
C10H18NO2SBr
951240-65-6

C10H18NO2SBr

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
2.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
3.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
4.1: n-butyllithium / tetrahydrofuran / -15 °C
4.2: tetrahydrofuran / -50 °C
5.1: sodium borohydride / methanol
6.1: phenyl chloroformate / toluene
7.1: hydrogen bromide; acetic acid / Heating
View Scheme
C17H25O3SN
951240-66-7

C17H25O3SN

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
2.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
3.1: n-butyllithium / tetrahydrofuran / -15 °C
3.2: tetrahydrofuran / -50 °C
4.1: sodium borohydride / methanol
5.1: phenyl chloroformate / toluene
6.1: hydrogen bromide; acetic acid / Heating
View Scheme
C13H17ON
951240-71-4

C13H17ON

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
2.1: n-butyllithium / tetrahydrofuran / -15 °C
2.2: tetrahydrofuran / -50 °C
3.1: sodium borohydride / methanol
4.1: phenyl chloroformate / toluene
5.1: hydrogen bromide; acetic acid / Heating
View Scheme
C14H19ON
220503-22-0

C14H19ON

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / -15 °C
1.2: tetrahydrofuran / -50 °C
2.1: sodium borohydride / methanol
3.1: phenyl chloroformate / toluene
4.1: hydrogen bromide; acetic acid / Heating
View Scheme
C15H21ON

C15H21ON

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium borohydride / methanol
2: phenyl chloroformate / toluene
3: hydrogen bromide; acetic acid / Heating
View Scheme
C9H15NO4S

C9H15NO4S

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 1.68 g / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / 0 °C
2.1: bromine / CH2Cl2 / 0.5 h / 0 °C
3.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C
4.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C
5.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C
6.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
7.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
8.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
9.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
10.1: n-butyllithium / tetrahydrofuran / -15 °C
10.2: tetrahydrofuran / -50 °C
11.1: sodium borohydride / methanol
12.1: phenyl chloroformate / toluene
13.1: hydrogen bromide; acetic acid / Heating
View Scheme
C9H15NO3S
951240-61-2

C9H15NO3S

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: bromine / CH2Cl2 / 0.5 h / 0 °C
2.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C
3.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C
4.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C
5.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
6.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
7.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
8.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
9.1: n-butyllithium / tetrahydrofuran / -15 °C
9.2: tetrahydrofuran / -50 °C
10.1: sodium borohydride / methanol
11.1: phenyl chloroformate / toluene
12.1: hydrogen bromide; acetic acid / Heating
View Scheme
C9H15NO3SBr2

C9H15NO3SBr2

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C
2.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C
3.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C
4.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
5.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
6.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
7.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
8.1: n-butyllithium / tetrahydrofuran / -15 °C
8.2: tetrahydrofuran / -50 °C
9.1: sodium borohydride / methanol
10.1: phenyl chloroformate / toluene
11.1: hydrogen bromide; acetic acid / Heating
View Scheme
C9H14NO3SBr
951240-62-3

C9H14NO3SBr

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C
2.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C
3.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C
4.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
5.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
6.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
7.1: n-butyllithium / tetrahydrofuran / -15 °C
7.2: tetrahydrofuran / -50 °C
8.1: sodium borohydride / methanol
9.1: phenyl chloroformate / toluene
10.1: hydrogen bromide; acetic acid / Heating
View Scheme
3-methoxyphenylboronic acid
10365-98-7

3-methoxyphenylboronic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C
2.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C
3.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h
4.1: n-butyllithium / tetrahydrofuran / -15 °C
4.2: tetrahydrofuran / -50 °C
5.1: sodium borohydride / methanol
6.1: phenyl chloroformate / toluene
7.1: hydrogen bromide; acetic acid / Heating
View Scheme
(+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine
132697-07-5

(+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phenyl chloroformate / toluene
2: hydrogen bromide; acetic acid / Heating
View Scheme
Multi-step reaction with 2 steps
1: 1) Proton sponge, vinyl chloroformate, 2) HCl gas / 1) 1,2-dichloroethane, reflux, 5 h, 2) EtOH, reflux, 3 h
2: aq. HBr / acetic acid / 18 h / Heating
View Scheme
(3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine
143919-34-0

(3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / toluene / 2 h / Heating
2: 1.) 48percent HBr, glacial AcOH, 2.) aq. NaOH / 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol / 25 - 35 °C
2.1: HO-
2.2: 2 h / Reflux
3.1: hydrogen bromide / acetic acid / Reflux
View Scheme
(3RS,4SR)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

(3RS,4SR)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / methanol / 3 h / 25 °C
2: 97 percent / toluene / 2 h / Heating
3: 1.) 48percent HBr, glacial AcOH, 2.) aq. NaOH / 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h
View Scheme
C20H23NO3

C20H23NO3

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid for 18h; Heating / reflux;
Stage #2: With sodium hydroxide; water at 10 - 30℃; for 1h; pH=1.7;
n/a
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid In water at 10 - 60℃; for 18h; Heating / reflux;
Stage #2: With sodium hydroxide In water at 10 - 30℃; for 1h; pH=< 1.7;
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid In water at 50 - 60℃; for 18h; Heating / reflux;
Stage #2: With sodium hydroxide In water at 10 - 60℃; for 1h; pH=< 1.7;
(R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine
143919-32-8

(R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
2.1: sodium tetrahydroborate / methanol / 25 - 35 °C
3.1: ethanol / 25 - 35 °C
4.1: HO-
4.2: 2 h / Reflux
5.1: hydrogen bromide / acetic acid / Reflux
View Scheme
(3R,4S)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

(3R,4S)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol / 25 - 35 °C
2.1: ethanol / 25 - 35 °C
3.1: HO-
3.2: 2 h / Reflux
4.1: hydrogen bromide / acetic acid / Reflux
View Scheme
C17H27NO*C20H18O8
1184775-81-2, 145415-19-6

C17H27NO*C20H18O8

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: HO-
1.2: 2 h / Reflux
2.1: hydrogen bromide / acetic acid / Reflux
View Scheme
3-(isopropyloxy)phenylbromide
131738-73-3

3-(isopropyloxy)phenylbromide

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / -65 °C
2.1: ethyl acetate / 25 - 35 °C
3.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate
4.1: decalin / 190 - 195 °C
5.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
6.1: sodium tetrahydroborate / methanol / 25 - 35 °C
7.1: ethanol / 25 - 35 °C
8.1: HO-
8.2: 2 h / Reflux
9.1: hydrogen bromide / acetic acid / Reflux
View Scheme
1,3-dimethyl-4-piperidinone
4629-80-5

1,3-dimethyl-4-piperidinone

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / -65 °C
2.1: ethyl acetate / 25 - 35 °C
3.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate
4.1: decalin / 190 - 195 °C
5.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
6.1: sodium tetrahydroborate / methanol / 25 - 35 °C
7.1: ethanol / 25 - 35 °C
8.1: HO-
8.2: 2 h / Reflux
9.1: hydrogen bromide / acetic acid / Reflux
View Scheme
1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol
145340-44-9

1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: ethyl acetate / 25 - 35 °C
2.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate
3.1: decalin / 190 - 195 °C
4.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
5.1: sodium tetrahydroborate / methanol / 25 - 35 °C
6.1: ethanol / 25 - 35 °C
7.1: HO-
7.2: 2 h / Reflux
8.1: hydrogen bromide / acetic acid / Reflux
View Scheme
cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester

cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate
2.1: decalin / 190 - 195 °C
3.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
4.1: sodium tetrahydroborate / methanol / 25 - 35 °C
5.1: ethanol / 25 - 35 °C
6.1: HO-
6.2: 2 h / Reflux
7.1: hydrogen bromide / acetic acid / Reflux
View Scheme
C19H29NO4

C19H29NO4

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: decalin / 190 - 195 °C
2.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C
3.1: sodium tetrahydroborate / methanol / 25 - 35 °C
4.1: ethanol / 25 - 35 °C
5.1: HO-
5.2: 2 h / Reflux
6.1: hydrogen bromide / acetic acid / Reflux
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine
205999-74-2

4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 25℃;100%
With triethylamine In tetrahydrofuran at 20℃; for 2h;100%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 19h;100%
With triethylamine In tetrahydrofuran for 2h;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-[(3R,4R)-3,4-dimethyl-1-(trifluoromethane)sulfonylpiperidin-4-yl]phenyl trifluoromethanesulfonate

3-[(3R,4R)-3,4-dimethyl-1-(trifluoromethane)sulfonylpiperidin-4-yl]phenyl trifluoromethanesulfonate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃;100%
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl (3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanoate
170098-39-2

methyl (3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanoate

Conditions
ConditionsYield
In tetrahydrofuran at 40 - 45℃; for 4h;98%
In tetrahydrofuran at 45℃; for 4h;96%
In tetrahydrofuran at 40 - 45℃; for 18.5 - 19.5h;
Stage #1: 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol; acrylic acid methyl ester In tetrahydrofuran at 40 - 45℃; for 18.5 - 19.5h;
Stage #2: With hyflo supercel
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-oxocyclohex-1-en-1-yl 4-methylbenzenesulfonate
77708-66-8

3-oxocyclohex-1-en-1-yl 4-methylbenzenesulfonate

1-(3'-oxo-1'-cyclohexenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine
205999-78-6

1-(3'-oxo-1'-cyclohexenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 8h; Heating;90%
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-oxocyclopent-1-en-1-yl 4-methylbenzenesulfonate
205999-79-7

3-oxocyclopent-1-en-1-yl 4-methylbenzenesulfonate

1-(3'-oxo-1'-cyclopentenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine
205999-80-0

1-(3'-oxo-1'-cyclopentenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 8h; Heating;90%
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-cyclohexyl-3-hydroxypropyl (4-bromobenzene)sulfonate

3-cyclohexyl-3-hydroxypropyl (4-bromobenzene)sulfonate

(+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine
119193-09-8

(+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,2-dimethoxyethane for 8h; Heating;82%
ethyl N-[(2S)-2-benzyl-3-{[(4-bromophenyl)sulfonyl]oxy}propanoyl]glycinate
1352995-69-7

ethyl N-[(2S)-2-benzyl-3-{[(4-bromophenyl)sulfonyl]oxy}propanoyl]glycinate

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

ethyl N-{(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl}glycinate

ethyl N-{(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl}glycinate

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,2-dimethoxyethane at 25 - 85℃; Reflux;80%
phenylacetaldehyde
122-78-1

phenylacetaldehyde

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol
654647-95-7

3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol

Conditions
ConditionsYield
With pyridine; borane In ethanol at 25℃;71%
2-Benzylacrylic acid ethyl ester
20593-63-9

2-Benzylacrylic acid ethyl ester

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

C25H33NO3*ClH

C25H33NO3*ClH

Conditions
ConditionsYield
Stage #1: 2-Benzylacrylic acid ethyl ester; 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol In toluene for 4h; Reflux;
Stage #2: With hydrogenchloride In ethanol; toluene at 20℃; pH=1;
34.7%
methyl 2-benzylacrylate
3070-71-1

methyl 2-benzylacrylate

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoic acid methyl ester hydrochloride

(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoic acid methyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: methyl 2-benzylacrylate; 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol In toluene for 4h; Reflux;
Stage #2: With hydrogenchloride In methanol; toluene at 20℃; pH=1;
29.6%
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

2-benzylacrylic acid butyl ester

2-benzylacrylic acid butyl ester

(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoic acid butyl ester hydrochloride

(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoic acid butyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol; 2-benzylacrylic acid butyl ester In toluene for 4h; Reflux;
Stage #2: With hydrogenchloride In butan-1-ol at 20℃; pH=1;
24%
3-(2-thienyl)-propanoic acid chloride
5834-04-8

3-(2-thienyl)-propanoic acid chloride

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-3-thiophen-2-yl-propan-1-one

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-3-thiophen-2-yl-propan-1-one

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 90℃; for 2h;
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature;
5-methylhexanoyl chloride
5699-78-5

5-methylhexanoyl chloride

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-5-methyl-hexan-1-one

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-5-methyl-hexan-1-one

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature;
N-(2-benzoylethyl)-N,N,N-trimethylammonium iodide
5724-15-2

N-(2-benzoylethyl)-N,N,N-trimethylammonium iodide

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

(+)-1-(1-phenyl-1-oxoprop-3-yl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine

(+)-1-(1-phenyl-1-oxoprop-3-yl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide for 4h; Ambient temperature;
(-)-(1S)-1-(tert-Butyldimethylsiloxy)-1-cyclohexyl-3-hydroxypropane
132621-42-2

(-)-(1S)-1-(tert-Butyldimethylsiloxy)-1-cyclohexyl-3-hydroxypropane

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-{(3R,4R)-1-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propyl]-3,4-dimethyl-piperidin-4-yl}-phenol

3-{(3R,4R)-1-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-cyclohexyl-propyl]-3,4-dimethyl-piperidin-4-yl}-phenol

Conditions
ConditionsYield
With sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine 1) CH2Cl2, 0 deg C, 30 min, 2) DMF, reflux, 1 h; Multistep reaction;
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

Hexanoyl chloride
142-61-0

Hexanoyl chloride

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-hexan-1-one

1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-hexan-1-one

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature;
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

N,N,N-trimethyl-3-cyclohexyl-3-oxopropanaminium iodide

N,N,N-trimethyl-3-cyclohexyl-3-oxopropanaminium iodide

1-Cyclohexyl-3-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-propan-1-one

1-Cyclohexyl-3-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-propan-1-one

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide for 3h; Ambient temperature;
2-Benzylacrylic acid ethyl ester
20593-63-9

2-Benzylacrylic acid ethyl ester

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

4-(3-hydroxyphenyl)-3(R),4(R)-dimethyl-2'(SR)-(phenylmethyl)-1-piperidinepropanoic acid ethyl ester

4-(3-hydroxyphenyl)-3(R),4(R)-dimethyl-2'(SR)-(phenylmethyl)-1-piperidinepropanoic acid ethyl ester

Conditions
ConditionsYield
In methanol for 240h; Ambient temperature;8.0 g
Benzofuran-2-carboxylic acid
496-41-3

Benzofuran-2-carboxylic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-((3R,4R)-1-Benzofuran-2-ylmethyl-3,4-dimethyl-piperidin-4-yl)-phenol

3-((3R,4R)-1-Benzofuran-2-ylmethyl-3,4-dimethyl-piperidin-4-yl)-phenol

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
benzo[b]thiophene-2-carboxylic acid
6314-28-9

benzo[b]thiophene-2-carboxylic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-((3R,4R)-1-Benzo[b]thiophen-2-ylmethyl-3,4-dimethyl-piperidin-4-yl)-phenol

3-((3R,4R)-1-Benzo[b]thiophen-2-ylmethyl-3,4-dimethyl-piperidin-4-yl)-phenol

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

RTI-5989-1

RTI-5989-1

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-[(3R,4R)-3,4-Dimethyl-1-((Z)-3-phenyl-allyl)-piperidin-4-yl]-phenol

3-[(3R,4R)-3,4-Dimethyl-1-((Z)-3-phenyl-allyl)-piperidin-4-yl]-phenol

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
(E)-3-(2-methylphenyl)acrylic acid
939-57-1, 2373-76-4, 41397-71-1

(E)-3-(2-methylphenyl)acrylic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

RTI 5989-25

RTI 5989-25

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
trans-2-chlorocinnamic acid
704-96-1

trans-2-chlorocinnamic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

RTI-5989-23

RTI-5989-23

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-[(3R,4R)-3,4-Dimethyl-1-((1R,2S)-2-phenyl-cyclopropylmethyl)-piperidin-4-yl]-phenol

3-[(3R,4R)-3,4-Dimethyl-1-((1R,2S)-2-phenyl-cyclopropylmethyl)-piperidin-4-yl]-phenol

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
trans-2-phenylcyclopropane-1-carboxylic acid
939-90-2

trans-2-phenylcyclopropane-1-carboxylic acid

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

3-[(3R,4R)-3,4-Dimethyl-1-((1S,2S)-2-phenyl-cyclopropylmethyl)-piperidin-4-yl]-phenol

3-[(3R,4R)-3,4-Dimethyl-1-((1S,2S)-2-phenyl-cyclopropylmethyl)-piperidin-4-yl]-phenol

Conditions
ConditionsYield
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
BOC-glycine
4530-20-5

BOC-glycine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

{2-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

{2-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran for 1h; Ambient temperature;
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
119193-19-0

3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

{(S)-1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester

{(S)-1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran for 1h; Ambient temperature;

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