DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryChemical Names Top quality (3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine CAS No 119193-19-0 MF C13H19NO
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inquiry(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE CAS:119193-19-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specia
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Name (3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Molecular Structure Molecular Formula C13H19NO Molec
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYP
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inquiry(3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With hydrogen bromide In acetic acid Reflux; | 88% |
With sodium hydroxide; hydrogen bromide; acetic acid 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h; Yield given. Multistep reaction; |
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With hydrogen bromide In acetic acid for 18h; Heating; Yield given; | |
With hydrogen bromide; acetic acid Heating; |
C9H16NO3SBr
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C 2.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 3.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 4.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 5.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 6.1: n-butyllithium / tetrahydrofuran / -15 °C 6.2: tetrahydrofuran / -50 °C 7.1: sodium borohydride / methanol 8.1: phenyl chloroformate / toluene 9.1: hydrogen bromide; acetic acid / Heating View Scheme |
C13H25NO6SBrP
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 2.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 3.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 4.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 5.1: n-butyllithium / tetrahydrofuran / -15 °C 5.2: tetrahydrofuran / -50 °C 6.1: sodium borohydride / methanol 7.1: phenyl chloroformate / toluene 8.1: hydrogen bromide; acetic acid / Heating View Scheme |
C10H18NO2SBr
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 2.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 3.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 4.1: n-butyllithium / tetrahydrofuran / -15 °C 4.2: tetrahydrofuran / -50 °C 5.1: sodium borohydride / methanol 6.1: phenyl chloroformate / toluene 7.1: hydrogen bromide; acetic acid / Heating View Scheme |
C17H25O3SN
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 2.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 3.1: n-butyllithium / tetrahydrofuran / -15 °C 3.2: tetrahydrofuran / -50 °C 4.1: sodium borohydride / methanol 5.1: phenyl chloroformate / toluene 6.1: hydrogen bromide; acetic acid / Heating View Scheme |
C13H17ON
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 2.1: n-butyllithium / tetrahydrofuran / -15 °C 2.2: tetrahydrofuran / -50 °C 3.1: sodium borohydride / methanol 4.1: phenyl chloroformate / toluene 5.1: hydrogen bromide; acetic acid / Heating View Scheme |
C14H19ON
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran / -15 °C 1.2: tetrahydrofuran / -50 °C 2.1: sodium borohydride / methanol 3.1: phenyl chloroformate / toluene 4.1: hydrogen bromide; acetic acid / Heating View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium borohydride / methanol 2: phenyl chloroformate / toluene 3: hydrogen bromide; acetic acid / Heating View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: 1.68 g / triethylsilane; BF3*OEt2 / CH2Cl2 / 3 h / 0 °C 2.1: bromine / CH2Cl2 / 0.5 h / 0 °C 3.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C 4.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C 5.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C 6.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 7.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 8.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 9.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 10.1: n-butyllithium / tetrahydrofuran / -15 °C 10.2: tetrahydrofuran / -50 °C 11.1: sodium borohydride / methanol 12.1: phenyl chloroformate / toluene 13.1: hydrogen bromide; acetic acid / Heating View Scheme |
C9H15NO3S
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: bromine / CH2Cl2 / 0.5 h / 0 °C 2.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C 3.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C 4.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C 5.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 6.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 7.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 8.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 9.1: n-butyllithium / tetrahydrofuran / -15 °C 9.2: tetrahydrofuran / -50 °C 10.1: sodium borohydride / methanol 11.1: phenyl chloroformate / toluene 12.1: hydrogen bromide; acetic acid / Heating View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: 0.73 g / triethylamine / CH2Cl2 / 0.5 h / 0 °C 2.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C 3.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C 4.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 5.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 6.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 7.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 8.1: n-butyllithium / tetrahydrofuran / -15 °C 8.2: tetrahydrofuran / -50 °C 9.1: sodium borohydride / methanol 10.1: phenyl chloroformate / toluene 11.1: hydrogen bromide; acetic acid / Heating View Scheme |
C9H14NO3SBr
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: (R)-1-Me-3,3-Ph-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane-N,N-diethylaniline complex / tetrahydrofuran / 16 h / 0 - 20 °C 2.1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / 0 - 20 °C 3.1: CuBr*SMe2 / tetrahydrofuran; diethyl ether / -40 - -35 °C 4.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 5.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 6.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 7.1: n-butyllithium / tetrahydrofuran / -15 °C 7.2: tetrahydrofuran / -50 °C 8.1: sodium borohydride / methanol 9.1: phenyl chloroformate / toluene 10.1: hydrogen bromide; acetic acid / Heating View Scheme |
3-methoxyphenylboronic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium carbonate / Pd(Ph3P)4 / ethanol; toluene; H2O / 0.75 h / 80 °C 2.1: anisole; triflic acid / CH2Cl2 / 0.5 h / 0 °C 3.1: sodium cyanoborohydride / acetonitrile; H2O / 0.5 h 4.1: n-butyllithium / tetrahydrofuran / -15 °C 4.2: tetrahydrofuran / -50 °C 5.1: sodium borohydride / methanol 6.1: phenyl chloroformate / toluene 7.1: hydrogen bromide; acetic acid / Heating View Scheme |
(+)-1,3(R),4(R)-Trimethyl-4-(3-methoxyphenyl)piperidine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phenyl chloroformate / toluene 2: hydrogen bromide; acetic acid / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 1) Proton sponge, vinyl chloroformate, 2) HCl gas / 1) 1,2-dichloroethane, reflux, 5 h, 2) EtOH, reflux, 3 h 2: aq. HBr / acetic acid / 18 h / Heating View Scheme |
(3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / toluene / 2 h / Heating 2: 1.) 48percent HBr, glacial AcOH, 2.) aq. NaOH / 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h View Scheme | |
Multi-step reaction with 3 steps 1.1: ethanol / 25 - 35 °C 2.1: HO- 2.2: 2 h / Reflux 3.1: hydrogen bromide / acetic acid / Reflux View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaBH4 / methanol / 3 h / 25 °C 2: 97 percent / toluene / 2 h / Heating 3: 1.) 48percent HBr, glacial AcOH, 2.) aq. NaOH / 1.) reflux, 19 h, 2.) MeOH, pH 10.3-10.5, 25 deg C, 1.5 h View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid for 18h; Heating / reflux; Stage #2: With sodium hydroxide; water at 10 - 30℃; for 1h; pH=1.7; | n/a |
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid In water at 10 - 60℃; for 18h; Heating / reflux; Stage #2: With sodium hydroxide In water at 10 - 30℃; for 1h; pH=< 1.7; | |
Stage #1: C20H23NO3 With hydrogen bromide; acetic acid In water at 50 - 60℃; for 18h; Heating / reflux; Stage #2: With sodium hydroxide In water at 10 - 60℃; for 1h; pH=< 1.7; |
(R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 2.1: sodium tetrahydroborate / methanol / 25 - 35 °C 3.1: ethanol / 25 - 35 °C 4.1: HO- 4.2: 2 h / Reflux 5.1: hydrogen bromide / acetic acid / Reflux View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 25 - 35 °C 2.1: ethanol / 25 - 35 °C 3.1: HO- 3.2: 2 h / Reflux 4.1: hydrogen bromide / acetic acid / Reflux View Scheme |
C17H27NO*C20H18O8
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: HO- 1.2: 2 h / Reflux 2.1: hydrogen bromide / acetic acid / Reflux View Scheme |
3-(isopropyloxy)phenylbromide
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: n-butyllithium / tetrahydrofuran / -65 °C 2.1: ethyl acetate / 25 - 35 °C 3.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate 4.1: decalin / 190 - 195 °C 5.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 6.1: sodium tetrahydroborate / methanol / 25 - 35 °C 7.1: ethanol / 25 - 35 °C 8.1: HO- 8.2: 2 h / Reflux 9.1: hydrogen bromide / acetic acid / Reflux View Scheme |
1,3-dimethyl-4-piperidinone
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: n-butyllithium / tetrahydrofuran / -65 °C 2.1: ethyl acetate / 25 - 35 °C 3.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate 4.1: decalin / 190 - 195 °C 5.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 6.1: sodium tetrahydroborate / methanol / 25 - 35 °C 7.1: ethanol / 25 - 35 °C 8.1: HO- 8.2: 2 h / Reflux 9.1: hydrogen bromide / acetic acid / Reflux View Scheme |
1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: ethyl acetate / 25 - 35 °C 2.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate 3.1: decalin / 190 - 195 °C 4.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 5.1: sodium tetrahydroborate / methanol / 25 - 35 °C 6.1: ethanol / 25 - 35 °C 7.1: HO- 7.2: 2 h / Reflux 8.1: hydrogen bromide / acetic acid / Reflux View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: (2S,3S)-di-4-toluoyltartaric acid / ethanol / 20 h / 25 - 35 °C / Resolution of racemate 2.1: decalin / 190 - 195 °C 3.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 4.1: sodium tetrahydroborate / methanol / 25 - 35 °C 5.1: ethanol / 25 - 35 °C 6.1: HO- 6.2: 2 h / Reflux 7.1: hydrogen bromide / acetic acid / Reflux View Scheme |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: decalin / 190 - 195 °C 2.1: n-butyllithium / tetrahydrofuran / 3 h / -60 - -55 °C 3.1: sodium tetrahydroborate / methanol / 25 - 35 °C 4.1: ethanol / 25 - 35 °C 5.1: HO- 5.2: 2 h / Reflux 6.1: hydrogen bromide / acetic acid / Reflux View Scheme |
di-tert-butyl dicarbonate
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 25℃; | 100% |
With triethylamine In tetrahydrofuran at 20℃; for 2h; | 100% |
With triethylamine In tetrahydrofuran at 0 - 20℃; for 19h; | 100% |
With triethylamine In tetrahydrofuran for 2h; |
trifluoromethylsulfonic anhydride
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃; | 100% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃; | 100% |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
acrylic acid methyl ester
methyl (3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanoate
Conditions | Yield |
---|---|
In tetrahydrofuran at 40 - 45℃; for 4h; | 98% |
In tetrahydrofuran at 45℃; for 4h; | 96% |
In tetrahydrofuran at 40 - 45℃; for 18.5 - 19.5h; | |
Stage #1: 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol; acrylic acid methyl ester In tetrahydrofuran at 40 - 45℃; for 18.5 - 19.5h; Stage #2: With hyflo supercel |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
3-oxocyclohex-1-en-1-yl 4-methylbenzenesulfonate
1-(3'-oxo-1'-cyclohexenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran for 8h; Heating; | 90% |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
3-oxocyclopent-1-en-1-yl 4-methylbenzenesulfonate
1-(3'-oxo-1'-cyclopentenyl)-(3R,4R)-dimethyl-(3-hydroxyphenyl)piperidine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran for 8h; Heating; | 90% |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
(+)-1-(3(S)-3-hydroxy-3-cyclohexylpropyl)-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,2-dimethoxyethane for 8h; Heating; | 82% |
ethyl N-[(2S)-2-benzyl-3-{[(4-bromophenyl)sulfonyl]oxy}propanoyl]glycinate
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,2-dimethoxyethane at 25 - 85℃; Reflux; | 80% |
phenylacetaldehyde
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol
Conditions | Yield |
---|---|
With pyridine; borane In ethanol at 25℃; | 71% |
2-Benzylacrylic acid ethyl ester
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Stage #1: 2-Benzylacrylic acid ethyl ester; 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol In toluene for 4h; Reflux; Stage #2: With hydrogenchloride In ethanol; toluene at 20℃; pH=1; | 34.7% |
methyl 2-benzylacrylate
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Stage #1: methyl 2-benzylacrylate; 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol In toluene for 4h; Reflux; Stage #2: With hydrogenchloride In methanol; toluene at 20℃; pH=1; | 29.6% |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
Stage #1: 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol; 2-benzylacrylic acid butyl ester In toluene for 4h; Reflux; Stage #2: With hydrogenchloride In butan-1-ol at 20℃; pH=1; | 24% |
3-(2-thienyl)-propanoic acid chloride
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 90℃; for 2h; | |
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature; |
5-methylhexanoyl chloride
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature; |
N-(2-benzoylethyl)-N,N,N-trimethylammonium iodide
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide for 4h; Ambient temperature; |
(-)-(1S)-1-(tert-Butyldimethylsiloxy)-1-cyclohexyl-3-hydroxypropane
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine 1) CH2Cl2, 0 deg C, 30 min, 2) DMF, reflux, 1 h; Multistep reaction; |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Hexanoyl chloride
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In N,N-dimethyl-formamide for 1h; Ambient temperature; |
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide for 3h; Ambient temperature; |
2-Benzylacrylic acid ethyl ester
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
In methanol for 240h; Ambient temperature; | 8.0 g |
Benzofuran-2-carboxylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
benzo[b]thiophene-2-carboxylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
(E)-3-phenylacrylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
cis-cinnamic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
(E)-3-(2-methylphenyl)acrylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
trans-2-chlorocinnamic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
(1S*,2R*)-2-phenylcyclopropane-1-carboxylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
trans-2-phenylcyclopropane-1-carboxylic acid
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With sodium dihydro-bis-(2-methoxyethoxy)aluminate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1.) THF, RT, 1 h, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction; |
BOC-glycine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran for 1h; Ambient temperature; |
t-Boc-L-valine
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol
Conditions | Yield |
---|---|
With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran for 1h; Ambient temperature; |
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