dl-2,6-Diamino-4-hexynoic acid, a lysine analog, was synthesized by the interaction of N-(4-chloro-2-butynyl)phthalimide and the sodium salt of ethyl acetamidomalonate. A two-step hydrolysis yielded the desired acetylenic diamino acid. dl-Lysine, identical with the known amino acid, was obtained...

The reaction of 1,4-dichloro-2-butyne with potassium phthalimide yielded N-(4-chloro-2-butynyl)phthalimide, which was subsequently condensed with ethyl acetamidomalonate. Acid hydrolysis of the condensation product gave 2,6-diamino-4-hexynoic acid. Growth inhibition of Leuconostoc dextranicum 80...

5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These...

Different alkyl amide (15a–l) and alkyl amine (16a–e) derivatives of 7,8-dimethoxy-3-hydroxy-2-(4-methoxyphenyl)benzopyran-4-one were synthesized and evaluated for their anticancer activity against five different cancer cell lines using SRB assay. Compounds 15e, 15i, 15j and 16a–e showed sign...

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. Increasing evidence has shown that β-amyloid protein (Aβ) production is the key pathological cause of AD. 7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one (AO-2), a natural diarylheptanoid, is prev...

In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to be more persuasive and selective approach towards designing of antiamoebic ag...

2-(2-Methoxyethoxy)-toluene and 2-(2-dimethylaminoethoxy)-toluene have been lithiated using sec-BuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles, including but-1-ene oxide, leading to a new synthesis of 2-ethylchroman.

Metabolism of tamoxifen N-oxide by phenobarbitone-induced rat liver microsomes gave a major metabolite which was identified as E-1-[4-(2-dimethylaminoethoxy)phenyl]-1,2-diphenyl-1-buten-3-ol N-oxide (α-hydroxytamoxifen N-oxide) by comparison of mass spectral properties with synthetic material. ...

A 9-day repeated cutaneous toxicity study in the New Zealand White rabbit was conducted using 6-h occluded contact with 0 (water control), 50, 250 and 500 mg dimethylaminoethoxyethanol (DMEE)/kg. There were no clinical signs, and no effects on body weight, food consumption or serum chemistry. He...

Malondialdehyde (MDA), 4-Hydroxy-2-(E)-Nonenal (HNE) and 4-Hydroxy-2-(E)-Hexenal (HHE) are reactive aldehydes found in foods and are formed due to decomposition of polyunsaturated fatty acid hydroperoxides. In the present study, sixteen food categories were analyzed for the aforementioned aldehy...

A Pd-catalyzed asymmetric decarboxylative [4 + 2] cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach. The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and w...

Hydrazones of type 4-((E)-2- benzylidenehydrazinyl)benzonitriles were obtained by the condensation of 4-cyanophenylhydrazine hydrochloride separately with 4-diethylaminosalicylaldehyde(M1), 5-nitrosalicylaldehyde(M2), 5-chlorosalicylaldehyde(M3), 2-hydroxylnaphthylaldehyde(M4), 2-acetylpyridine(...

Preeclampsia (PE) is a leading cause of pregnancy complications, affecting 3–7% of pregnant women worldwide. The pathophysiology of preeclampsia involves a redox imbalance, oxidative stress and a reduced nitric oxide (NO) bioavailability. The molecular and cellular mechanisms leading to the dys...

The reaction of [Cr(urea)6]Cl3·3H2O with H2salen (H2salen = N,N′-ethylenebis(salicylaldimine) in water–methanol mixture (40:60 v/v) under reflux yielded the complex bis{N-(2-aminoethyl)salicylaldiminato}chromium(III) chloride monohydrate, [Cr(aesaldmn)2]Cl·H2O. The complex was characterized ...

Several N-enamine derivatives of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedione have been synthesized in the reaction of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedione with various β-dicarbonyl compounds. The obtained derivatives exhibited cytotoxicity in vitro comparable or lower to that...

The title complexes trans(O)-(Co(aeida)Cl(H2O)] (A) and mer(N)-[CoCl (i-dtma)(H2O)] ClO4 (B) crystallize as a conglomerate (H2aeida = N-(2-aminoethyl)-N-(carboxymethyl)glycine, Hi-dtma = N,N-bis(2-aminoethyl)glycine). The X-ray crystallographic analysis shows that single crystals of A and B are ...

A potentially heptadentate ligand H3L (N,N′-bis(2-hydroxybenzyl)-1,3-bis[(2-aminoethyl)amino]-2-propanol) and its two Ni(II) complexes, [Ni(H2L)H2O](H2O)3ClO4 (1) and [Ni(H2L)(H2O)](H2O)Cl (2) were prepared and characterized. X-ray structural analyses indicate that complex 1 has a distorted oct...

A novel alcohol and phenol containing polyamine ligand H2L (H2L = N,N′-bis(2-hydroxybenzyl)-1,3-bis[(2-aminoethyl) amino]-2-propanol) and its Co(III) and Cu(II) complexes, [CoL]ClO4 (1) and [Cu(H2L)Cl]ClO4 · CH3OH · H2O (2) have been synthesized and characterized. Single crystal X-ray diffrac...

The polydendate bis(phosphino)amine, tris{2-(N,N-bis(diphenylphosphino)aminoethyl}amine 1 has been prepared in a single step from the reaction of tris(2-aminoethyl)amine with six equivalents of PPh2Cl in the presence of NEt3 in THF. Oxidation of 1 with aqueous H2O2, elemental sulfur or grey sele...

The present paper describes the synthesis of a new chemically modified cellulose microfiber through oxidation with sodium periodate and functionalization with N,N′-bis (2-aminoethyl)-1,2-ethanediamine for the fast and selective preconcentration of Cd(II) ions in flow system analysis. The new so...