BackgroundThe RemiPCA SAFE Network was established to set standards and monitor maternal and neonatal outcomes when using remifentanil for labour analgesia. The aim of this analysis was to describe the development of the network standard and to report maternal and neonatal outcome data, includin...

BackgroundDuring labour, remifentanil patient-controlled analgesia is used as an alternative to neuraxial analgesia. Remifentanil is associated with hypoventilation and respiratory depression but the frequency of serious maternal and neonatal adverse events is unknown. The aim of this study was ...

SummaryObjectivesTo identify and collect clinical isolates of multidrug resistant Gram negative bacteria and to perform antimicrobial susceptibility testing using an extended panel of antibiotics including tigecycline, colistin, aztreonam, piperacillin/tazobactam and ampicillin/sulbactam.

Macrolides have been used in the treatment of infectious diseases since the late 1950s. Since that time, a finding of antagonistic action between erythromycin and spiramycin in clinical isolates1 led to evidence of the biochemical mechanism and to the current understanding of inducible or consti...

Infective endocarditis (IE) can be induced by bacteremia attributable to dental procedures. To prevent this disease, prophylactic administration of antimicrobials prior to dental procedures has been recommended in several countries. However, no prospective study has proved its efficacy in a clin...

In our previous study on discovering novel types of CCR3 antagonists, we found a fluoronaphthalene derivative (1) that exhibited potent CCR3 inhibitory activity with an IC50 value of 20 nM. However, compound 1 also inhibited human cytochrome P450 2D6 (CYP2D6) with an IC50 value of 400 nM. In ord...

Modifications to an N-methyl-(quinolin-4-yl)oxypropanamide scaffold were explored to discover leads for developing new radioligands for PET imaging of brain TSPO (translocator protein), a biomarker of neuroinflammation. Whereas contraction of the quinolinyl portion of the scaffold or cyclization...

A compound previously reported to be tetramethylammonium hydroxide monohydrate is re-examined, and actually found to be a heretofore unknown dihydrate. Stoichiometric considerations suggest that this dihydrate is a channel framework clathrate hydrate. Authentic tetramethylammonium hydroxide mono...

At 10–20 K the broad room temperature IR bands of the hydrogen bonded cluster anions in tetramethylammonium fluoride and hydroxide monohydrates and monohydrates-dn are resolved into a number of components. The band patterns are consonant with distortion of formally tetrahedral H4F2O22− and H6O4...

N,N,N-trimethyl-1-adamantylammonium fluoride forms two crystalline hydrates, a trihydrate and a hemihydrate. The IR spectrum of the trihydrate demonstrates the presence of H20 bound by strong electrostatic hydrogen bonds in a framework clathrate structure. The trihydrate can be recrystallized fr...

An equilibrium vapor pressure study of the dissociation of tetraethylammonium fluoride·2.75H2O to the dihydrate demonstrates that hydrogen bonds between H2O and F−, and between H2O and H2O are broken in this process. This conclusion is based on comparison of the observed enthalpy of dissociatio...

Tetramethylammonium fluoride trihydrate and tetrahydrate are framework clathrate hydrates that form at 0°C; once formed these hydrates remain as stable, crystalline solids at 25°C. However, stoichiometric 4:1 and 3:1 mixtures of water and tetramethylammonium fluoride, whether prepared by evapo...

Amino acid conjugation is a route of metabolism for both a variety of xenobiotic carboxylic acids and also bile acids. However, knowledge of the overall enzymology (including multiplicity of enzymes, substrate selectivity, catalytic mechanism, protein structure, polymorphisms, and gene regulatio...

Amino acid conjugation is a route of metabolism for various xenobiotic carboxylic acids and bile acids; however, knowledge of the enzymology (e.g., multiplicity of enzymes, substrate selectivity, catalytic mechanism, and protein structure), polymorphisms, and gene regulation is not as advanced a...

In this study four novel random polymers, comprising benzothiadiazole and benzotriazole as the accepting units and benzodithiophene as the donor unit, were synthesized via Stille polymerization reaction. Moreover, effects of fluorine atom and π bridges on optical, electrochemical and optoelectr...

With the use of N-donor ligands in coordination chemistry receiving significant interest and attention in the last few decades, benzotriazole has emerged as an ideal molecule that provides many synthetic advantages and reliable routes towards polynuclear coordination clusters and coordination po...

With contrast to the traditional techniques of identifying and synthesizing new corrosion inhibitors in wet lab, a prior dry-lab process, followed by a wet-lab process is suggested by using cheminformatics tools. Quantum chemical method is used to explore the relationship between the inhibitor m...

Concurrent acetylation–dispersive liquid–liquid microextraction (DLLME) combined with gas chromatography–mass spectrometry (GC–MS) has been proposed for the sensitive determination of five polar benzotriazolic compounds (1H-benzotriazole, BTri; 4 and 5-methyl-1H-benzotriazole, 4-TTri and 5-T...

The Cu(I) coordination polymer [Cu3(μ3-I)3(μ-btzMe)(NCCH3)]n (btzMe = 1-methyl-1H-benzotriazole) was prepared and characterized by X-Ray diffraction. The compound showed strong green emission upon excitation with wavelengths below 475 nm, with lifetime of 47 μs. The emission was attributed to...

Reaction of nitroarenes 1 with tris(benzotriazol-1-yl)methyl 2 anion afforded para-bis(benzotriazol-1-yl)methylated products 3 which, upon treatment with zinc bromide and hydrochloric acid, yielded the corresponding p-nitroarylaldehydes 4 in good yields.