SummaryOxidative deamination of L-cystine by snake venom L-amino acid oxidase from Crotalus terrificus terrificus was studied. Formation of S-(2-oxo-2-carboxyethylthio)cysteine (OCETC) was shown by ion-exchange chromatography and by its reduction to S-(2-hydroxy-2-carboxyethylthio)cysteine by so...

The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2-(chloromethyl)pyrimidine with carbon monoxide in the presence of palladium acetate and 1,1′-bis(diphenylphosphino)ferrocene is described. The new process uses re...

DABCO catalyzed, highly regioselective γ-addition of β-keto esters has been achieved in the aldol reaction with isatins to afford γ-(3-hydroxy-2-oxindole)-β-keto ester structural framework under metal-free condition. The generality of the method has been demonstrated by screening series of i...

A new ruthenium 2,6-diacetylpyridine complex was synthesized and applied in the atom-economic synthesis of enol esters through Markovnikov-directed addition of carboxylic acids to terminal alkynes. The ruthenium complex [RuCl(dap)(PPh3)2]+BArF− was synthesized from [RuCl2(PPh3)2] and the corresp...

This review summarizes results from the literature concerning the synthesis and chemical reactivity of 4-hydroxy-2(1H)-quinolone as well as its reactions that are reported. Most imaginable reaction types have been successfully applied and used, as many of the synthetized compounds exhibit intere...

Based on the structure of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester (1), which exhibits selective cytotoxicity against a tumorigenic cell line, (2,4-dimethoxyphenyl)-(4-hydroxy-3-methyl-6-phenylbenzofuran-2-yl)-methanone (18m) was designed and synthesized as a biologica...

Human prepro atrial natriuretic factor 26–55, 56–92, and 104–123 as well as human atrial natriuretic factor (4–28) in the present investigation increased renal cortical and medullary cyclic GMP levels and maximally enhanced particulate guanylate cyclase activity [E.C. 4.6.1.2] two-fold in wh...

Publisher SummaryThe heart influences renal functions through the release of humoral substances. Dense core granules, resembling secretory granules, were observed in the atria of mammalian hearts. The granules were in close association with the golgi complex and contained a protein material. DeB...

SummaryIntroductionPlasma atrial natriuretic peptide levels (proANP (1–98)), a parameter of myocardial dysfunction, have been reported to be increased in critically ill patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The aim of the study was to examine if proANP ...

Natriuretic peptides differentially modulate endocrine and behavioral stress responses in animal and human studies. Especially atrial natriuretic peptide inhibits the hypothalamic–pituitary–adrenocortical axis and exerts anxiolytic actions, while C-type natriuretic peptide activates the stress...

Endogenous cardenolides are digoxin-like substances and ouabain-like substances that have been implicated in the pathogenesis of hypertension and mood disorders in clinical and pre-clinical studies. Regulatory signals for endogenous cardenolides are still unknown. These endogenous compounds are ...

Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopat...

We have cloned the mouse bcl-2 (mbcl-2) genomic locus and analyzed it in detail. The gene is comprised of two exons separated by more than 15 kb. Two species of mRNAs are produced, and DNA sequencing analysis shows that they code for two proteins differing at their C terminus: a 7.5 kb transcrip...

Direct or catalytic condensation of diacylferrocenes (acyl = formyl, acetyl, and benzoyl) and anilines or benzylamines with titanium tetrachloride as a catalyst resulted in the corresponding diimines 1–3, respectively. Reduction of these imines with sodium borohydride or lithium aluminum hydrid...

Reactions of 1-{[2-(arylazo)phenyl]iminomethyl}-2-phenol, HLsal, 1, [where H represents the dissociable protons upon complexation and aryl groups of HLsal are phenyl for HL1sal, p-methylphenyl for HL2sal, and p-chlorophenyl for HL3sal], ligands with Ru(H)(CO)(Cl)(PPh3)3 afforded complexes of com...

Single electron transfer (SET)-promoted photoaddition reactions between fullerene C60 and both various alkyl (Me, Et, i-Pr, t-Bu)- and para-substituted (p-Me, p-OMe, p-F, p-CF3) arene ring containing, N-α-trimethylsilyl-N-alkyl-N-benzylamines were explored to gain information about photoproduct...

Clinical development of ROCK inhibitors has so far been limited by systemic or local ROCK-associated side effects. A soft drug approach, which involves predictable metabolic inactivation of an active compound to a nontoxic metabolite, could represent an attractive way to obtain ROCK inhibitors w...

Based on our previous results on the ascertained potent growth inhibition effect against a panel of 60 human tumors cell lines at National Cancer Institute of Bethesda (NCI), we have synthesized a novel series of thirty-one 2-[N-methyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxaline...

The collision-induced dissociation (CID) products b2-b4 from Leu-enkephalin are examined with infrared multiple-photon dissociation (IR-MPD) spectroscopy and gas-phase hydrogen/deuterium exchange (HDX). Infrared spectroscopy reveals that b2 exclusively adopts oxazolone structures, protonated at ...

Experiments were performed to investigate the effects of morphine and [d-Ala2, d-Leu5]enkephalin on supraoptic cells in hypothalamic slices in vitro. To ensure the presence of a steady background activity, the cells were recorded with glutamate-filled glass microelectrodes and the level of activ...