High pressures phase behavior data for the CO2/tetrahydrofurfuryl methacrylate (THFMA) systems are presented at (313.2–393.2) K and up to 22.07 MPa. The system exhibits the Type-I phase behavior with a continuous mixture-critical curve. The solubilities of poly(tetrahydrofurfuryl methacrylate) ...

Experimental measurements of densities and ultrasonic speeds for the binary mixtures of benzonitrile with methyl/ethyl/n-butyl methacrylates over the entire composition range were carried out in the temperature range 293.15 K–318.15 K and atmospheric pressure of 0.1 MPa. Using the experimental ...

The cold-flow properties of diesel fuel are considered as the determining factors of diesel utilization and popularization. Pour-point depressants (PPDs) are often added to diesel to remediate issues with fluidity in cold climates. In this study, a series of benzyl methacrylate-methacrylate copo...

An industrial and economic carbonylation of amines with carbon monoxide and sulfur has been developed for the synthesis of S-alkyl thiocarbamate herbicides. In the presence of potassium carbonate and solvent DMSO, S-alkyl thiocarbamates, such as thiobencarb and orbencarb (herbicides) are synthes...

Three-dimensional X-ray structure analysis of the cognition activator dihydro-1H-pyrrolizine-3,5(2H, 6H)- dione (‘Rolziracetam’) indicates that the molecule in the crystalline state is a diptych with a folding dihedral angle about the NC(8) bond axis of 167.7°, in which the five-membered ri...

A series of multi-substituted oximes were prepared and their potencies for inhibiting lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were evaluated in vitro. Among them, compounds 3a, 3b, and 3m were identified to display a micromolar potency for inhibiting Lp-PLA2 in whole human pla...

The density functional theory (DFT) and Hatree–Fock (HF) method was performed at 6-311++G∗∗ level to derive the equilibrium geometry, vibrational wavenumbers, infrared intensities and Raman scattering activities of 2,3,4,5,6 pentafluorobenzoic acid molecule (PFBA). The conformer study of the mo...

A method for the trace analysis of fluorobenzoic acids (FBAs) via IC–MS based on solid-phase extraction (SPE) prior to isocratic anion exchange chromatography is described. Up to 23 different fluorobenzoic acids were enriched and determined simultaneously. Solid-phase extraction on hydrophilic–...

A method for the ultra trace analysis of 21 fluorobenzoic acids (FBAs) via GC–MS based on solid-phase extraction (SPE) and derivatization with BF3·MeOH is described. All fluorobenzoic acids were enriched and determined simultaneously. Solid-phase extraction on hydrophilic–lipophilic-balanced ...

A solid-phase extraction (SPE) procedure using C18 stationary phase was optimized for the preconcentration of 19 fluorinated derivatives of benzoic acid (FBA): mono-, di-, tri-, and tetrafluorosubstituted in the ring, trifluoromethylbenzoic acid and 3,5-bistrifluoromethyl benzoic acid from undil...

A new chain europium complex [Eu(2,3-DFBA)3·(H2O)2]n (2,3-DFBA=2,3-difluorobenzoate) was synthesized by solvent method. X-ray single-crystal diffraction analysis revealed that Eu3+ ions were linked through 2,3-DFBA groups via alternate bidentate-bridging and tridentate chelating-bridging coordi...

Publisher SummaryThis chapter explores that dimedone is a versatile precursor for annulated heterocycles. Dimedone(1) is an alicyclic compound having 1,3-dicarbonyl groups flanked by a methylene group and exists in a tautomeric transenolized form where intramolecular hydrogen bonding is not poss...

The radiation effect on the thermal stability of poly(oxymethylene) diacetate (POMDA) in film has been investigated on irradiation up to 1000 kGy in air with a 60Co gamma-ray source. The gel permeation chromatography (GPC) indicated that the molecular weight of POMDA was lowered in the polydispe...

Photoabsorption cross sections of newly produced gas-phase anion of acetyloxy iodide, CH3CO2I−, are obtained by photofragmentation spectroscopy in the spectral range 2.48–3.60 eV. The photoabsorption spectrum is dominated by two broad bands located well below the vertical detachment energy. Pho...

Syntheses for [(diphenylphosphinoyl)methyl]-4,5-dihydrooxazole (2) and [(diarylphosphinoyl)methyl]benzoxazoles [aryl = phenyl (3), tolyl (4), 2-trifluoromethylphenyl (5) and 3,5-bis(trifluoromethyl)phenyl (6)] have been developed. Each ligand has been characterized by spectroscopic methods and s...

We studied how tryptophan methyl ester and related compounds inhibit binding of estrone to rat α-fetoprotein and find that: (a) like chymotrypsin, α-fetoprotein binds tryptophan esters with higher affinity than tryptophan or its amides; (b) the affinity of α-fetoprotein for tryptophan methyl ...

Monofluorination of β-keto esters with Selectfluor® (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2,2,2]octane bis(tetrafluoroborate)) using CpTiCl3 as a catalyst, followed by amination with diazodicarboxylates using a Cu/Ph-Box catalyst leads to α-fluoro-α-hydrazino-β-keto esters in good yie...

A new protecting group, 1,2-dimethoxy-4,5-dimethylene, for acyclic amino acid derivatives could be introduced by N,N-dialkylation with 1,2-bis(bromomethyl)-4,5-dimethoxybenzene (1) and removed via amine de-alkylation with acyl chlorides. The method can be used with base-induced [2,3] and [1,2] S...

In this study, the effect of fluorine upon the heme-binding ability of the xanthone nucleus was investigated for 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone (F2C5). 2-Fluoro-1,3-dimethoxybenzene was prepared by a new, improved method and used to build up the xanthone nucleus. The i...

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 ...