ObjectiveTo perform a meta-analysis of all available studies on the effect of prophylactic somatostatin administration on prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and post-ERCP hyperamylasemia (PEHA).

The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and development in this area has faced a challenge, mainly attributed to the la...

Somatostatin is a naturally occurring peptide found throughout the central and peripheral nervous systems, the D (δ) cells of the pancreatic islets and gastrointestinal tract and in many other structures. It exists as two active forms—somatostatin-14 (primary form in the brain and pancreatic i...

Many neurological diseases are related to disturbances of somatostatin- (SOM-) expressing interneurons in the cingulate cortex. Therefore, their role within the circuitry of the cingulate cortex needs to be investigated. We describe here the physiological time course of SOM effects onto pyramida...

Somatostatin receptors (SSTR) are upregulated in the cells of origin that define numerous neuroendocrine neoplasms. PET imaging with 68Ga-DOTATATE allows specific targeting of SSTR2A, a single species of SSTR receptor, which is commonly overexpressed in a variety of gastroenteropancreatic neuroe...

When 2,6-di-O-tert-butyldimethylsilylated cyclomalto-oligosaccharides (cyclodextrins) are treated with allyl or methyl iodide and NaH in dry tetrahydrofuran, O-2 → O-3 migration of the secondary 2-O-tert-butyldimethylsilyl groups occurs, leading to 2-O-alk(en)yl-3,6-di-O-tert-butyldimethylsilyl...

An efficient and chemoselective procedure for preparing highly organosoluble 3,6-di-O-tert-butyldimethylsilyl (TBDMS)-chitosan and chitooligosaccharides is reported. The selective modification of the chitooligosaccharides with 0.50 degree of N-acetylation was achieved by using TBDMSCl as the rea...

Two hair-dye chemicals, HC Blue No. 1 and HC Blue No. 2, were assessed for the ability to produce chromosome breakage and/or spindle malformation in vivo by evaluating the capacity of these compounds to induce micronuclei in polychromatic erythrocytes of mouse bone marrow. Initial studies were c...

We design novel graphyne/blue phosphorene van der Waals (vdW) heterostructures (G/BP) under the external electric fields (Efield) and strains. It is demonstrated that the G/BP is a type-I semiconductor with a direct band gap of approximately 0.378 eV. The external Efield and strains not only hav...

Methylene blue (MB) is representative of a class of dyestuffs that are resistant to biodegradation. In this study, MB was degraded in an aqueous suspension of SrFe12O19 powder under visible illumination. SrFe12O19 is a type of traditional magnet and its semiconductor characteristics were elucida...

Sulfation of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and structurally related hydroxamic acids by rat and human sulfotransferases was studied. There was a clear sex and age difference in the sulfation of N-OH-AAF and the other hydroxamic acids by rat liver cytosols: adult male ...

The binding of AABP4′F and ABP4′F residues to rat liver and kidney DNA in vivo was studied at different periods of time after administration of N-[G-3H]hydroxy-AABP4′F at dose levels of 5 and 25 mg/kg body weight. DNA preparations from both organs were hydrolyzed enzymatically at pH 8–9 with...

Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex through disruption of EED/H3K27me3 binding. Modification of the indole and benzyl moieties of screening hit 1 provided analogs with substantially improved b...

The sulfonylurea derivative, tolbutamide, and the phenylalanine derivative, N-benzoyl-d-phenylalanine (NBDP), both of which stimulate insulin secretion through interaction with the sulfonylurea receptor (SUR1), were studied for their ability to increase the [Ca2+]i and to interact with the gluco...

El uso de infusiones de anís estrellado para el tratamientodel cólico del lactante tiene un amplio arraigo cultural,sin cuestionar su posible toxicidad. En el último añose han descrito en nuestro país varios casos de lactantescon patología neurológica aguda asociada a sintomatologíadigest...

Purpose: To evaluate the long-term performance of the Anis circular intraocular lens (IOL).Setting: Center for IOL Research, Storm Eye Institute, Charleston, South Carolina.Materials: Fifteen human autopsy eyes with an Anis circular IOL submitted between 1985 and 1993 were evaluated. The eyes we...

We present the high-energy neutrino Monte Carlo event generator ANIS (All Neutrino Interaction Simulation). The program provides a detailed and flexible neutrino event simulation for high-energy neutrino detectors, such as AMANDA, ANTARES or ICECUBE. It generates neutrinos of any flavor accordin...

Accurate, threat-specific alarm systems might play a role in the evolution of joint-nesting systems by offsetting the high costs associated with joint nesting. The smooth-billed ani, a joint-nesting cooperatively breeding bird, produces at least two distinct classes of vocal alarms. Anis give ‘...

Impedance measurement of cells using electric cell-substrate impedance sensing (ECIS) is widely accepted as an effective method to assess cell status. However, the sensitive frequency drifts over time with the changes of culture condition according to the built circuit model and experimental res...

Neuropeptide Y (NPY) has been isolated and sequence from brain extracts of the European common frog, Rana temporaria. Plasma desorption mass spectroscopy of the purified peptide indicated a molecular mass of 4243.3 Da which was in agreement with that deduced from the sequence (4243.7 Da), incorp...