Purpose Cynarin, a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells, was found in Echinacea purpurea by a new pharmaceutical screening method: After Flowing Through Immobilized Receptor (AFTIR; Dong et al., J Med Che...
Herein we describe a water-based protocol that generates Au nanoparticles (AuNPs) by mixing aqueous solutions of HAuCl4 and cynarin (a natural product extract from artichoke leaf). Based on the observations from 1 H NMR spectrum of AuNPs, a polyol oxidation mechanism by metal ions which ...
Recent studies revealed that reactive oxygen species, antioxidants and related redox signals are key elements in the regulation of plant defense responses, including the synthesis of secondary metabolites. In this work the potential of artichoke (Cynara scolymus L.) cell suspensions to produce c...
Background: Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP)...
Although herbal ingredients could be used to increase bioactive compounds in food products, it is more crucial to investigate the effect of processing on their bioaccessibility and their content. In this study, artichoke leaf powder (ALP) was added to wheat flour (WF) at ratios of 0:100, 3:97, 6...
This work was aimed at the study of the chemical composition in phenolic compounds responsible for the high antiacetylcholinesterase activity of aqueous extracts (decoctions) from Helichrysum stoechas aerial parts. Chlorogenic acid, cynarin, and arzanol were the main components of decoctions, de...
The original version of this article unfortunately contained an error in the article title. There is a incorrect term Lamiaceae inadvertently appeared in the title, instead it should be Asteraceae.
Labile (+)-6-tuliposide B, an antimicrobial compound produced by tulip, was synthesized in nine steps from d-glucose via the Baylis–Hillman reaction of 2-(tert-butyldimethylsilyloxy)-acetaldehyde with 6-O-acryloyl-1-O-(2-trimethylsilylethyl)-β-d-glucopyranoside, followed by a mild deprotection...
6-Tuliposide B is a secondary metabolite occurring specifically in tulip anthers. Recently, a potent antibacterial activity of 6-tuliposide B has been reported. However, its molecular target has not yet been established, nor its action mechanism. To shed light on such issues, 6-tuliposide B and ...
The enzyme MurA performs an essential step in peptidoglycan biosynthesis and is therefore a target for the discovery of novel antibacterial compounds. We report here the inhibition of MurA by natural products from tulips (tulipalines and tuliposides), and the structure–activity relationships of...
The investigation of leaves stems and flowers of Tulipa turkestanica afforded, in addition to 6-tuliposide A, 1-tuliposide A, tuliposide D and the lactonized aglycones tulipalin A and (-)-tulipalin B, two new tuliposides. The structure of the new tuliposides were determined by spectral methods ...
The investigation of Alstroemeria revoluta afforded a new tuliposide, tuliposide D, along with the known 6-tuliposide A. The structures of the isolated compounds were established by spectral methods.
A reinvestigation of Alstroemeria revoluta afforded, in addition to tuliposides A and D, a new tuliposide. The structure of the new tuliposide was determined by spectral methods to be 1-[4-(4-hydroxy-2-methylenebutanoate)-2-methylenebutanoate]-6-(4-hydroxy-2-m ethylenebutanoate)-β-d-glucopyran...
We developed a method for rapid and reliable determination of tulipaline A (α-methylene-γ-butyrolactone) and tuliposide A. In this process we identified two isomers of the tuliposide A which are spontaneously interconverted into each other. In bulb scales of tulip (Tulipa gesneriana) cv. Ape...
6-Tuliposides A (6-PosA) and B (6-PosB) are major secondary metabolites in tulip (Tulipa gesneriana), having an acyl group at the C-6 position of d-glucose. They serve as precursors of the antimicrobial α-methylene-γ-butyrolactones tulipalins A (PaA) and B (PaB). The conversions of 6-PosA/6-Po...
6‐Tuliposides A (PosA) and B (PosB), which are the major secondary metabolites in tulip (Tulipa gesneriana), are enzymatically converted to the antimicrobial lactonized aglycons, tulipalins A (PaA) and B (PaB), respectively. We recently identified a PosA‐converting enzyme (TCEA) as the first r...
Glucocorticoid-induced apoptosis is a well-recognized physiological regulator of T-cell number and function. Alisol B acetate, a triterpene from Alisma Plantago-aquatica, has a glucocorticoid-like structure, and may have a similar function like glucocorticoid-induced apoptosis in both vascular s...
The anti-tumor potential of components from Chinese herbal medicines has been greatly concerned. Alisol B acetate, a triterpene from Alismatis rhizoma, induced apoptotic cell death in human hormone-resistant prostate cancer PC-3 cells in a time- and concentration-dependent manner. A good correla...
Herbal drugs were screened for their activity in reversing multidrug resistance (MDR) in P-glycoprotein (P-gp) over-expressing cancer cells. Through bio-assay guided fractionation an active compound was isolated from Rhizoma Alismatis, the underground part of Alisma orientale and the chemical st...
Purpose To investigate protective effects of alisol B 23-acetate (AB23A) against hepatotoxity and cholestasis induced by 17α-ethinylestradiol (EE) in association with farnesoid X receptor (FXR) activation in vivo and in vitro. Methods The cholestatic liver injury model was established by subc...
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