Centrifugal partition chromatography coupled with evaporative light scattering detection was applied to separate and purify alisol B and alisol B 23-acetate from a chloroform soluble extract of Alisma orientale. The chloroform soluble fraction (870 mg) of A. orientale was separated utilizing a t...
Liver resection has become a common treatment for liver tumors and hepatocellular carcinoma over the past decades. However, after surgery, the remnant livers in some patients fail to regenerate. Therefore, there is an urgent medical need to develop drugs that can promote liver regeneration. The ...
Intrahepatic cholestasis is a clinical syndrome with systemic and intrahepatic accumulation of excessive toxic bile acids that ultimately cause hepatobiliary injury. Appropriate regulation of bile acids in hepatocytes is critically important for protection against liver injury. In the present st...
Ovarian cancer is the first leading cause of death among gynecologic malignancies worldwide. Discovery of new chemotherapeutic drugs is still imperative for the improvement of the survival rate. This study aims to investigate the anti-cancer potential of alisol B 23-acetate (AB23), a protostan...
Pregnane X receptor (PXR) is a key regulator of the induction of drug metabolizing enzymes. PXR has been studied for its importance in drug-drug or herb-drug interactions, and it is also a molecular target for the treatment of inflammatory and metabolic diseases. This study aims to determine n...
A series of alisol A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in vitro. The preliminary investigation demonstrates that simple modifications of the parent structure of alisol A can produce a number of potentially important de...
Chemical modifications were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure–activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytot...
The practice of in-situ leaching of the ion-adsorption type rare earths ore with ammonium sulfate could only leach most of rare earth in ion-exchangeable phase, but not the colloidal sediment phase. Therefore, the reduction leaching of rare earth from the ion-adsorption type rare earths ore with...
Laterite-nickel ore was roasted with ammonium sulfate to extract magnesium by a single-factor experiment, and an orthogonal test was employed to optimize the conditions. The optimum roasting conditions were: calcination temperature, 450°C; calcination time, 120 min; molar ratio of reactants, 2 ...
In the present paper, we study the response of crystalline ammonium ferrous sulfate as a function of the irradiation dose and temperature. The dose studied ranged from 33.5 to 546kGy. The temperature regimen varied from 77K (liquid nitrogen) to 311K. The analysis of the samples was made by UV sp...
The potential of indigenous iron-oxidizing microorganisms enriched at initial neutral pH of the sewage sludge for bioleaching of heavy metals was investigated at initial neutral pH of the sludge using ammonium ferrous sulfate (FAS) and ferrous sulfate (FS) as an energy sources in two different s...
Purpose The main purpose of this study was to establish bioavailability data in humans for the new (Fe) fortification compound ferrous ammonium phosphate (FAP), which was specially developed for fortification of difficult-to-fortify foods where soluble Fe compounds cannot be used due to their ne...
There is still an urgent requirement for more sensitive, cost-effective methods for detection and susceptibility testing of mycobacteria in clinical samples. We have been investigating a simple bacteriophage-based system which could be used for both purposes. As this depends upon the detection...
This work describes the characterization of various Fricke-Agarose-Xylenol gels (FXG) dosimeters using NMR relaxometry and MRI analysis. Using X-rays from a clinical linear accelerator (LINAC), the gels were irradiated in the dose range from 0Gy to 20Gy. The photon sensitivity of the FXGs was me...
The metathesis of unsaturated oleochemicals is an excellent tool for generating α,ω-difunctional substrates, which are useful intermediates for polymer synthesis. This article describes the cross metathesis of allyl acetate and cis -1,4-diacetoxy-2-butene with methyl 10-undecenoate...
Poly[2‐(methacryloyloxy)ethyl oleate‐co‐pentafluorophenyl methacrylate] [P(MAEO‐co‐PFPMA)] random copolymers with oleate and pentafluorophenyl side‐chain pendants were synthesized. These copolymers were utilized as dual‐reactive polymeric scaffolds in a range of post‐polymerization modif...
NMR analyses of O-acetylmandelate (OAM) esters of a variety of crowded and conformationally locked cyclitol derivatives and other alcohols were carried out to examine the reliability of the use of OAM as a chiral anisotropy reagent (CAR) for the determination of the absolute configuration of an ...
(R)‐(−)‐α‐Methoxy phenyl acetic acid, (S)‐(−)‐1,1′‐(2‐naphthol), and (R)‐(+)‐α‐methoxy‐α‐trifluoromethyl phenyl acetic acid were evaluated as chiral shift reagents (CSRs) for 1H NMR spectroscopic resolution and determination of R and S enantiomers of modafinil (MDL) in bulk drugs...
A novel class of 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine derivatives was designed, synthesized and evaluated as human nitric oxide synthase (NOS) inhibitors. Structure–activity relationship studies based on various basic amine side chains attached at the 1-position of the 2,3,4,...
Ethyl 2-cyano-4,4,4-trifluoro-3-(phenylamino)but-2-enoates have been synthesized by reaction of ethyl 2-cyanoacetate with trifluoroacetimidoyl chloride derivatives using sodium hydride in acetonitrile by conventional and microwave irradiation methods. Then, intramolecular cyclization of these pr...
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