A diamine-containing oxyethylene unit, 2,2-bis[4-[2-(4-aminophenoxy)ethoxy]phenyl]propane (BAEPP), was used as a monomer with various aromatic tetracarboxylic dianhydrides to synthesize polyimides via a conventional two-step procedure. The diamine was prepared through the nucleophilic displaceme...

A series of novel 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis c...

A series of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-diones were synthesized and their euglycemic and hypolipidemic activities were investigated in Wistar male rats. Based on the in vivo data in rats, compound 4a was ident...

Pd(II), Cu(II) and Zn(II) complexes (1–3) based on 4′-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2,2′:6′,2″-terpyridine were synthesized and characterized by UV, IR, NMR, EPR, HRMS, elemental analyses, and molar conductivity measurements. The cytotoxicity of these complexes against HL-60, BGC-823...

A new series of 1-ethoxy-3-(4-aryl)-1-phenyl-1H-benzo[f]chromenes have been synthesized efficiently. The procedure involves the multicomponent reaction of 2-naphthol, acetophenone derivatives, and triethyl orthobenzoate catalyzing by efficient bis(2-anilinotropone) Ti complex.

Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kainic acid (K...

A novel series of substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methylquinazolin-4-amines were synthesized and evaluated for their in vitro antiproliferative activity. Among them, compound 7a exhibited the best potency, with IC50 values of 0.029–0.147 μM against four types of ca...

3,3-Dialkyl-5-(bromomethyl)-1-pyrrolinium bromides, prepared via bromocyclization of N-(2,2-dialkyl-4-pentenylidene)amines by means of bromine in dichloromethane, were reduced to 4,4-dialkyl-2-(bromomethyl)pyrrolidines for the first time using borane dimethyl sulfide in dichloromethane. Furtherm...

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor and N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Recent studies have suggested that increased brain KYNA levels are involved in psychiatric disorder...

Many O-methyl and N-methyl groups in natural products are depleted in 13C relative to the rest of the molecule. These methyl groups are derived from the C-1 tetrahydrofolate pool via l-methionine, the principle donor of methyl units. Depletion could occur at a number of steps in the pathway. We ...

The dataset describes the catabolism of the 20 proteogenics amino acids and their end products by Thermoanaerobacter strain AK85 under different electron scavenging conditions with an emphasis on the branched-chain amino acids as reported in Scully and Orlygsson, 2019.

Elevated levels of chlorpyrifos‑methyl have been detected in plant-based Atlantic salmon feeds. To evaluate the potential negative effects of long-term and continuous dietary exposure to chlorpyrifos‑methyl in fish, we fed juvenile Atlantic salmon three concentrations (0.1, 1.0 and 8.0 mg/kg) of...

A simple Mannich condensation reaction furnished 1-(pyridin-2-yl amino)methyl napthalene-2-ol using 2-aminopyridine, naphthalene-2-ol and formaldehyde as starting materials. Then, a complete spectroscopic documentation of synthesized compound was carried out using analytical techniques such as F...

Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) informati...

The absolute configuration of genkwanol B isolated from Daphne genkwa was studied and assigned as C-2 (R), C-3 (S), C-8 (S), C-2'́ (S) and C-3'́ (R) by modified Mosher's method and the X-ray analysis of a pentamethyl ether acetate.

A novel biflavonoid, genkwanol B, was isolated from the roots of Daphne genkwa. The structure of genkwanol B was determined on the basis of chemical studies and spectroscopic data, including NOESY and HMBC experiments.

A novel biflavonoid, genkwanol C, was isolated from the roots of Daphne genkwa. The absolute structure of genkwanol C was determined on the basis of spectroscopic data including CD spectrum and modified Mosher's method.

Gas chromatographic behaviour of chelates derived from the aromatic β-diketones 1-phenylbutane-1,3-dione and 4,4,4-trifluoro-1-(pentafluorophenyl)butane- 1,3-dione and reported. Although the chelates of the non-fluorinated ligand fail to elute from a wide range of liquid phase and supports, sev...

The effect of C-2 substitution on the stereoselective reduction of steroid C-3 ketones with lithium tris-(R,S-1,2-dimethylpropyl)-borohydride and sodium borohydride was investigated. The C-2 mono- and di-substituted chloro and methyl derivatives were predominantly reduced to one of the epimeric ...

Excess molar enthalpies, measured at 298.15 K in a flow microcalorimeter, are reported for x1CH3(CH2)5CH3+x2C2H5C(CH3)2OCH3+x3CH3O(CH2)2OCH3. Smooth representations of the results are presented and used to construct constant excess molar enthalpy contours on a Roozeboom diagram. It is shown that...