As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:24280-93-1
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inquiryItems Standard Result Appearance White or almost white crystalline powder Almost white crystalline powder
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryUnique advantages for Mycophenolic acid Cas 24280-93-1 High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white crystalline powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg/dru
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
High purity, all the standards are around 99%; NRM, HPLC, Lc-MS/MS methods valued and certified, ensure the accurate purity; All the standards attached COA and MSDS; More than 80 kinds of mycotoxin standards can be provided; Accurate stock; Comp
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:mycophenolic acid The alias:mycophenolic acid from penicillium*brevi-compactu; CAS NO:24280-93-1 Molecular formula:C17H19O6 Molecular weight:319.3297 Product Quality 12 years of chemical raw materials Mature operation of the industry
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inquiryMycophenolic acid Basic information Product Name: Mycophenolic acid Synonyms: 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carbo
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:24280-93-1
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiry1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:24280-93-1
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:24280-93-1
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:24280-93-1
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inquiryMycophenolic acid CAS:24280-93-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Good quality ,competitive price. Appearance:white to almost white crystalline powder Storage:store in sealed container Package:25kgs/fiber drum Application:intermediate of Mycophenolate mofetil Transportation:by sea or by air Port:hangzhou airpor
98.5%min HPLC Appearance:White or almost white crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:24280-93-1
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:24280-93-1
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:24280-93-1
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate
mycophenolic acid
Conditions | Yield |
---|---|
With lithium hydroxide In methanol for 12h; | 98% |
With lithium hydroxide In methanol at 23℃; for 5h; | 93% |
With lithium hydroxide In methanol; water at 25℃; for 1h; | 71% |
methyl mycophenolate
mycophenolic acid
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In tetrahydrofuran; water at 25℃; for 24h; | 96% |
With lithium hydroxide In tetrahydrofuran for 3h; Ambient temperature; | 85% |
With water; lithium hydroxide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 66% |
7-hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-one
mycophenolic acid
Conditions | Yield |
---|---|
With jones reagent In acetone at -30℃; for 5h; | 61% |
D-glucose
mycophenolic acid
Conditions | Yield |
---|---|
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; effect of the spore concentration, effect of addition of various adsorbents; | |
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Celite; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; various drug-resistant, methionine or glutamate auxotrophic mutants, effect of L-methionine concentration, effect of L-glutamate concentration; |
7-O-Methylmycophenolic acid
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 189 mg / ethyl acetate 2: BCl3 / CH2Cl2 / 12 h / 20 °C 3: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: ethyl acetate 2: 86 percent / BCl3 / CH2Cl2 / 192 h 3: LiOH / H2O View Scheme |
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: BCl3 / CH2Cl2 / 12 h / 20 °C 2: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 86 percent / BCl3 / CH2Cl2 / 192 h 2: LiOH / H2O View Scheme |
(E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Jones reagent / acetone / 4 h / -30 °C 2: 189 mg / ethyl acetate 3: BCl3 / CH2Cl2 / 12 h / 20 °C 4: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: CrO3, acid / acetone / -30 °C 2: ethyl acetate 3: 86 percent / BCl3 / CH2Cl2 / 192 h 4: LiOH / H2O View Scheme |
6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: O3 / methanol / -78 °C 1.2: Me2S / methanol / 3 h / -10 - 20 °C 2.1: Jones reagent / acetone / 4 h / -30 °C 3.1: 189 mg / ethyl acetate 4.1: BCl3 / CH2Cl2 / 12 h / 20 °C 5.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 2: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 3: Jones reagent / acetone / 4 h / -30 °C 4: 189 mg / ethyl acetate 5: BCl3 / CH2Cl2 / 12 h / 20 °C 6: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: O3, Me2S / CH2Cl2; pyridine / -78 °C 2: CrO3, acid / acetone / -30 °C 3: ethyl acetate 4: 86 percent / BCl3 / CH2Cl2 / 192 h 5: LiOH / H2O View Scheme |
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 100 percent / K2CO3 / methanol / 6 h 2.1: O3 / methanol / -78 °C 2.2: Me2S / methanol / 3 h / -10 - 20 °C 3.1: Jones reagent / acetone / 4 h / -30 °C 4.1: 189 mg / ethyl acetate 5.1: BCl3 / CH2Cl2 / 12 h / 20 °C 6.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1: 100 percent / K2CO3 / methanol / 6 h 2: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 3: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 4: Jones reagent / acetone / 4 h / -30 °C 5: 189 mg / ethyl acetate 6: BCl3 / CH2Cl2 / 12 h / 20 °C 7: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: K2CO3 / methanol 2: O3, Me2S / CH2Cl2; pyridine / -78 °C 3: CrO3, acid / acetone / -30 °C 4: ethyl acetate 5: 86 percent / BCl3 / CH2Cl2 / 192 h 6: LiOH / H2O View Scheme |
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 89 percent / NaBH4 / methanol / 0.5 h 2.1: Et3N / CH2Cl2 / 2.5 h / 25 °C 3.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 4.1: 100 percent / K2CO3 / methanol / 6 h 5.1: O3 / methanol / -78 °C 5.2: Me2S / methanol / 3 h / -10 - 20 °C 6.1: Jones reagent / acetone / 4 h / -30 °C 7.1: 189 mg / ethyl acetate 8.1: BCl3 / CH2Cl2 / 12 h / 20 °C 9.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 10 steps 1: 89 percent / NaBH4 / methanol / 0.5 h 2: Et3N / CH2Cl2 / 2.5 h / 25 °C 3: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 4: 100 percent / K2CO3 / methanol / 6 h 5: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 6: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 7: Jones reagent / acetone / 4 h / -30 °C 8: 189 mg / ethyl acetate 9: BCl3 / CH2Cl2 / 12 h / 20 °C 10: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 9 steps 1: 89 percent / NaBH4 / methanol 2: Et3N / CH2Cl2 / 1.5 h 3: NaBH4 / dimethylformamide 4: K2CO3 / methanol 5: O3, Me2S / CH2Cl2; pyridine / -78 °C 6: CrO3, acid / acetone / -30 °C 7: ethyl acetate 8: 86 percent / BCl3 / CH2Cl2 / 192 h 9: LiOH / H2O View Scheme |
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: Et3N / CH2Cl2 / 2.5 h / 25 °C 2.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 3.1: 100 percent / K2CO3 / methanol / 6 h 4.1: O3 / methanol / -78 °C 4.2: Me2S / methanol / 3 h / -10 - 20 °C 5.1: Jones reagent / acetone / 4 h / -30 °C 6.1: 189 mg / ethyl acetate 7.1: BCl3 / CH2Cl2 / 12 h / 20 °C 8.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 9 steps 1: Et3N / CH2Cl2 / 2.5 h / 25 °C 2: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 3: 100 percent / K2CO3 / methanol / 6 h 4: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 5: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 6: Jones reagent / acetone / 4 h / -30 °C 7: 189 mg / ethyl acetate 8: BCl3 / CH2Cl2 / 12 h / 20 °C 9: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: Et3N / CH2Cl2 / 1.5 h 2: NaBH4 / dimethylformamide 3: K2CO3 / methanol 4: O3, Me2S / CH2Cl2; pyridine / -78 °C 5: CrO3, acid / acetone / -30 °C 6: ethyl acetate 7: 86 percent / BCl3 / CH2Cl2 / 192 h 8: LiOH / H2O View Scheme |
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 2.1: 100 percent / K2CO3 / methanol / 6 h 3.1: O3 / methanol / -78 °C 3.2: Me2S / methanol / 3 h / -10 - 20 °C 4.1: Jones reagent / acetone / 4 h / -30 °C 5.1: 189 mg / ethyl acetate 6.1: BCl3 / CH2Cl2 / 12 h / 20 °C 7.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 2: 100 percent / K2CO3 / methanol / 6 h 3: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 4: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 5: Jones reagent / acetone / 4 h / -30 °C 6: 189 mg / ethyl acetate 7: BCl3 / CH2Cl2 / 12 h / 20 °C 8: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1: NaBH4 / dimethylformamide 2: K2CO3 / methanol 3: O3, Me2S / CH2Cl2; pyridine / -78 °C 4: CrO3, acid / acetone / -30 °C 5: ethyl acetate 6: 86 percent / BCl3 / CH2Cl2 / 192 h 7: LiOH / H2O View Scheme |
6-[5-(3,3-dimethyl-oxiranyl)-3-methyl-pent-2-enyl]-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 2: Jones reagent / acetone / 4 h / -30 °C 3: 189 mg / ethyl acetate 4: BCl3 / CH2Cl2 / 12 h / 20 °C 5: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme |
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dihydroxy-benzoic acid methyl ester
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 88 percent / NaH / dimethylformamide 2: 89 percent / NaBH4 / methanol 3: Et3N / CH2Cl2 / 1.5 h 4: NaBH4 / dimethylformamide 5: K2CO3 / methanol 6: O3, Me2S / CH2Cl2; pyridine / -78 °C 7: CrO3, acid / acetone / -30 °C 8: ethyl acetate 9: 86 percent / BCl3 / CH2Cl2 / 192 h 10: LiOH / H2O View Scheme |
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 2: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 3: pivalic acid / xylene / 6 h / 135 - 140 °C 4: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 5: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
4-Hydroxy-2-methoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1.) NaH / 1.) DMF, 0 ged C, 15 min, 2.) DMF, a) 0 deg C, 30 min, b) RT, 30 min 2: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature 3: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 4: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 5: pivalic acid / xylene / 6 h / 135 - 140 °C 6: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 7: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
2,4-Dimethoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature 2: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 3: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 4: pivalic acid / xylene / 6 h / 135 - 140 °C 5: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 6: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
[6-methoxy-4-(2-methoxyethoxymethoxy)-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl]-acetaldehyde
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 2: pivalic acid / xylene / 6 h / 135 - 140 °C 3: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 4: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
6-(2-hydroxy-3-methylbut-3-enyl)-5-methoxy-7-(2-methoxyethoxymethoxy)-4-methyl-3H-isobenzofuran-2-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pivalic acid / xylene / 6 h / 135 - 140 °C 2: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 3: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 2: 98 percent / aq. LiOH / methanol / 12 h View Scheme |
7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 79 percent / benzyl trimethyl ammonium dichloroiodate, NaHCO3 / CH2Cl2; methanol / Ambient temperature 2: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h 3: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 4: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 5: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C 2: tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 16 h / 20 - 100 °C / Inert atmosphere 3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C 2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 24 h / 100 °C 3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C View Scheme |
7-hydroxy-6-iodo-5-methoxy-4-methylisobenzofuran-1(3H)-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h 2: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 3: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 4: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme |
6-Iodo-5-methoxy-4-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-3H-isobenzofuran-1-one
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 2: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 3: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme |
(E)-6-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilanyl-ethoxymethoxy)-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid methyl ester
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 2: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme |
Ethyl E-6-<1,3-Dihydro-4-(tert-butyldimethylsilyloxy)-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl>-4-methyl-4-hexenoate
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / nBu4NF / tetrahydrofuran / 1 h 2: 93 percent / aq. LiOH / methanol / 5 h / 23 °C View Scheme | |
Multi-step reaction with 2 steps 1: 83 percent / n-Bu4NF / tetrahydrofuran / 0.25 h / 25 °C 2: 71 percent / LiOH / methanol; H2O / 1 h / 25 °C View Scheme |
(E)-6-acetoxy-4-methyl-4-hexenal
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 84 percent / NaBH4 / ethanol / 0.42 h / 25 °C 2: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature 3: K2CO3 / methanol / 24 h / Ambient temperature 4: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 5: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 6: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 7: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 8: conc. HCl / methanol / 4.5 h / Heating 9: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme |
<(2E)-6-Hydroxy-3-methyl-2-hexenyl>acetat
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature 2: K2CO3 / methanol / 24 h / Ambient temperature 3: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 4: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 5: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 6: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 7: conc. HCl / methanol / 4.5 h / Heating 8: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme |
(E)-6-((tert-butyldimethylsilyl)oxy)-3-methylhex-2-en-1-yl acetate
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: K2CO3 / methanol / 24 h / Ambient temperature 2: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 3: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 4: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 5: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 6: conc. HCl / methanol / 4.5 h / Heating 7: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme |
(E)-3-methyl-6-<(tert-butyldimethylsilyl)oxy>-2-hexen-1-ol
mycophenolic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 2: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 3: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 4: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 5: conc. HCl / methanol / 4.5 h / Heating 6: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme |
Conditions | Yield |
---|---|
With sulfuric acid for 2h; Heating; | 100% |
With sulfuric acid for 20h; Ambient temperature; | 95% |
With toluene-4-sulfonic acid for 2h; Reflux; | 95.86% |
mycophenolic acid
Conditions | Yield |
---|---|
With sodium methylate In methanol; ethyl acetate at 20℃; for 1h; Product distribution / selectivity; Charcoal; | 97% |
With sodium methylate In methanol; ethyl acetate at 20℃; for 0.5h; Product distribution / selectivity; | 94% |
With sodium methylate In methanol; ISOPROPYLAMIDE at 20℃; for 0.166667h; Product distribution / selectivity; | 92% |
Conditions | Yield |
---|---|
With trimethylbenzylammonium bromide; potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h; | 96% |
mycophenolic acid
allyl bromide
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 18h; | 93% |
ethanol
mycophenolic acid
ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 2h; Reflux; | 92% |
mycophenolic acid
A
7-hydroxy-5-methoxy-4-methyl-6-(2-(2-methyl-5-oxotetrahydrofuran-2-yl)ethyl)isobenzofuran-1(3H)-one
B
mycochromanic acid
Conditions | Yield |
---|---|
With sulfuric acid In acetic acid for 4h; Heating; | A 5% B 90% |
mycophenolic acid
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide
Conditions | Yield |
---|---|
In methanol at 20℃; for 12h; | 90% |
lauric anhydride
mycophenolic acid
(E)-6-(1,3-dihydro-4-dodecanoyloxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 120h; | 90% |
mycophenolic acid
tert-butyldimethylsilyl chloride
(E)-6-(4-tert-butyldimethylsilyloxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Inert atmosphere; | 89% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 88h; | 60% |
Conditions | Yield |
---|---|
Stage #1: 1-hydroxy-pyrrolidine-2,5-dione; mycophenolic acid In acetonitrile Cooling with ice; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile for 24.5h; | 89% |
mycophenolic acid
nor-O-methylmycophenolic acid
Conditions | Yield |
---|---|
With lithium iodide | 88.5% |
With pyridine; 2,3,5-trimethyl-pyridine; lithium iodide at 120℃; for 18h; | 74% |
mycophenolic acid
glycine ethyl ester hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h; | 86% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine Inert atmosphere; | 86% |
mycophenolic acid
tert-butylamine
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid t-butylamine salt
Conditions | Yield |
---|---|
In ethyl acetate at 22 - 60℃; for 1h; Product distribution / selectivity; | 85.6% |
Conditions | Yield |
---|---|
toluene-4-sulfonic acid at 160℃; for 5h; Product distribution / selectivity; | 84% |
(1S)-10-camphorsulfonic acid at 150 - 155℃; for 8h; Product distribution / selectivity; | 84% |
at 160℃; for 5h; Product distribution / selectivity; | 84% |
mycophenolic acid
tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate
(E)-tert-butyl 2-((2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethyl)(methyl)amino)ethylcarbamate
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h; | 84% |
(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)
mycophenolic acid
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 40℃; for 60h; Temperature; Darkness; | 83.9% |
Conditions | Yield |
---|---|
With pyridine; dmap at 0℃; | 83% |
With pyridine; dmap at 20℃; | 62% |
mycophenolic acid
tert-butyl 2-(2-aminoethoxy)ethylcarbamate
(E)-tert-butyl 2-(2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethoxy)ethylcarbamate
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h; | 83% |
mycophenolic acid
3-(5-Carboxy-3-methyl-pent-2t-enyl)-4-hydroxy-6-hydroxymethyl-2-methoxy-toluol; 6-(6-Hydroxy-4-hydroxymethyl-2-methoxy-3-methyl-phenyl)-4-methyl-hex-4t-ensaeure
Conditions | Yield |
---|---|
With lithium hydroxide In water for 96h; Heating; | 82% |
mycophenolic acid
Conditions | Yield |
---|---|
Stage #1: mycophenolic acid; α,β-D-glucuronate With 4-methyl-morpholine In acetonitrile at 20℃; for 2h; Molecular sieve; Inert atmosphere; Stage #2: With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate In acetonitrile at 20℃; for 3h; Inert atmosphere; Molecular sieve; | 82% |
mycophenolic acid
(R)-leucine methyl ester hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h; | 81% |
mycophenolic acid
propargyl bromide
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene; acetonitrile at 20℃; for 48h; | 81% |
mycophenolic acid
4-chloro-3-trifluoromethyl-aniline
Conditions | Yield |
---|---|
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 80% |
mycophenolic acid
triethylamine
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid triethylamine salt
Conditions | Yield |
---|---|
In ethyl acetate at 10 - 60℃; for 1h; Product distribution / selectivity; | 78.7% |
In ethyl acetate for 0.5h; |
mycophenolic acid
D-alanine methyl ester hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h; | 77% |
2-(triphenylphosphoranylidene)propionaldehyde
mycophenolic acid
(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal
Conditions | Yield |
---|---|
Stage #1: mycophenolic acid With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tetrahydrofuran; water; acetone at 20℃; for 1.5h; Stage #2: 2-(triphenylphosphoranylidene)propionaldehyde In benzene at 90℃; for 24h; Inert atmosphere; | 77% |
mycophenolic acid
isopropylamine
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid isopropylamine salt
Conditions | Yield |
---|---|
In ethyl acetate at 11 - 55℃; for 2h; | 75.1% |
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