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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Mycophenolic acid Manufacturer/High quality/Best price/In stock

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or almost white crystalline powder Almost white crystalline powder

High purity Mycophenolic acid with best price and good quality cas:24280-93-1

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 200.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha

Mycophenolic acid CAS 24280-93-1

Cas:24280-93-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Mycophenolic Acid CAS NO.24280-93-1

Cas:24280-93-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Mycophenolic acid Cas 24280-93-1 High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white crystalline powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg/dru

Top quality best price Mycophenolic acid Cas 24280-93-1 with good service and fast delivery

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $149.0 / 179.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Mycophenolic acid

Cas:24280-93-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Mycophenolic acid 24280-93-1 ISO Producer

Cas:24280-93-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Mycophenolic acid

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Pribolab PTE.LTD

High purity, all the standards are around 99%; NRM, HPLC, Lc-MS/MS methods valued and certified, ensure the accurate purity; All the standards attached COA and MSDS; More than 80 kinds of mycotoxin standards can be provided; Accurate stock; Comp

MSS1040 - Mycophenolic Acid

Cas:24280-93-1

Min.Order:1 Milligram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Mycophenolic acid

Cas:24280-93-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:mycophenolic acid The alias:mycophenolic acid from penicillium*brevi-compactu; CAS NO:24280-93-1 Molecular formula:C17H19O6 Molecular weight:319.3297 Product Quality 12 years of chemical raw materials Mature operation of the industry

CAS:24280-93-1/mycophenolic acid/High purity

Cas:24280-93-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Mycophenolic acid Basic information Product Name: Mycophenolic acid Synonyms: 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carbo

Mycophenolic acid

Cas:24280-93-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Mycophenolic acid

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 24280-93-1 with best quality

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Mycophenolic acid/ LIDE PHARMA- Factory supply / Best price

Cas:24280-93-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Cas 24280-93-1 Mycophenolic Acid, High Purity Mycophenolic Acid!!!

Cas:24280-93-1

Min.Order:10 Gram

Negotiable

Type:Other

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Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Mycophenolic acid

Cas:24280-93-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Mycophenolic acid 24280-93-1

Cas:24280-93-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Purity Mycophenolic acid / micofenolicoacido / nsc-129185 100% Safe Customs Clearance

Cas:24280-93-1

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply Mycophenolic Acid CAS 24280-93-1 for Scientific Research use only

Cas:24280-93-1

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Mycophenolic acid Immune inhibitors

Cas:24280-93-1

Min.Order:1 Kilogram

FOB Price: $35.0 / 50.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Mycophenolic acid CAS:24280-93-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

Mycophenolic acid CAS:24280-93-1

Cas:24280-93-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Mycophenolic acid

Cas:24280-93-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:24280-93-1

Cas:24280-93-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

Good quality ,competitive price. Appearance:white to almost white crystalline powder Storage:store in sealed container Package:25kgs/fiber drum Application:intermediate of Mycophenolate mofetil Transportation:by sea or by air Port:hangzhou airpor

Mycophenolic acid

Cas:24280-93-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

98.5%min HPLC Appearance:White or almost white crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Mycophenolic acid 98.5%min HPLC Pharmaceutica Antibiotics Alkaloid made in china

Cas:24280-93-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Mycophenolic acid 24280-93-1

Cas:24280-93-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Mycophenolic Acid CAS NO.24280-93-1

Cas:24280-93-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Mycophenolic Acid

Cas:24280-93-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Mycophenolic acid

Cas:24280-93-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate
32483-51-5

ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol for 12h;98%
With lithium hydroxide In methanol at 23℃; for 5h;93%
With lithium hydroxide In methanol; water at 25℃; for 1h;71%
methyl mycophenolate
31858-66-9

methyl mycophenolate

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
With lithium hydroxide monohydrate In tetrahydrofuran; water at 25℃; for 24h;96%
With lithium hydroxide In tetrahydrofuran for 3h; Ambient temperature;85%
With water; lithium hydroxide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;66%
7-hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-one
31327-49-8

7-hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
With jones reagent In acetone at -30℃; for 5h;61%
D-glucose
50-99-7

D-glucose

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; effect of the spore concentration, effect of addition of various adsorbents;
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Celite; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; various drug-resistant, methionine or glutamate auxotrophic mutants, effect of L-methionine concentration, effect of L-glutamate concentration;
7-O-Methylmycophenolic acid
38877-93-9

7-O-Methylmycophenolic acid

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 189 mg / ethyl acetate
2: BCl3 / CH2Cl2 / 12 h / 20 °C
3: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: ethyl acetate
2: 86 percent / BCl3 / CH2Cl2 / 192 h
3: LiOH / H2O
View Scheme
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide
60435-90-7

5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: BCl3 / CH2Cl2 / 12 h / 20 °C
2: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 86 percent / BCl3 / CH2Cl2 / 192 h
2: LiOH / H2O
View Scheme
(E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal
545392-47-0

(E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Jones reagent / acetone / 4 h / -30 °C
2: 189 mg / ethyl acetate
3: BCl3 / CH2Cl2 / 12 h / 20 °C
4: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: CrO3, acid / acetone / -30 °C
2: ethyl acetate
3: 86 percent / BCl3 / CH2Cl2 / 192 h
4: LiOH / H2O
View Scheme
6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one
207398-37-6

6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: O3 / methanol / -78 °C
1.2: Me2S / methanol / 3 h / -10 - 20 °C
2.1: Jones reagent / acetone / 4 h / -30 °C
3.1: 189 mg / ethyl acetate
4.1: BCl3 / CH2Cl2 / 12 h / 20 °C
5.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C
2: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
3: Jones reagent / acetone / 4 h / -30 °C
4: 189 mg / ethyl acetate
5: BCl3 / CH2Cl2 / 12 h / 20 °C
6: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: O3, Me2S / CH2Cl2; pyridine / -78 °C
2: CrO3, acid / acetone / -30 °C
3: ethyl acetate
4: 86 percent / BCl3 / CH2Cl2 / 192 h
5: LiOH / H2O
View Scheme
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester
207398-36-5

3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 100 percent / K2CO3 / methanol / 6 h
2.1: O3 / methanol / -78 °C
2.2: Me2S / methanol / 3 h / -10 - 20 °C
3.1: Jones reagent / acetone / 4 h / -30 °C
4.1: 189 mg / ethyl acetate
5.1: BCl3 / CH2Cl2 / 12 h / 20 °C
6.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: 100 percent / K2CO3 / methanol / 6 h
2: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C
3: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
4: Jones reagent / acetone / 4 h / -30 °C
5: 189 mg / ethyl acetate
6: BCl3 / CH2Cl2 / 12 h / 20 °C
7: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: K2CO3 / methanol
2: O3, Me2S / CH2Cl2; pyridine / -78 °C
3: CrO3, acid / acetone / -30 °C
4: ethyl acetate
5: 86 percent / BCl3 / CH2Cl2 / 192 h
6: LiOH / H2O
View Scheme
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester
207402-09-3

3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 89 percent / NaBH4 / methanol / 0.5 h
2.1: Et3N / CH2Cl2 / 2.5 h / 25 °C
3.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
4.1: 100 percent / K2CO3 / methanol / 6 h
5.1: O3 / methanol / -78 °C
5.2: Me2S / methanol / 3 h / -10 - 20 °C
6.1: Jones reagent / acetone / 4 h / -30 °C
7.1: 189 mg / ethyl acetate
8.1: BCl3 / CH2Cl2 / 12 h / 20 °C
9.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1: 89 percent / NaBH4 / methanol / 0.5 h
2: Et3N / CH2Cl2 / 2.5 h / 25 °C
3: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
4: 100 percent / K2CO3 / methanol / 6 h
5: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C
6: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
7: Jones reagent / acetone / 4 h / -30 °C
8: 189 mg / ethyl acetate
9: BCl3 / CH2Cl2 / 12 h / 20 °C
10: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1: 89 percent / NaBH4 / methanol
2: Et3N / CH2Cl2 / 1.5 h
3: NaBH4 / dimethylformamide
4: K2CO3 / methanol
5: O3, Me2S / CH2Cl2; pyridine / -78 °C
6: CrO3, acid / acetone / -30 °C
7: ethyl acetate
8: 86 percent / BCl3 / CH2Cl2 / 192 h
9: LiOH / H2O
View Scheme
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester
207402-10-6

3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: Et3N / CH2Cl2 / 2.5 h / 25 °C
2.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
3.1: 100 percent / K2CO3 / methanol / 6 h
4.1: O3 / methanol / -78 °C
4.2: Me2S / methanol / 3 h / -10 - 20 °C
5.1: Jones reagent / acetone / 4 h / -30 °C
6.1: 189 mg / ethyl acetate
7.1: BCl3 / CH2Cl2 / 12 h / 20 °C
8.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1: Et3N / CH2Cl2 / 2.5 h / 25 °C
2: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
3: 100 percent / K2CO3 / methanol / 6 h
4: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C
5: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
6: Jones reagent / acetone / 4 h / -30 °C
7: 189 mg / ethyl acetate
8: BCl3 / CH2Cl2 / 12 h / 20 °C
9: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: Et3N / CH2Cl2 / 1.5 h
2: NaBH4 / dimethylformamide
3: K2CO3 / methanol
4: O3, Me2S / CH2Cl2; pyridine / -78 °C
5: CrO3, acid / acetone / -30 °C
6: ethyl acetate
7: 86 percent / BCl3 / CH2Cl2 / 192 h
8: LiOH / H2O
View Scheme
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-methanesulfonyloxymethyl-2,4-dimethoxy-benzoic acid methyl ester

3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-methanesulfonyloxymethyl-2,4-dimethoxy-benzoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
2.1: 100 percent / K2CO3 / methanol / 6 h
3.1: O3 / methanol / -78 °C
3.2: Me2S / methanol / 3 h / -10 - 20 °C
4.1: Jones reagent / acetone / 4 h / -30 °C
5.1: 189 mg / ethyl acetate
6.1: BCl3 / CH2Cl2 / 12 h / 20 °C
7.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C
2: 100 percent / K2CO3 / methanol / 6 h
3: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C
4: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
5: Jones reagent / acetone / 4 h / -30 °C
6: 189 mg / ethyl acetate
7: BCl3 / CH2Cl2 / 12 h / 20 °C
8: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: NaBH4 / dimethylformamide
2: K2CO3 / methanol
3: O3, Me2S / CH2Cl2; pyridine / -78 °C
4: CrO3, acid / acetone / -30 °C
5: ethyl acetate
6: 86 percent / BCl3 / CH2Cl2 / 192 h
7: LiOH / H2O
View Scheme
6-[5-(3,3-dimethyl-oxiranyl)-3-methyl-pent-2-enyl]-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one
545392-50-5

6-[5-(3,3-dimethyl-oxiranyl)-3-methyl-pent-2-enyl]-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C
2: Jones reagent / acetone / 4 h / -30 °C
3: 189 mg / ethyl acetate
4: BCl3 / CH2Cl2 / 12 h / 20 °C
5: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C
View Scheme
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dihydroxy-benzoic acid methyl ester
207398-35-4

3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dihydroxy-benzoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 88 percent / NaH / dimethylformamide
2: 89 percent / NaBH4 / methanol
3: Et3N / CH2Cl2 / 1.5 h
4: NaBH4 / dimethylformamide
5: K2CO3 / methanol
6: O3, Me2S / CH2Cl2; pyridine / -78 °C
7: CrO3, acid / acetone / -30 °C
8: ethyl acetate
9: 86 percent / BCl3 / CH2Cl2 / 192 h
10: LiOH / H2O
View Scheme
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde
24953-96-6

(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature
2: 67 percent / tetrahydrofuran / 0.67 h / -40 °C
3: pivalic acid / xylene / 6 h / 135 - 140 °C
4: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
5: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
4-Hydroxy-2-methoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one
193277-88-2

4-Hydroxy-2-methoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, 0 ged C, 15 min, 2.) DMF, a) 0 deg C, 30 min, b) RT, 30 min
2: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature
3: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature
4: 67 percent / tetrahydrofuran / 0.67 h / -40 °C
5: pivalic acid / xylene / 6 h / 135 - 140 °C
6: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
7: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
2,4-Dimethoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one
193277-77-9

2,4-Dimethoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature
2: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature
3: 67 percent / tetrahydrofuran / 0.67 h / -40 °C
4: pivalic acid / xylene / 6 h / 135 - 140 °C
5: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
6: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
[6-methoxy-4-(2-methoxyethoxymethoxy)-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl]-acetaldehyde
172151-14-3

[6-methoxy-4-(2-methoxyethoxymethoxy)-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl]-acetaldehyde

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 67 percent / tetrahydrofuran / 0.67 h / -40 °C
2: pivalic acid / xylene / 6 h / 135 - 140 °C
3: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
4: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
6-(2-hydroxy-3-methylbut-3-enyl)-5-methoxy-7-(2-methoxyethoxymethoxy)-4-methyl-3H-isobenzofuran-2-one
193277-85-9

6-(2-hydroxy-3-methylbut-3-enyl)-5-methoxy-7-(2-methoxyethoxymethoxy)-4-methyl-3H-isobenzofuran-2-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pivalic acid / xylene / 6 h / 135 - 140 °C
2: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
3: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
(E)-6-[6-Methoxy-4-(2-methoxy-ethoxymethoxy)-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid ethyl ester

(E)-6-[6-Methoxy-4-(2-methoxy-ethoxymethoxy)-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid ethyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
2: 98 percent / aq. LiOH / methanol / 12 h
View Scheme
7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
24282-61-9

7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 79 percent / benzyl trimethyl ammonium dichloroiodate, NaHCO3 / CH2Cl2; methanol / Ambient temperature
2: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h
3: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C
4: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature
5: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C
2: tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 16 h / 20 - 100 °C / Inert atmosphere
3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C
2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 24 h / 100 °C
3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C
View Scheme
7-hydroxy-6-iodo-5-methoxy-4-methylisobenzofuran-1(3H)-one
188291-73-8

7-hydroxy-6-iodo-5-methoxy-4-methylisobenzofuran-1(3H)-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h
2: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C
3: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature
4: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
6-Iodo-5-methoxy-4-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-3H-isobenzofuran-1-one
188291-75-0

6-Iodo-5-methoxy-4-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-3H-isobenzofuran-1-one

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C
2: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature
3: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
(E)-6-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilanyl-ethoxymethoxy)-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid methyl ester
188291-78-3

(E)-6-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilanyl-ethoxymethoxy)-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid methyl ester

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature
2: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
Ethyl E-6-<1,3-Dihydro-4-(tert-butyldimethylsilyloxy)-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl>-4-methyl-4-hexenoate
138768-43-1

Ethyl E-6-<1,3-Dihydro-4-(tert-butyldimethylsilyloxy)-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl>-4-methyl-4-hexenoate

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / nBu4NF / tetrahydrofuran / 1 h
2: 93 percent / aq. LiOH / methanol / 5 h / 23 °C
View Scheme
Multi-step reaction with 2 steps
1: 83 percent / n-Bu4NF / tetrahydrofuran / 0.25 h / 25 °C
2: 71 percent / LiOH / methanol; H2O / 1 h / 25 °C
View Scheme
(E)-6-acetoxy-4-methyl-4-hexenal
35334-60-2

(E)-6-acetoxy-4-methyl-4-hexenal

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 84 percent / NaBH4 / ethanol / 0.42 h / 25 °C
2: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature
3: K2CO3 / methanol / 24 h / Ambient temperature
4: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
5: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
6: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
7: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
8: conc. HCl / methanol / 4.5 h / Heating
9: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme
<(2E)-6-Hydroxy-3-methyl-2-hexenyl>acetat
100045-79-2

<(2E)-6-Hydroxy-3-methyl-2-hexenyl>acetat

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature
2: K2CO3 / methanol / 24 h / Ambient temperature
3: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
4: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
5: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
6: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
7: conc. HCl / methanol / 4.5 h / Heating
8: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme
(E)-6-((tert-butyldimethylsilyl)oxy)-3-methylhex-2-en-1-yl acetate
100045-80-5

(E)-6-((tert-butyldimethylsilyl)oxy)-3-methylhex-2-en-1-yl acetate

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: K2CO3 / methanol / 24 h / Ambient temperature
2: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
3: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
4: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
5: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
6: conc. HCl / methanol / 4.5 h / Heating
7: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme
(E)-3-methyl-6-<(tert-butyldimethylsilyl)oxy>-2-hexen-1-ol
100045-81-6

(E)-3-methyl-6-<(tert-butyldimethylsilyl)oxy>-2-hexen-1-ol

mycophenolic acid
24280-93-1

mycophenolic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
2: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
3: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
4: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
5: conc. HCl / methanol / 4.5 h / Heating
6: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme
methanol
67-56-1

methanol

mycophenolic acid
24280-93-1

mycophenolic acid

methyl mycophenolate
31858-66-9

methyl mycophenolate

Conditions
ConditionsYield
With sulfuric acid for 2h; Heating;100%
With sulfuric acid for 20h; Ambient temperature;95%
With toluene-4-sulfonic acid for 2h; Reflux;95.86%
mycophenolic acid
24280-93-1

mycophenolic acid

sodium mycophenolate

sodium mycophenolate

Conditions
ConditionsYield
With sodium methylate In methanol; ethyl acetate at 20℃; for 1h; Product distribution / selectivity; Charcoal;97%
With sodium methylate In methanol; ethyl acetate at 20℃; for 0.5h; Product distribution / selectivity;94%
With sodium methylate In methanol; ISOPROPYLAMIDE at 20℃; for 0.166667h; Product distribution / selectivity;92%
mycophenolic acid
24280-93-1

mycophenolic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl (4-O-benzyl)mycophenolate
1186295-41-9

benzyl (4-O-benzyl)mycophenolate

Conditions
ConditionsYield
With trimethylbenzylammonium bromide; potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h;96%
mycophenolic acid
24280-93-1

mycophenolic acid

allyl bromide
106-95-6

allyl bromide

(E)-allyl 6-(4-(allyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

(E)-allyl 6-(4-(allyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 18h;93%
ethanol
64-17-5

ethanol

mycophenolic acid
24280-93-1

mycophenolic acid

ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate
32483-51-5

ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 2h; Reflux;92%
mycophenolic acid
24280-93-1

mycophenolic acid

A

7-hydroxy-5-methoxy-4-methyl-6-(2-(2-methyl-5-oxotetrahydrofuran-2-yl)ethyl)isobenzofuran-1(3H)-one
26675-76-3

7-hydroxy-5-methoxy-4-methyl-6-(2-(2-methyl-5-oxotetrahydrofuran-2-yl)ethyl)isobenzofuran-1(3H)-one

B

mycochromanic acid
24243-38-7

mycochromanic acid

Conditions
ConditionsYield
With sulfuric acid In acetic acid for 4h; Heating;A 5%
B 90%
mycophenolic acid
24280-93-1

mycophenolic acid

trimethylsilyldiazomethane

trimethylsilyldiazomethane

5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide
60435-90-7

5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide

Conditions
ConditionsYield
In methanol at 20℃; for 12h;90%
lauric anhydride
645-66-9

lauric anhydride

mycophenolic acid
24280-93-1

mycophenolic acid

(E)-6-(1,3-dihydro-4-dodecanoyloxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
59058-47-8

(E)-6-(1,3-dihydro-4-dodecanoyloxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 120h;90%
mycophenolic acid
24280-93-1

mycophenolic acid

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(E)-6-(4-tert-butyldimethylsilyloxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid
1451181-22-8

(E)-6-(4-tert-butyldimethylsilyloxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Inert atmosphere;89%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 88h;60%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

mycophenolic acid
24280-93-1

mycophenolic acid

C21H23NO8

C21H23NO8

Conditions
ConditionsYield
Stage #1: 1-hydroxy-pyrrolidine-2,5-dione; mycophenolic acid In acetonitrile Cooling with ice;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile for 24.5h;
89%
mycophenolic acid
24280-93-1

mycophenolic acid

nor-O-methylmycophenolic acid
31858-65-8

nor-O-methylmycophenolic acid

Conditions
ConditionsYield
With lithium iodide88.5%
With pyridine; 2,3,5-trimethyl-pyridine; lithium iodide at 120℃; for 18h;74%
mycophenolic acid
24280-93-1

mycophenolic acid

glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

methyl ester N-mycophenoylglycine

methyl ester N-mycophenoylglycine

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;86%
mycophenolic acid
24280-93-1

mycophenolic acid

2',3'-isopropylidene adenosine
362-75-4

2',3'-isopropylidene adenosine

C30H35N5O9
1532533-29-1

C30H35N5O9

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine Inert atmosphere;86%
mycophenolic acid
24280-93-1

mycophenolic acid

tert-butylamine
75-64-9

tert-butylamine

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid t-butylamine salt
1000853-04-2

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid t-butylamine salt

Conditions
ConditionsYield
In ethyl acetate at 22 - 60℃; for 1h; Product distribution / selectivity;85.6%
2-(morpholin-4-yl)ethanol
622-40-2

2-(morpholin-4-yl)ethanol

mycophenolic acid
24280-93-1

mycophenolic acid

mycophenolate mofetil
115007-34-6

mycophenolate mofetil

Conditions
ConditionsYield
toluene-4-sulfonic acid at 160℃; for 5h; Product distribution / selectivity;84%
(1S)-10-camphorsulfonic acid at 150 - 155℃; for 8h; Product distribution / selectivity;84%
at 160℃; for 5h; Product distribution / selectivity;84%
mycophenolic acid
24280-93-1

mycophenolic acid

tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate
263162-13-6

tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate

(E)-tert-butyl 2-((2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethyl)(methyl)amino)ethylcarbamate
1333040-76-8

(E)-tert-butyl 2-((2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethyl)(methyl)amino)ethylcarbamate

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h;84%
(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)
125074-46-6, 31246-62-5, 31246-63-6, 31246-66-9, 53261-25-9

(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)

mycophenolic acid
24280-93-1

mycophenolic acid

C34H44Cl2N2O12Pt

C34H44Cl2N2O12Pt

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 40℃; for 60h; Temperature; Darkness;83.9%
mycophenolic acid
24280-93-1

mycophenolic acid

acetic anhydride
108-24-7

acetic anhydride

7-O-Acetylmycophenolic acid
31377-08-9

7-O-Acetylmycophenolic acid

Conditions
ConditionsYield
With pyridine; dmap at 0℃;83%
With pyridine; dmap at 20℃;62%
mycophenolic acid
24280-93-1

mycophenolic acid

tert-butyl 2-(2-aminoethoxy)ethylcarbamate
127828-22-2

tert-butyl 2-(2-aminoethoxy)ethylcarbamate

(E)-tert-butyl 2-(2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethoxy)ethylcarbamate
1333040-60-0

(E)-tert-butyl 2-(2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethoxy)ethylcarbamate

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h;83%
mycophenolic acid
24280-93-1

mycophenolic acid

3-(5-Carboxy-3-methyl-pent-2t-enyl)-4-hydroxy-6-hydroxymethyl-2-methoxy-toluol; 6-(6-Hydroxy-4-hydroxymethyl-2-methoxy-3-methyl-phenyl)-4-methyl-hex-4t-ensaeure
31848-65-4

3-(5-Carboxy-3-methyl-pent-2t-enyl)-4-hydroxy-6-hydroxymethyl-2-methoxy-toluol; 6-(6-Hydroxy-4-hydroxymethyl-2-methoxy-3-methyl-phenyl)-4-methyl-hex-4t-ensaeure

Conditions
ConditionsYield
With lithium hydroxide In water for 96h; Heating;82%
mycophenolic acid
24280-93-1

mycophenolic acid

α,β-D-glucuronate

α,β-D-glucuronate

mycophenolic acid-O-acyl-β-D-glucopyranuronoside benzyl ester

mycophenolic acid-O-acyl-β-D-glucopyranuronoside benzyl ester

Conditions
ConditionsYield
Stage #1: mycophenolic acid; α,β-D-glucuronate With 4-methyl-morpholine In acetonitrile at 20℃; for 2h; Molecular sieve; Inert atmosphere;
Stage #2: With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate In acetonitrile at 20℃; for 3h; Inert atmosphere; Molecular sieve;
82%
mycophenolic acid
24280-93-1

mycophenolic acid

(R)-leucine methyl ester hydrochloride
5845-53-4, 6322-53-8, 7517-19-3

(R)-leucine methyl ester hydrochloride

methyl ester N-mycophenoyl-D-leucine

methyl ester N-mycophenoyl-D-leucine

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;81%
mycophenolic acid
24280-93-1

mycophenolic acid

propargyl bromide
106-96-7

propargyl bromide

prop-2-yn-1-yl (E)-6-(6-methoxy-7-methyl-3-oxo-4-(prop-2-yn-1-yloxy)-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

prop-2-yn-1-yl (E)-6-(6-methoxy-7-methyl-3-oxo-4-(prop-2-yn-1-yloxy)-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene; acetonitrile at 20℃; for 48h;81%
mycophenolic acid
24280-93-1

mycophenolic acid

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

(E)-N-(4-chloro-3-(trifluoromethyl)phenyl)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide

(E)-N-(4-chloro-3-(trifluoromethyl)phenyl)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;80%
mycophenolic acid
24280-93-1

mycophenolic acid

triethylamine
121-44-8

triethylamine

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid triethylamine salt
66341-85-3

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid triethylamine salt

Conditions
ConditionsYield
In ethyl acetate at 10 - 60℃; for 1h; Product distribution / selectivity;78.7%
In ethyl acetate for 0.5h;
mycophenolic acid
24280-93-1

mycophenolic acid

D-alanine methyl ester hydrochloride
14316-06-4

D-alanine methyl ester hydrochloride

methyl ester N-mycophenoyl-D-alanine

methyl ester N-mycophenoyl-D-alanine

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;77%
2-(triphenylphosphoranylidene)propionaldehyde
24720-64-7

2-(triphenylphosphoranylidene)propionaldehyde

mycophenolic acid
24280-93-1

mycophenolic acid

(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal
24280-92-0

(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal

Conditions
ConditionsYield
Stage #1: mycophenolic acid With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tetrahydrofuran; water; acetone at 20℃; for 1.5h;
Stage #2: 2-(triphenylphosphoranylidene)propionaldehyde In benzene at 90℃; for 24h; Inert atmosphere;
77%
mycophenolic acid
24280-93-1

mycophenolic acid

isopropylamine
75-31-0

isopropylamine

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid isopropylamine salt
1000853-03-1

6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid isopropylamine salt

Conditions
ConditionsYield
In ethyl acetate at 11 - 55℃; for 2h;75.1%
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