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YUNBIO TECH CO.,LTD

Our Strength: -Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs. -Innovative: We are focusing on the development of new products and keep close relationships with

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Floxuridine Manufacturer/High quality/Best price/In stock

Cas:50-91-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or almost white crystalline powder Storage:2-8°C Package:100g/bo

Manufacturer supply Floxuridine CAS 50-91-9 with high purity

Cas:50-91-9

Min.Order:100 Gram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-Fluoro-2'-Deoxyuridine

Cas:50-91-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% (+)-5-Fluoro-2'-deoxyuridine 50-91-9 Producer

Cas:50-91-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Fluoro-2'-deoxyuridine

Cas:50-91-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Fludarabine Phosphate CAS:50-91-9 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerabilit

Factory Supply 5-Fluoro-2'-Deoxyuridine

Cas:50-91-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--50-91-9--Floxuridine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship

TIANFUCHEM--50-91-9--Floxuridine factory price

Cas:50-91-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

50-91-9 Floxuridine

Cas:50-91-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 50-91-9 with best quality

Cas:50-91-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name Floxuridine Synonyms Fluorodeoxyuridine; Fluoruridine deoxyribose; 2'-Deoxy-5-fluorouridine; (+)-5-Fluoro-2'-deoxyuridine Molecular Structure

Floxuridine 50-91-9

Cas:50-91-9

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Floxuridine 50-91-9

Cas:50-91-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Floxuridine CAS:50-91-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Floxuridine CAS:50-91-9

Cas:50-91-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Floxuridine

Cas:50-91-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 50-91-9 Floxuridine (250 mg)

Cas:50-91-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Floxuridine

Cas:50-91-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High Purity Floxuridine CAS: 50-91-9

Cas:50-91-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Floxuridine Synonyms: Floxuridine (250 mg);5-fluoro-1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione;5-F-2'--dU;Floxuridine API;1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil 5-Fluor

Floxuridine 99% Manufactuered in China best quality

Cas:50-91-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Floxuridine

Cas:50-91-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

FLOXURIDINE

Cas:50-91-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

5-F-2'-dU

Cas:50-91-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Doxifluridine

Cas:50-91-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Floxuridine

Cas:50-91-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 5-fluoro-2'-deoxyuridine

Cas:50-91-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Floxuridine 50-91-9Appearance:Powder Storage:preserve in well sealed container, store in cool and dry place, away from strong light and heat, when store under above condition, the retest date is 2 years away from manufacture date. Package:according t

Floxuridine 50-91-9

Cas:50-91-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High Purity Floxuridine CAS: 50-91-9

Cas:50-91-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:White solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application: Antiviral; antineoplastic. Transportation:AS PER YOUR REQ

Floxuridine

Cas:50-91-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Floxuridine

Cas:50-91-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Floxuridine

Cas:50-91-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Floxuridine CAS No.: 50-91-9 Molecule Formula:C9H11FN2O5 Molecule Weight:246.19 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING

High Quality Floxuridine

Cas:50-91-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

5-fluoro-1-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)uracil
1384553-43-8

5-fluoro-1-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)uracil

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 3h;98%
3',5'-di-O-(p-chlorobenzoyl)-5-fluoro-2'-deoxy-β-uridine
1582-79-2

3',5'-di-O-(p-chlorobenzoyl)-5-fluoro-2'-deoxy-β-uridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With methanol; ammonia at 10 - 25℃;86.2%
With ammonia In methanol at 30℃; for 16h;
With methanol; barium methoxide
5-fluorouracil
51-21-8

5-fluorouracil

7-methyl-2′-deoxyguanosine hydroiodide

7-methyl-2′-deoxyguanosine hydroiodide

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With potassium dihydrogenphosphate; Escherichia coli thymidine phosphorylase; Escherichia coli purine nucleoside phosphorylase In aq. buffer at 20℃; for 20h; pH=7.5; Enzymatic reaction;81%
5-fluorouracil
51-21-8

5-fluorouracil

2'-deoxyuridine
951-78-0

2'-deoxyuridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
at 37℃; for 16h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli, ammonium acetate buffer pH 5.8;62%
With purine nucleoside phosphorylase; uridine phosphorylase In aq. phosphate buffer; dimethyl sulfoxide at 80℃; for 3h; Enzymatic reaction;
5-fluorouracil
51-21-8

5-fluorouracil

thymidine
50-89-5

thymidine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With Lactobacillus animalis ATCC 35046 2’-N-deoxyribosyltransferase immobilized in DEAE-Sepharose In aq. buffer at 30℃; pH=7; Concentration; Reagent/catalyst; Green chemistry; Enzymatic reaction;35%
With thymidine phosphorylase In aq. phosphate buffer at 37℃; for 0.2h; pH=6.8; Enzymatic reaction;
With ammonium dihydrogen phosphate; ammonia In water at 45 - 55℃; for 45h; pH=6.6; Large scale; Enzymatic reaction;
With recobinant purine nucleoside phosphorylase from Escherichia coli In aq. phosphate buffer pH=6.8; Heating; Enzymatic reaction;
5-fluorouracil
51-21-8

5-fluorouracil

5-Methyluridine
1463-10-1

5-Methyluridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With lactobacillus animalis ATCC 35046 at 30℃; for 0.5h; pH=7; aq. buffer; Enzymatic reaction;22%
5-fluoro-O3',O5'-bis-(4-methyl-benzoyl)-2'-deoxy-uridine
7585-89-9

5-fluoro-O3',O5'-bis-(4-methyl-benzoyl)-2'-deoxy-uridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With methanol; barium methoxide
With methanol; barium methoxide
2'-deoxyuridine
951-78-0

2'-deoxyuridine

acetyl hypofluorite
78948-09-1

acetyl hypofluorite

A

(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
3180-64-1, 13964-07-3, 119180-46-0, 119180-47-1

(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione

B

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
3180-64-1, 13964-07-3, 119180-46-0, 119180-47-1

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione

C

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

D

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

E

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In acetic acid Product distribution; different solvents (AcOH,H2O), various nucleosides;A n/a
B n/a
C n/a
D n/a
E 5 % Chromat.
2'-deoxyuridine
951-78-0

2'-deoxyuridine

acetyl hypofluorite
78948-09-1

acetyl hypofluorite

A

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
3180-64-1, 13964-07-3, 119180-46-0, 119180-47-1

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione

B

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

C

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

D

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In acetic acid Yield given. Further byproducts given. Yields of byproduct given;
2'-deoxyuridine
951-78-0

2'-deoxyuridine

A

(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
3180-64-1, 13964-07-3, 119180-46-0, 119180-47-1

(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione

B

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

C

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

D

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With acetyl hypofluorite In water Yield given. Further byproducts given;A n/a
B n/a
C n/a
D 5 % Chromat.
2'-deoxyuridine
951-78-0

2'-deoxyuridine

A

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
3180-64-1, 13964-07-3, 119180-46-0, 119180-47-1

(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione

B

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

C

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

D

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With acetyl hypofluorite In acetic acid Further byproducts given. Yields of byproduct given;A n/a
B n/a
C n/a
D 5 % Chromat.
With acetyl hypofluorite In water Yield given. Further byproducts given. Yields of byproduct given;
3',5'-O-dicaproyl-floxuridine
3415-69-8

3',5'-O-dicaproyl-floxuridine

A

3'-O-caproyl-floxuridine
123739-84-4

3'-O-caproyl-floxuridine

B

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Subtilisin;A 22 % Chromat.
B 71 % Chromat.
3',5'-O-dicaproyl-floxuridine
3415-69-8

3',5'-O-dicaproyl-floxuridine

A

3'-O-caproyl-floxuridine
123739-84-4

3'-O-caproyl-floxuridine

B

5'-O-caproyl-floxuridine
123739-81-1

5'-O-caproyl-floxuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
3',5'-O-dicaproyl-floxuridine
3415-69-8

3',5'-O-dicaproyl-floxuridine

A

5'-O-caproyl-floxuridine
123739-81-1

5'-O-caproyl-floxuridine

B

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Pseudomonas fluorescens;A 74 % Chromat.
B 26 % Chromat.
3',5'-di-O-butanoyl-5-fluoro-2'-deoxyuridine
3343-22-4

3',5'-di-O-butanoyl-5-fluoro-2'-deoxyuridine

A

3'-O-butanoyl-5-fluoro-2'-deoxyuridine
7207-60-5

3'-O-butanoyl-5-fluoro-2'-deoxyuridine

B

5'-O-butanoyl-5-fluoro-2'-deoxyuridine
7207-61-6

5'-O-butanoyl-5-fluoro-2'-deoxyuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
3',5'-O-dioctanoyl-floxuridine
3415-70-1

3',5'-O-dioctanoyl-floxuridine

A

3'-O-octanoyl-floxuridine
86977-19-7

3'-O-octanoyl-floxuridine

B

5'-O-octanoyl-floxuridine
118694-10-3

5'-O-octanoyl-floxuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
3',5'-O-didecanoyl-floxuridine
7207-65-0

3',5'-O-didecanoyl-floxuridine

A

3'-O-decanoyl-floxuridine
118694-11-4

3'-O-decanoyl-floxuridine

B

5'-O-decanoyl-floxuridine
118694-12-5

5'-O-decanoyl-floxuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
3',5'-O-dilauroyl-floxuridine
7207-66-1

3',5'-O-dilauroyl-floxuridine

A

3'-O-lauroyl-floxuridine
118694-13-6

3'-O-lauroyl-floxuridine

B

5'-O-lauroyl-floxuridine
118694-14-7

5'-O-lauroyl-floxuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzime concentration dependence;
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In triethylamine at 70℃; for 0.5h;
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
119003-28-0, 119068-00-7

Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In triethylamine at 70℃; for 0.5h;
2'-deoxy-5-fluoro-5'-O-(1,3-dithian-2-yl)uridine
110238-43-2

2'-deoxy-5-fluoro-5'-O-(1,3-dithian-2-yl)uridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In methanol; water Product distribution; Mechanism; Ambient temperature; Irradiation; other 5'-O-substituted 2'-deoxy-5-fluorouridine, var. solvents (saturated or no with nitrous oxide);
3-dimethylsulfoxyimidyl-5-fluorouridine
110238-48-7

3-dimethylsulfoxyimidyl-5-fluorouridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
In methanol; water at 20℃; Product distribution; Mechanism; Irradiation; other 3-substituted 5-fluorouridine and 2'-deoxy-5-fluorouridine, var. solvents saturated with oxygen or nitrogen;
3'-(7-carboxyheptanoyl)-5-fluoro-2'-deoxyuridine
111245-27-3

3'-(7-carboxyheptanoyl)-5-fluoro-2'-deoxyuridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With esterase (porcine liver) at 37.5℃; for 2h; Product distribution; In vitro drug release studies: enzymatic and nonenzymatic processes; var. reaction cond.;
5'-(Cortisol-21-phosphoryl)-5-fluoro-2'-deoxyuridine ammonium salt

5'-(Cortisol-21-phosphoryl)-5-fluoro-2'-deoxyuridine ammonium salt

A

hydrocortisone 21-phosphate
3863-59-0

hydrocortisone 21-phosphate

B

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With barium dihydroxide at 90 - 95℃; for 0.25h; Product distribution;
5-fluoro-O3',O5'-dipropionyl-2'-deoxy-uridine
4564-21-0

5-fluoro-O3',O5'-dipropionyl-2'-deoxy-uridine

A

Propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

B

Propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil
110522-47-9, 7207-56-9

1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil

A

5'-O-acetyl-floxuridine
2823-52-1

5'-O-acetyl-floxuridine

B

3′-O-acetyl-5-fluoro-2′-deoxyuridine
2059-38-3

3′-O-acetyl-5-fluoro-2′-deoxyuridine

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence;
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine
2691-71-6

3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With sodium methylate In methanol Ambient temperature;
With sodium hydroxide In methanol at 20 - 30℃; Large scale;
Carbonic acid 4,5-dimethoxy-2-nitro-benzyl ester (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Carbonic acid 4,5-dimethoxy-2-nitro-benzyl ester (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

A

carbon dioxide
124-38-9

carbon dioxide

B

4,5-dimethoxy-2-nitrosobenzaldehyde
119137-07-4

4,5-dimethoxy-2-nitrosobenzaldehyde

C

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With sodium phosphate buffer at 4℃; Product distribution; Irradiation; var. times;
2-((S)-2-Formylamino-4-methylsulfanyl-butyrylamino)-2-methyl-propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
287731-60-6

2-((S)-2-Formylamino-4-methylsulfanyl-butyrylamino)-2-methyl-propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

A

(S)-3,3-Dimethyl-6-(2-methylsulfanyl-ethyl)-piperazine-2,5-dione

(S)-3,3-Dimethyl-6-(2-methylsulfanyl-ethyl)-piperazine-2,5-dione

B

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With phosphate buffer; peptide deformylase from E. coli pH=7.4; Enzyme kinetics; deformylation; intramolecular cyclization;
mono-4-methoxytrityl chloride
14470-28-1

mono-4-methoxytrityl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

5'-O-(4-monomethoxytrityl)-2'-deoxy-5-fluorouridine
103767-37-9

5'-O-(4-monomethoxytrityl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With pyridine for 48h; Ambient temperature;100%
With pyridine at 20℃; for 5h;94%
In pyridine for 24h; Ambient temperature;86%
vinyl oleate
3896-58-0

vinyl oleate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

5'-O-oleoyl-FUdR
143767-53-7

5'-O-oleoyl-FUdR

B

3'-O-oleoyl-FUdR

3'-O-oleoyl-FUdR

C

3',5'-dioleoyl floxuridine
7207-70-7

3',5'-dioleoyl floxuridine

Conditions
ConditionsYield
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 40℃; for 9h; regioselective reaction;A n/a
B 99%
C n/a
acetic anhydride
108-24-7

acetic anhydride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil
110522-47-9, 7207-56-9

1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil

Conditions
ConditionsYield
With pyridine at 20℃; for 8h;97%
With dmap In pyridine
With pyridine at 0℃; for 5h;
With dmap; triethylamine In dichloromethane at -10 - 5℃; Large scale;
2-nitrophenylmethyl bromide
3958-60-9

2-nitrophenylmethyl bromide

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3-(o-nitrobenzyl)-2'-deoxy-5-fluorouridine
98653-16-8

3-(o-nitrobenzyl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature;97%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)dione
150109-68-5

1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)dione

Conditions
ConditionsYield
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 0℃; Inert atmosphere;
Stage #2: 5-Fluoro-2'-deoxyuridine In dichloromethane at 20℃; Inert atmosphere;
97%
Stage #1: 5-Fluoro-2'-deoxyuridine With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 2h;
91%
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h;
Stage #1: 5-Fluoro-2'-deoxyuridine With 1H-imidazole In dichloromethane for 0.5h; Inert atmosphere; Cooling with ice;
Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 20℃; for 1h; Inert atmosphere;
vinyl pivalate
3377-92-2

vinyl pivalate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

3'-O-pivaloyl-FUdR
1072440-12-0

3'-O-pivaloyl-FUdR

B

1-<2'-deoxy-5'-O-(trimethylacetyl)-β-D-ribofuranosyl>-5-fluorouracil
107036-58-8

1-<2'-deoxy-5'-O-(trimethylacetyl)-β-D-ribofuranosyl>-5-fluorouracil

Conditions
ConditionsYield
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 66h; Reactivity; Temperature; Time; regioselective reaction;A 96%
B n/a
trityl chloride
76-83-5

trityl chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)-5-fluorouracil
101039-89-8

1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)-5-fluorouracil

Conditions
ConditionsYield
Stage #1: trityl chloride; 5-Fluoro-2'-deoxyuridine With pyridine at 100℃; for 0.5h;
Stage #2: methanesulfonyl chloride at 20℃; for 2h;
95%
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
104495-48-9

1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With dmap In pyridine for 4h; Ambient temperature;94%
With pyridine at 20℃; Inert atmosphere;92%
With pyridine; triethylamine at 20℃; for 20h;87%
chloromethyl ester

chloromethyl ester

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3-n-butoxybutyryloxymethyl-2'-deoxy-5-fluorouridine

3-n-butoxybutyryloxymethyl-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With sodium iodide; potassium carbonate92.2%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

2'-deoxy-5-fluoro-5'-O-<(4-methylphenyl)sulfonyl>uridine
10054-41-8

2'-deoxy-5-fluoro-5'-O-<(4-methylphenyl)sulfonyl>uridine

Conditions
ConditionsYield
With pyridine; triethylamine at 0 - 20℃; for 24h;90%
With pyridine at 0 - 5℃; for 48h;65%
With pyridine at 4℃; for 4h;63%
1-bromomethyl-3-nitrobenzene
3958-57-4

1-bromomethyl-3-nitrobenzene

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3-(m-nitrobenzyl)-2'-deoxy-5-fluorouridine
98653-17-9

3-(m-nitrobenzyl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature;90%
benzoic acid
65-85-0

benzoic acid

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

2,3'-anhydro-5'-O-benzoyl-5-fluoro-2'-deoxyuridine
507232-12-4

2,3'-anhydro-5'-O-benzoyl-5-fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In N,N-dimethyl-formamide at 25℃; for 1.5h; Mitsunobu reaction;90%
succinic acid anhydride
108-30-5

succinic acid anhydride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3',5'-bis(3-carboxypropionyl)-5-fluoro-2'-deoxyuridine
99194-70-4

3',5'-bis(3-carboxypropionyl)-5-fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With dmap In pyridine for 12h; Ambient temperature;88%
vinyl benzoate
769-78-8

vinyl benzoate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

5'-O-benzoyl-FUdR
1006381-74-3

5'-O-benzoyl-FUdR

B

(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate
1995-83-1

(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

C

3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine
2691-71-6

3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 66h; Reactivity; Time; Temperature; regioselective reaction;A n/a
B 88%
C n/a
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3',5'-di-O-benzhydryl-5-fluoro-2'-deoxyuridine
1454883-43-2

3',5'-di-O-benzhydryl-5-fluoro-2'-deoxyuridine

Conditions
ConditionsYield
With palladium dichloride In 1,2-dichloro-ethane at 85℃; for 16h; Inert atmosphere;85%
With palladium dichloride In 1,2-dichloro-ethane at 85℃; Inert atmosphere;
trityl chloride
76-83-5

trityl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-(2-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-5-fluorouracil
4031-24-7, 10343-71-2, 103285-11-6

1-(2-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-5-fluorouracil

Conditions
ConditionsYield
With pyridine for 1h; Heating;84%
With pyridine; dmap at 20 - 100℃; for 17h; Inert atmosphere;84.4%
With pyridine; dmap at 80℃; for 5h;81%
stearyl 2-trimethylammonioethyl phosphate
65956-63-0

stearyl 2-trimethylammonioethyl phosphate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Phosphoric acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester octadecyl ester
86976-76-3

Phosphoric acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester octadecyl ester

Conditions
ConditionsYield
With phospholipase D from Streptomyces sp. AA 586 In chloroform; water at 45℃; for 6h; sodium acetate buffer, CaCl2, pH 5.8;84%
1-bromomethyl-4-nitro-benzene
100-11-8

1-bromomethyl-4-nitro-benzene

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

3-(p-nitrobenzyl)-2'-deoxy-5-fluorouridine
98653-18-0

3-(p-nitrobenzyl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature;84%
benzoic acid
65-85-0

benzoic acid

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

2,3'-anhydro-5'-O-benzoyl-5-fluoro-2'-deoxvuridine

2,3'-anhydro-5'-O-benzoyl-5-fluoro-2'-deoxvuridine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In N,N-dimethyl-formamide for 0.75h;84%
(triphenylphosphine)gold(I) chloride
14243-64-2

(triphenylphosphine)gold(I) chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

(5-fluoro-2'-deoxyuridinato-N3)(triphenylphosphine)gold(I)

(5-fluoro-2'-deoxyuridinato-N3)(triphenylphosphine)gold(I)

Conditions
ConditionsYield
With KOH In tetrahydrofuran; water under argon; gold complex, ligand and KOH were dissolved in H2O/THF; stirring at 50-60°C; precipitation by evaporation of THF; filtered off; recrystallization from THF with addition of diethylether; elem.anal., IR, NMR;83.8%
2-chloro-1,3-dimethyl-1,3,2-diazaphospholidine
6069-36-9

2-chloro-1,3-dimethyl-1,3,2-diazaphospholidine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

2'-deoxy-5-fluoro-3',5'-bis-O-(1,3-dimethyl-1,3-diaza-2-phosphacyclopentan-2-yl)uridine
96502-21-5

2'-deoxy-5-fluoro-3',5'-bis-O-(1,3-dimethyl-1,3-diaza-2-phosphacyclopentan-2-yl)uridine

Conditions
ConditionsYield
With triethylamine In chloroform at 0 - 20℃; for 1h;83%
vinyl 2-butenoate

vinyl 2-butenoate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

5'-O-crotonyl-FUdR
1118767-44-4

5'-O-crotonyl-FUdR

B

3'-O-crotonyl-FUdR
1072440-07-3

3'-O-crotonyl-FUdR

C

3',5'-di-O-crotonyl-FUdR
1072440-08-4

3',5'-di-O-crotonyl-FUdR

Conditions
ConditionsYield
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 43h; Reactivity; Time; Temperature; regioselective reaction;A n/a
B 83%
C n/a
tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

1-((2R,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

1-((2R,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;83%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;80%
vinyl acetate
108-05-4

vinyl acetate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

5'-O-acetyl-floxuridine
2823-52-1

5'-O-acetyl-floxuridine

B

Acetic acid (2R,3S)-2-acetoxymethyl-5-((S)-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
7207-56-9, 110522-47-9

Acetic acid (2R,3S)-2-acetoxymethyl-5-((S)-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

C

3′-O-acetyl-5-fluoro-2′-deoxyuridine
2059-38-3

3′-O-acetyl-5-fluoro-2′-deoxyuridine

Conditions
ConditionsYield
PS (Pseudomonas sp. lipase) In 1,4-dioxaneA 8.1%
B 8.5%
C 82%
PPL (Porcine pancreas lipase) In 1,4-dioxaneA 49.3%
B 0.4%
C 25.7%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine
129816-30-4

5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h;82%
With 1H-imidazole In N,N-dimethyl-formamide at -30℃; for 5.5h;77%
With pyridine; 1H-imidazole at 20℃; for 24h; Inert atmosphere;76%
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h;
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 4h;
morpholine
110-91-8

morpholine

2-Bromopropionyl chloride
7148-74-5

2-Bromopropionyl chloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

5'-O-(2-morpholinopropionyl)-2'-deoxy-5-fluorouridine
80667-47-6

5'-O-(2-morpholinopropionyl)-2'-deoxy-5-fluorouridine

Conditions
ConditionsYield
In 1,4-dioxane; pyridine; methanol; dichloromethane82%
vinyl 2-ethylhexanoate
397249-28-4

vinyl 2-ethylhexanoate

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

A

3'-O-(2-ethylhexanoyl)-FUdR
1118767-25-1

3'-O-(2-ethylhexanoyl)-FUdR

B

5'-O-(2-ethylhexanoyl)-FUdR
1118767-43-3

5'-O-(2-ethylhexanoyl)-FUdR

Conditions
ConditionsYield
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 90h; Reactivity; Temperature; Time; regioselective reaction;A 82%
B n/a
2-acetoxytetrahydrofuran
1608-67-9

2-acetoxytetrahydrofuran

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

2'-deoxy-5-fluoro-3-(2-tetrahydrofuranyl)uridine
103782-09-8

2'-deoxy-5-fluoro-3-(2-tetrahydrofuranyl)uridine

Conditions
ConditionsYield
With acetic acid; triethylamine; tin(IV) chloride In methanol; dichloromethane81.7%

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