Our Strength: -Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs. -Innovative: We are focusing on the development of new products and keep close relationships with
Cas:50-91-9
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:50-91-9
Min.Order:1 Kilogram
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Min.Order:100 Gram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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Min.Order:5 Kiloliter
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Type:Manufacturers
inquiryName:Fludarabine Phosphate CAS:50-91-9 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerabilit
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Min.Order:25 Kilogram
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inquiryTIANFUCHEM--50-91-9--Floxuridine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship
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Min.Order:1 Metric Ton
FOB Price: $2000.0
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryName Floxuridine Synonyms Fluorodeoxyuridine; Fluoruridine deoxyribose; 2'-Deoxy-5-fluorouridine; (+)-5-Fluoro-2'-deoxyuridine Molecular Structure
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:50-91-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryFloxuridine CAS:50-91-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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Min.Order:1 Gram
Negotiable
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1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Min.Order:10 Kilogram
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inquiryProduct Name: Floxuridine Synonyms: Floxuridine (250 mg);5-fluoro-1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione;5-F-2'--dU;Floxuridine API;1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil 5-Fluor
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Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
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Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:50-91-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiryFloxuridine 50-91-9Appearance:Powder Storage:preserve in well sealed container, store in cool and dry place, away from strong light and heat, when store under above condition, the retest date is 2 years away from manufacture date. Package:according t
We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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Min.Order:100 Gram
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Type:Lab/Research institutions
inquirysuperior quality Appearance:White solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application: Antiviral; antineoplastic. Transportation:AS PER YOUR REQ
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Product name: Floxuridine CAS No.: 50-91-9 Molecule Formula:C9H11FN2O5 Molecule Weight:246.19 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING
5-fluoro-1-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)uracil
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With sodium methylate In methanol at 20℃; for 3h; | 98% |
Conditions | Yield |
---|---|
With methanol; ammonia at 10 - 25℃; | 86.2% |
With ammonia In methanol at 30℃; for 16h; | |
With methanol; barium methoxide |
Conditions | Yield |
---|---|
With potassium dihydrogenphosphate; Escherichia coli thymidine phosphorylase; Escherichia coli purine nucleoside phosphorylase In aq. buffer at 20℃; for 20h; pH=7.5; Enzymatic reaction; | 81% |
Conditions | Yield |
---|---|
at 37℃; for 16h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli, ammonium acetate buffer pH 5.8; | 62% |
With purine nucleoside phosphorylase; uridine phosphorylase In aq. phosphate buffer; dimethyl sulfoxide at 80℃; for 3h; Enzymatic reaction; |
Conditions | Yield |
---|---|
With Lactobacillus animalis ATCC 35046 2’-N-deoxyribosyltransferase immobilized in DEAE-Sepharose In aq. buffer at 30℃; pH=7; Concentration; Reagent/catalyst; Green chemistry; Enzymatic reaction; | 35% |
With thymidine phosphorylase In aq. phosphate buffer at 37℃; for 0.2h; pH=6.8; Enzymatic reaction; | |
With ammonium dihydrogen phosphate; ammonia In water at 45 - 55℃; for 45h; pH=6.6; Large scale; Enzymatic reaction; | |
With recobinant purine nucleoside phosphorylase from Escherichia coli In aq. phosphate buffer pH=6.8; Heating; Enzymatic reaction; |
Conditions | Yield |
---|---|
With lactobacillus animalis ATCC 35046 at 30℃; for 0.5h; pH=7; aq. buffer; Enzymatic reaction; | 22% |
Conditions | Yield |
---|---|
With methanol; barium methoxide | |
With methanol; barium methoxide |
2'-deoxyuridine
acetyl hypofluorite
A
(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
B
(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
C
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
D
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
E
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In acetic acid Product distribution; different solvents (AcOH,H2O), various nucleosides; | A n/a B n/a C n/a D n/a E 5 % Chromat. |
2'-deoxyuridine
acetyl hypofluorite
A
(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
B
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
C
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
D
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In acetic acid Yield given. Further byproducts given. Yields of byproduct given; |
2'-deoxyuridine
A
(5S,6R)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
B
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
C
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
D
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With acetyl hypofluorite In water Yield given. Further byproducts given; | A n/a B n/a C n/a D 5 % Chromat. |
2'-deoxyuridine
A
(5R,6S)-5-Fluoro-6-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione
B
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
C
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
D
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With acetyl hypofluorite In acetic acid Further byproducts given. Yields of byproduct given; | A n/a B n/a C n/a D 5 % Chromat. |
With acetyl hypofluorite In water Yield given. Further byproducts given. Yields of byproduct given; |
3',5'-O-dicaproyl-floxuridine
A
3'-O-caproyl-floxuridine
B
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Subtilisin; | A 22 % Chromat. B 71 % Chromat. |
3',5'-O-dicaproyl-floxuridine
A
3'-O-caproyl-floxuridine
B
5'-O-caproyl-floxuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
3',5'-O-dicaproyl-floxuridine
A
5'-O-caproyl-floxuridine
B
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Pseudomonas fluorescens; | A 74 % Chromat. B 26 % Chromat. |
3',5'-di-O-butanoyl-5-fluoro-2'-deoxyuridine
A
3'-O-butanoyl-5-fluoro-2'-deoxyuridine
B
5'-O-butanoyl-5-fluoro-2'-deoxyuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
3',5'-O-dioctanoyl-floxuridine
A
3'-O-octanoyl-floxuridine
B
5'-O-octanoyl-floxuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
3',5'-O-didecanoyl-floxuridine
A
3'-O-decanoyl-floxuridine
B
5'-O-decanoyl-floxuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
3',5'-O-dilauroyl-floxuridine
A
3'-O-lauroyl-floxuridine
B
5'-O-lauroyl-floxuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzime concentration dependence; |
Acetic acid (4R,5S)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In triethylamine at 70℃; for 0.5h; |
Acetic acid (4S,5R)-5-fluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-hexahydro-pyrimidin-4-yl ester
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In triethylamine at 70℃; for 0.5h; |
2'-deoxy-5-fluoro-5'-O-(1,3-dithian-2-yl)uridine
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In methanol; water Product distribution; Mechanism; Ambient temperature; Irradiation; other 5'-O-substituted 2'-deoxy-5-fluorouridine, var. solvents (saturated or no with nitrous oxide); |
3-dimethylsulfoxyimidyl-5-fluorouridine
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
In methanol; water at 20℃; Product distribution; Mechanism; Irradiation; other 3-substituted 5-fluorouridine and 2'-deoxy-5-fluorouridine, var. solvents saturated with oxygen or nitrogen; |
3'-(7-carboxyheptanoyl)-5-fluoro-2'-deoxyuridine
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With esterase (porcine liver) at 37.5℃; for 2h; Product distribution; In vitro drug release studies: enzymatic and nonenzymatic processes; var. reaction cond.; |
Conditions | Yield |
---|---|
With barium dihydroxide at 90 - 95℃; for 0.25h; Product distribution; |
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil
A
5'-O-acetyl-floxuridine
B
3′-O-acetyl-5-fluoro-2′-deoxyuridine
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
porcine liver esterase In water at 37℃; Rate constant; pH=7.00; enzyme concentration dependence; |
Conditions | Yield |
---|---|
With sodium methylate In methanol Ambient temperature; | |
With sodium hydroxide In methanol at 20 - 30℃; Large scale; |
A
carbon dioxide
B
4,5-dimethoxy-2-nitrosobenzaldehyde
C
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With sodium phosphate buffer at 4℃; Product distribution; Irradiation; var. times; |
2-((S)-2-Formylamino-4-methylsulfanyl-butyrylamino)-2-methyl-propionic acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
B
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With phosphate buffer; peptide deformylase from E. coli pH=7.4; Enzyme kinetics; deformylation; intramolecular cyclization; |
mono-4-methoxytrityl chloride
5-Fluoro-2'-deoxyuridine
5'-O-(4-monomethoxytrityl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
With pyridine for 48h; Ambient temperature; | 100% |
With pyridine at 20℃; for 5h; | 94% |
In pyridine for 24h; Ambient temperature; | 86% |
vinyl oleate
5-Fluoro-2'-deoxyuridine
A
5'-O-oleoyl-FUdR
C
3',5'-dioleoyl floxuridine
Conditions | Yield |
---|---|
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 40℃; for 9h; regioselective reaction; | A n/a B 99% C n/a |
acetic anhydride
5-Fluoro-2'-deoxyuridine
1-(2'-deoxy-3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil
Conditions | Yield |
---|---|
With pyridine at 20℃; for 8h; | 97% |
With dmap In pyridine | |
With pyridine at 0℃; for 5h; | |
With dmap; triethylamine In dichloromethane at -10 - 5℃; Large scale; |
2-nitrophenylmethyl bromide
5-Fluoro-2'-deoxyuridine
3-(o-nitrobenzyl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature; | 97% |
tert-butyldimethylsilyl chloride
5-Fluoro-2'-deoxyuridine
1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)dione
Conditions | Yield |
---|---|
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 0℃; Inert atmosphere; Stage #2: 5-Fluoro-2'-deoxyuridine In dichloromethane at 20℃; Inert atmosphere; | 97% |
Stage #1: 5-Fluoro-2'-deoxyuridine With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 2h; | 91% |
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h; | |
Stage #1: 5-Fluoro-2'-deoxyuridine With 1H-imidazole In dichloromethane for 0.5h; Inert atmosphere; Cooling with ice; Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 20℃; for 1h; Inert atmosphere; |
vinyl pivalate
5-Fluoro-2'-deoxyuridine
A
3'-O-pivaloyl-FUdR
B
1-<2'-deoxy-5'-O-(trimethylacetyl)-β-D-ribofuranosyl>-5-fluorouracil
Conditions | Yield |
---|---|
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 66h; Reactivity; Temperature; Time; regioselective reaction; | A 96% B n/a |
trityl chloride
methanesulfonyl chloride
5-Fluoro-2'-deoxyuridine
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)-5-fluorouracil
Conditions | Yield |
---|---|
Stage #1: trityl chloride; 5-Fluoro-2'-deoxyuridine With pyridine at 100℃; for 0.5h; Stage #2: methanesulfonyl chloride at 20℃; for 2h; | 95% |
4,4'-dimethoxytrityl chloride
5-Fluoro-2'-deoxyuridine
1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With dmap In pyridine for 4h; Ambient temperature; | 94% |
With pyridine at 20℃; Inert atmosphere; | 92% |
With pyridine; triethylamine at 20℃; for 20h; | 87% |
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With sodium iodide; potassium carbonate | 92.2% |
p-toluenesulfonyl chloride
5-Fluoro-2'-deoxyuridine
2'-deoxy-5-fluoro-5'-O-<(4-methylphenyl)sulfonyl>uridine
Conditions | Yield |
---|---|
With pyridine; triethylamine at 0 - 20℃; for 24h; | 90% |
With pyridine at 0 - 5℃; for 48h; | 65% |
With pyridine at 4℃; for 4h; | 63% |
1-bromomethyl-3-nitrobenzene
5-Fluoro-2'-deoxyuridine
3-(m-nitrobenzyl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature; | 90% |
benzoic acid
5-Fluoro-2'-deoxyuridine
2,3'-anhydro-5'-O-benzoyl-5-fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In N,N-dimethyl-formamide at 25℃; for 1.5h; Mitsunobu reaction; | 90% |
succinic acid anhydride
5-Fluoro-2'-deoxyuridine
3',5'-bis(3-carboxypropionyl)-5-fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With dmap In pyridine for 12h; Ambient temperature; | 88% |
vinyl benzoate
5-Fluoro-2'-deoxyuridine
A
5'-O-benzoyl-FUdR
B
(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate
C
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 66h; Reactivity; Time; Temperature; regioselective reaction; | A n/a B 88% C n/a |
1,1-Diphenylmethanol
5-Fluoro-2'-deoxyuridine
3',5'-di-O-benzhydryl-5-fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With palladium dichloride In 1,2-dichloro-ethane at 85℃; for 16h; Inert atmosphere; | 85% |
With palladium dichloride In 1,2-dichloro-ethane at 85℃; Inert atmosphere; |
trityl chloride
5-Fluoro-2'-deoxyuridine
1-(2-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-5-fluorouracil
Conditions | Yield |
---|---|
With pyridine for 1h; Heating; | 84% |
With pyridine; dmap at 20 - 100℃; for 17h; Inert atmosphere; | 84.4% |
With pyridine; dmap at 80℃; for 5h; | 81% |
stearyl 2-trimethylammonioethyl phosphate
5-Fluoro-2'-deoxyuridine
Phosphoric acid (2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester octadecyl ester
Conditions | Yield |
---|---|
With phospholipase D from Streptomyces sp. AA 586 In chloroform; water at 45℃; for 6h; sodium acetate buffer, CaCl2, pH 5.8; | 84% |
1-bromomethyl-4-nitro-benzene
5-Fluoro-2'-deoxyuridine
3-(p-nitrobenzyl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 2h; Ambient temperature; | 84% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In N,N-dimethyl-formamide for 0.75h; | 84% |
(triphenylphosphine)gold(I) chloride
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With KOH In tetrahydrofuran; water under argon; gold complex, ligand and KOH were dissolved in H2O/THF; stirring at 50-60°C; precipitation by evaporation of THF; filtered off; recrystallization from THF with addition of diethylether; elem.anal., IR, NMR; | 83.8% |
2-chloro-1,3-dimethyl-1,3,2-diazaphospholidine
5-Fluoro-2'-deoxyuridine
2'-deoxy-5-fluoro-3',5'-bis-O-(1,3-dimethyl-1,3-diaza-2-phosphacyclopentan-2-yl)uridine
Conditions | Yield |
---|---|
With triethylamine In chloroform at 0 - 20℃; for 1h; | 83% |
5-Fluoro-2'-deoxyuridine
A
5'-O-crotonyl-FUdR
B
3'-O-crotonyl-FUdR
C
3',5'-di-O-crotonyl-FUdR
Conditions | Yield |
---|---|
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 43h; Reactivity; Time; Temperature; regioselective reaction; | A n/a B 83% C n/a |
tert-butylchlorodiphenylsilane
5-Fluoro-2'-deoxyuridine
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 83% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h; | 80% |
vinyl acetate
5-Fluoro-2'-deoxyuridine
A
5'-O-acetyl-floxuridine
B
Acetic acid (2R,3S)-2-acetoxymethyl-5-((S)-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
C
3′-O-acetyl-5-fluoro-2′-deoxyuridine
Conditions | Yield |
---|---|
PS (Pseudomonas sp. lipase) In 1,4-dioxane | A 8.1% B 8.5% C 82% |
PPL (Porcine pancreas lipase) In 1,4-dioxane | A 49.3% B 0.4% C 25.7% |
tert-butyldimethylsilyl chloride
5-Fluoro-2'-deoxyuridine
5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h; | 82% |
With 1H-imidazole In N,N-dimethyl-formamide at -30℃; for 5.5h; | 77% |
With pyridine; 1H-imidazole at 20℃; for 24h; Inert atmosphere; | 76% |
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h; | |
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 4h; |
morpholine
2-Bromopropionyl chloride
5-Fluoro-2'-deoxyuridine
5'-O-(2-morpholinopropionyl)-2'-deoxy-5-fluorouridine
Conditions | Yield |
---|---|
In 1,4-dioxane; pyridine; methanol; dichloromethane | 82% |
vinyl 2-ethylhexanoate
5-Fluoro-2'-deoxyuridine
A
3'-O-(2-ethylhexanoyl)-FUdR
B
5'-O-(2-ethylhexanoyl)-FUdR
Conditions | Yield |
---|---|
With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate In tetrahydrofuran at 50℃; for 90h; Reactivity; Temperature; Time; regioselective reaction; | A 82% B n/a |
2-acetoxytetrahydrofuran
N,O-bis-(trimethylsilyl)-acetamide
5-Fluoro-2'-deoxyuridine
2'-deoxy-5-fluoro-3-(2-tetrahydrofuranyl)uridine
Conditions | Yield |
---|---|
With acetic acid; triethylamine; tin(IV) chloride In methanol; dichloromethane | 81.7% |
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