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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Methoxy-4-nitrobenzoic acid Manufacturer/High quality/Best price/In stock

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Methoxy-4-Mitrobenzoic Acid supplier in China

Cas:5081-36-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appeara

3-Methoxy-4-nitrobenzoic Acid

Cas:5081-36-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Nitro-m-anisic acid

Cas:5081-36-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--5081-36-7--3-Methoxy-4-nitrobenzoic acid in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--5081-36-7--3-Methoxy-4-nitrobenzoic acid in stock

Cas:5081-36-7

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Methoxy-4-nitrobenzoic acid)

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 5081-36-7 with competitive price

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name:3-Methoxy-4-nitrobenzoic acid CAS No:5081-36-7 Appearance:Pale yellow solid Content:98% Appearance:Pale yellow solid Storage:Store in cool and dry place, away from sun light. Pack

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Methoxy-4-nitrobenzoic acid 5081-36-7

Cas:5081-36-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3-Methoxy-4-nitrobenzoic acid CAS:5081-36-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

3-Methoxy-4-nitrobenzoic acid CAS:5081-36-7

Cas:5081-36-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Methoxy-4-Mitrobenzoic Acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-Methoxy-4-Mitrobenzoic Acid

Cas:5081-36-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

3-Methoxy-4-nitrobenzoic acidCAS NO.: 5081-36-7

Cas:5081-36-7

Min.Order:1 Gram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Methoxy-4-nitrobenzoic acid Synonyms: 3-METHOXY-4-NITROBENZOIC ACIID;3-METHOXY-4-NITROBENZOIC ACID, 98+%;4-AMino-3-Methoxybenzoic acid (Methyl, ethyl);Benzoic acid, 3-methoxy-4-nitro-;4-Nitro-3-methoxybenzoic acid;4-Nitro-m-anis

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-methoxy-4-nitrobenzoic Acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Methoxy-4-nitro-benzoic acid cas no. 5081-36-7 97%

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

High Purity 3-Methoxy-4-Mitrobenzoic Acid 5081-36-7

Cas:5081-36-7

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-Methoxy-4-Mitrobenzoic Acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Methoxy-4-nitrobenzoic acid

Cas:5081-36-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

3-methoxy-4-nitrotoluene
38512-82-2

3-methoxy-4-nitrotoluene

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With potassium permanganate; sodium carbonate In water for 1.5h; Heating;100%
With potassium permanganate87%
With potassium permanganate; sodium hydrogencarbonate In water for 4h; Heating;73%
methanol
67-56-1

methanol

3-fluoro-4-nitrobenzoic acid
403-21-4

3-fluoro-4-nitrobenzoic acid

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Stage #1: methanol With sodium methylate In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;
Stage #2: 3-fluoro-4-nitrobenzoic acid In tetrahydrofuran at 0 - 25℃; for 1h; Inert atmosphere;
100%
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 2h;
methyl 3-methoxy-4-nitrobenzoate
5081-37-8

methyl 3-methoxy-4-nitrobenzoate

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With water In methanol for 2h; Reflux;96%
With sodium hydroxide In tetrahydrofuran at 20℃; for 15h;86%
With sodium hydroxide In methanol for 0.5h; Yield given;
With sodium hydroxide In tetrahydrofuran; methanol; water at 20℃; for 12h;5.1 g
With lithium hydroxide In methanol; water at 20℃; for 20h;
methyl 3-fluoro-4-nitrobenzoate
185629-31-6

methyl 3-fluoro-4-nitrobenzoate

methanol
67-56-1

methanol

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Stage #1: methanol With sodium hydride In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: methyl 3-fluoro-4-nitrobenzoate In tetrahydrofuran at 0 - 20℃; for 2h;
82%
1-(3-methoxy-4-nitrophenyl)ethanone
22106-39-4

1-(3-methoxy-4-nitrophenyl)ethanone

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With copper (II) nitrate tetrahydrate; oxygen In acetonitrile at 180℃; under 18751.9 Torr; for 1.5h; Green chemistry;77%
3-hydroxy-4-nitro-benzoic acid
619-14-7

3-hydroxy-4-nitro-benzoic acid

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
durch Methylierung;
Multi-step reaction with 3 steps
1: thionyl chloride / 15 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C
3: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 90 °C
2: water / methanol / 2 h / Reflux
View Scheme
3-methoxy-4-nitrobenzaldehyde
80410-57-7

3-methoxy-4-nitrobenzaldehyde

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
durch Oxydation;
With potassium permanganate
With silver(l) oxide
3-(3-Methoxy-4-nitrophenyl)-2-propenoic acid
118510-04-6

3-(3-Methoxy-4-nitrophenyl)-2-propenoic acid

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With potassium permanganate; sodium carbonate
Multi-step reaction with 2 steps
1: alkali; potassium permanganate / ein wahrscheinlich unreines Praeparat
2: silver oxide
View Scheme
3-fluoro-4-nitrobenzoic acid
403-21-4

3-fluoro-4-nitrobenzoic acid

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With potassium hydroxide
Multi-step reaction with 2 steps
1.1: methanol; hexane; dichloromethane / 0.67 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
2.2: 2 h / 0 - 20 °C
View Scheme
3-Methoxybenzoic acid
586-38-9

3-Methoxybenzoic acid

A

3-methoxy-2-nitrobenzoic acid
4920-80-3

3-methoxy-2-nitrobenzoic acid

B

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid; acetic anhydride at -10 - -5℃;
3-methoxy-4-nitrobenzamide
92241-87-7

3-methoxy-4-nitrobenzamide

A

3-methoxy-4-nitroanilin
16292-88-9

3-methoxy-4-nitroanilin

B

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
at 85℃; Hofmann rearrangement;A 13 g
B 5 g
acetic anhydride
108-24-7

acetic anhydride

3-Methoxybenzoic acid
586-38-9

3-Methoxybenzoic acid

HNO3+H2SO4

HNO3+H2SO4

A

3-methoxy-2-nitrobenzoic acid
4920-80-3

3-methoxy-2-nitrobenzoic acid

B

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
at -10 - -5℃;
3-methoxy-4-nitrobenzoic acid chloride
67579-92-4

3-methoxy-4-nitrobenzoic acid chloride

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 5 g / 85 °C / Hofmann rearrangement
View Scheme
2-nitro-5-methylphenol
700-38-9

2-nitro-5-methylphenol

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / aq. NaOH / H2O / 80 °C
2: 100 percent / KMnO4, Na2CO3 / H2O / 1.5 h / Heating
View Scheme
3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid / 0 - 10 °C / Aus Benzol krystallisiert 2-Nitro-3-methoxy-benzaldehyd aus; die beiden anderen Isomeren koennen nach Entfernung des Benzols durch Destillation mit Wasserdampf getrennt werden
2: silver oxide
View Scheme
2-fluoro-4-methyl-1-nitrobenzene
446-34-4

2-fluoro-4-methyl-1-nitrobenzene

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous potassium permanganate solution
2: methanol. KOH-solution
View Scheme
3-methoxy-4-nitrobenzaldehyde
80410-57-7

3-methoxy-4-nitrobenzaldehyde

A

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

B

C8H7(18)FO2
129841-10-7

C8H7(18)FO2

Conditions
ConditionsYield
With potassium carbonate; N,N-dimethyl-formamide at 140℃;
3-Bromo-4-nitrobenzoic acid
101420-81-9

3-Bromo-4-nitrobenzoic acid

sodium methylate
124-41-4

sodium methylate

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
With carbon disulfide at 20℃; for 2h;
methyl 3-hydroxy-4-nitrobenzoate
713-52-0

methyl 3-hydroxy-4-nitrobenzoate

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2: sodium hydroxide / methanol; tetrahydrofuran; water / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C
2: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C
View Scheme
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

3-methoxy-4-nitrobenzoic acid chloride
67579-92-4

3-methoxy-4-nitrobenzoic acid chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran; dichloromethane at 0 - 20℃; for 3h;100%
With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 3h;100%
With thionyl chloride In toluene for 1h; Heating / reflux;100%
methanol
67-56-1

methanol

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

methyl 3-methoxy-4-nitrobenzoate
5081-37-8

methyl 3-methoxy-4-nitrobenzoate

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;100%
With thionyl chloride at 0 - 20℃;100%
With sulfuric acid Reflux; Inert atmosphere;95%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

methylamine hydrochloride
593-51-1

methylamine hydrochloride

3-methoxy-N-methyl-4-nitrobenzamide
878160-13-5

3-methoxy-N-methyl-4-nitrobenzamide

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-nitrobenzoic acid; methylamine hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0833333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;
100%
With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 18h;
morpholine
110-91-8

morpholine

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

(3-methoxy-4-nitrophenyl)(morpholino)methanone
761440-55-5

(3-methoxy-4-nitrophenyl)(morpholino)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;100%
Stage #1: 3-methoxy-4-nitrobenzoic acid With thionyl chloride In toluene at 120℃; for 2h; Inert atmosphere;
Stage #2: morpholine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 1h;
92%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 16h;88.85%
Stage #1: 3-methoxy-4-nitrobenzoic acid With thionyl chloride In toluene for 2h; Reflux;
Stage #2: morpholine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 1h;
75%
Ala-OtBu
21691-50-9

Ala-OtBu

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

C15H20N2O6
1147133-55-8

C15H20N2O6

Conditions
ConditionsYield
With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 24h;95%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl 3-methoxy-4-nitrobenzoate
190330-62-2

benzyl 3-methoxy-4-nitrobenzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 21h; Inert atmosphere;93.9%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

3-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide
876126-59-9

3-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;90%
Stage #1: 3-methoxy-4-nitrobenzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 1h;
Stage #2: 4-Amino-1-methylpiperidine In dichloromethane at 20℃; for 16h; Product distribution / selectivity;
Stage #1: 3-methoxy-4-nitrobenzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 1h;
Stage #2: 4-Amino-1-methylpiperidine In dichloromethane at 20℃; for 16h; Product distribution / selectivity;
Stage #1: 3-methoxy-4-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 105 - 120℃; for 1.5h; Heating / reflux;
Stage #2: 4-Amino-1-methylpiperidine With triethylamine In toluene at 55 - 65℃; for 1h;
Stage #3: With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h;
C17H18N2O5

C17H18N2O5

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

C25H23N3O9

C25H23N3O9

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-nitrobenzoic acid With 2-chloro-1-methyl-pyridinium iodide; triethylamine In dichloromethane Reflux; Inert atmosphere;
Stage #2: C17H18N2O5 In dichloromethane for 5h; Inert atmosphere; Reflux;
90%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

ethylamine
75-04-7

ethylamine

C10H12N2O4

C10H12N2O4

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 16h;87.93%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

A

3-methoxy-4-phenylureidophenylacetic acid

3-methoxy-4-phenylureidophenylacetic acid

B

3-methoxy-4-nitrobenzoic acid chloride
67579-92-4

3-methoxy-4-nitrobenzoic acid chloride

Conditions
ConditionsYield
With thionyl chlorideA 87%
B n/a
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

tert-butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate 0.5 oxalic acid salt

tert-butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate 0.5 oxalic acid salt

tert-butyl 7-(3-methoxy-4-nitrobenzoyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate

tert-butyl 7-(3-methoxy-4-nitrobenzoyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;86%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

methylamine
74-89-5

methylamine

3-methoxy-N-methyl-4-nitrobenzamide
878160-13-5

3-methoxy-N-methyl-4-nitrobenzamide

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-nitrobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: methylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 18h;
83%
With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃;78%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

potassium 3-methoxy-4-nitrobenzoate

potassium 3-methoxy-4-nitrobenzoate

Conditions
ConditionsYield
With potassium tert-butylate In ethanol for 1h;83%
With potassium tert-butylate In ethanol for 1h;
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-Butyl 3-methoxy-4-nitrobenzoate
123330-91-6

tert-Butyl 3-methoxy-4-nitrobenzoate

Conditions
ConditionsYield
With pyridine; toluene-4-sulfonic acid In dichloromethane at 40℃; for 16h;83%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

methylamine
74-89-5

methylamine

3-methylamino-4-nitro-benzoic acid
214778-10-6

3-methylamino-4-nitro-benzoic acid

Conditions
ConditionsYield
In water at 100℃;82%
In water at 100 - 105℃;75%
With hydrogenchloride73%
With potassium carbonate In methanol; water at 160℃; for 0.0833333h; Microwave irradiation;68%
With potassium carbonate In methanol; water at 160℃; for 0.0833333h; Irradiation;68%
4-(4-methoxyphenyl)-1,3-thiazol-2-amine
2104-04-3

4-(4-methoxyphenyl)-1,3-thiazol-2-amine

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

3-methoxy-N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-nitrobenzamide

3-methoxy-N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In acetonitrile at 65℃;82%
4-fluoropiperidine hydrochloride

4-fluoropiperidine hydrochloride

3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

(4-fluoropiperidin-1-yl)(3-methoxy-4-nitrophenyl)methanone

(4-fluoropiperidin-1-yl)(3-methoxy-4-nitrophenyl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;82%
3-methoxy-4-nitrobenzoic acid
5081-36-7

3-methoxy-4-nitrobenzoic acid

(S)-octahydropyrrolo[1,2-a]pyrazine
93643-24-4

(S)-octahydropyrrolo[1,2-a]pyrazine

(S)-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(3-methoxy-4-nitrophenyl)methanone

(S)-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)(3-methoxy-4-nitrophenyl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;81%

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