Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:62571-86-2
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inquiryProduct name captopril appearance white or almost white crystalline powder solubility freely soluble in water,in m
Cas:62571-86-2
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryUnique advantages for Captopril CAS 62571-86-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:-20°C Freezer Package:1kg/foil ba
Cas:62571-86-2
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inquirySpecifications Captopril, cas 62571-86-2 Purity: 99% white crystalline powder MF: C9H14NO3S USP standard Captopril, cas 62571-86-2 COA: ITEMS SPECIFICATION Appearance
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:62571-86-2
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
captopril product Name: captopril Synonyms: (2s)-1-(3-mercapto-2-methylpropionyl)-l-proline; (s,s)-1-(d-3-mercapto-2-methyl-1-oxopropyl)-l-proline; 1-(2-methyl-3-sulfanylpropanoyl)proline; (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid
Cas:62571-86-2
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:62571-86-2
Min.Order:1 Metric Ton
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Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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Min.Order:1 Kilogram
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Cas:62571-86-2
Min.Order:10 Kilogram
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Type:Trading Company
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Cas:62571-86-2
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Type:Lab/Research institutions
inquiryroduct Name captopril Synonyms (2s)-1-(3-mercapto-2-methylpropionyl)-l-proline; (s,s)-1-(d-3-mercapto-2-methyl-1-oxopropyl)-l-proline; 1-(2-methyl-3-sulfanylpropanoyl)proline; (2S)-1-[(2S)-2-methyl-3-sulfan
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers
Cas:62571-86-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:62571-86-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:62571-86-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:62571-86-2
Min.Order:10 Gram
FOB Price: $1.25
Type:Trading Company
inquiryCaptopril CAS:62571-86-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:62571-86-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:62571-86-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:62571-86-2
Min.Order:1 Kilogram
FOB Price: $8.0 / 10.0
Type:Trading Company
inquiryCaptopril CAS: 62571-86-2 Specifications product name captopril appearance white or almost white crystalline powder solubility freely soluble in water,in methylene chlo
Main Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA ca
β-hydroxy-α-methyl-N-acryloyl-(S)-proline
captopril
Conditions | Yield |
---|---|
Stage #1: β-hydroxy-α-methyl-N-acryloyl-(S)-proline With thionyl chloride In tetrahydrofuran at 20℃; for 5h; Stage #2: With ammonium sulfide In tetrahydrofuran at 0 - 20℃; for 3.5h; | 87% |
(S)-1-((S)-3-tert-Butylsulfanyl-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid tert-butyl ester
captopril
Conditions | Yield |
---|---|
With mercury(II) diacetate; trifluoroacetic acid Yield given; |
Conditions | Yield |
---|---|
In chloroform-d1 at 25℃; Equilibrium constant; |
A
captopril
B
N-(6-Methyl-pyridin-2-yl)-3-((S)-2-phenyl-butyrylamino)-benzamide
Conditions | Yield |
---|---|
In chloroform-d1 at 25℃; Equilibrium constant; |
A
captopril
B
N-(6-Methyl-pyridin-2-yl)-3-((R)-2-phenyl-butyrylamino)-benzamide
Conditions | Yield |
---|---|
In chloroform-d1 at 25℃; Equilibrium constant; |
captopril
Conditions | Yield |
---|---|
With ammonium sulfide In methanol for 24h; Heating; | 1.86 g |
With sodium hydrogen sulfide In water; toluene at 125℃; under 10343.2 Torr; for 0.5h; Temperature; Time; Inert atmosphere; Flow reactor; |
1-(3-bromo-2S-methylpropionyl)-pyrrolidine-2S-carboxylic acid
captopril
Conditions | Yield |
---|---|
With ammonium sulfide In methanol for 24h; Heating; | 1.95 g |
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Captopril disulfide
A
oxytocin
B
captopril
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Equilibrium constant; pH 7.0; |
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Captopril disulfide
A
captopril
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0; |
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Captopril disulfide
A
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
B
captopril
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Equilibrium constant; pH 7.0; |
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Captopril disulfide
A
captopril
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0; |
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0; |
A
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
B
captopril
Conditions | Yield |
---|---|
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0; |
(2S,2'S)-1-<3-(Acetylthio)-2-methylpropionyl>prolin-methylester
captopril
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 5h; Hydrolysis; |
S-Nitrosocaptopril
captopril
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; sodium hydrogensulfite In phosphate buffer at 25℃; pH=7.4; Kinetics; Substitution; |
dehydrochlorinationby-product-N-acryloylproline
captopril
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 47 percent / H2O; tetrahydrofuran / 48 h / 20 °C / ultrasound 2.1: 70 percent / H2 / 5 percent Pd/C / ethyl acetate / 4 h / 20 °C / 760 Torr 3.1: SOCl2 / tetrahydrofuran / 5 h / 20 °C 3.2: 87 percent / aq. NH4SH / tetrahydrofuran / 3.5 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 70 percent / aq. KOH / acetone / 3 h / 20 °C 2.1: 47 percent / H2O; tetrahydrofuran / 48 h / 20 °C / ultrasound 3.1: 70 percent / H2 / 5 percent Pd/C / ethyl acetate / 4 h / 20 °C / 760 Torr 4.1: SOCl2 / tetrahydrofuran / 5 h / 20 °C 4.2: 87 percent / aq. NH4SH / tetrahydrofuran / 3.5 h / 0 - 20 °C View Scheme |
β-hydroxy-α-methylene-N-acryloyl-(S)-proline
captopril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 70 percent / H2 / 5 percent Pd/C / ethyl acetate / 4 h / 20 °C / 760 Torr 2.1: SOCl2 / tetrahydrofuran / 5 h / 20 °C 2.2: 87 percent / aq. NH4SH / tetrahydrofuran / 3.5 h / 0 - 20 °C View Scheme |
proline tert-butyl ester
captopril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: trifluoroacetic acid, mercuric acetate View Scheme |
sulfuric acid
1-(3-bromo-2S-methylpropionyl)-pyrrolidine-2S-carboxylic acid
zinc
captopril
Conditions | Yield |
---|---|
With hydrogenchloride; sodium bicarbonate In hexane; ethyl acetate |
GLUTATHIONE
A
prop-2-ene-1-thiol
B
Oxidized glutathione
C
S-glutathionylthio-captopril
D
captopril
Conditions | Yield |
---|---|
at 20℃; for 20h; pH=6.5; aq. phosphate buffer; |
GLUTATHIONE
A
prop-2-ene-1-thiol
B
S-glutathionylthio-captopril
C
captopril
Conditions | Yield |
---|---|
at 20℃; for 3h; pH=6.5; aq. phosphate buffer; |
Conditions | Yield |
---|---|
at 20℃; for 0.3h; pH=6.5; aq. phosphate buffer; |
(2S)-1-[(2S)-3-acetylthio-2-methylpropanoyl]pyrrolidine-2-carboxylic acid
captopril
Conditions | Yield |
---|---|
With ammonia |
L-proline
captopril
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide 2: ammonia View Scheme |
Captopril disulfide
captopril
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; zinc In dichloromethane; water at 80℃; under 4500.45 Torr; Acidic conditions; |
Conditions | Yield |
---|---|
With sodium hydroxide at 0 - 20℃; for 3h; pH=7 - 9; | |
With sodium hydroxide at 0 - 20℃; for 3h; pH=7 - 9; | |
With sodium hydroxide at 0 - 20℃; for 3h; pH=7 - 9; |
captopril
Conditions | Yield |
---|---|
at 20℃; for 0.5h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide for 0.5h; | 96% |
captopril
Conditions | Yield |
---|---|
Stage #1: captopril With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In tetrahydrofuran; water Stage #2: 1-(hexadecynyl)-1,2-benziodoxol-3(1H)-one In tetrahydrofuran; water at 23℃; for 0.0833333h; | 94% |
3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromene-2-one
captopril
1-{(S)-3-[(2-oxo-2H-chromene-3-carbonyl)thio]-2-methylpropanoyl}pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile at 25℃; for 1h; | 92% |
Conditions | Yield |
---|---|
In methanol at 20℃; | 91.4% |
captopril
Conditions | Yield |
---|---|
With di-tert-butyl peroxide; water-d2; ethydiphenylphosphine oxide In dichloromethane at 20℃; for 10h; Solvent; Irradiation; Green chemistry; | 91% |
Conditions | Yield |
---|---|
With sodium hydroxide In water | 90.3% |
7-methoxy-3-(1H-benzotriazol-1-ylcarbonyl)-2H-chromene-2-one
captopril
1-{(S)-3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)thio]-2-methylpropanoyl}pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile at 25℃; for 1h; | 90% |
3-(1H-benzotriazol-1-ylcarbonyl)-7-(diethylamino)-2H-chromen-2-one
captopril
1-((S)-3-{[7-(diethylamino)-2-oxo-2H-chromene-3-carbonyl]thio}-2-methylpropanoyl)pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile at 25℃; for 1h; | 90% |
captopril
(S)-1-((S)-2-methyl-3-(((triisopropylsilyl)ethynyl)thio)propanoyl)pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: captopril With N,N,N',N'-tetramethylguanidine In tetrahydrofuran; water at 20℃; for 0.0833333h; Stage #2: 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one In tetrahydrofuran; water at 20℃; for 0.0833333h; chemoselective reaction; | 90% |
Conditions | Yield |
---|---|
In water Kinetics; soln. captopril in water (pH adjusted to 4.3) was added dropwise to soln. HOCbl*HCl in water (pH adjusted to 6.6), final react. mixt. pH 4.2, 3 h at 0°C in the dark; soln. was poured into chilled acetone (-20°C), ppt. was filtered,washed with chilled acetone (-20°C), Et2O (-20°C) and dri ed in vacuo (50°C, 5E-2 mbar) overnight; | 88% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 12h; Inert atmosphere; | 86% |
In N,N-dimethyl-formamide at 20℃; for 5h; |
Conditions | Yield |
---|---|
With sulfuric acid In acetone at 20℃; for 12h; Condensation; | 84% |
captopril
1-(1-oxo-2-methylpropyl)-L-proline
Conditions | Yield |
---|---|
With triethyl borane; tributylphosphine; triethyl phosphite In acetonitrile for 36h; Irradiation; | 83% |
methanol
captopril
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 60℃; | 82% |
With thionyl chloride at 0 - 60℃; for 7h; | 50% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 48h; Inert atmosphere; | 76.3% |
captopril
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; Schlenk technique; | 75% |
captopril
ethyl iodide
Conditions | Yield |
---|---|
Stage #1: captopril With potassium carbonate In acetone at 20℃; for 1h; Stage #2: ethyl iodide In acetone at 50℃; for 24h; | 72% |
captopril
Conditions | Yield |
---|---|
Stage #1: (S)-N-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-propylpentanamide; captopril In methanol; water at 20℃; for 0.0833333h; Stage #2: With potassium hydrogencarbonate In methanol; water | 71% |
captopril
Conditions | Yield |
---|---|
Stage #1: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-propylpentan-1-one; captopril In methanol; water at 20℃; for 0.0833333h; Stage #2: With potassium hydrogencarbonate In methanol; water | 70% |
captopril
Conditions | Yield |
---|---|
In dichloromethane at -78℃; for 1h; | 68% |
captopril
Conditions | Yield |
---|---|
Stage #1: (S)-N-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxobutan-2-yl)-2-propylpentanamide; captopril In methanol; water at 20℃; for 0.0833333h; Stage #2: With potassium hydrogencarbonate In methanol; water | 68% |
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 5 - 20℃; for 1h; | 65% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In toluene for 0.0833333h; | 63% |
Conditions | Yield |
---|---|
With pyridine; (1,2-dimethoxyethane)dichloronickel(II); (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In N,N-dimethyl-formamide; acetonitrile at 20℃; for 0.5h; Inert atmosphere; Sealed tube; Irradiation; | 61% |
captopril
acetyl chloride
(2S)-1-[(2S)-3-acetylthio-2-methylpropanoyl]pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at -5 - 20℃; for 4.5h; pH=8 - 9; | 59.8% |
With triethylamine In dichloromethane at -5 - 20℃; for 4.5h; pH=8-9; | 503.9 mg |
for 0.0833333h; |
Conditions | Yield |
---|---|
With NH3 In water (inert atmosphere); pH 8.5, stirring 1 h; concn. (vac.), cooling to 4°C for 1 d, filtration, washing (H2O),drying (vac.); elem. anal.; | 51% |
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