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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Trifluridine Manufacturer/High quality/Best price/In stock

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20℃ Package:50g/bottle; 1

Good quality Trifluridine/ Trifluorothymidine CAS 70-00-8 with favorable price

Cas:70-00-8

Min.Order:50 Gram

FOB Price: $60.0 / 80.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

70-00-8 Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:W

Trifluridine (100 mg)

Cas:70-00-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Trifluridine

Cas:70-00-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Trifluridine 70-00-8 GMP Manufacturer

Cas:70-00-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2'-Deoxy-5-(trifluoromethyl)-uridine

Cas:70-00-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

We are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare

Trifluridine

Cas:70-00-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

70-00-8 Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 70-00-8 with best quality

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Trifluorothymidine cas70-00-8

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $13.0 / 20.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

1.Broad-spectrum antiviral drugs. 2.Inhibit herpes simplex virus, adenovirus, herpes zoster virus,HSV-I ,HSV-II and CMV Appearance:White powder Storage:RT. Package:25kg drum Application:Eye Treatment Drug; Anti-Infective ;Antiviral Transportation

Trifluridine

Cas:70-00-8

Min.Order:2 Kilogram

FOB Price: $1.0

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China Manufacturer Produce Trifluridine High Quality High Purity CAS 70-00-8

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Trifluridine 70-00-8

Cas:70-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $30.0 / 35.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Amoxicillin sodium Penicillin drugs

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $130.0 / 185.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Trifluridine CAS:70-00-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Trifluridine CAS:70-00-8

Cas:70-00-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Trifluridine

Cas:70-00-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Antiviral Powder Trifluridine CAS 70-00-8 For Anti-fection Quick details of Trifluridine powder Product Name: Trifluridine Synonyms: 2,4(1h,3h)-pyrimidinedione,1-(2-deoxy-beta-d-ribofuranosyl)-5-(trifluorometh;Trifluridine (Viroptic);VIROPTIC;

Trifluridine

Cas:70-00-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Trifluridine

Cas:70-00-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Trifluridine

Cas:70-00-8

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Trifluridine 70-00-8

Cas:70-00-8

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Trifluridine

Cas:70-00-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

5-TrifluoroThymidine

Cas:70-00-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Trifluridine

Cas:70-00-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C24H17Cl2F3N2O7

C24H17Cl2F3N2O7

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With methanol; sodium methylate at 4 - 6℃; for 3.5h;97%
5-trifluoromethyl-2′-deoxyuridine-3′,5′-diacetate
65499-42-5

5-trifluoromethyl-2′-deoxyuridine-3′,5′-diacetate

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With ammonia In methanol at 20℃;95%
With ammonia In methanol at 0 - 20℃; for 16h;84%
With ammonia In methanol at 20℃; for 19h;76%
2'-deoxyuridine
951-78-0

2'-deoxyuridine

Langlois reagent
2926-29-6

Langlois reagent

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With tert.-butylhydroperoxide In water at -3 - 60℃; for 2h; Temperature; Inert atmosphere;94.3%
With tert.-butylhydroperoxide In water at -5 - 65℃; for 3h; Inert atmosphere; Large scale;94.8%
With tert-butyl alcohol In water at 0 - 20℃; for 3h;59%
With mesoporous graphitic carbon nitride In dimethyl sulfoxide at 25℃; Irradiation;47%
With acetone In water at 20℃; for 40h; UV-irradiation; Inert atmosphere;44%
5-(trifluoromethyl)uridine
21618-67-7

5-(trifluoromethyl)uridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Stage #1: 5-(trifluoromethyl)uridine With sodium hydrogencarbonate; carbonic acid dimethyl ester In N,N-dimethyl-formamide at 120℃; for 8h;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 55℃; for 10h;
Stage #3: With palladium on activated charcoal; hydrogen; sodium hydroxide In water; N,N-dimethyl-formamide at 15℃; under 4500.45 Torr; for 12h; pH=7 - 8;
86.4%
1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil
129664-47-7

1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With sodium methylate In methanol at 20 - 30℃; for 4h;82.5%
With methanol; sodium methylate for 1h; Ambient temperature;67%
3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine
65499-42-5

3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With ammonia In methanol for 10h; Ambient temperature;82%
Togni's reagent II
887144-94-7

Togni's reagent II

2'-deoxyuridine
951-78-0

2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With copper(l) iodide In N,N-dimethyl-formamide at 80℃; for 23h; Inert atmosphere; Sealed tube; regioselective reaction;76%
iodotrifluoromethane
2314-97-8

iodotrifluoromethane

2'-deoxyuridine
951-78-0

2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide for 24h; Inert atmosphere; Irradiation;71%
With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;68%
With iron(III) sulfate; sulfuric acid; dihydrogen peroxide In water; dimethyl sulfoxide at 40 - 50℃; for 0.333333h;58%
5-(trifluoromethyl)-3',5'-di-O-trityl-2'-deoxyuridine
76513-99-0

5-(trifluoromethyl)-3',5'-di-O-trityl-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With formic acid at 0℃; for 0.0166667h;40%
Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester
89143-01-1

Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

A

5'-O-hexanoyl-2'-deoxy-5-trifluoromethyluridine
89143-05-5

5'-O-hexanoyl-2'-deoxy-5-trifluoromethyluridine

B

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Pseudomonas fluorescens;A 62 % Chromat.
B 6 % Chromat.
5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

thymidine
50-89-5

thymidine

A

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

B

thymin
65-71-4

thymin

Conditions
ConditionsYield
With thymidine phosphorylase from Escherichia coli In phosphate buffer at 35℃; for 2h; pH=7.0; Title compound not separated from byproducts;A 47 % Chromat.
B n/a
3',5'-di-O-acetyl-2'-deoxyuridine
13030-62-1

3',5'-di-O-acetyl-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 33 percent / XeF2 / 1 h / Ambient temperature
2: 82 percent / NH3 / methanol / 10 h / Ambient temperature
View Scheme
3',5'-di-O-trityl-5-iodo-2'-deoxyuridine
76513-98-9

3',5'-di-O-trityl-5-iodo-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) copper powder / 1.) HMPA, 120 deg C, 2.5 h, 2.) 45 deg C, 12 h
2: 40 percent / 98percent formic acid / 0.02 h / 0 °C
View Scheme
5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hexamethyldisilazane / 1,2-dichloro-ethane / 0.75 h / Heating
2: 80 percent / zinc chloride / CHCl3 / 15 h / Ambient temperature
3: 67 percent / sodium methoxide, methanol / 1 h / Ambient temperature
View Scheme
5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine
7057-43-4

5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / zinc chloride / CHCl3 / 15 h / Ambient temperature
2: 67 percent / sodium methoxide, methanol / 1 h / Ambient temperature
View Scheme
5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

thymidine
50-89-5

thymidine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With thymidine phosphorylase In aq. phosphate buffer at 37℃; for 1h; pH=6.8; Enzymatic reaction;
2'-deoxyuridine
951-78-0

2'-deoxyuridine

5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

A

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

B

uracil
66-22-8

uracil

Conditions
ConditionsYield
With pyrimidine nucleoside phosphorylase from Bacillus subtilis (E.C. 2.4.2.3) immobilized on Sepabeads EC-EP In aq. phosphate buffer at 20℃; for 10h; pH=7.5; Reagent/catalyst; Enzymatic reaction;
2'-deoxyuridine
951-78-0

2'-deoxyuridine

5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With immobilized Bacillus psychrosaccharolyticus CECT 4074 nucleoside 2'-deoxyribosyltransferase In aq. phosphate buffer at 37℃; for 2h; pH=7.5; Concentration; Enzymatic reaction;
With purine nucleoside phosphorylase; uridine phosphorylase In aq. phosphate buffer; dimethyl sulfoxide at 80℃; for 3h; pH=7; Enzymatic reaction;
5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 20 - 125 °C
2: copper dichloride / chloroform / 24 h / 20 - 30 °C
3: sodium methylate / methanol / 4 h / 20 - 30 °C
View Scheme
5-Iodo-2'-deoxyuridine
54-42-2

5-Iodo-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / 16 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -60 °C
2.2: 16 h / 20 °C
3.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C
3.2: 16 h / 20 °C
4.1: ammonia / methanol / 16 h / 0 - 20 °C
View Scheme
3',5'-O-diacetyl-5-iodo-2'-deoxyuridine
1956-30-5

3',5'-O-diacetyl-5-iodo-2'-deoxyuridine

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -60 °C
1.2: 16 h / 20 °C
2.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C
2.2: 16 h / 20 °C
3.1: ammonia / methanol / 16 h / 0 - 20 °C
View Scheme
(N3-para-(methylene)bis(methoxybenzene))-5-iodo-2′-deoxyuridine-3′,5′-diacetate

(N3-para-(methylene)bis(methoxybenzene))-5-iodo-2′-deoxyuridine-3′,5′-diacetate

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C
1.2: 16 h / 20 °C
2.1: ammonia / methanol / 16 h / 0 - 20 °C
View Scheme
2-deoxy-D-ribose
36792-88-8

2-deoxy-D-ribose

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetyl chloride / 0.5 h / 5 - 10 °C
1.2: 5 h / 5 - 10 °C
2.1: dmap; triethylamine / toluene / 2 h / 25 - 30 °C
3.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C
4.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C
4.2: 3 h / 25 - 30 °C
5.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C
View Scheme
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / toluene / 2 h / 25 - 30 °C
2.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C
3.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C
3.2: 3 h / 25 - 30 °C
4.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C
View Scheme
methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose
4330-34-1

methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C
2.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C
2.2: 3 h / 25 - 30 °C
3.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C
View Scheme
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride
4330-21-6

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

5-trifluoromethyluracil
54-20-6

5-trifluoromethyluracil

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C
1.2: 3 h / 25 - 30 °C
2.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C
View Scheme
(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate
7057-46-7

(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With methanol; sodium methylate at 10 - 15℃; for 1.5h; Temperature;39 g
[(2R,3R,4R)-3,4-diacetoxy-5-chlorotetrahydrofuran-2-yl]methyl acetate
40554-98-1

[(2R,3R,4R)-3,4-diacetoxy-5-chlorotetrahydrofuran-2-yl]methyl acetate

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetonitrile / 3 h / 45 °C
2.1: acetyl chloride; methanol / 10 h / 0 °C
3.1: carbonic acid dimethyl ester; sodium hydrogencarbonate / N,N-dimethyl-formamide / 8 h / 120 °C
3.2: 10 h / 55 °C
3.3: 12 h / 15 °C / 4500.45 Torr / pH 7 - 8
View Scheme
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine
133128-06-0

5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine

Conditions
ConditionsYield
With pyridine; dmap at 0 - 20℃; for 21h;96%
With pyridine at 20℃; for 41.5h; Inert atmosphere;72%
With pyridine
chloro-bis-(2-methoxy-phenyl)-phenyl-methane
854751-16-9

chloro-bis-(2-methoxy-phenyl)-phenyl-methane

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

5-Trifluoromethyl-5'-dimethoxytrityl-2'-deoxyuridine

5-Trifluoromethyl-5'-dimethoxytrityl-2'-deoxyuridine

Conditions
ConditionsYield
With dmap In pyridine; dichloromethane96%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-(trifluoromethyl)uridine
127978-84-1

5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-(trifluoromethyl)uridine

Conditions
ConditionsYield
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h;93%
With pyridine for 12h; Ambient temperature;88%
acetic anhydride
108-24-7

acetic anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine
65499-42-5

3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine

Conditions
ConditionsYield
dmap In acetonitrile92%
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

5-carboxy-2'-deoxyuridine
14599-46-3

5-carboxy-2'-deoxyuridine

Conditions
ConditionsYield
With sodium hydroxide at 37℃; for 36h; pH=10;90%
bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate

bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine
133128-06-0

5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine

Conditions
ConditionsYield
With lithium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Heating;87%
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

methylamine
74-89-5

methylamine

2'-deoxy-5-(N,N'-dimethylamidinyl)uridine

2'-deoxy-5-(N,N'-dimethylamidinyl)uridine

Conditions
ConditionsYield
With water at 60℃; for 24h;84%
arachidic anhydride
55726-22-2

arachidic anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Icosanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-icosanoyloxymethyl-tetrahydro-furan-3-yl ester
89143-03-3

Icosanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-icosanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
dmap In acetonitrile80%
3-fluorobenzoic acid anhydride
56666-54-7

3-fluorobenzoic acid anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

3',5'-di-O-(m-fluorobenzoyl)-2'-deoxy-5-trifluoromethyluridine
99502-68-8

3',5'-di-O-(m-fluorobenzoyl)-2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
dmap In acetonitrile72%
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

chloromethyl n-heptanoate
76068-79-6

chloromethyl n-heptanoate

3-n-heptanoyloxymethyl-2'-deoxy-5-trifluoromethyluridine
161632-25-3

3-n-heptanoyloxymethyl-2'-deoxy-5-trifluoromethyluridine

Conditions
ConditionsYield
With sodium iodide; potassium carbonate71.3%
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

3',5'-O-TPDS-α,α,α-trifluorothymidine
133100-91-1

3',5'-O-TPDS-α,α,α-trifluorothymidine

Conditions
ConditionsYield
With pyridine for 3h; Ambient temperature;70%
p-methylbenzoic anhydride
13222-85-0

p-methylbenzoic anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate
7057-46-7

(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate

Conditions
ConditionsYield
dmap In acetonitrile68%
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

2'-deoxy-3',5'-di-O-(tetrahydro-2-furyl)-5-trifluoromethyluridine
93298-69-2

2'-deoxy-3',5'-di-O-(tetrahydro-2-furyl)-5-trifluoromethyluridine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In 1,4-dioxane for 0.5h; Ambient temperature;67%
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

C10H9F3N2O4
123822-62-8

C10H9F3N2O4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In acetonitrile at -15 - 0℃; for 3.16667h;67%
4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

Hexanoyl chloride
142-61-0

Hexanoyl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester
110073-57-9

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine66%
n-hexanoic anhydride
2051-49-2

n-hexanoic anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester
89143-01-1

Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
dmap In acetonitrile64%
4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
99502-67-7

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions
ConditionsYield
With pyridine62%
capric anhydride
2082-76-0

capric anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Decanoic acid (2R,3S,5R)-2-decanoyloxymethyl-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
89142-99-4

Decanoic acid (2R,3S,5R)-2-decanoyloxymethyl-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
dmap In acetonitrile59%
4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

Hexanoyl chloride
142-61-0

Hexanoyl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hexanoyloxy-tetrahydro-furan-2-ylmethyl ester
110073-58-0

4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hexanoyloxy-tetrahydro-furan-2-ylmethyl ester

Conditions
ConditionsYield
With pyridine57%
benzoyl chloride
98-88-4

benzoyl chloride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

N3-benzoyl-2'-deoxy-5-(trifluoromethyl)uridine
95969-47-4

N3-benzoyl-2'-deoxy-5-(trifluoromethyl)uridine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl acetamide for 12h; Ambient temperature;56%
palmitic anhydride
623-65-4

palmitic anhydride

2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexadecanoyloxymethyl-tetrahydro-furan-3-yl ester
89143-02-2

Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexadecanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
dmap In acetonitrile53%
2'-deoxy-5-trifluoromethyluridine
70-00-8

2'-deoxy-5-trifluoromethyluridine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
89144-54-7

Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions
ConditionsYield
With pyridine52%

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