Trifluridine supplier | CasNO.70-00-8

Name
Trifluridine
EINECS 200-722-8
CAS No. 70-00-8
Article Data32
CAS DataBase
Density 1.646 g/cm³
Solubility
Melting Point 190-193 °C(lit.)
Formula C₁₀H₁₁F₃N₂O₅
Boiling Point
Molecular Weight 296.203
Flash Point
Transport Information
Appearance Almost white crystalline power
Safety 22-36
Risk Codes 20/21/22-40
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Uridine, 2'-deoxy-5-(trifluoromethyl)-(7CI);2'-Deoxy-5-(trifluoromethyl)uridine;5-(Trifluoromethyl)-2'-deoxyuridine;5-(Trifluoromethyl)deoxyuridine;5-Trifluoromethyl-2'-deoxy-b-uridine;5-Trifluorothymidine;NSC 529182;NSC 75520;Trifluorothymidine;Viroptic;
PSA 104.55000
LogP -0.80390

Synthetic route

: C24H17Cl2F3N2O7

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With methanol; sodium methylate at 4 - 6℃; for 3.5h;	97%

: 65499-42-5
5-trifluoromethyl-2′-deoxyuridine-3′,5′-diacetate

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With ammonia In methanol at 20℃;	95%
With ammonia In methanol at 0 - 20℃; for 16h;	84%
With ammonia In methanol at 20℃; for 19h;	76%

: 951-78-0
2'-deoxyuridine

: 2926-29-6
Langlois reagent

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In water at -3 - 60℃; for 2h; Temperature; Inert atmosphere;	94.3%
With tert.-butylhydroperoxide In water at -5 - 65℃; for 3h; Inert atmosphere; Large scale;	94.8%
With tert-butyl alcohol In water at 0 - 20℃; for 3h;	59%
With mesoporous graphitic carbon nitride In dimethyl sulfoxide at 25℃; Irradiation;	47%
With acetone In water at 20℃; for 40h; UV-irradiation; Inert atmosphere;	44%

: 21618-67-7
5-(trifluoromethyl)uridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Stage #1: 5-(trifluoromethyl)uridine With sodium hydrogencarbonate; carbonic acid dimethyl ester In N,N-dimethyl-formamide at 120℃; for 8h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 55℃; for 10h; Stage #3: With palladium on activated charcoal; hydrogen; sodium hydroxide In water; N,N-dimethyl-formamide at 15℃; under 4500.45 Torr; for 12h; pH=7 - 8;	86.4%

: 129664-47-7
1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With sodium methylate In methanol at 20 - 30℃; for 4h;	82.5%
With methanol; sodium methylate for 1h; Ambient temperature;	67%

: 65499-42-5
3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With ammonia In methanol for 10h; Ambient temperature;	82%

: 887144-94-7
Togni's reagent II

: 951-78-0
2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With copper(l) iodide In N,N-dimethyl-formamide at 80℃; for 23h; Inert atmosphere; Sealed tube; regioselective reaction;	76%

: 2314-97-8
iodotrifluoromethane

: 951-78-0
2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide for 24h; Inert atmosphere; Irradiation;	71%
With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;	68%
With iron(III) sulfate; sulfuric acid; dihydrogen peroxide In water; dimethyl sulfoxide at 40 - 50℃; for 0.333333h;	58%

: 76513-99-0
5-(trifluoromethyl)-3',5'-di-O-trityl-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With formic acid at 0℃; for 0.0166667h;	40%

: 89143-01-1
Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

A: 89143-05-5
5'-O-hexanoyl-2'-deoxy-5-trifluoromethyluridine

B: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With phosphate buffer In N,N-dimethyl-formamide at 25℃; for 18h; enzym: Pseudomonas fluorescens;	A 62 % Chromat. B 6 % Chromat.

: 54-20-6
5-trifluoromethyluracil

: 50-89-5
thymidine

A: 70-00-8
2'-deoxy-5-trifluoromethyluridine

B: 65-71-4
thymin

Conditions

Conditions	Yield
With thymidine phosphorylase from Escherichia coli In phosphate buffer at 35℃; for 2h; pH=7.0; Title compound not separated from byproducts;	A 47 % Chromat. B n/a

...Expand

: 13030-62-1
3',5'-di-O-acetyl-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 33 percent / XeF2 / 1 h / Ambient temperature 2: 82 percent / NH3 / methanol / 10 h / Ambient temperature View Scheme

: 76513-98-9
3',5'-di-O-trityl-5-iodo-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) copper powder / 1.) HMPA, 120 deg C, 2.5 h, 2.) 45 deg C, 12 h 2: 40 percent / 98percent formic acid / 0.02 h / 0 °C View Scheme

: 54-20-6
5-trifluoromethyluracil

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hexamethyldisilazane / 1,2-dichloro-ethane / 0.75 h / Heating 2: 80 percent / zinc chloride / CHCl3 / 15 h / Ambient temperature 3: 67 percent / sodium methoxide, methanol / 1 h / Ambient temperature View Scheme

: 7057-43-4
5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / zinc chloride / CHCl3 / 15 h / Ambient temperature 2: 67 percent / sodium methoxide, methanol / 1 h / Ambient temperature View Scheme

: 54-20-6
5-trifluoromethyluracil

: 50-89-5
thymidine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With thymidine phosphorylase In aq. phosphate buffer at 37℃; for 1h; pH=6.8; Enzymatic reaction;

: 951-78-0
2'-deoxyuridine

: 54-20-6
5-trifluoromethyluracil

A: 70-00-8
2'-deoxy-5-trifluoromethyluridine

B: 66-22-8
uracil

Conditions

Conditions	Yield
With pyrimidine nucleoside phosphorylase from Bacillus subtilis (E.C. 2.4.2.3) immobilized on Sepabeads EC-EP In aq. phosphate buffer at 20℃; for 10h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

...Expand

: 951-78-0
2'-deoxyuridine

: 54-20-6
5-trifluoromethyluracil

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With immobilized Bacillus psychrosaccharolyticus CECT 4074 nucleoside 2'-deoxyribosyltransferase In aq. phosphate buffer at 37℃; for 2h; pH=7.5; Concentration; Enzymatic reaction;
With purine nucleoside phosphorylase; uridine phosphorylase In aq. phosphate buffer; dimethyl sulfoxide at 80℃; for 3h; pH=7; Enzymatic reaction;

: 54-20-6
5-trifluoromethyluracil

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 2 h / 20 - 125 °C 2: copper dichloride / chloroform / 24 h / 20 - 30 °C 3: sodium methylate / methanol / 4 h / 20 - 30 °C View Scheme

: 54-42-2
5-Iodo-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: pyridine / 16 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -60 °C 2.2: 16 h / 20 °C 3.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C 3.2: 16 h / 20 °C 4.1: ammonia / methanol / 16 h / 0 - 20 °C View Scheme

: 1956-30-5
3',5'-O-diacetyl-5-iodo-2'-deoxyuridine

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -60 °C 1.2: 16 h / 20 °C 2.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C 2.2: 16 h / 20 °C 3.1: ammonia / methanol / 16 h / 0 - 20 °C View Scheme

: (N3-para-(methylene)bis(methoxybenzene))-5-iodo-2′-deoxyuridine-3′,5′-diacetate

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: copper(l) iodide; potassium fluoride / N,N-dimethyl-formamide / 16 h / 60 °C 1.2: 16 h / 20 °C 2.1: ammonia / methanol / 16 h / 0 - 20 °C View Scheme

: 36792-88-8
2-deoxy-D-ribose

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: acetyl chloride / 0.5 h / 5 - 10 °C 1.2: 5 h / 5 - 10 °C 2.1: dmap; triethylamine / toluene / 2 h / 25 - 30 °C 3.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C 4.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C 4.2: 3 h / 25 - 30 °C 5.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: acetyl chloride / 0.5 h / 5 - 10 °C
1.2: 5 h / 5 - 10 °C
2.1: dmap; triethylamine / toluene / 2 h / 25 - 30 °C
3.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C
4.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C
4.2: 3 h / 25 - 30 °C
5.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C
View Scheme

: 51255-17-5, 51255-18-6, 60134-26-1, 89577-26-4, 96038-80-1, 96039-31-5, 144301-84-8, 144301-85-9
1-O-methyl-2-deoxy-D-ribofuranoside

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dmap; triethylamine / toluene / 2 h / 25 - 30 °C 2.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C 3.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C 3.2: 3 h / 25 - 30 °C 4.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C View Scheme

: 4330-34-1
methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogenchloride; acetyl chloride; acetic acid / 1,4-dioxane; chloroform / 3.25 h / 10 - 15 °C 2.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C 2.2: 3 h / 25 - 30 °C 3.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C View Scheme

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 54-20-6
5-trifluoromethyluracil

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane / 3 h / 120 - 125 °C 1.2: 3 h / 25 - 30 °C 2.1: sodium methylate; methanol / 1.5 h / 10 - 15 °C View Scheme

: 7057-46-7
(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With methanol; sodium methylate at 10 - 15℃; for 1.5h; Temperature;	39 g

: 40554-98-1
[(2R,3R,4R)-3,4-diacetoxy-5-chlorotetrahydrofuran-2-yl]methyl acetate

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetonitrile / 3 h / 45 °C 2.1: acetyl chloride; methanol / 10 h / 0 °C 3.1: carbonic acid dimethyl ester; sodium hydrogencarbonate / N,N-dimethyl-formamide / 8 h / 120 °C 3.2: 10 h / 55 °C 3.3: 12 h / 15 °C / 4500.45 Torr / pH 7 - 8 View Scheme

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 133128-06-0
5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine

Conditions

Conditions	Yield
With pyridine; dmap at 0 - 20℃; for 21h;	96%
With pyridine at 20℃; for 41.5h; Inert atmosphere;	72%
With pyridine

: 854751-16-9
chloro-bis-(2-methoxy-phenyl)-phenyl-methane

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 5-Trifluoromethyl-5'-dimethoxytrityl-2'-deoxyuridine

Conditions

Conditions	Yield
With dmap In pyridine; dichloromethane	96%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 127978-84-1
5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-(trifluoromethyl)uridine

Conditions

Conditions	Yield
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 25℃; for 1h;	93%
With pyridine for 12h; Ambient temperature;	88%

: 108-24-7
acetic anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 65499-42-5
3',5'-di-O-acetyl-5-(trifluoromethyl)-2'-deoxyuridine

Conditions

Conditions	Yield
dmap In acetonitrile	92%

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 14599-46-3
5-carboxy-2'-deoxyuridine

Conditions

Conditions	Yield
With sodium hydroxide at 37℃; for 36h; pH=10;	90%

: bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 133128-06-0
5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine

Conditions

Conditions	Yield
With lithium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Heating;	87%

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 74-89-5
methylamine

: 2'-deoxy-5-(N,N'-dimethylamidinyl)uridine

Conditions

Conditions	Yield
With water at 60℃; for 24h;	84%

: 55726-22-2
arachidic anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 89143-03-3
Icosanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-icosanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
dmap In acetonitrile	80%

: 56666-54-7
3-fluorobenzoic acid anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 99502-68-8
3',5'-di-O-(m-fluorobenzoyl)-2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
dmap In acetonitrile	72%

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 76068-79-6
chloromethyl n-heptanoate

: 161632-25-3
3-n-heptanoyloxymethyl-2'-deoxy-5-trifluoromethyluridine

Conditions

Conditions	Yield
With sodium iodide; potassium carbonate	71.3%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 133100-91-1
3',5'-O-TPDS-α,α,α-trifluorothymidine

Conditions

Conditions	Yield
With pyridine for 3h; Ambient temperature;	70%

: 13222-85-0
p-methylbenzoic anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 7057-46-7
(2R,3S,5R)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl-4-methylbenzoate

Conditions

Conditions	Yield
dmap In acetonitrile	68%

: 1191-99-7
2,3-dihydro-2H-furan

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 93298-69-2
2'-deoxy-3',5'-di-O-(tetrahydro-2-furyl)-5-trifluoromethyluridine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane for 0.5h; Ambient temperature;	67%

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 123822-62-8
C10H9F3N2O4

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In acetonitrile at -15 - 0℃; for 3.16667h;	67%

: 874-60-2
4-methyl-benzoyl chloride

: 142-61-0
Hexanoyl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 110073-57-9
4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
With pyridine	66%

...Expand

: 2051-49-2
n-hexanoic anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 89143-01-1
Hexanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
dmap In acetonitrile	64%

: 874-60-2
4-methyl-benzoyl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 99502-67-7
4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
With pyridine	62%

: 2082-76-0
capric anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 89142-99-4
Decanoic acid (2R,3S,5R)-2-decanoyloxymethyl-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
dmap In acetonitrile	59%

: 874-60-2
4-methyl-benzoyl chloride

: 142-61-0
Hexanoyl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 110073-58-0
4-Methyl-benzoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hexanoyloxy-tetrahydro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
With pyridine	57%

...Expand

: 98-88-4
benzoyl chloride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 95969-47-4
N3-benzoyl-2'-deoxy-5-(trifluoromethyl)uridine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl acetamide for 12h; Ambient temperature;	56%

: 623-65-4
palmitic anhydride

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 89143-02-2
Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hexadecanoyloxymethyl-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
dmap In acetonitrile	53%

: 70-00-8
2'-deoxy-5-trifluoromethyluridine

: 112-67-4
n-hexadecanoyl chloride

: 89144-54-7
Hexadecanoic acid (2R,3S,5R)-5-(2,4-dioxo-5-trifluoromethyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Conditions

Conditions	Yield
With pyridine	52%

Trifluridine Chemical Properties

IUPAC Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl) pyrimidine-2,4-dione
Empirical Formula: C₁₀H₁₁F₃N₂O₅
Molecular Weight: 296.1999g/mol
EINECS: 200-722-8
Structure of Trifluridine (CAS NO.70-00-8):

Index of Refraction: 1.534
Molar Refractivity: 55.92 cm³
Molar Volume: 179.8 cm³
Polarizability: 22.17×10^-24cm³
Surface Tension: 56.1 dyne/cm
Density: 1.646 g/cm³
Melting Point: 190-193 °C(lit.)
Product Categories: Pharmaceutical Raw Materials;Pyrimidine series;API intermediates;Nucleotides and Nucleosides;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Nucleotides
Canonical SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
InChI: InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChIKey: VSQQQLOSPVPRAZ-RRKCRQDMSA-N

Trifluridine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LDLo	intravenous	400mg/kg (400mg/kg)		Government Reports Announcements. Vol. 74(9), Pg. 60, 1974.
mouse	LD50	intraperitoneal	1931mg/kg (1931mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	intravenous	3381mg/kg (3381mg/kg)		Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. Vol. -, Pg. 260, 1967.
rat	LD50	intravenous	2946mg/kg (2946mg/kg)	LIVER: OTHER CHANGES	Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. Vol. -, Pg. 260, 1967.

Trifluridine Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 20/21/22-40
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 22-36
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: XP2087500
Hazard Note: Keep Cold

Trifluridine Specification

Trifluridine , its cas register number is 70-00-8. It also can be called 2'-Deoxy-5-(trifluoromethyl)uridine ; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-(trifluoromethyl)- ; 5-(Trifluoromethyl)deoxyuridine ; 5-Trifluoro-2'-deoxythymidine ; 5-Trifluoromethyl-2-deoxyuridine ; F3DThd ; F3T ; F3TDR ; NSC 529182 ; NSC 75520 ; TFDU ;
Trifluoromethyldeoxyuridine ; Trifluorothymidine ; Trifluridina ; Trifluridine ; Trifluridinum ; UNII-RMW9V5RW38 ; Uridine, 2'-deoxy-5-(trifluoromethyl)- ; Viroptic .

Product Name

Trifluridine

Synthetic route

Trifluridine Chemical Properties

Trifluridine Toxicity Data With Reference

Trifluridine Safety Profile

Trifluridine Specification

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