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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

1. Usage of Atomoxetine hcl Psychotherapeutic, Anti Depressant 2. Sinoway's advantage: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms :

Atomoxetine hcl powder with GMP certification

Cas:82248-59-7

Min.Order:100 Gram

FOB Price: $500.0 / 800.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Atomoxetine Hydrochloride

Cas:82248-59-7

Min.Order:1

Negotiable

Type:Other

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% atomoxetine hydrochloride 82248-59-7 Producer

Cas:82248-59-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

1. Best quality in your requirement 2. Competitive price in China market 3. mature Technical support 4. Professional logistic support 5 . Full experience of large numbers containers loading in Chinese sea port 6 Fast shipment by reputed shipping

99.7% Pure Atomoxetine Hydrochloride for Anxiolytic Drug

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $25.0 / 45.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Chinese Name: Tomoxetine Hydrochloride Chinese alias: atromoxitin hydrochloride; (R) - N-methyl-3-(2-methylphenoxy) - 3-phenylpropylamine hydrochloride English Name: atomoxetine hydrochloride English alias: (r) - tomoxetine hydrochloride; Atomox

atomoxetine hydrochloride/Cas:82248-59-7 /Tomoxetine Hydrochloride

Cas:82248-59-7

Min.Order:25 Metric Ton

FOB Price: $3.0 / 5.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Atomoxetine hydrochloride / LIDE PHARMA- Factory supply / Best price

Cas:82248-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Atomoxetine Hydrochloride CAS 82248-59-7

Cas:82248-59-7

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--82248-59-7--Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 82248-59-7 with best quality

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Atomoxetine hydrochloride Brand SHXLCHEM CAS No. 82248-59-7 EINECS 20

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

CAS 82248-59-7 Atomoxetine Hydrochloride C17H21NO HCl White Crystaline Powder

Cas:82248-59-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

♦ We are one of the domestic largest manufacturers of API; ♦ We are always supplier of products with higher quality and at more competitive price; ♦ We are supplier of safe and ecofriendly products ; ♦ We pr

Manufacturer of Atomoxetine hydrochloride at Factory Price

Cas:82248-59-7

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Hot Sale! Factory Supply High Quality Atomoxetine Hydrochloride Raw Materials CAS 82248-59-7

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenepropanamine,N-methyl-g-(2-methylphenoxy)-,hydrochloride (1:1), (gR)- 82248-59-7

Cas:82248-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Atomoxetine hydrochloride manufacturer with low price

Cas:82248-59-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Atomoxetine hydrochloride CAS:82248-59-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Atomoxetine hydrochloride CAS:82248-59-7

Cas:82248-59-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Atomoxetine hcl

Cas:82248-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:82248-59-7

Cas:82248-59-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Pharmaceutical Powder Atomoxetine Hydrochloride For Anti-Depressant CAS NO.82248-59-7

Cas:82248-59-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

kern enterprises

ProName: Pharmaceutical Powder Atomoxetine Hydr... CasNo: 82248-59-7 Molecular Formula: C17H22ClNO Appearance: white powder Application: Pharmaceuticals; Health and Medical DeliveryTime: within 24 hours after your payment

Atomoxetine hydrochloride

Cas:82248-59-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Atomoxetine hcl 82248-59-7

Cas:82248-59-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Atomoxetine Hydrochloride CAS 82248-59-7

Cas:82248-59-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Synthetic route

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether99%
With hydrogenchloride In acetic acid butyl ester; water at 22 - 25℃; Product distribution / selectivity;99.8%
With hydrogenchloride In ethyl acetate at 12 - 18℃; Product distribution / selectivity;95%
ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=11 - 12;
99%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=11 - 12;
94%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium phosphate; copper(l) iodide In toluene for 24h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=12 - 14;
82%
(R)-tomoxetine (S)-(+)-mandelate
83113-55-7

(R)-tomoxetine (S)-(+)-mandelate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-tomoxetine (S)-(+)-mandelate In ethyl acetate at 20℃; Heating / reflux;
Stage #2: With hydrogenchloride In acetic acid butyl ester at 15 - 20℃; for 2h; Product distribution / selectivity;
97%
Stage #1: (R)-tomoxetine (S)-(+)-mandelate With sodium hydroxide In water; ethyl acetate at 73 - 74℃; Heating / reflux;
Stage #2: With hydrogenchloride In water; ethyl acetate at 18 - 20℃; Product distribution / selectivity;
84%
Stage #1: (R)-tomoxetine (S)-(+)-mandelate In acetic acid butyl ester at 20℃; Heating / reflux;
Stage #2: With hydrogenchloride In acetic acid butyl ester; water at 18 - 20℃; for 1h; Product distribution / selectivity;
79.7%
-(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane
114446-47-8

-(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane

methylamine
74-89-5

methylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
In ethanol; water at 130℃; for 3h;95%
R-(-)-atomoxetine-S-(+)-mandelate

R-(-)-atomoxetine-S-(+)-mandelate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: R-(-)-atomoxetine-S-(+)-mandelate With sodium hydroxide In water at 40 - 45℃; for 0.166667h; Large scale;
Stage #2: With hydrogenchloride In water at 20℃; Large scale;
95%
C17H21NO*C8H8O3

C17H21NO*C8H8O3

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: C17H21NO*C8H8O3 With potassium carbonate In ethyl acetate pH=1 - 2;
Stage #2: With hydrogenchloride In tert-butyl methyl ether pH=1 - Ca. 2; Solvent;
92.2%
(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-(2-methylphenoxy)propanamine
134619-78-6

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-(2-methylphenoxy)propanamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol89%
With hydrogenchloride In ethanol Ambient temperature;88.7%
(S)-tomoxetine (S)-(+)-mandelate
872996-05-9

(S)-tomoxetine (S)-(+)-mandelate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-tomoxetine (S)-(+)-mandelate With water; sodium hydroxide In tert-butyl methyl ether for 1h;
Stage #2: With hydrogenchloride In tert-butyl methyl ether at 0 - 5℃; for 2h; pH=2 - 3;
82.4%
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

C7H7X

C7H7X

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine; C7H7X In ethyl acetate at 77℃;
Stage #2: With hydrogenchloride In water; acetone pH=1 - 2;
73%
C17H21NO*C8H8O3

C17H21NO*C8H8O3

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: C17H21NO*C8H8O3 With potassium carbonate In ethyl acetate
Stage #2: With hydrogenchloride In isopropyl alcohol
72.6%
ortho-cresol
95-48-7

ortho-cresol

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate Yield given. Multistep reaction;
ortho-cresol
95-48-7

ortho-cresol

methylamine
74-89-5

methylamine

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate
51699-49-1

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate

A

-(+)-tomoxetine hydrochloride
82857-39-4

-(+)-tomoxetine hydrochloride

B

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate With 3 A molecular sieve; oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; for 36h;
Stage #2: methylamine With water In tetrahydrofuran at 65℃;
Stage #3: ortho-cresol With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate In diethyl ether at -10 - 0℃;
butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester
118856-08-9

butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
2.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
4.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
4.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
5.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
6.1: 99 percent / HCl / diethyl ether
View Scheme
(3S) ethyl β-butyryloxy-β-phenyl propionate
838841-85-3

(3S) ethyl β-butyryloxy-β-phenyl propionate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
3.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
3.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
4.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
5.1: 99 percent / HCl / diethyl ether
View Scheme
Ethyl 3-hydroxy-3-phenylpropanoate
5764-85-2

Ethyl 3-hydroxy-3-phenylpropanoate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
2.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
3.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
5.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
5.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
6.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
7.1: 99 percent / HCl / diethyl ether
View Scheme
Multi-step reaction with 3 steps
1.1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h
2.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
3.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
3.2: H2O / tetrahydrofuran / 65 °C
3.3: PPh3; DEAD; HCl (g) / diethyl ether / -10 - 0 °C
View Scheme
(S)-3-phenyl-1,3-propanediol
96854-34-1

(S)-3-phenyl-1,3-propanediol

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
2.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
2.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
3.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
4.1: 99 percent / HCl / diethyl ether
View Scheme
benzaldehyde
100-52-7

benzaldehyde

SASRIN-maleidobenzoic acid resin

SASRIN-maleidobenzoic acid resin

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
4.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
6.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
6.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
7.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
8.1: 99 percent / HCl / diethyl ether
View Scheme
(1S) 3-phenyl-3-hydroxypropyl methanesulfonate
115290-77-2

(1S) 3-phenyl-3-hydroxypropyl methanesulfonate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C
1.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C
2.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
3.1: 99 percent / HCl / diethyl ether
View Scheme
(R)-3-(2-methylphenoxy)-3-phenylprop-1-yl methanesulfonate
115290-79-4

(R)-3-(2-methylphenoxy)-3-phenylprop-1-yl methanesulfonate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C
2: 99 percent / HCl / diethyl ether
View Scheme
1-phenyl-1,3-propanediol
4850-49-1

1-phenyl-1,3-propanediol

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
2.2: H2O / tetrahydrofuran / 65 °C
2.3: PPh3; DEAD; HCl (g) / diethyl ether / -10 - 0 °C
View Scheme
3-hydroxy-3-phenylpropanenitrile
73627-97-1, 121617-17-2, 132203-26-0, 17190-29-3

3-hydroxy-3-phenylpropanenitrile

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi
2: NaHCO3 / tetrahydrofuran
3: LiAlH4 / tetrahydrofuran / Heating
4: 1) DEAD, Ph3P
View Scheme
(1R)-3-amino-1-phenyl-1-propanol
138750-31-9

(1R)-3-amino-1-phenyl-1-propanol

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaHCO3 / tetrahydrofuran
2: LiAlH4 / tetrahydrofuran / Heating
3: 1) DEAD, Ph3P
View Scheme
((R)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

((R)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran / Heating
2: 1) DEAD, Ph3P
View Scheme
(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / CH2Cl2 / 2 h / Heating
2: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C
3: 88.7 percent / HCl gas / ethanol / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 95 percent / CH2Cl2
2: Ph3P, DEAD / diethyl ether
3: 89 percent / HCl / ethanol
View Scheme
(S)-3-hydroxy-N-methyl-3-phenylpropanamide
76183-10-3, 134619-76-4

(S)-3-hydroxy-N-methyl-3-phenylpropanamide

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97.6 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 95 percent / CH2Cl2 / 2 h / Heating
3: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C
4: 88.7 percent / HCl gas / ethanol / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 98 percent / LiAlH4 / diethyl ether
2: 95 percent / CH2Cl2
3: Ph3P, DEAD / diethyl ether
4: 89 percent / HCl / ethanol
View Scheme
(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine
134619-77-5

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C
2: 88.7 percent / HCl gas / ethanol / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: Ph3P, DEAD / diethyl ether
2: 89 percent / HCl / ethanol
View Scheme
3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature
2: 95 percent / ethanol; H2O / 3 h / 130 °C
View Scheme
ortho-cresol
95-48-7

ortho-cresol

colloid/al platinum

colloid/al platinum

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature
2: 95 percent / ethanol; H2O / 3 h / 130 °C
View Scheme
ethyl (3R)-3-hydroxy-3-phenylpropionate
33401-74-0

ethyl (3R)-3-hydroxy-3-phenylpropionate

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78 percent / H2O
2: 98 percent / LiAlH4 / diethyl ether
3: 95 percent / CH2Cl2
4: Ph3P, DEAD / diethyl ether
5: 89 percent / HCl / ethanol
View Scheme
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