As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:115290-81-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:115290-81-8
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:115290-81-8
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:115290-81-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:115290-81-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL CAS:115290-81-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
Cas:115290-81-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:115290-81-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:115290-81-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:115290-81-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:115290-81-8
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:115290-81-8
Min.Order:100 Gram
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:115290-81-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:115290-81-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:115290-81-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:115290-81-8
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:115290-81-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:115290-81-8
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryOur advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient
Cas:115290-81-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:115290-81-8
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:115290-81-8
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Manufacturers
inquirybest seller Application:API
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Manufacturers
inquiry1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:115290-81-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry(R)-3-iodo-1-phenyl-1-propanol
methylamine
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 23℃; for 2h; | 99% |
In tetrahydrofuran; water at 25℃; for 12h; Inert atmosphere; enantioselective reaction; | 98% |
In tetrahydrofuran; water at 20℃; | 85% |
(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating; | 93% |
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 89% |
β-Methylaminoethyl phenyl ketone hydrochloride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction; | 93% |
Multi-step reaction with 2 steps 1: potassium borohydride / tetrahydrofuran / 66 °C 2: sodium hydrogencarbonate / chloroform; water View Scheme |
(1R) 3-phenyl-3-hydroxypropyl methanesulfonate
methylamine
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 65℃; for 24h; | 91% |
In tetrahydrofuran; water at 60 - 65℃; for 4h; | 80% |
In tetrahydrofuran; water at 65℃; for 3h; | 837 mg |
N-methyl-3-phenylprop-2-en-1-amine
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Stage #1: N-methyl-3-phenylprop-2-en-1-amine With L-diisopinocampheylborane In 1,2-dimethoxyethane at 30℃; for 2h; Stage #2: With dihydrogen peroxide; potassium hydroxide In 1,2-dimethoxyethane at 20℃; for 2h; | 90.67% |
(R)-6-phenyl-1,3-oxazinan-2-one R-7a
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 90% |
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Reflux; | 86% |
Phenyl vinyl ketone
methylamine
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Stage #1: Phenyl vinyl ketone; methylamine With sodium carbonate In water; isopropyl alcohol at 20℃; for 2h; Inert atmosphere; Stage #2: With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); sodium formate In water; isopropyl alcohol at 40℃; for 10h; pH=7; Inert atmosphere; enantioselective reaction; | 79% |
(1R)-3-chloro-1-phenylpropanol
methylamine
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With potassium iodide In methanol; water at 80℃; for 8h; | 72% |
With sodium iodide In water |
3-methylamino-1-phenyl-propan-1-ol; hydrochloride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Stage #1: 3-methylamino-1-phenyl-propan-1-ol; hydrochloride With sodium hydrogencarbonate In chloroform; water Stage #2: With (S)-Mandelic acid In acetone | 46% |
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Heating; |
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol for 20h; Ambient temperature; Yield given; |
methylamine
3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate
A
(S)-N-methyl-3-amino-1-phenyl-1-propanol
B
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Stage #1: 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate With 3 A molecular sieve; oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; for 36h; Stage #2: methylamine With water In tetrahydrofuran at 65℃; |
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 90℃; for 1.5h; |
Benzoylacetonitrile
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 74 percent / borane-dimethylsulfide complex; polymer-supported chiral sulfonamide / tetrahydrofuran / Heating 2: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C 3: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating View Scheme |
(1R)-3-amino-1-phenyl-1-propanol
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C 2: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 2: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme | |
Multi-step reaction with 2 steps 1: NaHCO3 / tetrahydrofuran 2: LiAlH4 / tetrahydrofuran / Heating View Scheme |
butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 3: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 4: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme |
Ethyl 3-hydroxy-3-phenylpropanoate
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 4: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 5: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h 2.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 3.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 3.2: H2O / tetrahydrofuran / 65 °C View Scheme |
ethyl (R)-3-hydroxy-3-phenylpropanoate
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 2: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 3: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 3 steps 1: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 2: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 3: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme |
(R)-3-phenyl-1,3-dihydroxypropane
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 2: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: 74 percent / triethylamine / diethyl ether / 3 h / -10 - 0 °C 2: 837 mg / H2O; tetrahydrofuran / 3 h / 65 °C View Scheme |
benzaldehyde
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: tetrahydrofuran; hexane / 1 h / -78 °C 2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 4.1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 6.1: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme |
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium hexamethyldisilazide / tetrahydrofuran / 2 h / 20 °C 2: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C 3: HCl / methanol; H2O / 1.5 h / 90 °C View Scheme |
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C 2: HCl / methanol; H2O / 1.5 h / 90 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / ethanol; H2O / 20 °C 2: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C 3: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 4: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 5: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme |
3-hydroxy-3-phenylpropanenitrile
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C 2: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 3: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 4: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi 2: NaHCO3 / tetrahydrofuran 3: LiAlH4 / tetrahydrofuran / Heating View Scheme |
(R)-3-acetyloxy-3-phenylpropanenitrile
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 2: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 3: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme |
ethyl 3-oxo-3-phenylpropionate
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / H2 / RuBr2((S)-(6,6'-(MeO)2-biphenyl-2,2'-diyl)bis(Ph2-phosphane) / ethanol / 18 h / 50 °C / 760.05 Torr 2: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 3: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 4: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme |
1-phenyl-1,3-propanediol
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 2.2: H2O / tetrahydrofuran / 65 °C View Scheme |
3-(benzyl methylamino)-1-phenylpropan-1-one hydrochloride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr 2: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 50 percent / concd. HCl / ethanol / 4 h / Heating 2: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr 3: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature View Scheme |
ortho-methylphenyl iodide
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
atomoxetine hydrochloride
Conditions | Yield |
---|---|
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=11 - 12; | 99% |
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=11 - 12; | 94% |
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium phosphate; copper(l) iodide In toluene for 24h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=12 - 14; | 82% |
4-chlorobenzotrifluoride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-fluoxetine
Conditions | Yield |
---|---|
With sodium hydride In dimethyl sulfoxide at 80 - 90℃; for 1h; | 92% |
In N,N-dimethyl acetamide | 86% |
In N,N-dimethyl acetamide | 86% |
2-Fluorotoluene
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-tomoxetine
Conditions | Yield |
---|---|
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium hydroxide In dimethyl sulfoxide at 130℃; for 1h; Stage #2: 2-Fluorotoluene In dimethyl sulfoxide at 130℃; | 89.51% |
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In dimethyl sulfoxide for 0.25h; Stage #2: With Potassium benzoate In dimethyl sulfoxide at 50 - 55℃; for 1h; Stage #3: 2-Fluorotoluene In dimethyl sulfoxide at 50 - 120℃; for 6.25 - 7.25h; | |
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h; |
4-Fluorobenzotrifluoride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-fluoxetine
Conditions | Yield |
---|---|
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In N,N-dimethyl acetamide; paraffin oil at 90℃; for 0.5h; Inert atmosphere; Stage #2: 4-Fluorobenzotrifluoride In N,N-dimethyl acetamide; paraffin oil at 100℃; for 5h; Inert atmosphere; | 88% |
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
atomoxetine hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine; C7H7X In ethyl acetate at 77℃; Stage #2: With hydrogenchloride In water; acetone pH=1 - 2; | 73% |
2-Fluorotoluene
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With sodium hydride 1) DMSO, 2) DMSO; Yield given. Multistep reaction; |
2-methylchlorobenzene
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-tomoxetine
Conditions | Yield |
---|---|
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction; |
2-Chloroanisole
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
Conditions | Yield |
---|---|
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction; |
ortho-cresol
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
atomoxetine hydrochloride
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate Yield given. Multistep reaction; |
4-chlorobenzotrifluoride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
(R)-fluoxetine hydrochloride
Conditions | Yield |
---|---|
With sodium hydride 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min; Yield given. Multistep reaction; | |
With sodium hydride 1.) N,N-dimethylacetamide, a) 0 deg C, 5 min, b) 70 deg C, 30 min, 2.) N,N-dimethylacetamide, 100 deg C, 3 h; Yield given. Multistep reaction; | |
With sodium hydride 1,) 0 deg C, then 70 deg C, 30 min; 2.) 2.5 h, 100 deg C; Yield given. Multistep reaction; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View