(R)-3-(Methylamino)-1-phenylpropanol supplier

Name
(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL
EINECS
CAS No. 115290-81-8
Article Data36
CAS DataBase
Density 1.017 g/cm³
Solubility
Melting Point
Formula C₁₀H₁₅NO
Boiling Point 286.1 °C at 760 mmHg
Molecular Weight 165.235
Flash Point 114.8 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL;(R)-3-(methylamino)-1-phenylpropanol;(1R)-(+)-3-(Methylamino)-1-phenylpropan-1-ol;(3R)-N-Methyl-3-hydroxy-3-phenylpropylamine;(R)-3-Hydroxy-N-methyl-3-phenylpropylamine;(R)-N-Methyl-3-hydroxy-3-phenylpropylamine;(R)-N-Methyl-3-phenyl-3-hydroxypropylamine;Atomoxetine Related Compound A (10 mg) (3-(Methylamino)-1-phenylpropan-1-ol)
PSA 32.26000
LogP 1.72040

Synthetic route

: 127073-84-1
(R)-3-iodo-1-phenyl-1-propanol

: 74-89-5
methylamine

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
In tetrahydrofuran; water at 23℃; for 2h;	99%
In tetrahydrofuran; water at 25℃; for 12h; Inert atmosphere; enantioselective reaction;	98%
In tetrahydrofuran; water at 20℃;	85%

: 502697-62-3
(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;	93%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	89%

: 2538-50-3
β-Methylaminoethyl phenyl ketone hydrochloride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction;	93%
Multi-step reaction with 2 steps 1: potassium borohydride / tetrahydrofuran / 66 °C 2: sodium hydrogencarbonate / chloroform; water View Scheme

: 115290-78-3
(1R) 3-phenyl-3-hydroxypropyl methanesulfonate

: 74-89-5
methylamine

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
In tetrahydrofuran; water at 65℃; for 24h;	91%
In tetrahydrofuran; water at 60 - 65℃; for 4h;	80%
In tetrahydrofuran; water at 65℃; for 3h;	837 mg

: 60960-88-5
N-methyl-3-phenylprop-2-en-1-amine

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: N-methyl-3-phenylprop-2-en-1-amine With L-diisopinocampheylborane In 1,2-dimethoxyethane at 30℃; for 2h; Stage #2: With dihydrogen peroxide; potassium hydroxide In 1,2-dimethoxyethane at 20℃; for 2h;	90.67%

: 406218-18-6
(R)-6-phenyl-1,3-oxazinan-2-one R-7a

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	90%

: (3R)-3-phenyl-3-hydroxypropionic acid methyl amide

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Reflux;	86%

: 768-03-6
Phenyl vinyl ketone

: 74-89-5
methylamine

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: Phenyl vinyl ketone; methylamine With sodium carbonate In water; isopropyl alcohol at 20℃; for 2h; Inert atmosphere; Stage #2: With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); sodium formate In water; isopropyl alcohol at 40℃; for 10h; pH=7; Inert atmosphere; enantioselective reaction;	79%

: 100306-33-0
(1R)-3-chloro-1-phenylpropanol

: 74-89-5
methylamine

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With potassium iodide In methanol; water at 80℃; for 8h;	72%
With sodium iodide In water

: 57256-92-5
3-methylamino-1-phenyl-propan-1-ol; hydrochloride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: 3-methylamino-1-phenyl-propan-1-ol; hydrochloride With sodium hydrogencarbonate In chloroform; water Stage #2: With (S)-Mandelic acid In acetone	46%

: ((R)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;

: (R)-3-(N-benzyl-N-methylamino)-1-phenylpropanol hydrochloride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol for 20h; Ambient temperature; Yield given;

: 74-89-5
methylamine

: 51699-49-1
3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate

A: 114133-37-8
(S)-N-methyl-3-amino-1-phenyl-1-propanol

B: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Stage #1: 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate With 3 A molecular sieve; oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; for 36h; Stage #2: methylamine With water In tetrahydrofuran at 65℃;

...Expand

: 823182-36-1
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 90℃; for 1.5h;

: 614-16-4
Benzoylacetonitrile

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 74 percent / borane-dimethylsulfide complex; polymer-supported chiral sulfonamide / tetrahydrofuran / Heating 2: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C 3: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating View Scheme

: 138750-31-9
(1R)-3-amino-1-phenyl-1-propanol

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C 2: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 2: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
Multi-step reaction with 2 steps 1: NaHCO3 / tetrahydrofuran 2: LiAlH4 / tetrahydrofuran / Heating View Scheme

: 118856-08-9
butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 3: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 4: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme

: 5764-85-2
Ethyl 3-hydroxy-3-phenylpropanoate

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 4: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 5: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h 2.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 3.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 3.2: H2O / tetrahydrofuran / 65 °C View Scheme

: 72656-47-4
ethyl (R)-3-hydroxy-3-phenylpropanoate

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 2: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 3: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
Multi-step reaction with 3 steps 1: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 2: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 3: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme

: 103548-16-9
(R)-3-phenyl-1,3-dihydroxypropane

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
Multi-step reaction with 2 steps 1: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 2: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme
Multi-step reaction with 2 steps 1: 74 percent / triethylamine / diethyl ether / 3 h / -10 - 0 °C 2: 837 mg / H2O; tetrahydrofuran / 3 h / 65 °C View Scheme

: 100-52-7
benzaldehyde

SASRIN-maleidobenzoic acid resin: SASRIN-maleidobenzoic acid resin

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: tetrahydrofuran; hexane / 1 h / -78 °C 2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 4.1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 6.1: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
4.1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
6.1: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme

: (6R)-2-((S)-1-triisopropylsilyloxyethyl)-6-phenyl-1,3-oxazinan-4-one

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: lithium hexamethyldisilazide / tetrahydrofuran / 2 h / 20 °C 2: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C 3: HCl / methanol; H2O / 1.5 h / 90 °C View Scheme

: 823182-35-0
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C 2: HCl / methanol; H2O / 1.5 h / 90 °C View Scheme

: 96-09-3
styrene oxide

1-chloro-1-phenylethene, 1,2-dichloro-1-phenyl-ethane, benzaldehyde, benzoic acid: 1-chloro-1-phenylethene, 1,2-dichloro-1-phenyl-ethane, benzaldehyde, benzoic acid

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 80 percent / ethanol; H2O / 20 °C 2: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C 3: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 4: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 5: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme

: 73627-97-1, 121617-17-2, 132203-26-0, 17190-29-3
3-hydroxy-3-phenylpropanenitrile

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C 2: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 3: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 4: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
Multi-step reaction with 3 steps 1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi 2: NaHCO3 / tetrahydrofuran 3: LiAlH4 / tetrahydrofuran / Heating View Scheme

: 198561-42-1
(R)-3-acetyloxy-3-phenylpropanenitrile

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 2: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C 3: 89 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 90 percent / H2 / RuBr2((S)-(6,6'-(MeO)2-biphenyl-2,2'-diyl)bis(Ph2-phosphane) / ethanol / 18 h / 50 °C / 760.05 Torr 2: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 3: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 4: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C View Scheme

: 4850-49-1
1-phenyl-1,3-propanediol

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 2.2: H2O / tetrahydrofuran / 65 °C View Scheme

: 5409-62-1
3-(benzyl methylamino)-1-phenylpropan-1-one hydrochloride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr 2: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature View Scheme

: 98-86-2
acetophenone

sulfur: sulfur

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 50 percent / concd. HCl / ethanol / 4 h / Heating 2: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr 3: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature View Scheme

: 615-37-2
ortho-methylphenyl iodide

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 82248-59-7
atomoxetine hydrochloride

Conditions

Conditions	Yield
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=11 - 12;	99%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=11 - 12;	94%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium phosphate; copper(l) iodide In toluene for 24h; Ullmann type reaction; Heating / reflux; Stage #2: With hydrogenchloride In water pH=1 - 2; Stage #3: With sodium hydroxide In water pH=12 - 14;	82%

: 98-56-6
4-chlorobenzotrifluoride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 54910-89-3, 57226-07-0, 100568-02-3, 100568-03-4
(R)-fluoxetine

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide at 80 - 90℃; for 1h;	92%
In N,N-dimethyl acetamide	86%
In N,N-dimethyl acetamide	86%

: 95-52-3
2-Fluorotoluene

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 105314-52-1, 105314-53-2, 63940-51-2, 83015-26-3
(R)-tomoxetine

Conditions

Conditions	Yield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium hydroxide In dimethyl sulfoxide at 130℃; for 1h; Stage #2: 2-Fluorotoluene In dimethyl sulfoxide at 130℃;	89.51%
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In dimethyl sulfoxide for 0.25h; Stage #2: With Potassium benzoate In dimethyl sulfoxide at 50 - 55℃; for 1h; Stage #3: 2-Fluorotoluene In dimethyl sulfoxide at 50 - 120℃; for 6.25 - 7.25h;
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h;

: 402-44-8
4-Fluorobenzotrifluoride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 54910-89-3, 57226-07-0, 100568-02-3, 100568-03-4
(R)-fluoxetine

Conditions

Conditions	Yield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In N,N-dimethyl acetamide; paraffin oil at 90℃; for 0.5h; Inert atmosphere; Stage #2: 4-Fluorobenzotrifluoride In N,N-dimethyl acetamide; paraffin oil at 100℃; for 5h; Inert atmosphere;	88%

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

C7H7X: C7H7X

: 82248-59-7
atomoxetine hydrochloride

Conditions

Conditions	Yield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine; C7H7X In ethyl acetate at 77℃; Stage #2: With hydrogenchloride In water; acetone pH=1 - 2;	73%

: 95-52-3
2-Fluorotoluene

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: rac-tomoxetine hydrochloride

Conditions

Conditions	Yield
With sodium hydride 1) DMSO, 2) DMSO; Yield given. Multistep reaction;

: 95-49-8
2-methylchlorobenzene

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 105314-52-1, 105314-53-2, 63940-51-2, 83015-26-3
(R)-tomoxetine

Conditions

Conditions	Yield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;

: 766-51-8
2-Chloroanisole

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 112066-67-8
(R)-3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine

Conditions

Conditions	Yield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;

: 95-48-7
ortho-cresol

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 82248-59-7
atomoxetine hydrochloride

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate Yield given. Multistep reaction;

: 98-56-6
4-chlorobenzotrifluoride

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 114247-09-5
(R)-fluoxetine hydrochloride

Conditions

Conditions	Yield
With sodium hydride 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min; Yield given. Multistep reaction;
With sodium hydride 1.) N,N-dimethylacetamide, a) 0 deg C, 5 min, b) 70 deg C, 30 min, 2.) N,N-dimethylacetamide, 100 deg C, 3 h; Yield given. Multistep reaction;
With sodium hydride 1,) 0 deg C, then 70 deg C, 30 min; 2.) 2.5 h, 100 deg C; Yield given. Multistep reaction;

(R)-3-(Methylamino)-1-phenylpropanol Specification

The (R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine is an organic compound with the formula C₁₀H₁₅NO. The systematic name of this chemical is (1S)-3-(methylamino)-1-phenylpropan-1-ol. With the CAS registry number 115290-81-8, it is also named as benzenemethanol, α-[2-(methylamino)ethyl]-, (alphaS)-.

Physical properties about (R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine are: (1)ACD/LogP: 0.34; (2)#H bond acceptors: 2; (3)#H bond donors: 2; (4)#Freely Rotating Bonds: 5; (5)Polar Surface Area: 12.47 Å²; (6)Index of Refraction: 1.53; (7)Molar Refractivity: 50.2 cm³; (8)Molar Volume: 162.3 cm³; (9)Polarizability: 19.9×10^-24cm³; (10)Surface Tension: 39.4 dyne/cm; (11)Density: 1.017 g/cm³; (12)Flash Point: 114.8 °C; (13)Enthalpy of Vaporization: 55.47 kJ/mol; (14)Boiling Point: 286.1 °C at 760 mmHg; (15)Vapour Pressure: 0.00126 mmHg at 25°C.

Uses of (R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine: it can be used to produce N-methyl-3,3-diphenylpropylamine. It will need reagent CF₃SO₃H. The yield is about 83%.

You can still convert the following datas into molecular structure:
(1)SMILES: O[C@H](c1ccccc1)CCNC
(2)InChI: InChI=1/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3/t10-/m0/s1
(3)InChIKey: XXSDCGNHLFVSET-JTQLQIEIBS
(4)Std. InChI: InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3/t10-/m0/s1
(5)Std. InChIKey: XXSDCGNHLFVSET-JTQLQIEISA-N

Product Name

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Synthetic route

(R)-3-(Methylamino)-1-phenylpropanol Specification

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