Product Name

  • Name

    (S)-2-Benzylsuccinic acid

  • EINECS 609-742-5
  • CAS No. 3972-36-9
  • Article Data22
  • CAS DataBase
  • Density 1.29 g/cm3
  • Solubility
  • Melting Point 164.0 to 168.0 °C
  • Formula C11H12O4
  • Boiling Point 331.4 °C at 760 mmHg
  • Molecular Weight 208.214
  • Flash Point 168.4 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 3972-36-9 ((S)-2-Benzylsuccinic acid)
  • Hazard Symbols
  • Synonyms s-2-benzylsuccinic acid;Butanedioicacid, (phenylmethyl)-, (2S)- (9CI);Butanedioic acid, (phenylmethyl)-, (S)-;(-)-Benzylsuccinic acid;(S)-Benzylsuccinic acid;2(S)-Benzyl-3-carboxypropionic acid;L-(-)-Benzylsuccinic acid;
  • PSA 74.60000
  • LogP 1.40460

Synthetic route

(S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoic acid
1141895-98-8

(S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With dihydrogen peroxide; lithium hydroxide In tetrahydrofuran; water at 0℃;100%
bis[(S)-3-methyl-2-phenylbutylammonium] (S)-2-benzylsuccinate

bis[(S)-3-methyl-2-phenylbutylammonium] (S)-2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In water98.8%
phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate
140903-48-6

phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 2h; Ambient temperature;97%
(Z)-2-benzylidenesuccinic acid
65756-81-2

(Z)-2-benzylidenesuccinic acid

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; triethylamine; Ru2Cl4((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2 In tetrahydrofuran; toluene at 35℃; under 2206.5 Torr; for 24h; op = 90percent, var. cat. RuHCl*2<(+)-BINAP>; Title compound not separated from byproducts;A 94%
B n/a
(3S)-4-[(3aS,6R,7aS)-tetrahydro-8,8-dimethyl-2,2-dioxido-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoic acid
787635-23-8

(3S)-4-[(3aS,6R,7aS)-tetrahydro-8,8-dimethyl-2,2-dioxido-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide at 0 - 20℃; for 13h;93%
2-benzylidenesuccinic acid
5653-88-3

2-benzylidenesuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen In methanol at 50℃; under 760.051 Torr; for 10h; Molecular sieve; Inert atmosphere; Large scale;81%
(Z)-2-benzylidenesuccinic acid
65756-81-2

(Z)-2-benzylidenesuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal at 75℃; for 3h;10%
2-benzylsuccinic acid
36092-42-9

2-benzylsuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With (R)-1-phenyl-ethyl-amine
diethyl (S)-2-benzylsuccinate

diethyl (S)-2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol
trans-phenylitaconic acid
5653-88-3, 65756-81-2, 46427-07-0

trans-phenylitaconic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With formic acid; CF3SO3; triethylamine In dimethyl sulfoxide at 44.9℃; Rate constant;
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-4-(Diphenylphosphino)-2-<(diphenylphosphino)-methyl>-N-phenoxycarbonylpyrrolidine In methanol; benzene at 20℃; under 760 Torr; for 4h;
trans-phenylitaconic acid
5653-88-3, 65756-81-2, 46427-07-0

trans-phenylitaconic acid

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; triethylamine; complex of Rh(COD)*BF4 and (4R,5R)-(+)-MOD-DIOP In methanol at 30℃; under 760 Torr; for 40h;A 79 % Spectr.
B n/a
With hydrogen; triethylamine; <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3 In tetrahydrofuran; ethanol at 35℃; under 1520 Torr; for 24h; RuHCl-bis<(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3; hydrogen; triethylamine In tetrahydrofuran; ethanol at 50℃; under 3800 Torr; for 24h; Title compound not separated from byproducts;
With hydrogen; triethylamine; hydridobis((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)ruthenium, PF6 salt In tetrahydrofuran; ethanol at 50℃; under 2280 Torr; for 24h; Yield given. Title compound not separated from byproducts;
With RuCl2(C6F5CN)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl); hydrogen; triethylamine In tetrahydrofuran; ethanol at 50℃; under 3800 Torr; for 24h; Title compound not separated from byproducts;
diethyl (2S)-2-benzyl-3-cyanosuccinate

diethyl (2S)-2-benzyl-3-cyanosuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogenchloride In acetic acid for 10h; Heating;
(S)-3-benzyl-4-methoxy-4-oxobutanoic acid
182247-45-6

(S)-3-benzyl-4-methoxy-4-oxobutanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol
diazomethane
186581-53-3, 908094-01-9

diazomethane

methanol
67-56-1

methanol

(R)-3-Benzyl-pent-4-enenitrile
193147-43-2

(R)-3-Benzyl-pent-4-enenitrile

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

...Expand
(R)-2-benzyl-5-methyl-4-hexenoic acid

(R)-2-benzyl-5-methyl-4-hexenoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide; ozone 1.) MeOH; Yield given. Multistep reaction;
(S)-4-(tert-butoxy)-4-oxo-2-(1-phenylmethyl)butanoic acid
337518-87-3

(S)-4-(tert-butoxy)-4-oxo-2-(1-phenylmethyl)butanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃;0.34 g
N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>
123191-44-6

N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>

benzylmagnesium chloride
6921-34-2

benzylmagnesium chloride

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
Stage #1: N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>; benzylmagnesium chloride In tetrahydrofuran; diethyl ether at -78℃; for 3h;
Stage #2: With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 0℃; for 7h; Title compound not separated from byproducts;
...Expand
1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one
127392-81-8

1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
2.1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
3.1: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
2.1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
3.1: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
hydrocinnamic acid chloride
645-45-4

hydrocinnamic acid chloride

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C
1.2: 91 percent / tetrahydrofuran; toluene / 16 h
2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
3.1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
4.1: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C
1.2: 91 percent / tetrahydrofuran; toluene / 16 h
2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
3.1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
4.1: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 2 h / 0 °C
2: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 - 20 °C
3: trifluoroacetic acid / dichloromethane / 48 h
4: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
View Scheme
1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate
787635-22-7

1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
2: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
2: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
Z-methyl 4-(phenyl)-3-methoxycarbonylbut-3-enoate
65756-82-3

Z-methyl 4-(phenyl)-3-methoxycarbonylbut-3-enoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / methanol / 12 h / Heating
2: 10 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

methylacetylene metal salt

methylacetylene metal salt

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: t-BuOK / 2-methyl-propan-2-ol / Heating
2: NaOH / methanol / 12 h / Heating
3: 10 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
View Scheme
Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate
131288-25-0

Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
2: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
(5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one
155956-29-9

(5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 79 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C to r.t., overnight
2: 94 percent / BuLi / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 10 min, 2.) 0 deg C, 1 h
3: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
4: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
(S)-3-Benzyl-4-oxo-4-((R)-3,3,5-trimethyl-2-oxo-pyrrolidin-1-yl)-butyric acid tert-butyl ester
215373-19-6

(S)-3-Benzyl-4-oxo-4-((R)-3,3,5-trimethyl-2-oxo-pyrrolidin-1-yl)-butyric acid tert-butyl ester

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / BuLi / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 10 min, 2.) 0 deg C, 1 h
2: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
3: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
dimethyl 2-benzylsuccinate
35262-43-2

dimethyl 2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) porcine pancrease lipase, 3) porcine pancrease lipase / 1) 0.1M KHPO4 buffer (pH = 7.2), 3) 0.1M KHPO4 buffer (pH = 7.2)
2: 1M NaOH / methanol
View Scheme
ethyl (R)-2-hydroxy-3-phenylpropanoate
15399-05-0, 15399-27-6, 20918-87-0, 20918-88-1

ethyl (R)-2-hydroxy-3-phenylpropanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8.7 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature
2: conc. aq. HCl / acetic acid / 10 h / Heating
View Scheme
1,4-diethyl 2-benzylsuccinate
21654-18-2, 79909-18-5

1,4-diethyl 2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: α-chymotrypsin, aq. NaOH
2: aq. NaOH / ethanol
View Scheme
(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one
136159-65-4

(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 - 20 °C
2: trifluoroacetic acid / dichloromethane / 48 h
3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.5 h / Large scale
1.2: Large scale
1.3: Large scale
2.1: Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen / methanol / 10 h / 50 °C / 760.05 Torr / Molecular sieve; Inert atmosphere; Large scale
View Scheme
cis-hexahydroisoindoline
1470-99-1, 1220913-24-5

cis-hexahydroisoindoline

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

mitiglinide
145375-43-5

mitiglinide

Conditions
ConditionsYield
Stage #1: (2S)-benzylsuccinic acid With 1H-imidazole; thionyl chloride; triethylamine In ethyl acetate at -10 - -5℃; for 6h;
Stage #2: cis-hexahydroisoindoline In ethyl acetate at 20℃; for 18h;		87%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(2-trimethylsilanyl-ethyl) ester
182247-47-8

(S)-2-Benzyl-succinic acid bis-(2-trimethylsilanyl-ethyl) ester

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

(S)-2-Benzyl-succinic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
4-nitro-phenol
100-02-7

4-nitro-phenol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester
157060-06-5

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide
21715-90-2

endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester
204187-32-6

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

(S)-2-Benzyl-succinic acid dibenzotriazol-1-yl ester

(S)-2-Benzyl-succinic acid dibenzotriazol-1-yl ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-benzyl-butan-1,4-diol
190185-60-5

(S)-2-benzyl-butan-1,4-diol

Conditions
ConditionsYield
With borane-THF
methanol
67-56-1

methanol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

dimethyl (S)-(-)-benzylsuccinate

dimethyl (S)-(-)-benzylsuccinate

Conditions
ConditionsYield
With toluene-4-sulfonic acid
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
113867-24-6

(S)-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid at 20℃; for 8h;
With sulfuric acid In water at 60℃; for 0.333333h;

(S)-2-Benzylsuccinic acid Chemical Properties

Following is the structure of Butanedioicacid, 2-(phenylmethyl)-, (2S)- , hydrochloride (1:1) (CAS NO.3972-36-9):
                       
Empirical Formula: C11H12O4
Molecular Weight: 208.2106
Index of Refraction: 1.567
Molar Refractivity: 52.78 cm3
Molar Volume: 161.3 cm3 
Density: 1.29 g/cm3
Flash Point: 168.4 °C
Surface Tension: 57.3 dyne/cm
Enthalpy of Vaporization: 60.6 kJ/mol
Boiling Point: 331.4 °C at 760 mmHg
Vapour Pressure of Butanedioicacid, 2-(phenylmethyl)-, (2S)- , hydrochloride (1:1) (CAS NO.3972-36-9): 6.23E-05 mmHg at 25 °C 
Product Categories of Butanedioicacid, 2-(phenylmethyl)-, (2S)- , hydrochloride (1:1) (CAS NO.3972-36-9): Pharmaceutical material and intermeidates; Acids and Derivatives; APIs Intermediate
SMILES: O=C(O)C[C@@H](C(=O)O)Cc1ccccc1
InChI: InChI=1/C11H12O4/c12-10(13)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13)(H,14,15)/t9-/m0/s1
InChIKey: GTOFKXZQQDSVFH-VIFPVBQEBD

(S)-2-Benzylsuccinic acid Specification

 Butanedioicacid, 2-(phenylmethyl)-, (2S)- , its cas register number 3972-36-9. It also can be called (S)-2-Benzylsuccinic acid .

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