1,1-Hexamethylenehydrazine supplier

Name
1-AMINOHOMOPIPERIDINE
EINECS
CAS No. 5906-35-4
Article Data11
CAS DataBase
Density 0.984 g/mL at 25 °C(lit.)
Solubility
Melting Point 86.0-86.5 °C
Formula C6H14 N2
Boiling Point 165 °C(lit.)
Molecular Weight 114.191
Flash Point 133 °F
Transport Information
Appearance
Safety A poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1H-Azepine,1-aminohexahydro- (7CI,8CI); (Azepan-1-yl)amine; 1,1-Hexamethylenehydrazine;1-Aminoazepane; 1-Aminohexahydro-1H-azepine; 1-Aminohexahydroazepine;1-Aminohexamethyleneimine; 1-Aminohomopiperidine; 1-Aminoperhydroazepine;Hexahydro-1H-azepin-1-amine; N-Aminoazacycloheptane; N-Aminohexahydroazepine;N-Aminohexamethyleneimine; N-Aminohexamethylenimine; N-Aminohomopiperidine; N-Aminoperhydroazepine;NSC 221198; NSC 82329
PSA 29.26000
LogP 1.37430

Synthetic route

: 1310-73-2
sodium hydroxide

: (R)-3-aminoazepan-2-one hydrochloride

: 5906-35-4
1-azepanylamine

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water; ethyl acetate	90%

: 629-03-8
1 ,6-dibromohexane

: 7803-57-8
hydrazine hydrate

: 5906-35-4
1-azepanylamine

Conditions

Conditions	Yield
In methanol for 25.5h; Reflux;	45%

: 111-49-9
hexamethylene imine

: 5906-35-4
1-azepanylamine

: 21223-22-3
(CH2)6NNH2*BH3

: 7732-18-5
water

A: 1333-74-0
hydrogen

B: 11113-50-1
boric acid

C: 5906-35-4
1-azepanylamine

Conditions

Conditions	Yield
In water
In water

...Expand

: 5906-35-4
1-azepanylamine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 94621-04-2
(hexahydro-1H azepinyl-1 amino)-3 ethoxycarbonyl-2 propenoate d'ethyle

Conditions

Conditions	Yield
In methanol for 1h; Ambient temperature;	98%

: 1450-14-2
1,1,1,2,2,2-hexamethyldisilane

: 5906-35-4
1-azepanylamine

: 121667-16-1
1-homopiperidine

Conditions

Conditions	Yield
With potassium hydride In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 24h; Ambient temperature;	97%

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 5906-35-4
1-azepanylamine

: (hexahydro-1H-azepinyl-1 amino)-2 ethoxycarbonyl-1 cyclopentene

Conditions

Conditions	Yield
With sodium sulfite In diethyl ether for 24h; Ambient temperature;	95%

: 698-63-5
5-nitrofurane-2-carboxaldehyde

: 5906-35-4
1-azepanylamine

: 1-(5-nitrofurfurylideneamino)azepane

Conditions

Conditions	Yield
for 0.25h; Heating;	94%

: 40398-01-4
2-chloro-6-methylphenyl isocyanate

: 5906-35-4
1-azepanylamine

: 1-Azepan-1-yl-3-(2-chloro-6-methyl-phenyl)-urea

Conditions

Conditions	Yield
In benzene Heating;	92%

: 5906-35-4
1-azepanylamine

: 28556-81-2
2,6-dimethylphenylisocyanate

: 1-Azepan-1-yl-3-(2,6-dimethyl-phenyl)-urea

Conditions

Conditions	Yield
In benzene Heating;	92%

: 5906-35-4
1-azepanylamine

: 393-52-2
2-Fluorobenzoyl chloride

: 2-fluoro-N-(1-azepanyl)benzamide

Conditions

Conditions	Yield
With triethylamine In diethyl ether for 2h; Ambient temperature;	92%

: 25784-91-2
2-chloro-5-nitrobenzoylchloride

: 5906-35-4
1-azepanylamine

: 150929-61-6
2-chloro-5-nitro-N-(1-azepanyl)benzamide

Conditions

Conditions	Yield
With triethylamine In diethyl ether for 2h; Ambient temperature;	90%

: 5906-35-4
1-azepanylamine

: 614-68-6
2-tolyl isocyanate

: 1-Azepan-1-yl-3-o-tolyl-urea

Conditions

Conditions	Yield
In benzene Heating;	88%

: 83490-71-5
N‑methyl‑2‑oxo‑2‑phenylacetamide

: 5906-35-4
1-azepanylamine

: 2-[(E)-Azepan-1-ylimino]-N-methyl-2-phenyl-acetamide

Conditions

Conditions	Yield
With acetic acid In ethanol for 24h; Heating;	88%

: 5906-35-4
1-azepanylamine

: 183232-64-6
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic chloride

: 5-(4-bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid azepan-1-ylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;	88%

: 500-22-1
3-pyridinecarboxaldehyde

: 5906-35-4
1-azepanylamine

: 125142-75-8
Azepan-1-yl-[1-pyridin-3-yl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In ethanol for 0.5h; heating on a steam bath;	87%

: 5906-35-4
1-azepanylamine

: 108-90-7
chlorobenzene

: C12H18N2

Conditions

Conditions	Yield
With potassium tert-butylate; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 120℃; for 5h;	87%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 5906-35-4
1-azepanylamine

: 1159014-98-8
ethyl 2-(azepan-1-ylimino)propanoate

Conditions

Conditions	Yield
In ethanol at 0 - 20℃;	87%
In ethanol at 20℃; for 4h;

: 5906-35-4
1-azepanylamine

: 134-81-6
benzil

: 109541-25-5
2-[(Z)-Azepan-1-ylimino]-1,2-diphenyl-ethanone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 24h; Ambient temperature;	86%
With acetic acid In ethanol for 20h; Ambient temperature;	58%

: 5906-35-4
1-azepanylamine

: 98-15-7
3-chlorotrifluoromethylbenzene

: C13H17F3N2

Conditions

Conditions	Yield
With potassium tert-butylate; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 120℃; for 4.5h;	86%

: 95-49-8
2-methylchlorobenzene

: 5906-35-4
1-azepanylamine

: C13H20N2

Conditions

Conditions	Yield
With potassium tert-butylate; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 120℃; for 5h;	85%

: 5906-35-4
1-azepanylamine

: 374589-65-8
2-(4-chlorophenyl)-2-phenyl-1,3-dioxolane

: C21H26N2O2

Conditions

Conditions	Yield
With potassium tert-butylate; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 120℃; for 6h;	85%

: 5906-35-4
1-azepanylamine

: 54253-55-3
N-methyleneazepan-1-amine

Conditions

Conditions	Yield
	85%

: 5328-37-0
L-arabinose

: 5906-35-4
1-azepanylamine

: (2S,3R,4S)-5-(azepan-1-ylimino)pentane-1,2,3,4-tetrol

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	85%

: 5906-35-4
1-azepanylamine

: 2043-61-0
cyclohexanecarbaldehyde

: 125142-76-9
Azepan-1-yl-[1-cyclohexyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In ethanol for 0.5h; heating on a steam bath;	84%

: 5906-35-4
1-azepanylamine

: 104-49-4
1,4-diisocyanatobenzene

: 1,1′-(1,4-phenylene)bis(3-(azepan-1-yl)urea)

Conditions

Conditions	Yield
With N,N'-dimethylpiperazine In tetrahydrofuran at 0 - 50℃; for 4.5h;	84%

: 1121-60-4
pyridine-2-carbaldehyde

: 5906-35-4
1-azepanylamine

: N-(2-pyridinylmethylene)hexahydro-1H-azepin-1-amine

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	83%

: 796875-26-8
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid

: 5906-35-4
1-azepanylamine

: 1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid azepan-1-ylamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h;	82%

: 5906-35-4
1-azepanylamine

: 195609-20-2
2-fluoro-5-nitrophenylacetic acid chloride

: 195609-28-0
N-(Azepan-1-yl)(2-fluoro-5-nitrophenyl)acetamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform for 2h; Ambient temperature;	81%

: 5464-11-9
2-methylthio-2-imidazoline hydroiodide

: 5906-35-4
1-azepanylamine

: 2-[(1-perhydroazepinyl)]iminoimidazolidine hydriodide

Conditions

Conditions	Yield
In ethanol for 8h; Condensation; Heating;	81%

: 131543-46-9
Glyoxal

: 5906-35-4
1-azepanylamine

: N,N'-(1,2-ethanediylidene)bishexahydro-1H-azepin-1-amine

Conditions

Conditions	Yield
In methanol; water at 20℃; for 1h;	80%

: 1003-41-4
4H-thiopyran-4-one

: 5906-35-4
1-azepanylamine

: 1-(hexahydro-1H-azepin-1-yl)-4-thiopyridone

Conditions

Conditions	Yield
In ethanol	79%

: 120-57-0
piperonal

: 5906-35-4
1-azepanylamine

: 16987-38-5
N-(1,3-benzodioxol-5-ylmethylene)azepan-1-amine

Conditions

Conditions	Yield
In ethanol for 7.5h; Heating;	79%

1,1-Hexamethylenehydrazine Chemical Properties

IUPAC Name: Azepan-1-amine
Synonyms : 1-Aminohexahydroazepine ; 1-Azepanamine ; 1H-Azepin-1-amine, hexahydro- ; 1,1-Hexamethylenehydrazine
Product Categories: Heterocyclic Compounds
CAS NO: 5906-35-4
Molecular Formula of 1,1-Hexamethylenehydrazine (CAS NO.5906-35-4) :C₆H₁₄N₂
Molecular Weight of 1,1-Hexamethylenehydrazine (CAS NO.5906-35-4) :114.19
Molecular structure of 1,1-Hexamethylenehydrazine (CAS NO.5906-35-4) :
EINECS: 227-609-6
Index of Refraction:1.478
Surface Tension: 34 dyne/cm
Density: 0.929 g/cm³
Flash Point: 56.1 °C
Enthalpy of Vaporization: 40.2 kJ/mol
Boiling Point: 165.6 °C at 760 mmHg
Vapour Pressure: 1.86 mmHg at 25°C

1,1-Hexamethylenehydrazine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LDLo	oral	300mg/kg (300mg/kg)		Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 93

1,1-Hexamethylenehydrazine Safety Profile

A poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Codes Irritant Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR UN 1993 3/PG 3
WGK Germany 3
RTECS CM3165000
HazardClass 3.2
PackingGroup III

Product Name

1-AMINOHOMOPIPERIDINE

Synthetic route

1,1-Hexamethylenehydrazine Chemical Properties

1,1-Hexamethylenehydrazine Toxicity Data With Reference

1,1-Hexamethylenehydrazine Safety Profile

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