1-Ethoxy-2,2-difluoroethanol supplier

Name
DIFLUOROACETALDEHYDE ETHYL HEMIACETAL
EINECS
CAS No. 148992-43-2
Article Data16
CAS DataBase
Density 1.145g/cm³
Solubility
Melting Point
Formula C4H8 F2 O2
Boiling Point 85.1°C at 760 mmHg
Molecular Weight 126.103
Flash Point 46.2°C
Transport Information
Appearance
Safety Risk Statements 10
Safety Statements 16
RIDADR 3271
Risk Codes 10
Molecular Structure
Hazard Symbols
Synonyms Difluoroacetaldehydeethyl hemiacetal
PSA 29.46000
LogP 0.60640

Synthetic route

: 454-31-9
ethyl difluoroacetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 2.75h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h;	60%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h; Reagent/catalyst; Solvent;	60%

: 64-17-5
ethanol

: 454-31-9
ethyl difluoroacetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride 1.) Et2O, THF, -78 deg C, 3 h, 2.) Et2O, THF, rt, 2 h;

: 454-31-9
ethyl difluoroacetate

A: 359-13-7
difluoroethanol

B: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
With sodium tetrahydroborate; cerium(III) chloride In methanol; water at -15℃; for 1h; Title compound not separated from byproducts;
With ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); hydrogen; sodium ethanolate In ethanol at 25℃; under 22502.3 Torr; for 4h; Reagent/catalyst; Solvent; Temperature; Pressure;

: 433-53-4
difluoroacetic acid methyl ester

: 64-19-7
acetic acid

A: 129660-32-8
difluoroacetaldehyde methyl hemiacetal

B: C4H6F4O2

C: C6H10F4O3

D: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
Stage #1: difluoroacetic acid methyl ester With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 15℃; under 7500.75 Torr; for 8h; Large scale; Stage #2: acetic acid In methanol at 66℃; under 15.7516 Torr; Reagent/catalyst; Solvent; Pressure; Temperature; Large scale;

...Expand

: 454-31-9
ethyl difluoroacetate

A: 359-13-7
difluoroethanol

B: 129660-32-8
difluoroacetaldehyde methyl hemiacetal

C: 148992-43-2
1-ethoxy-2,2-difluoroethanol

Conditions

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 15℃; under 7500.75 Torr; for 8.16667h; Pressure;

...Expand

: 106-42-3
para-xylene

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1314534-86-5
1,1-difluoro-2,2-bis(2',5'-dimethylphenyl)ethane

Conditions

Conditions	Yield
With boron trifluoride monohydrate In water at 0℃; for 0.5h; Friedel Crafts hydroxyalkylation;	98%

: 79-46-9
2-nitropropane

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1,1-difluoro-3-methyl-3-nitro-2-butanol

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran	96%
With potassium carbonate In tetrahydrofuran Ambient temperature;	82%

: 115306-75-7
3-(tertbutyldimethylsiloxyl)propylamine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (E)-N-(3-((tert-butyldimethylsilyl)oxy)propyl)-2,2-difluoroethan-1-imine

Conditions

Conditions	Yield
In benzene for 18h; Dean-Stark; Reflux;	94%

: 6456-74-2
Glycine tert-butyl ester

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: tert-butyl (E)-2-((2,2-difluoroethylidene)amino)acetate

Conditions

Conditions	Yield
In benzene for 18h; Dean-Stark; Reflux;	93%

: 33543-55-4
p-nitrophenoxyamine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: C8H6F2N2O3

Conditions

Conditions	Yield
at 50℃; for 24h; Sealed tube; Acidic conditions;	93%

: 626-35-7
nitroacetic acid ethyl ester

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: ethyl 4,4-difluoro-3-hydroxy-2-nitro-2-butanoate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Ambient temperature;	92%
With 2,8,9-(i-Pr)3-2,5,8,9-tetraza-1-phosphabicyclo[3,3,3]undecen In tetrahydrofuran

: 104-94-9
4-methoxy-aniline

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: N-(2,2-difluoroethylidene)-4-methoxyaniline

Conditions

Conditions	Yield
In toluene at 100℃; for 3h;	91%

: 89524-99-2
methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (Z)-2-Acetylamino-4,4-difluoro-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In dichloromethane	91%

: 13013-02-0
methyl 4-nitrobutyrate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: methyl 6,6-difluoro-5-hydroxy-4-nitrohexanoate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Ambient temperature;	90%

: 540-36-3
para-difluorobenzene

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1314534-92-3
1,1-difluoro-2,2-bis(2',5'-difluorophenyl)ethane

Conditions

Conditions	Yield
With boron trifluoride monohydrate In water at 20℃; for 5h; Friedel Crafts hydroxyalkylation;	90%

: 38100-30-0
O-(2-nitrophenyl)hydroxylamine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: C8H6F2N2O3

Conditions

Conditions	Yield
at 50℃; for 24h; Sealed tube; Acidic conditions;	90%

: 34627-78-6
1-(benzo[d][1,3]dioxol-5-yl)allyl acetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-1,1-difluoropent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	89%

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 94831-79-5
O-(4-cyanophenyl)hydroxylamine

: C9H6F2N2O

Conditions

Conditions	Yield
at 50℃; for 24h; Sealed tube; Acidic conditions;	89%

: 100945-15-1
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: N-benzyloxycarbonyl-2-amino-4,4-difluoro-2-butenoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester With potassium tert-butylate In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: 1-ethoxy-2,2-difluoroethanol In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;	87%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (αR)-N-(2,2-difluoroethylidene)(α-methylbenzyl)amine

Conditions

Conditions	Yield
In toluene at 100℃; for 3h;	86%

: 456-55-3
1-trifluoromethoxybenzene

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1314534-88-7
1,1-difluoro-2,2-bis[p-(trifluoromethoxy)benzene]ethane

Conditions

Conditions	Yield
With boron trifluoride monohydrate In water at 0℃; for 1h; Friedel Crafts hydroxyalkylation;	86%

: 1-(quinolin-4-yl)allyl acetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (2S,3R)-1,1-difluoro-3-(quinolin-4-yl)pent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	86%

: 104-86-9
4-chlorobenzylamine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 906559-43-1
C9H8ClF2N

Conditions

Conditions	Yield
In toluene at 0 - 100℃; for 2h;	85%

: 41801-73-4
4'-Methoxy-acetophenon-cyclohexylimin

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 4,4-difluoro-3-hydroxy-1-(4-methoxyphenyl)-1-butanone

Conditions

Conditions	Yield
In hexane Heating;	84%

: 622-30-0
N-benzyl hydroxylalmine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: N-benzyl C-(difluoromethyl)nitrone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 0.1h; Dean-Stark; Reflux;	84%
With toluene-4-sulfonic acid In toluene for 0.5h; Reflux; Dean-Stark;

: 1337953-40-8
1-acetoxy-1-(4-bromophenyl)-2-propylene

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (2S,3R)-3-(4-bromophenyl)-1,1-difluoropent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	84%

: 108-03-2
1-Nitropropane

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1,1-difluoro-3-nitro-2-pentanol

Conditions

Conditions	Yield
With 2,8,9-(i-Pr)3-2,5,8,9-tetraza-1-phosphabicyclo[3.3.3]undecen In tetrahydrofuran	83%
With potassium carbonate In tetrahydrofuran Ambient temperature;	68%

: 3590-37-2
ethyl 3-nitropropanoate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: ethyl 5,5-difluoro-4-hydroxy-3-nitropentanoate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Ambient temperature;	82%

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 169172-22-9
3-acetoxy-3-(4-(trifluoromethyl)phenyl)-1-propene

: (2S,3R)-1,1-difluoro-3-(4-(trifluoromethyl)phenyl)pent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	82%

: 61691-82-5
1'-acetoxyestragole

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (2S,3R)-1,1-difluoro-3-(4-methoxyphenyl)pent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	82%

: 53933-47-4
N-((1S)-1-phenylethyl)hydroxylamine

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: N-(S)-(α-methylbenzyl)-C-(difluoromethyl)nitrone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 0.5h; Reflux; Dean-Stark;	80%

: 7217-71-2
1-phenyl-2-propenyl acetate

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: (2S,3R)-1,1-difluoro-3-phenylpent-4-en-2-ol

Conditions

Conditions	Yield
With C49H36Cl2IrN2O6P2; potassium carbonate In tetrahydrofuran; ethanol; isopropyl alcohol at 100℃; for 24h; Inert atmosphere; Sealed tube; Molecular sieve; enantioselective reaction;	80%

: 75-52-5
nitromethane

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 1,1-difluoro-3-nitro-2-propanol

Conditions

Conditions	Yield
With 2,8,9-(i-Pr)3-2,5,8,9-tetraza-1-phosphabicyclo[3,3,3]undecen In tetrahydrofuran	79%
With potassium carbonate In tetrahydrofuran for 3h; Ambient temperature;	65%
With sodium carbonate
With sodium carbonate at 20 - 60℃;
With sodium carbonate at 20 - 60℃;

: 148992-43-2
1-ethoxy-2,2-difluoroethanol

: 100-46-9
benzylamine

: 148628-63-1
N-(2,2-difluoroethylidene)benzylamine

Conditions

Conditions	Yield
In toluene at 100℃; for 1h;	78%
In toluene Reflux;
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark;

1-Ethoxy-2,2-difluoroethanol Chemical Properties

Molecular Structure:

Molecular Formula: C₄H₈F₂O₂
Molecular Weight: 126.1019
Product Name: 1-Ethoxy-2,2-difluoroethanol
Synonyms of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): Difluoroacetaldehyde ethyl hemiacetal
CAS NO: 148992-43-2
Product Categories: Fluorinated Building Blocks ; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds ; Synthetic Organic Chemistry
Index of Refraction: 1.356
Molar Refractivity: 24.1 cm³
Molar Volume: 110 cm³
Surface Tension: 23.1 dyne/cm
Density: 1.145 g/cm³
Flash Point: 46.2 °C
Enthalpy of Vaporization: 37.95 kJ/mol
Boiling Point: 85.1 °C at 760 mmHg
Vapour Pressure of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): 44.9 mmHg at 25°C

1-Ethoxy-2,2-difluoroethanol Safety Profile

Risk Statements of 1-Ethoxy-2,2-difluoroethanol (CAS NO.148992-43-2): 10
R10: Flammable.
Safety Statements: 16
S16: Keep away from sources of ignition.
RIDADR: 3271

Product Name

DIFLUOROACETALDEHYDE ETHYL HEMIACETAL

Synthetic route

1-Ethoxy-2,2-difluoroethanol Chemical Properties

1-Ethoxy-2,2-difluoroethanol Safety Profile

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