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ProName: High purity Ethyl difluoroacetate with... CasNo: 454-31-9 Molecular Formula: C4H6F2O2 Appearance: colorless transparent liquid Application: Pharmaceutical & Agrochemical Intermed... DeliveryTime: within in 5-7 wo

Ethyl Difluoroacetate

Cas:454-31-9

Min.Order:1 Metric Ton

FOB Price: $3.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Ethyl difluoroacetate

Cas:454-31-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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hangzhou verychem science and technology co.ltd

Product name: Ethyl difluoroacetate Cas No: 454-31-9 Assay: 98%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelv

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl Difluorocetate supplier in China

Cas:454-31-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. mixed container: we can mix different items in one container. 2. quality control: before shipment, we can provide free sample for test. inspection before shipping. 3. packing: we can pack according to your requireme

Ethyl Difluoroacetate CAS 454-31-9

Cas:454-31-9

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl Difluorocetate

Cas:454-31-9

Min.Order:1

Negotiable

Type:Other

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Jinan Finer Chemical Co., Ltd

Product description: Product name Ethyl difluoroacetate CAS number 454-31-9 Assay ≥99% Appearance Colorless liquid Capacity 200mt/year Application Pharmaceutical intermediate

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 454-31-9 Aceticacid, 2,2-difluoro-, ethyl ester

Cas:454-31-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Ethyl Difluoroacetate

Cas:454-31-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Ethyl difluoroacetate Manufacturer/High quality/Best price/In stock

Cas:454-31-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 6.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---Ethyl difluoroacetate

Cas:454-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 454-31-9 with best quality

Cas:454-31-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ethyl difluoroacetate/ LIDE PHARMA- Factory supply / Best price

Cas:454-31-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS 454-31-9 Name Ethyl difluoroacetate Appearance Clear colorless liquid Application Used as solvent Appearance: Colorless L

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 454-31-9 Ethyl difluoroacetate

Cas:454-31-9

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Aceticacid, 2,2-difluoro-, ethyl ester 454-31-9

Cas:454-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Anesthetic Agents, Anti-Allergic Agents, Ethyl difluoroacetate CAS:454-31-9

Cas:454-31-9

Min.Order:1 Kilogram

FOB Price: $62.0 / 68.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ethyl difluoroacetate CAS:454-31-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

Ethyl difluoroacetate CAS:454-31-9

Cas:454-31-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Aceticacid, 2,2-difluoro-, ethyl ester

Cas:454-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

ethyldifluoracetat

Cas:454-31-9

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Aceticacid, 2,2-difluoro-, ethyl ester

Cas:454-31-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl Difluoroacetic

Cas:454-31-9

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

ethyl difluoroacetate

Cas:454-31-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

ethyl difluoroacetate

Cas:454-31-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL DIFLUOROACETATE

Cas:454-31-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl difluoroacetate

Cas:454-31-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole; [Zr(2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine)2] In benzene-d6 for 2.5h; Catalytic behavior; UV-irradiation; Inert atmosphere; Schlenk technique;98%
With 1,2,3-trimethoxybenzene; (3,5-dimethyl-2-(2-pyridyl)pyrrolide)3ZrCl; 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole In benzene-d6 at 33℃; for 0.5h; Time; Irradiation; Glovebox;85%
With N,N,N,N,-tetramethylethylenediamine In dimethylsulfoxide-d6 at 20℃; for 15h; Irradiation;41%
Stage #1: Ethyl bromodifluoroacetate With zinc In tetrahydrofuran at 20 - 50℃; for 1h; Inert atmosphere;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0℃; Product distribution / selectivity;
~ 90 %Chromat.
With hydrogen; nickel; triethylamine In ethanol at 80℃; under 3750.38 - 7500.75 Torr;
ethanol
64-17-5

ethanol

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With N,N-dimethyl acetamide for 4h; Product distribution / selectivity; Inert atmosphere; Sealed tube; Cooling with ice;96%
With sodium carbonate at 5 - 20℃; for 1h; Product distribution / selectivity; Inert atmosphere;77%
at 20℃; for 0.5h;
ethanol
64-17-5

ethanol

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With sulfuric acid at 0 - 70℃; for 2h; Temperature;93.98%
1,1-diethoxy-2,2-difluoro-ethane
36589-84-1

1,1-diethoxy-2,2-difluoro-ethane

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With dihydrogen peroxide; vanadia at 5℃; for 5h;89.9%
1,1,2,2-tetrafluoroethyl ethyl ether
512-51-6

1,1,2,2-tetrafluoroethyl ethyl ether

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With sulfuric acid In water at 54 - 56℃; for 1h;87%
Stage #1: Ethyl 1,1,2,2-tetrafluoroethyl ether With sulfuric acid; hydrogen fluoride In ethanol; water at -20 - 50℃; for 24h; Autoclave;
Stage #2: With sodium hydrogencarbonate at 20℃; under 760.051 Torr; for 1h; Reagent/catalyst;
86%
With nitric acid
With sulfuric acid
With water; fluorinated γ-alumina at 180℃; for 0.0202778h; Product distribution / selectivity; Inert atmosphere; Gas phase;
ethanol
64-17-5

ethanol

1,1,2,2-tetrafluoroethyl ethyl ether
512-51-6

1,1,2,2-tetrafluoroethyl ethyl ether

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With sulfuric acid; silica gel at 50℃; for 24h; Time; Autoclave;86%
ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; triethylamine In ethanol at 30℃; under 750.075 - 3000.3 Torr;75%
With zinc In N,N-dimethyl-formamide at 70℃; Yield given;
1-Heptene
592-76-7

1-Heptene

ethyl 2,2-difluoro-2-iodoacetate
7648-30-8

ethyl 2,2-difluoro-2-iodoacetate

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

Ethyl 2,2-Difluoro-4-iodononanoate
127224-10-6

Ethyl 2,2-Difluoro-4-iodononanoate

Conditions
ConditionsYield
With hydroquinone; nickel dichloride; zinc In tetrahydrofuran; water 1) RT, 15 min, 2) RT, 20 min;A 70%
B 17%
ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ethanol; zinc for 1 - 3h; Product distribution / selectivity; Heating / reflux;A 9.7%
B 61.6%
C 0.4%
ethanol
64-17-5

ethanol

difluoroacetonitrile
359-12-6

difluoroacetonitrile

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With sulfuric acid In water at 10 - 120℃; for 14h;57%
2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

2,2,3,3-tetrafluoro-4-hydroxy-4-methyl-pentanedioic acid diethyl ester

2,2,3,3-tetrafluoro-4-hydroxy-4-methyl-pentanedioic acid diethyl ester

Conditions
ConditionsYield
Stage #1: 2-oxo-propionic acid ethyl ester; Ethyl bromodifluoroacetate In N,N-dimethyl-formamide at -20℃;
Stage #2: With Tetrakis(dimethylamino)ethylen In N,N-dimethyl-formamide at -20 - 20℃;
A n/a
B 25%
Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

1,3,5-tris(4-methoxybenzyl)hexahydro-1,3,5-triazine
58837-16-4

1,3,5-tris(4-methoxybenzyl)hexahydro-1,3,5-triazine

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

1-(4'-methoxybenzyl)-3,3-difluoroazetidin-2-one

1-(4'-methoxybenzyl)-3,3-difluoroazetidin-2-one

C

3,3,5,5-tetrafluoro-1-(4-methoxy-benzyl)-piperidine-2,4-dione

3,3,5,5-tetrafluoro-1-(4-methoxy-benzyl)-piperidine-2,4-dione

D

5,5-difluoro-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-4-one

5,5-difluoro-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-4-one

Conditions
ConditionsYield
Stage #1: Ethyl bromodifluoroacetate With chloro-trimethyl-silane; zinc In tetrahydrofuran for 0.416667h;
Stage #2: 1,3,5-tris(4-methoxybenzyl)hexahydro-1,3,5-triazine In tetrahydrofuran at 25℃; for 3h;
A n/a
B 25%
C n/a
D n/a
ethyl 1,1-dichloroacetate
535-15-9

ethyl 1,1-dichloroacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With potassium fluoride In ethanol; water at 100℃; for 40h; Solvent; Concentration;21%
With potassium fluoride; C6H9BO4 In ISOPROPYLAMIDE at 20 - 75℃; Halex reaction;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

α-(trimethylsilyl)difluoroacetic acid ethyl ester
205865-67-4

α-(trimethylsilyl)difluoroacetic acid ethyl ester

C

trifluoroacetyltrimethylsilane ethyltrimethylsilyl ketal
565214-84-8

trifluoroacetyltrimethylsilane ethyltrimethylsilyl ketal

D

2,3-diethoxy-1,1,1,4,4,4-hexafluoro-2,3-bis-trimethylsilanyloxy-butane

2,3-diethoxy-1,1,1,4,4,4-hexafluoro-2,3-bis-trimethylsilanyloxy-butane

Conditions
ConditionsYield
With tetrabutylammomium bromide In tetrahydrofuran at -25℃; Electrochemical reaction; Further byproducts given;A 8%
B 8 % Spectr.
C 33 % Spectr.
D 1 % Spectr.
Difluoroacetic acid
381-73-7

Difluoroacetic acid

ethanol
64-17-5

ethanol

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With sulfuric acid
acetyl fluoride
557-99-3

acetyl fluoride

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With fluorine at 100℃; ueber Kupferdrahtnetz und Umsetzen der Reaktionsprodukte mit absol.Aethanol;
diethyl ether
60-29-7

diethyl ether

1,1,2,3,4,4-hexafluoro-2-butene
17976-35-1

1,1,2,3,4,4-hexafluoro-2-butene

A

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With potassium hydroxide; potassium permanganate 1.) 60 degC, water; Yield given. Multistep reaction. Yields of byproduct given;
Difluoroacetic acid
381-73-7

Difluoroacetic acid

sodium ethanolate
141-52-6

sodium ethanolate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; sodium fluoride 1.) -78 deg C, 15 min, 2.) triglyme; Yield given. Multistep reaction;
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

A

ethane
74-84-0

ethane

B

Fluoroacetic acid
144-49-0

Fluoroacetic acid

C

ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

D

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

E

ethyl acetate
141-78-6

ethyl acetate

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide for 2h; Quantum yield; Irradiation;
1,1,2,2-tetrafluoroethyl ethyl ether
512-51-6

1,1,2,2-tetrafluoroethyl ethyl ether

sulfuric acid
7664-93-9

sulfuric acid

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

diethyl sulfate
64-67-5

diethyl sulfate

difluoroacetate_of sodium

difluoroacetate_of sodium

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

acetyl fluoride
557-99-3

acetyl fluoride

fluorine

fluorine

copper wire

copper wire

A

ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

Conditions
ConditionsYield
at 100℃; Umsetzen der Reaktionsprodukte mit absol.Aethanol bei -80grad,zuletzt bei Siedetemperatur;
N-benzylidene benzylamine
780-25-6

N-benzylidene benzylamine

α-(trimethylsilyl)difluoroacetic acid ethyl ester
205865-67-4

α-(trimethylsilyl)difluoroacetic acid ethyl ester

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

N-benzylidene-α-(trimethylsilyl)benzylamine
53986-95-1

N-benzylidene-α-(trimethylsilyl)benzylamine

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium fluoride at 50℃; for 12h;
Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

ethyl acrylate
140-88-5

ethyl acrylate

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

2,2-difluoroglutaric acid diethyl ester
428-97-7

2,2-difluoroglutaric acid diethyl ester

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; water; copper In tetrahydrofuran Michael Addition;A 10 %Spectr.
B 52 %Spectr.
Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

phenylboronic acid
98-80-6

phenylboronic acid

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

ethyl 2,2-difluoro-2-phenylacetate
2248-46-6

ethyl 2,2-difluoro-2-phenylacetate

Conditions
ConditionsYield
With 2,2':6,2''-terpyridine; nickel chloride dimethyl ether; potassium carbonate In 1,4-dioxane at 80℃; for 8h; Schlenk technique; Inert atmosphere;A 7 %Spectr.
B 1 %Spectr.
With [2,2]bipyridinyl; [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; potassium carbonate In 1,4-dioxane at 80℃; for 8h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;A 6 %Spectr.
B 89 %Spectr.
1-ethenyl-2-pyrrolidinone
88-12-0

1-ethenyl-2-pyrrolidinone

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

4-biphenylboronic acid
5122-94-1

4-biphenylboronic acid

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

C

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester
73789-98-7

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); 4,4'-dibromo-2,2'-bipyridine; potassium carbonate In tetrahydrofuran at 80℃; for 24h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;A 15 %Spectr.
B 53 %Spectr.
C 13 %Spectr.
1-ethenyl-2-pyrrolidinone
88-12-0

1-ethenyl-2-pyrrolidinone

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

4-biphenylboronic acid
5122-94-1

4-biphenylboronic acid

A

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

B

ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

ethyl 4-([1,1'-biphenyl]-4-yl)-2,2-difluoro-4-(2-oxopyrrolidin-1-yl)butanoate

C

C10H13F2NO3

C10H13F2NO3

D

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester
73789-98-7

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester

Conditions
ConditionsYield
With bis(triphenylphosphine)nickel(II) chloride; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In tetrahydrofuran at 80℃; for 24h; Concentration; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;A 13 %Spectr.
B 49 %Spectr.
C 7 %Spectr.
D 36 %Spectr.
ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

difluoroethanol
359-13-7

difluoroethanol

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; triethylamine In ethanol at 45℃; under 7500.75 - 30003 Torr; for 5h; Temperature; Time; Pressure;
ethyl 2,2-difluoro-2-iodoacetate
7648-30-8

ethyl 2,2-difluoro-2-iodoacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; triethylamine In tetrahydrofuran at 100℃; under 750.075 - 15001.5 Torr;
With diethylzinc In hexane; [D3]acetonitrile at -20℃; for 8h; Schlenk technique; Inert atmosphere;
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

1-ethoxy-2,2-difluoroethanol
148992-43-2

1-ethoxy-2,2-difluoroethanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 2.75h;100%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h;60%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at -78℃; for 3h; Reagent/catalyst; Solvent;60%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C13H23NO3

C13H23NO3

C15H23F2NO4

C15H23F2NO4

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;100%
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;100%
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;100%
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;100%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C13H23NO3

C13H23NO3

C15H23F2NO4

C15H23F2NO4

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;100%
(S)-{(1α,5α,6α)-3-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hex-6-yl}carbamic acid tert-butyl ester
681425-32-1

(S)-{(1α,5α,6α)-3-[4-(5-aminomethyl-2-oxooxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hex-6-yl}carbamic acid tert-butyl ester

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

(S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester
681425-33-2

(S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 15h;99%
With triethylamine In methanol at 20℃; for 15h;99%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

5-(aminomethyl)-2-chloropyridine
97004-04-1

5-(aminomethyl)-2-chloropyridine

N-(2-chloro-5-aminomethylpyridine)-1,1-difluoroacetamide
1135440-09-3

N-(2-chloro-5-aminomethylpyridine)-1,1-difluoroacetamide

Conditions
ConditionsYield
at 100℃; for 1h; Reflux;99%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

Conditions
ConditionsYield
at 85℃; Product distribution / selectivity;A 99%
B n/a
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C14H23NO3

C14H23NO3

C16H23F2NO4

C16H23F2NO4

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 0 - 20℃; for 2h; Inert atmosphere;99%
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;99%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C13H22FNO3

C13H22FNO3

C15H22F3NO4

C15H22F3NO4

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 0 - 20℃; Inert atmosphere;99%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

benzophenone
119-61-9

benzophenone

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

diphenylmethyl trimethylsilyl ether
14629-59-5

diphenylmethyl trimethylsilyl ether

Conditions
ConditionsYield
With magnesium In 1-methyl-pyrrolidin-2-one at 20℃; Inert atmosphere;98%
tert-butyl 3-acetylpiperidine-1-carboxylate
858643-92-2

tert-butyl 3-acetylpiperidine-1-carboxylate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

tert-butyl 3-(4,4-difluoro-3-oxobutanoyl)piperidine-1-carboxylate

tert-butyl 3-(4,4-difluoro-3-oxobutanoyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In benzene at 0 - 20℃; for 5h; Inert atmosphere;98%
With potassium tert-butylate In benzene at 0 - 20℃; for 5h; Inert atmosphere;97%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

phenethylamine
64-04-0

phenethylamine

2,2-difluoro-N-(2-phenylethyl)acetamide

2,2-difluoro-N-(2-phenylethyl)acetamide

Conditions
ConditionsYield
In dichloromethane for 16h; Reflux; Inert atmosphere;98%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

histamine
51-45-6

histamine

2,2-difluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide

2,2-difluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide

Conditions
ConditionsYield
In dichloromethane for 16h; Reflux; Inert atmosphere;98%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran
484-51-5

5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

7-(difluoromethyl)-7-hydroxy-4,9-dimethoxy-6,7-dihydro-5H-furo[3,2-g]chromen-5-one
376384-40-6

7-(difluoromethyl)-7-hydroxy-4,9-dimethoxy-6,7-dihydro-5H-furo[3,2-g]chromen-5-one

Conditions
ConditionsYield
With lithium hydride In tetrahydrofuran Heating;97%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

diethyl (3,3-difluoro-2-oxopropyl)phosphonate
1023327-32-3

diethyl (3,3-difluoro-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: Diethyl methylphosphonate With n-butyllithium In tetrahydrofuran; hexane at -95℃; for 1h; Inert atmosphere;
Stage #2: ethyl difluoroacetate In tetrahydrofuran; hexane at -95 - -90℃; for 1h; Inert atmosphere;
97%
Stage #1: Diethyl methylphosphonate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h;
Stage #2: ethyl difluoroacetate In tetrahydrofuran at -78 - 0℃; Further stages.;
82%
With n-butyllithium In tetrahydrofuran; hexane at -78 - -65℃; for 3h;
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

2,2-difluoroacetamide
359-38-6

2,2-difluoroacetamide

Conditions
ConditionsYield
With ammonia In ethanol at 0 - 25℃; for 2.5h;96%
With ammonia
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

1-(3-fluoro-4-methoxyphenyl)ethanone
455-91-4

1-(3-fluoro-4-methoxyphenyl)ethanone

4,4-difluoro-1-(3-fluoro-4-methoxyohenyl)-butane-1,3-dione
170570-77-1

4,4-difluoro-1-(3-fluoro-4-methoxyohenyl)-butane-1,3-dione

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate In tert-butyl methyl ether96%
With hydrogenchloride; sodium methylate In tert-butyl methyl ether96%
With hydrogenchloride; sodium methylate In tert-butyl methyl ether96%
formic acid
64-18-6

formic acid

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Conditions
ConditionsYield
sulfuric acid at 70℃; Product distribution / selectivity;A 96%
B n/a
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

ethyl acetate
141-78-6

ethyl acetate

ethyl 4,4-difluoro-3-oxobutyrate
352-24-9

ethyl 4,4-difluoro-3-oxobutyrate

Conditions
ConditionsYield
Stage #1: ethyl acetate With sodium ethanolate at 25℃;
Stage #2: ethyl difluoroacetate at 10 - 65℃;
Stage #3: With sulfuric acid; water at 20 - 25℃; for 0.333333h; Product distribution / selectivity;
95.5%
With multielement hydrotalcite at 55℃; for 8h; Catalytic behavior; Temperature; Reagent/catalyst; Green chemistry;88.9%
With lithium diisopropyl amide In diethyl ether at -70℃; for 4h;82%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

phenylacetylene
536-74-3

phenylacetylene

1,1-difluoro-4-phenyl-3-butyn-2-one
117710-72-2

1,1-difluoro-4-phenyl-3-butyn-2-one

Conditions
ConditionsYield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere;
Stage #2: ethyl difluoroacetate With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;
95%
With n-butyllithium; boron trifluoride diethyl etherate 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 90 min; Yield given. Multistep reaction;
With n-butyllithium; boron trifluoride diethyl etherate 1.) hexane, THF, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 1.5 h; Yield given. Multistep reaction;
With n-butyllithium; boron trifluoride diethyl etherate
benzoimidazole
51-17-2

benzoimidazole

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

1-(difluoromethyl)-1H-benzo[d]imidazole
84941-15-1

1-(difluoromethyl)-1H-benzo[d]imidazole

Conditions
ConditionsYield
With potassium hydroxide In acetonitrile at 60℃; for 6h; Concentration; Solvent; Temperature; Sealed tube;95%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

difluoroethanol
359-13-7

difluoroethanol

Conditions
ConditionsYield
With hydrogen at 110℃; under 3750.38 - 15001.5 Torr; for 4h; Temperature; Pressure; Autoclave;93.3%
With C39H53ClN2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 20℃; under 38002.6 Torr; for 16h; Glovebox; Autoclave;93%
With lithium aluminium tetrahydride In tetrahydrofuran at -10℃; for 1h;44.6%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

1-(2-anilinophenyl)ethan-1-one
23699-74-3

1-(2-anilinophenyl)ethan-1-one

2-(difluoromethyl)-1-phenylquinolin-4(1H)-one
837364-34-8

2-(difluoromethyl)-1-phenylquinolin-4(1H)-one

Conditions
ConditionsYield
With lithium hydride In tetrahydrofuran for 1h; Heating;93%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

4'-benzyloxy-acetophenone
54696-05-8

4'-benzyloxy-acetophenone

4,4-difluoromethyl-1-(4-benzyloxyphenyl)-butane-1,3-dione

4,4-difluoromethyl-1-(4-benzyloxyphenyl)-butane-1,3-dione

Conditions
ConditionsYield
With sodium methylate In methanol93%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

1-cyclohexenyl methyl ketone
932-66-1

1-cyclohexenyl methyl ketone

4,4-difluoro-1-[2-cyclohexenyl]-butane-1,3-dione

4,4-difluoro-1-[2-cyclohexenyl]-butane-1,3-dione

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate93%
With hydrogenchloride; sodium methylate93%
ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C10H11FN2O

C10H11FN2O

C12H11F3N2O2

C12H11F3N2O2

Conditions
ConditionsYield
With dmap In methanol at 20℃; for 12h;92.8%
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