10-Hydroxydecanoic Acid supplier

Name
10-Hydroxydecanoic Acid
EINECS 216-848-1
CAS No. 1679-53-4
Article Data46
CAS DataBase
Density 1.013 g/cm³
Solubility
Melting Point 75-77 °C(lit.)
Formula C₁₀H₂₀O₃
Boiling Point 330.8 °C at 760 mmHg
Molecular Weight 188.267
Flash Point 168.1 °C
Transport Information
Appearance White powder crystal
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 10-Hydroxydecanoicacid;NSC 15139;
PSA 57.53000
LogP 2.18410

Synthetic route

: 5579-79-3
Oxacycloundecan-2-one

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With sodium hydroxide	99%
With potassium hydroxide In ethanol for 2h; Hydrolysis; Heating;	96.2%
With sodium hydroxide In dimethyl sulfoxide for 0.416667h; Thermodynamic data; ΔH;

: 92038-37-4
10-acetoxydecanoic acid

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With sodium hydroxide	92%
With potassium hydroxide

: 52633-92-8
2,2,2-trichloroethyl 10-hydroxydecanoate

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With tellurium; sodium tetrahydroborate In N,N-dimethyl-formamide Ambient temperature;	92%

: 1,3-Dioxa-cyclotridecane-4,13-dione

A: 111-20-6
1,10-decanedioic acid

B: 112-47-0
1,10-Decanediol

C: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 6h;	A n/a B 10% C 82%

...Expand

: 112-43-6
10-Undecen-1-ol

: 64-19-7
acetic acid

A: 1679-53-4
10-hydroxydecanoic acid

B: 92038-37-4
10-acetoxydecanoic acid

Conditions

Conditions	Yield
Stage #1: 10-Undecen-1-ol; acetic acid With ozone In dichloromethane at 0℃; Stage #2: With hydroxylamine hydrochloride In dichloromethane at 0 - 20℃; Reagent/catalyst; Inert atmosphere;	A 21% B 76%

...Expand

: 4128-31-8
rac-octan-2-ol

castor oil: castor oil

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With aluminium(III) chloride hexahydrate; sodium hydroxide at 190℃; for 6h; Reagent/catalyst; Temperature; Time; Reflux;	76%

: 112-47-0
1,10-Decanediol

A: 111-20-6
1,10-decanedioic acid

B: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With copper oxide-chromium oxide; hydrogen at 250℃; under 7355.08 Torr;

: 4444-16-0
16-hydroxy-hexadec-6-enoic acid

A: 124-04-9
Adipic acid

B: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
bei der Ozonspaltung;

: 112-38-9
10-undecenoic acid

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
(i) O3, MeOH, (ii) NaBH4, aq. NaOH, EtOH, (iii) aq. HCl; Multistep reaction;

: 91057-51-1
10-Hydroxy-decin-(7)-saeure

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

: 69152-90-5
(Z)-10-hydroxy-8-decenoic acid

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
(i) Br2, CCl4, (ii) H2, Et3N, Raney-Ni, MeOH; Multistep reaction;

: 64-17-5
ethanol

: 10-Hydroxy-decanoic acid 4-nitro-phenyl ester

A: 100-02-7
4-nitro-phenol

B: 1679-53-4
10-hydroxydecanoic acid

C: 3639-35-8
10-hydroxydecanoic acid ethyl ester

Conditions

Conditions	Yield
With tris-buffer; ethylenediaminetetraacetic acid; acyl carrier protein-thioesterase at 37℃; Kinetics; Mechanism;

...Expand

: 1047-97-8
1,12-dioxacyclodocosane-2,13-dione

aqueous-alcoholic KOH-solution: aqueous-alcoholic KOH-solution

: 1679-53-4
10-hydroxydecanoic acid

: 56-23-5
tetrachloromethane

: 112-19-6
10-undecenyl acetate

: 10028-15-6
ozone

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
at -10 - 0℃; Hydrolysieren des Ozonids in saurer oder neutraler Loesung bei 95-100grad;

...Expand

: 112-19-6
10-undecenyl acetate

: 10028-15-6
ozone

: 64-19-7
acetic acid

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
at 0℃; Hydrolysieren des Ozonids in saurer oder neutraler Loesung bei 95-100grad;

...Expand

castor oil: castor oil

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With aqueous alkali at 180 - 230℃;
With aqueous alkali at 180 - 230℃;

: 71194-27-9
methyl 10-chloroundecanoate

concentrated KOH-solution: concentrated KOH-solution

: 1679-53-4
10-hydroxydecanoic acid

methyl ester of/the/ ι-oxy-capric acid: methyl ester of/the/ ι-oxy-capric acid

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With potassium hydroxide

mono-ω-undecenyl sulfate: mono-ω-undecenyl sulfate

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With potassium permanganate

monoundecen-(10)-yl sulfate: monoundecen-(10)-yl sulfate

: 1679-53-4
10-hydroxydecanoic acid

polymer(ic) sebacic acid anhydride: polymer(ic) sebacic acid anhydride

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With barium copper chromite; benzene at 250 - 260℃; under 169167 Torr; Hydrogenation.Hydrolyse des Reaktionsprodukts mit wss.-alkoh.NaOH;

potassium salt of/the/ sebacic acid monoethyl ester: potassium salt of/the/ sebacic acid monoethyl ester

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With ethanol; sodium man reinigt ueber das Acetylderivat;

potassium salt of/the/ sebacic acid monomethyl ester: potassium salt of/the/ sebacic acid monomethyl ester

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With ethanol; sodium man reinigt ueber das Acetylderivat;

ricinolic acid soap: ricinolic acid soap

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With aqueous alkali at 180 - 230℃;
With aqueous alkali at 180 - 230℃;

ricinus-oil: ricinus-oil

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; water; ortho-cresol at 190℃;

undecen-(10)-yl acetate: undecen-(10)-yl acetate

: 1679-53-4
10-hydroxydecanoic acid

Conditions

Conditions	Yield
With ozone; acetic acid at 0℃; Hydrolyse des Ozonids in saurer oder neutraler Loesung an der Luft bei 95-100grad;

: 141-22-0
Ricinoleic acid

: furan-2,3,5(4H)-trione pyridine (1:1)

copper bronze: copper bronze

A: 1679-53-4
10-hydroxydecanoic acid

B: 16630-91-4
2-methylheptanal

Conditions

Conditions	Yield
at 180 - 200℃;
at 180 - 200℃;

...Expand

: 67-56-1
methanol

: 1679-53-4
10-hydroxydecanoic acid

: 2640-94-0
methyl 10-hydroxydecanoate

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Heating;	99.3%
With sulfuric acid for 16h; Heating;	90%
With sulfuric acid

: 1679-53-4
10-hydroxydecanoic acid

: 64-17-5
ethanol

: 3639-35-8
10-hydroxydecanoic acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid for 3h; Heating / reflux;	98%
With sulfuric acid for 3h; Heating / reflux;	98%
With sulfuric acid for 15h; Reflux;	94%
With magnesium chloride at 20℃; for 18h;	89%

: 1005500-75-3
N-(methyl)-N-(p-toluenesulfonyl)ethynylamine

: 1679-53-4
10-hydroxydecanoic acid

: C20H31NO5S

Conditions

Conditions	Yield
With copper(l) chloride In dichloromethane at 20℃;	98%

: 1679-53-4
10-hydroxydecanoic acid

: 124-63-0
methanesulfonyl chloride

: 477775-67-0
mesylate of ethyl 10-hydroxydecanoate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; triethylamine In dichloromethane; water	97%
With sodium hydrogencarbonate; triethylamine In dichloromethane; water	97%
With sodium hydrogencarbonate; triethylamine In dichloromethane; water	97%
With sodium hydrogencarbonate; triethylamine In dichloromethane; water	97%
With sodium hydrogencarbonate; triethylamine In dichloromethane; water	97%

: 1679-53-4
10-hydroxydecanoic acid

poly(10-hydroxydecanoic acid), degree of polymerization > 200, Mn=1.82E4, Mw=3.40E4; monomer: 10-hydroxydecanoic acid: poly(10-hydroxydecanoic acid), degree of polymerization > 200, Mn=1.82E4, Mw=3.40E4; monomer: 10-hydroxydecanoic acid

Conditions

Conditions	Yield
tetrachlorobis(tetrahydrofuran)hafnium(IV) In o-xylene for 24h; Heating;	95%

: 1679-53-4
10-hydroxydecanoic acid

Reaxys ID: 11465383: Reaxys ID: 11465383

Conditions

Conditions	Yield
With molecular sevies 4A; tetrachlorobis(tetrahydrofuran)hafnium(IV) In o-xylene for 24h; Heating / reflux;	95%

: 1679-53-4
10-hydroxydecanoic acid

: 108-24-7
acetic anhydride

: 92038-37-4
10-acetoxydecanoic acid

Conditions

Conditions	Yield
With pyridine at 20℃; for 12h;	94%
With pyridine	94%
With pyridine at 20℃; for 24h;	93%
at 20℃; dann unter Erwaermen bis auf 90grad und Behandeln des Reaktionsprodukts mit Wasser;

: 1679-53-4
10-hydroxydecanoic acid

: 107-18-6
allyl alcohol

: 170117-44-9
allyl 10-hydroxydecanoate

Conditions

Conditions	Yield
With sulfuric acid Heating;	83%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 2h;	75%

: 110-87-2
3,4-dihydro-2H-pyran

: 1679-53-4
10-hydroxydecanoic acid

: 223400-49-5
10-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-decanoic acid

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In tetrahydrofuran for 14h; Ambient temperature;	82%

: 1679-53-4
10-hydroxydecanoic acid

A: 5579-79-3
Oxacycloundecan-2-one

B: 1047-97-8
1,12-dioxacyclodocosane-2,13-dione

Conditions

Conditions	Yield
With p-nitrobenzoic anhydride; scandium tris(trifluoromethanesulfonate) In tetrahydrofuran; acetonitrile for 5h; Heating;	A 77% B 2%
With dmap; di-2-thienyl carbonate; hafnium(IV) trifluoromethanesulfonate In toluene; acetonitrile at 100℃; for 5h;	A 70% B 5%
With RhCl(PPh3)3; bis(trifluoromethanesulfonyloxy)dimethylsilane; 1,2-bis(dimethylsilyl)benzene 1) benzene, RT, 6 h, 2) benzene, 80 deg C, 3 h, 3) benzene, 80 deg C, 9 h; Yield given. Multistep reaction. Yields of byproduct given;

: 1679-53-4
10-hydroxydecanoic acid

: 459-73-4
GlyOEt*HCl

: (10-hydroxydecanoyl)glycine

Conditions

Conditions	Yield
Stage #1: GlyOEt*HCl With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 0.166667h; Inert atmosphere; Stage #2: 10-hydroxydecanoic acid In dichloromethane at 0 - 20℃; for 14h; Inert atmosphere; Stage #3: With lithium hydroxide In tetrahydrofuran; methanol; water at 60℃; for 4h; Inert atmosphere;	77%

: 1679-53-4
10-hydroxydecanoic acid

: 58479-61-1
tert-butylchlorodiphenylsilane

: 868132-31-4
10-((tert-butyldiphenylsilyl)oxy)decanoic acid

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 15h; Inert atmosphere;	76%

: 1679-53-4
10-hydroxydecanoic acid

: 50530-12-6
10-bromodecanoic acid

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid a) r.t., 16 h, b) 100 deg C, 4 h;	75%
With hydrogen bromide; acetic acid
With sulfuric acid; hydrogen bromide
With hydrogen bromide; acetic acid

: 1679-53-4
10-hydroxydecanoic acid

: 1047-97-8
1,12-dioxacyclodocosane-2,13-dione

Conditions

Conditions	Yield
With hafnium(IV) trifluoromethanesulfonate In toluene at 110℃; for 48h; Concentration; Inert atmosphere;	74%
With benzenesulfonic acid; benzene
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 2: 23 percent / TiCl4, AgClO4, p-trifluoromethylbenzoic anhydride / CH2Cl2 / 3 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: Et3N / tetrahydrofuran 2: dimethylformamide / -42 deg C -> r.t. 3: 82 percent / methoxytri-n-butyltin / octane / Heating View Scheme

: 1679-53-4
10-hydroxydecanoic acid

A: 5579-79-3
Oxacycloundecan-2-one

B: 1081554-92-8
C20H38O5

Conditions

Conditions	Yield
With hydrotalcite; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran; chloroform for 18h; Reflux; Inert atmosphere;	A 73% B 9%

: 1679-53-4
10-hydroxydecanoic acid

: 5579-79-3
Oxacycloundecan-2-one

Conditions

Conditions	Yield
With dmap; oxalyl dichloride; Tropone; triethylamine In dichloromethane at 20℃; for 14h;	71%
With benzenesulfonic acid; benzene
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 2: 70 percent / TiCl4, AgClO4, p-trifluoromethylbenzoic anhydride / CH2Cl2 / 3 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: copper(l) chloride / dichloromethane / 20 °C 2: toluene-4-sulfonic acid / dichloromethane / 20 °C View Scheme

: 605-94-7
2,3-Dimethoxy-5-methyl-1,4-benzoquinone

: 1679-53-4
10-hydroxydecanoic acid

: 77712-32-4
2-(9-hydroxynonyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 80℃; for 4h;	70%
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 75℃; for 4h; Temperature; Time;	60%
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 75℃; for 2h;	60%

: 1679-53-4
10-hydroxydecanoic acid

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 175234-79-4
10--decanoic acid

Conditions

Conditions	Yield
With pyridine Ambient temperature;	69%
With pyridine

: 115-20-8
1,1,1-trichloroethanol

: 1679-53-4
10-hydroxydecanoic acid

: 52633-92-8
2,2,2-trichloroethyl 10-hydroxydecanoate

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	66%

: 1679-53-4
10-hydroxydecanoic acid

: 2614-88-2, 90554-82-8
sorbitoyl chloride

: 10-(2',4'-hexadienoyloxy)decanoic acid

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 2h; Acylation;	62.4%

: 1679-53-4
10-hydroxydecanoic acid

: 193545-66-3
(1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol

: (1S,2S)-2-(10-hydroxydecanoyl)amino-3-morpholino-1-phenyl-1-propanol

Conditions

Conditions	Yield
With 1,2-dichloro-ethane; triethylamine In dichloromethane	62%

: 1679-53-4
10-hydroxydecanoic acid

: DMTr-L-Prolinol

: DMTr-amide-L-prolinol

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 20h;	62%

10-Hydroxydecanoic Acid Specification

The 10-Hydroxydecanoic Acid, with the CAS registry number 1679-53-4, is a kind of crystalline. This chemical could be used to produce Rorifon with the function of depressing cough and reducing inspissated mucus, and it could be used in the synthesis of musk 105, 10-hydroxy-2-decenoic acid and could then be used in the cosmetics. Besides, it is irritant and may cause inflammation to the skin or other mucous membranes. In addition, it has the product categories which are including C10Fatty Acids; Carbonyl Compounds; Carboxylic Acids; Hydroxy fatty acids; Saturated fatty acids and derivatives.

The characteristics of this chemical are as below: (1)ACD/LogP: 1.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.16; (4)ACD/LogD (pH 7.4): -0.63; (5)ACD/BCF (pH 5.5): 2.9; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 44.26; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 10; (12)Polar Surface Area: 35.53; (13)Index of Refraction: 1.466; (14)Molar Refractivity: 51.47 cm³; (15)Molar Volume: 185.7 cm³; (16)Polarizability: 20.4×10^-24 cm³; (17)Surface Tension: 40.4 dyne/cm; (18)Density: 1.013 g/cm³; (19)Flash Point: 168.1 °C; (20)Enthalpy of Vaporization: 66.45 kJ/mol; (21)Boiling Point: 330.8 °C at 760 mmHg; (22)Vapour Pressure: 1.18E-05 mmHg at 25°C; (23)Exact Mass: 188.141245; (24)MonoIsotopic Mass: 188.141245; (25)Topological Polar Surface Area: 57.5; (26)Heavy Atom Count: 13; (27)Complexity: 123.

Use of this chemical: 10-Hydroxydecanoic Acid could react with methanol to produce 10-hydroxy-decanoic acid methyl ester. This reaction could happen in the presence of the reagent of concentrated sulfuric acid.

Production method of this chemical: oxacycloundecan-2-one could react to produce 10-hydroxy-decanoic acid. This reaction could happen in the presence of the reagent of aq. NaOH with the yield of 99%.

In adddition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C(CCCCC(=O)O)CCCCO
(2)InChI: InChI=1S/C10H20O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h11H,1-9H2,(H,12,13)
(3)InChIKey: YJCJVMMDTBEITC-UHFFFAOYSA-N

Product Name

10-Hydroxydecanoic Acid

Synthetic route

10-Hydroxydecanoic Acid Specification

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