2,2',4,4'-Tetrahydroxybenzophenone supplier

Name
2,2',4,4'-Tetrahydroxybenzophenone
EINECS 205-028-9
CAS No. 131-55-5
Article Data26
CAS DataBase
Density 1.526 g/cm³
Solubility Slightly soluble in water.
Melting Point 198-200 °C(lit.)
Formula C₁₃H₁₀O₅
Boiling Point 531.2 °C at 760 mmHg
Molecular Weight 246.219
Flash Point 289.2 °C
Transport Information
Appearance yellow to brown crystalline powder
Safety 26-36-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzophenone, 2,2,4,4-tetrahydroxy-;2,2',4,4'-Tetrahydroxybenzophenone (UV-2);Eusorb UV-246;di(2,4-dihydroxyphenyl)methanone;BP-2;Sumisorb 150;Uvinul D-50;Methanone, bis (2,4-dihydroxyphenyl)-;2,2',4,4'-Tetrahydroxy benzophenone (Benzophenone 2);bis(2,4-dihydroxyphenyl)methanone;Methanone,bis(2,4-dihydroxyphenyl)-;Seesorb 106;2,2',4,4'-Tetrahydroxy Benzophenone;2,2',4,4'-Tetrahydroxybenzophenone (BP-2);2,2'4,4'Tetrahydroxy Benzophenone (UV Absorber D50);
PSA 97.99000
LogP 1.74000

Synthetic route

: carbonylbis(benzene-4,1,3-triyl) tetraacetate

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
With hydrogenchloride In water at 20 - 100℃; for 6h; Temperature; Autoclave; Large scale;	82.1%

: 89-86-1
4-hydroxysalicylic acid

: 108-46-3
recorcinol

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
With zinc(II) chloride; trichlorophosphate at 65℃; for 3h; Inert atmosphere;	73%
With zinc(II) chloride; trichlorophosphate
With zinc(II) chloride at 125 - 140℃;

: 151-10-0
1,3-Dimethoxybenzene

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
With aluminium trichloride; 1,2-dichloro-ethane

2.4-dioxy-2'.4'-diacetoxy-benzophenone-imide: 2.4-dioxy-2'.4'-diacetoxy-benzophenone-imide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
With sulfuric acid
With sodium hydroxide

fluorescein chloride: fluorescein chloride

A: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

B benzoic acid , 2',4'-dioxy-benzophenone-carboxylic acid-(2), resorcinol: benzoic acid , 2',4'-dioxy-benzophenone-carboxylic acid-(2), resorcinol

Conditions

Conditions	Yield
With sodium hydroxide

: 131-54-4
bis(2-hydroxy-4-methoxyphenyl)-methanone

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
AlCl3

: 131-54-4
bis(2-hydroxy-4-methoxyphenyl)-methanone

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
With urea; AlCl3

: 3555-85-9
2,2',4,4'-tetramethoxybenzophenone

: 95-50-1
1,2-dichloro-benzene

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
AlCl3 In water

: 108-46-3
recorcinol

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: chloroform / 4 h / 20 - 65 °C / Large scale 1.2: Large scale 2.1: aluminum (III) chloride / N,N-dimethyl-formamide; cis-1,2-Dichloroethylene / 30 - 85 °C / Large scale 3.1: hydrogenchloride / water / 6 h / 20 - 100 °C / Autoclave; Large scale View Scheme

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 1214-24-0
3,6-dihydroxy-xanthen-9-one

Conditions

Conditions	Yield
In water at 220℃; under 1900 Torr;	100%
In water at 190℃; for 48h;	100%
In water at 200℃; for 6h; Sealed tube;	100%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 265975-39-1
2,2',4,4'-tetra-tert-butyldimethylsilyloxybenzophenone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; silylation;	96%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 96-32-2
bromoacetic acid methyl ester

: tetramethyl 2,2′,2″,2‴‐[(carbonylbis(benzene‐4,1,3‐triyl))tetrakis(oxy)]tetraacetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Williamson Ether Synthesis; Reflux;	93%
With potassium carbonate In acetone at 65℃;

: 5036-48-6
3-(1H-imidazol-1-yl)propan-1-amine

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 1325729-75-6
C19H19N3O4

Conditions

Conditions	Yield
In toluene; butan-1-ol for 5h; Inert atmosphere; Reflux;	92%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 117767-15-4
4-(6-hydrazino-1H-indazol-3-yl)-1,3-benzenediol

Conditions

Conditions	Yield
With ammonium chloride; hydrazine hydrate at 200 - 210℃; for 4h; sealed tube;	86%
With hydrazine hydrate at 200℃;

: 4224-69-5
methyl 2-(bromomethyl)propenoate

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: C18H16O7

Conditions

Conditions	Yield
With methyltriethylammonium monomethyl carbonate In acetonitrile at 15℃; for 48h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;	85.8%

: 4224-69-5
methyl 2-(bromomethyl)propenoate

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: C23H22O9

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 55℃; for 24h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;	85.5%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: C13H6(2)H4O5

Conditions

Conditions	Yield
With perchloric acid; d(4)-methanol at 75℃; for 72h; Inert atmosphere;	85%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 100-63-0
phenylhydrazine

: 117767-19-8
bis(2,4-dihydroxylphenyl)methanone phenylhydrazone

Conditions

Conditions	Yield
With ammonium chloride at 200 - 210℃; for 4h; sealed tube;	80%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 74-88-4
methyl iodide

: 3555-85-9
2,2',4,4'-tetramethoxybenzophenone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	79%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 117767-16-5
4-(6-hydroxy-1H-indazol-3-yl)-1,3-benzenediol

Conditions

Conditions	Yield
With ammonium chloride; hydrazine hydrate In water Heating;	75%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 119-26-6
(2,4-dinitro-phenyl)-hydrazine

: 2,2',4,4'-tetrahydroxybenzophenon-2,4-dinitrophenylhydrazone

Conditions

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 0.5h;	75%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 6959-48-4
3-chloromethylpyridinium chloride

: 2,2′-dihydroxy-4,4′-bis(pyridin-3-ylmethoxy)benzophenone

Conditions

Conditions	Yield
Stage #1: 2,2',4,4'-tetrahydroxybenzophenone With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: 3-chloromethylpyridinium chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 13h;	69%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 60-34-4
methylhydrazine

: 117767-17-6
4-(6-hydroxyl-1-methyl-H-indazol-3-yl)-1,3-benzenediol

Conditions

Conditions	Yield
With ammonium chloride at 200 - 210℃; for 4h; sealed tube;	63%

: 112-35-6
triethylene glucol monomethyl ether

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 2,2',4,4'-tetra(1'',4'',7'',10''-tetraoxaundecyl)benzophenone

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 24h;	52%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 77-78-1
dimethyl sulfate

: 3555-85-9
2,2',4,4'-tetramethoxybenzophenone

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetonitrile for 20h; Heating;	40%
With potassium carbonate In acetone for 8h; Reflux;	1.4 g

: 1611-56-9
1-Bromo-11-hydroxyundecane

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 2,2',4,4'-tetra(11''-hydroxy-1''-undecanoxy)benzophenon

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetonitrile for 24h; Heating;	35%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 108-24-7
acetic anhydride

: carbonylbis(benzene-4,1,3-triyl) tetraacetate

Conditions

Conditions	Yield
at 140℃; for 48h; Reflux;	30%
With pyridine

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 870-63-3
prenyl bromide

: 1316308-41-4
(5-hydroxy-2,2-dimethylchroman-6-yl)(2'-hydroxy-4'-(tertpentyloxy)phenyl)methanone

Conditions

Conditions	Yield
With Montmorillonite K10 clay at 90℃; Microwave irradiation;	6%

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 3555-85-9
2,2',4,4'-tetramethoxybenzophenone

Conditions

Conditions	Yield
With potassium carbonate; acetone; dimethyl sulfate
With potassium carbonate; dimethyl sulfate In [(2)H6]acetone; ethanol; water; ethyl acetate

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 3,6-dihydroxy-xanthen-9-one oxime

Conditions

Conditions	Yield
With ethanol; hydroxylamine hydrochloride; sodium acetate

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: (2,4-Dihydroxy-phenyl)-[4-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yloxy)-2-hydroxy-phenyl]-methanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: Bis-[4-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yloxy)-2-hydroxy-phenyl]-methanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: [2,4-Bis-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yloxy)-phenyl]-[4-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yloxy)-2-hydroxy-phenyl]-methanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile

: 4090-55-5
2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: Bis-[2,4-bis-(5,5-dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yloxy)-phenyl]-methanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile

: 51116-72-4
3-methylpentanoyl chloride

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 2,2',4,4'-tetra(3-methylvaleroyloxy)benzophenone

Conditions

Conditions	Yield
With pyridine at 50℃; for 2h;
In pyridine

: 131-55-5
2,2',4,4'-tetrahydroxybenzophenone

: 3282-30-2
pivaloyl chloride

: 2,2',4,4'-tetrapivaloyloxybenzophenone

Conditions

Conditions	Yield
With pyridine at 50℃; for 2h;
In pyridine

2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties

Molecular structure of Benzophenone-2 (CAS NO.131-55-5) is:

Product Name: Benzophenone-2
CAS Registry Number: 131-55-5
IUPAC Name: bis(2,4-dihydroxyphenyl)methanone
Molecular Weight: 246.2155 [g/mol]
Molecular Formula: C₁₃H₁₀O₅
XLogP3-AA: 2.4
H-Bond Donor: 4
H-Bond Acceptor: 5
EINECS: 205-028-9
Melting Point: 198-200 °C(lit.)
Surface Tension: 83.1 dyne/cm
Density: 1.526 g/cm³
Flash Point: 289.2 °C
Enthalpy of Vaporization: 83.7 kJ/mol
Boiling Point: 531.2 °C at 760 mmHg
Vapour Pressure: 6.69E-12 mmHg at 25°C
Product Categories: Industrial/Fine Chemicals;Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;C₁₃ to C₁₄;Carbonyl Compounds;Ketones

2,2',4,4'-Tetrahydroxybenzophenone Uses

Benzophenone-2 (CAS NO.131-55-5) is used for pharmaceutical intermediates, photographic materials, cosmetics anti-uv additive, etc.

2,2',4,4'-Tetrahydroxybenzophenone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	1220mg/kg (1220mg/kg)		Journal of the American College of Toxicology. Vol. 2(5), Pg. 35, 1983.

2,2',4,4'-Tetrahydroxybenzophenone Safety Profile

Hazard Codes: Harmful Xn,Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: DJ1892000

2,2',4,4'-Tetrahydroxybenzophenone Specification

Benzophenone-2 , its cas register number is 131-55-5. It also can be called 2,2',4,4'-Tetrahydroxybenzophenone ; Di(2,4-dihydroxyphenyl)methanone ; Bis(2,4-dihydroxyphenyl)methanone ; Benzophenone, 2,2',4,4'-tetrahydroxy- ; Methanone, bis(2,4-dihydroxyphenyl)- .It is a yellow to brown crystalline powder.

Product Name

2,2',4,4'-Tetrahydroxybenzophenone

Synthetic route

2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties

2,2',4,4'-Tetrahydroxybenzophenone Uses

2,2',4,4'-Tetrahydroxybenzophenone Toxicity Data With Reference

2,2',4,4'-Tetrahydroxybenzophenone Safety Profile

2,2',4,4'-Tetrahydroxybenzophenone Specification

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