2-Hydroxy-5-methoxybenzaldehyde supplier

Name
2-Hydroxy-5-methoxybenzaldehyde
EINECS 211-589-0
CAS No. 672-13-9
Article Data87
CAS DataBase
Density 1.232 g/cm³
Solubility Miscible with chloroform. Slightly miscible with water.
Melting Point 4 °C(lit.)
Formula C₈H₈O₃
Boiling Point 247.499 °C at 760 mmHg
Molecular Weight 152.15
Flash Point 108.071 °C
Transport Information
Appearance clear yellow liquid
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Anisaldehyde,6-hydroxy- (6CI,7CI,8CI);2-Formyl-4-methoxyphenol;2-Hydroxy-5-methoxybenzaldehyde;3-Methoxy-6-hydroxybenzaldehyde;4-Hydroxy-3-formylanisole;5-Methoxy-2-hydroxybenzaldehyde;5-Methoxysalicylaldehyde;NSC 30116;
PSA 46.53000
LogP 1.21330

Synthetic route

: 50-00-0
formaldehyd

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: formaldehyd With triethylamine; magnesium chloride In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Reflux; Stage #2: 4-methoxy-phenol In tetrahydrofuran Reflux;	100%
Stage #1: formaldehyd With triethylamine; magnesium chloride In tetrahydrofuran at 20 - 25℃; for 0.166667h; Stage #2: 4-methoxy-phenol In tetrahydrofuran Reflux;	100%
Stage #1: formaldehyd With triethylamine; magnesium chloride In tetrahydrofuran at 20℃; for 0.25h; Inert atmosphere; Stage #2: 4-methoxy-phenol In tetrahydrofuran for 16h; Inert atmosphere; Reflux;	99%

: 93-02-7
2,5-dimethoxybenzaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 12h; Inert atmosphere;	98%
With aluminum (III) chloride In dichloromethane at 20℃; for 12h; Inert atmosphere;	98%
With beryllium(II) chloride In toluene for 7h;	95%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;	47%
Stage #1: 2,5-dimethoxybenzaldehyde With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 4h; Stage #2: With water In dichloromethane at 0℃;

: 41951-76-2
2-hydroxy-5-methoxybenzyl alcohol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With air; (acryl-TEMPO)-co-(allylamine-treated chlorophyll b-Co(III) complex) immobilized on SiO2-covered Fe3O4 magnetic nanoparticles In water at 25℃; for 0.416667h;	96%
With oxygen In ethanol at 20℃; under 760.051 Torr; for 0.5h; Catalytic behavior; Green chemistry;	95%
With dihydrogen peroxide at 20℃; for 3.6h; Catalytic behavior; Green chemistry;	94%

: 67-66-3
chloroform

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide In water for 1h; Heating;	72%
With sodium hydroxide Reimer-Tiemann reaction; Heating;	65%
With sodium hydroxide at 70 - 80℃; for 0.5h;	48%

: 133503-46-5
1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 886-66-8
1,4-diphenyl-1,3-butadiyne

Conditions

Conditions	Yield
With copper(II) acetate monohydrate In acetonitrile for 2h; Reflux;	A n/a B 72%

: 224317-65-1
5-methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 2-(1-hydroxybut-3-yn-1-yl)-4-methoxyphenol

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate; tris(2,2'-bipyridine)nickel(II) tetrafluoroborate In N,N-dimethyl-formamide electrochem. reaction; magnesium rod anode, nickel foam grid cathode;	A 30% B 65%

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Reimer-Tiemann reaction;	60%
Multi-step reaction with 2 steps 1: 40 percent / BF3Et2O / CH2Cl2 / 14 h / Ambient temperature 2: 47 percent / H2O, HgO, BF3Et2O / tetrahydrofuran / 1 h / Ambient temperature View Scheme

: 80210-54-4
2-[1,3]Dithiolan-2-yl-4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water; mercury(II) oxide In tetrahydrofuran for 1h; Ambient temperature;	47%

: 100-97-0
hexamethylenetetramine

: 150-76-5
4-methoxy-phenol

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 73289-61-9
2-hydroxy-5-methoxyisophthaldehyde

Conditions

Conditions	Yield
In trifluoroacetic acid for 24h;	A n/a B 32%

...Expand

: 100-97-0
hexamethylenetetramine

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
in ein zuvor auf 165grad erhitztes Gemisch von Glycerin und Borsaeure bei 150grad und Behandeln des Reaktionsgemisches mit wss.H2SO4 bei 115grad;
With toluene-4-sulfonic acid In acetic acid for 5h; Duff Aldehyde Synthesis; Reflux; Inert atmosphere;

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 77-78-1
dimethyl sulfate

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 93-02-7
2,5-dimethoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide

...Expand

: 2612-02-4
5-methoxysalicylic acid

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
(i) SOCl2, Py, PE, (ii) H2, quinoline, sulfur, Pd-BaSO4, xylene; Multistep reaction;

: 4832-52-4
tris(phenylthio)methane

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With dimethyl(methylthio)sulfonium tetrafluoroborate; water 1.) CH2Cl2, room temp., 2 h; Yield given. Multistep reaction;

: 85630-18-8
N,N-diethyl-O-(4-methoxyphenyl)carbamate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 85630-27-9
O-(2-formyl-4-methoxy)phenyl N,N-diethylcarbamate

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium 1.) THF, -78 deg C, 1 h, 2.) to room temp., 8 to 12 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 98751-26-9
2-t-butoxy-5-methoxybenzaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid

: 2-Acetoxy-benzoic acid 2-formyl-4-methoxy-phenyl ester

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 50-78-2
aspirin

Conditions

Conditions	Yield
With hydroxide In 1,4-dioxane; water at 37℃; Rate constant; Thermodynamic data; var. temp., ΔH(excit.), ΔS)(excit.);

: 150-76-5
4-methoxy-phenol

paraformaldehyde: paraformaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With ethylmagnesium bromide; triethylamine 1.) THF, RT, 20 min, 2.) C6H6, reflux, 2.5 h; Yield given. Multistep reaction;

: 62536-85-0
2-acetoxy-5-methoxybenzaldehyde

alkali: alkali

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 64-19-7
acetic acid

...Expand

: 77287-58-2
2-iodo-5-methoxybenzaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 12 percent / t-BuOK, CuCl, pyridine / 1,2-dimethoxy-ethane / 3 h / Heating 2: CF3COOH View Scheme
Multi-step reaction with 2 steps 1: 1.) CuCl, 2.) pyridine, 1,3-dinitrobenzene / 1.) DME, 2.) reflux, 3 h 2: CF3COOH View Scheme

: 591-31-1
3-methoxy-benzaldehyde

2-oxy-phenylacetate sodium: 2-oxy-phenylacetate sodium

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 59 percent / I2, H5IO6 / acetic acid; H2O; H2SO4 / 2 h / 80 °C 2: 12 percent / t-BuOK, CuCl, pyridine / 1,2-dimethoxy-ethane / 3 h / Heating 3: CF3COOH View Scheme
Multi-step reaction with 3 steps 1: 59 percent / I2, H5IO6 / acetic acid; H2O; H2SO4 / 2 h / 80 °C 2: 1.) CuCl, 2.) pyridine, 1,3-dinitrobenzene / 1.) DME, 2.) reflux, 3 h 3: CF3COOH View Scheme

: 100-83-4
meta-hydroxybenzaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium persulfate; NaOH-solution; alkali / 30 - 35 °C / und Erhitzen des Reaktionsprodukts mit konz.Salzsaeure auf 70grad 2: aqueous NaOH-solution View Scheme

: 150-76-5
4-methoxy-phenol

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B Hg: Hg

: 1079921-21-3
2-(2-hydroxy-5-methoxyphenyl)-4-phenoxymethyl-1,3-dioxolane

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 538-43-2
1-phenoxy-2,3-propanediol

Conditions

Conditions	Yield
With water In methanol at 20℃; Quantum yield; Irradiation;	A n/a B 96 %Chromat.

: 1079921-26-8
2-(2-hydroxy-5-methoxyphenyl)-5-phenyl-1,3-dioxane

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 1570-95-2
2-phenylpropane-1, 3-diol

Conditions

Conditions	Yield
With water In methanol at 20℃; Quantum yield; Irradiation;	A n/a B 59 %Chromat.

: 773101-17-0
2-(2-hydroxy-5-methoxyphenyl)-1,3-dioxolane

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With water In methanol at 20℃; Quantum yield; Irradiation;	A n/a B 100 %Spectr.

: 1079921-29-1
2-(2-hydroxy-5-methoxyphenyl)-5,5-dimethyl-1,3-dioxane

A: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

B: 126-30-7
2,2-Dimethyl-1,3-propanediol

Conditions

Conditions	Yield
With water In methanol at 20℃; Quantum yield; Irradiation;	A n/a B 100 %Spectr.

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 4-methoxy-2-(trimethylsilyl)phenyl triflate

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide; 4-methoxy-2-(trimethylsilyl)phenyl triflate With tetrabutyl ammonium fluoride at 20℃; for 3h; Inert atmosphere; Stage #2: With water

...Expand

: 64-17-5
ethanol

: 150-76-5
4-methoxy-phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With chloroform; potassium hydroxide In water at 60℃; for 15h; Reimer-Tiemann Phenol Formylation;

: 150-76-5
4-methoxy-phenol

polyformaldehyde: polyformaldehyde

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With magnesium chloride In acetonitrile Reflux;

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 5307-05-1
1-hydroxy-4-methoxy-2-methylbenzene

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-5-methoxybenzaldehyde With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 1h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at 20℃; for 2.25h; Cooling with ice; Stage #3: With hydrogenchloride In tetrahydrofuran; water pH=< 2;	100%
With potassium hydroxide; hydrazine In ethylene glycol at 150℃; for 19h; Wolf-Kishner reduction; Inert atmosphere;	98%
With palladium 10% on activated carbon; hydrogen In acetic acid; ethyl acetate at 20℃; for 20h;	98%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 107-13-1
acrylonitrile

: 57543-71-2
6-methoxy-2H-chromene-3-carbonitrile

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane for 20h; Heating;	100%
With 1,4-diaza-bicyclo[2.2.2]octane for 12h; Reflux;	91.3%
With 1,4-diaza-bicyclo[2.2.2]octane at 50℃; for 20h; Addition; condenzation;	79%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 106-95-6
allyl bromide

: 71186-59-9
2-allyloxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Inert atmosphere; Reflux;	100%
With potassium carbonate In acetonitrile Heating;	99%
With potassium carbonate In acetonitrile for 1h; Heating;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 106-96-7
propargyl bromide

: 224317-65-1
5-methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone Substitution; Heating;	100%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h; Inert atmosphere;	100%
With potassium carbonate In acetonitrile at 20℃; for 24h;	95%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 100-39-0
benzyl bromide

: 56979-57-8
2-benzyloxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 60℃; Inert atmosphere;	100%
With caesium carbonate In acetone at 20℃;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	100%

: 9-ethyl-3-[(E)-2-nitrovinyl]-9H-carbazole

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 9-ethyl-3-(6-methoxy-3-nitro-2H-chromen-2-yl)-9H-carbazole

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane at 70℃; for 0.5h;	100%

: 1072-67-9
5-methylisoxazol-3-ylamine

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 415715-07-0
4-methoxy-2-[(5-methyl-3-isoxazolyl)imino]methylphenol

Conditions

Conditions	Yield
Reflux;	100%
In ethanol for 2h; Reflux;	90%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 654680-82-7
{(1R,3R,4S,6S)-4-amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl}methanol

: 2-[(1S,3S,4R,6R)-4-hydroxymethyl-3,7,7-trimethylbicyclo[4.1.0]heptan-3-yliminomethyl]-4-methoxyphenol

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 41951-76-2
2-hydroxy-5-methoxybenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 20℃; for 1h;	99.7%
With sodium tetrahydroborate	85%
With sodium tetrahydroborate In ethanol at 20℃; Cooling with ice;	85%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 105-53-3
diethyl malonate

: 35924-44-8
6-methoxycoumarin-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-5-methoxybenzaldehyde; diethyl malonate With piperidine; acetic acid In ethanol for 9h; Reflux; Stage #2: With ethanol; water; sodium hydroxide for 0.25h; Reflux;	99.2%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 870-63-3
prenyl bromide

: 139579-42-3
5-methoxy-2-(3-methylbut-2-enyloxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide Ambient temperature;	99%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 2h;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;
Stage #1: 2-hydroxy-5-methoxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: prenyl bromide In N,N-dimethyl-formamide at 20℃;

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 424788-79-4
trifluoro-methanesulfonic acid 2-formyl-4-methoxy-phenyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;	99%
With potassium carbonate In tetrahydrofuran at 120℃; for 0.1h; microwave heating;	87%
With triethylamine
With potassium carbonate In tetrahydrofuran at 120℃; for 0.1h; Microwave irradiation;

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 98-59-9
p-toluenesulfonyl chloride

: 329235-34-9
toluene-4-sulfonic acid 2-formyl-4-methoxy-phenyl ester

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water Inert atmosphere;	99%
With potassium carbonate In acetonitrile at 20℃; for 12h;	91%
With sodium hydroxide In dichloromethane; water at 20℃;	71%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 441068-94-6
2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 25℃; for 16h; Inert atmosphere;	99%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;	97%
With 1H-imidazole In N,N-dimethyl-formamide at 80℃; for 20h;	90%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 109-77-3
malononitrile

: 2-(2-Amino-3-cyano-6-methoxy-4H-chromen-4-yl)-malononitrile

Conditions

Conditions	Yield
With poly(N,N'-dibromo-N-ethyl-benzene-1,3-disulfonamide) In ethanol; water at 20℃; for 3h;	99%
With diethylamine In ethanol at 20℃; for 2.5h; Green chemistry;	94%
With piperidine In ethanol at 20℃;

O-Merrifield resin-bound 4-(2\-acetoacetylethyl)phenol: O-Merrifield resin-bound 4-(2\-acetoacetylethyl)phenol

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 13252-80-7
3-acetyl-6-methoxycoumarin

Conditions

Conditions	Yield
With piperidine In ethanol for 2.5h; Knoevenagel condensation; Heating;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 2969-81-5
4-bromoethylbutanoate

: 356039-75-3
ethyl 4-(2-formyl-4-methoxyphenoxy)butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 14660-52-7
ethyl 5-bromovalerate

: ethyl 5-(2-formyl-4-methoxyphenoxy)pentanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 98-88-4
benzoyl chloride

: 2-formyl-4-methoxyphenyl benzoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 586-75-4
4-chlorobenzoyl chloride

: 2-formyl-4-methoxyphenyl 4-bromobenzoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 100-07-2
4-methoxy-benzoyl chloride

: 2-formyl-4-methoxyphenyl 4-methoxybenzoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 66384-65-4
(E)-5-methoxy-2-hydroxybenzaldehyde oxime

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In ethanol at 60℃; for 3h; Inert atmosphere;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 498-66-8
norbornene

: C15H18O3

Conditions

Conditions	Yield
With [(1,5-cyclooctadiene)(OH)iridium(I)]2 In 1,4-dioxane at 60℃; for 6h; Inert atmosphere; Schlenk technique; Sealed tube; diastereoselective reaction;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: C15H13N3O2

: 263364-71-2
6-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one

Conditions

Conditions	Yield
With triethylamine In neat (no solvent) at 20℃; for 0.0833333h; Sonication;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 4392-24-9
Cinnamyl bromide

: 71186-59-9
2-allyloxy-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1677-46-9
4-hydroxy-1-methyl-2(1H)-quinolone

: 998-40-3
tributylphosphine

: 3-((2-hydroxy-5-methoxyphenyl)(tributylphosphonio)methyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-olate

Conditions

Conditions	Yield
With pyrrolidine; benzoic acid In tetrahydrofuran at 30℃; for 1h; Schlenk technique; Inert atmosphere;	99%

...Expand

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 21746-40-7
propylmaleimide

: 14316-06-4
D-alanine methyl ester hydrochloride

: methyl (1R,3S,3aR,6aS)-3-(2-hydroxy-5-methoxyphenyl)-1-methyl-4,6-dioxo-5-propyloctahydropyrrolo[3,4-c]pyrrole-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 125℃; for 0.5h; Microwave irradiation; Green chemistry; diastereoselective reaction;	99%

...Expand

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 3182-93-2
ethyl 2-amino-3-phenylpropanoate hydrochloride

: ethyl (E)-2-((2-hydroxy-5-methoxybenzylidene)amino)-3-phenylpropanoate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 24h; Inert atmosphere;	99%

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 17372-53-1
6-methoxycoumarin

Conditions

Conditions	Yield
With N,N-diethylaniline Wittig reaction; Reflux;	98%
With N,N-diethylaniline at 210 - 215℃; for 2.5h;	93.4%
With N,N-diethylaniline for 2.5h; Heating;	93%

2-Hydroxy-5-methoxybenzaldehyde Specification

The 2-Hydroxy-5-methoxybenzaldehyde with cas registry number of 672-13-9 is clear yellow liquid which is sensitive to air. This chemical is also known as 5-Methoxysalicylaldehyde. Its systematic name is called Benzaldehyde, 2-hydroxy-5-methoxy-. And its IUPAC name is named as 2-hydroxy-5-methoxybenzaldehyde. This chemical belongs to the following categories: Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Adehydes, Acetals & Ketones; Anisoles, Alkyloxy Compounds & Phenylacetates; Phenols. It has the EINECS registry number of 211-589-0.

The physical properties about this chemical are: (1)ACD/LogP: 1.53; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.52; (4)ACD/LogD (pH 7.4): 1.5 ; (5)#H bond acceptors: 3; (6)#H bond donors: 1; (7)#Freely Rotating Bonds: 3; (8)Index of Refraction: 1.587; (9)Molar Refractivity: 41.56 cm³; (10)Molar Volume: 123.5 cm³; (11)Surface Tension: 47.3 dyne/cm; (12)Density: 1.231 g/cm³; (13)Flash Point: 108.1 °C; (14)Enthalpy of Vaporization: 50.43 kJ/mol; (15)Boiling Point: 247.5 °C at 760 mmHg; (16)Vapour Pressure: 0.0162 mmHg at 25°C ; (17)Refractive index: 1.577-1.579.

Preparation of 2-Hydroxy-5-methoxybenzaldehyde: it can be made by 4-methoxy-phenol with 60% yield.

Uses of 2-Hydroxy-5-methoxybenzaldehyde: this chemical can react with nitroethene to give 6-methoxy-3-nitro-2H-chromene by using reagent n-Bu₂NH and solvent CHCl₃ at temperature 80 ℃. The reaction time is about 24 hours with 72% yield.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. Therefore, wear suitable protective clothing during using it to avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=Cc1cc(ccc1O)OC;
(2)InChI: InChI=1/C8H8O3/c1-11-7-2-3-8(10)6(4-7)5-9/h2-5,10H,1H3;
(3)InChIKey: FZHSPPYCNDYIKD-UHFFFAOYAD

The toxicity data is as follows:

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

mouse

LD50

intraperitoneal

125mg/kg (125mg/kg)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 228, 1954.

Product Name

2-Hydroxy-5-methoxybenzaldehyde

Synthetic route

2-Hydroxy-5-methoxybenzaldehyde Specification

Related Products

Hot Products