Conditions | Yield |
---|---|
With dipotassium peroxodisulfate In water; acetonitrile at 80℃; for 6h; Temperature; Reagent/catalyst; Solvent; | 83.5% |
2-(2-Methoxy-ethoxy)-isoindole-1,3-dione
2-methoxyethylamine
Conditions | Yield |
---|---|
With methylhydrazine In dichloromethane at -10℃; for 2h; | 77% |
(2-methoxyethyl)amine hydrochloride
2-methoxyethylamine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane at 20 - 25℃; for 1h; | 53.6% |
ethylene glycol
A
morpholine
B
4-methyl-morpholine
C
N-ethylmorpholine;
D
2-methoxy-ethanol
E
2-methoxyethylamine
Conditions | Yield |
---|---|
With ammonia; hydrogen at 200℃; for 0.00175h; Product distribution; 190 - 260 deg C; | A 46% B 2.1 % Chromat. C 1.4 % Chromat. D 0.7 % Chromat. E 0.6 % Chromat. |
methanol
(2-amino-ethyl)-nitroso-amidosulfuric acid
2-methoxyethylamine
Conditions | Yield |
---|---|
reagiert analog mit Alkohol und Propylalkohol; |
2-(2-methoxyethyl)isoindoline-1,3-dione
2-methoxyethylamine
Conditions | Yield |
---|---|
With sodium hydroxide | |
With potassium hydroxide In water |
1-methoxy-2-nitroethane
2-methoxyethylamine
Conditions | Yield |
---|---|
With ethanol; platinum at 20℃; under 73550.8 Torr; Hydrogenation; |
Conditions | Yield |
---|---|
With aluminum oxide; ammonia at 200 - 250℃; | |
With ammonia; nickel at 200 - 250℃; | |
With ammonia; hydrogen at 250℃; under 3750.38 Torr; for 2h; Reagent/catalyst; |
Conditions | Yield |
---|---|
With nickel Hydrogenation; |
N-(2-methoxy-ethyl)-2,4-dinitro-aniline
2-methoxyethylamine
Conditions | Yield |
---|---|
With sodium hydroxide |
(2-Methoxy-ethyl)-[2-methyl-prop-(Z)-ylidene]-amine
2-methoxyethylamine
Conditions | Yield |
---|---|
In water; benzonitrile Equilibrium constant; |
Conditions | Yield |
---|---|
With potassium chloride In water; dimethyl sulfoxide at 20℃; Rate constant; Equilibrium constant; |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20℃; Equilibrium constant; Rate constant; |
A
tris(5-methyl-2,4-dinitrophenyl)methane
B
2-methoxyethylamine
Conditions | Yield |
---|---|
In water; dimethyl sulfoxide at 25℃; Rate constant; |
A
tris(3,5-dimethyl-2,4-dinitrophenyl)methane
B
2-methoxyethylamine
Conditions | Yield |
---|---|
In water; dimethyl sulfoxide at 25℃; Rate constant; |
1-azido-2-methoxy-ethane
2-methoxyethylamine
Conditions | Yield |
---|---|
With triphenylphosphine 1.) THF, RT, 12 h, 2.) hydrolysis, RT, 12 h; Multistep reaction; |
(1S,2R,4R,6S)-6-Hydroxy-bicyclo[2.2.1]heptane-2-carboxylic acid (2-methoxy-ethyl)-amide
endo-6-hydroxybicyclo<2.2.1>heptane-endo-2-carboxylic acid lactone
B
2-methoxyethylamine
Conditions | Yield |
---|---|
In methanol; water at 30℃; Rate constant; |
ethanolamine
dimethyl sulfate
A
N-methyl-N-(2-methoxyethyl)amine
B
N,N-dimethyl-2-methoxyethylamine
C
2-methoxyethylamine
Conditions | Yield |
---|---|
With sodium hydride 1.) THF, room temp., 1 h; 2.) room temp., 1 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With phosphate buffer In water at 25℃; Mechanism; Rate constant; general acid catalysis; |
N-(o-methoxybenzylidene)-2-methoxyethylamine
A
ortho-anisaldehyde
B
2-methoxyethylamine
Conditions | Yield |
---|---|
With potassium chloride; 2-methoxyethylamine In water at 30℃; Rate constant; other amines, var. pH; |
(1R,2S,3R,4S)-3-(2-Methoxy-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
A
2-methoxyethylamine
B
3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
Conditions | Yield |
---|---|
With water at 38℃; Rate constant; |
Conditions | Yield |
---|---|
With water at 38℃; Rate constant; |
Conditions | Yield |
---|---|
With iodide; hydrogen cation In water at 25℃; Rate constant; pH dependence (pH = 0.5-3.0), μ = 1.0 with KCl; |
acrylonitrile
2-methoxyethylamine
N,N-bis(2-cyanoethyl)-2-methoxyethylamine
Conditions | Yield |
---|---|
In methanol for 48h; Heating; | 100% |
3,16α-diacetoxy-1,3,5(10)-estratrien-17-one
2-methoxyethylamine
17-(2-methoxyethylimino)estra-1,3,5(10)-triene-3,16α-diol
Conditions | Yield |
---|---|
for 3h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation; Stage #2: 2-methoxyethylamine at 220℃; for 0.0666667h; microwave irradiation; | 100% |
Conditions | Yield |
---|---|
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation; Stage #2: 2-methoxyethylamine at 180℃; for 0.05h; microwave irradiation; | 100% |
5-Bromo-3-[6-chloro-2-(2-methoxy-ethyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-1,3-dihydro-indol-2-one
2-methoxyethylamine
Conditions | Yield |
---|---|
100% |
ethyl trifluoroacetate,
2-methoxyethylamine
N-(2-methoxyethyl)trifluoroacetamide
Conditions | Yield |
---|---|
In diethyl ether for 24h; cooling; | 100% |
4-iodobenzenesulfonyl chloride
2-methoxyethylamine
4-iodo-N-[2-(methyloxy)ethyl]benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 100% |
2-(3-nitro-4-fluorophenyl)-5-phenylbenzoxazole
2-methoxyethylamine
2-[3-nitro-4-(2-methoxyethylamino)phenyl]-5-phenylbenzoxazole
Conditions | Yield |
---|---|
at 20℃; for 0.25h; | 100% |
3-methoxy-5-nitrobenzoic acid
2-methoxyethylamine
3-methoxy-N-(2-methoxyethyl)-5-nitrobenzamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 100% |
4-(4-chloro-2-nitrophenoxy)benzoyl chloride
2-methoxyethylamine
4-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide
Conditions | Yield |
---|---|
In 1,2-dichloro-ethane for 12h; | 100% |
10-(8'-isothiocyanato-3',6'-dioxaoct-1'-yl)-7,8-dimethylbenzo[g]pteridine-2,4-dione
2-methoxyethylamine
10-(9',11'-diaza-3',6',14'-trioxa-10'-thioxopentadec-1'-yl)-7,8-dimethylbenzo[g]pteridine-2,4-dione
Conditions | Yield |
---|---|
With triethylamine In chloroform for 2.5h; Reflux; | 100% |
2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carbaldehyde
2-methoxyethylamine
N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine
Conditions | Yield |
---|---|
Stage #1: 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carbaldehyde; 2-methoxyethylamine With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 24h; Stage #2: With water; sodium hydrogencarbonate In dichloromethane | 100% |
Stage #1: 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carbaldehyde; 2-methoxyethylamine With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 24h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane | 100% |
thiophene-2-carbaldehyde
2-methoxyethylamine
2-methoxy-N-(thiophen-2-ylmethylene)ethanamine
Conditions | Yield |
---|---|
at 60℃; for 6h; Inert atmosphere; | 100% |
With acetic acid In methanol at 25℃; for 4h; |
di(2,4,6-tri-O-acetyl-3-deoxy-3-(4-(methoxycarbonyl)-1H-1,2,3-triazol-1-yl)-β-D-galactopyranosyl)sulfane
2-methoxyethylamine
di(3-deoxy-3-(4-((2-methoxyethylamino)carbonyl)-1H-1,2,3-triazol-1-yl)-β-D-galactopyranosyl)sulfane
Conditions | Yield |
---|---|
With methanol for 28h; | 100% |
ortho-nitrofluorobenzene
2-methoxyethylamine
[2-(methyloxy)ethyl](2-nitrophenyl)amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 150℃; for 0.316667h; Sealed vial; | 100% |
In ethanol at 20℃; | |
In N,N-dimethyl-formamide at 20℃; | |
In dichloromethane at 20℃; for 8h; Inert atmosphere; | |
In dichloromethane for 6h; Inert atmosphere; |
2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-fluoro-benzaldehyde
2-methoxyethylamine
N-(2-(4-((2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)-3-fluorobenzylidene)-2-methoxyethanamine
Conditions | Yield |
---|---|
In dichloromethane Molecular sieve; | 100% |
2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid
2-methoxyethylamine
tert-butyl 1-(1-hydroxy-2-(2-methoxyethylamino)-2-oxoethyl)cyclobutylcarbamate
Conditions | Yield |
---|---|
Stage #1: 2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid; 2-methoxyethylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.166667h; Cooling with ice; Stage #2: With HATU In N,N-dimethyl-formamide for 1h; | 100% |
4-chloro-3-nitropyridine
2-methoxyethylamine
N-[2-(methyloxy)ethyl]-3-nitro-4-pyridinamine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 150℃; for 0.316667h; Microwave vial; | 100% |
2-methoxyethylamine
4-{[2-(methyloxy)ethyl]amino}-N-[2-(4-morpholinyl)ethyl]-3-nitrobenzamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 150℃; for 0.0833333h; Microwave irradiation; | 100% |
Methyl 2,2-dimethyl-3-hydroxypropionate
2-methoxyethylamine
3-hydroxy-N-(2-methoxyethyl)-2,2-dimethylpropanamide
Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; | 100% |
In methanol Reflux; | 95% |
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; | 100% |
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; | 100% |
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; | 100% |
Conditions | Yield |
---|---|
Stage #1: C14H13N3O3 With triethylamine In acetonitrile at 20℃; for 0.0833333h; Stage #2: With bis(pentafluorophenyl)carbonate In acetonitrile at 20℃; for 0.75h; Stage #3: 2-methoxyethylamine With triethylamine In acetonitrile at 20℃; for 18h; | 100% |
2-methoxyethylamine
Conditions | Yield |
---|---|
Stage #1: 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With bis(pentafluorophenyl)carbonate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #3: 2-methoxyethylamine With triethylamine In N,N-dimethyl-formamide at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 85℃; for 16h; Inert atmosphere; | 100% |
In ethanol at 20℃; for 24h; | 67% |
2-methoxyethylamine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In acetonitrile at 70℃; | 100% |
2-methoxyethylamine
Conditions | Yield |
---|---|
Stage #1: 4-(4-(((tert-butoxycarbonyl)amino)methyl)pyridin-2-yl)benzoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.166667h; Stage #2: 2-methoxyethylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 20h; | 100% |
Chemistry informtion about 2-Methoxyethylamine (CAS NO.109-85-3) is:
IUPAC Name: 2-Methoxyethanamine
Synonyms: 2-Aminoethyl Methyl Ether ; 2-Methoxyethylamine ; Rarechem Al Bw 0200 ; O-Methylethanolamine ; 1-Methoxy-2-Aminoethane ; 2-Methoxy-Ethanamin ; 2-Methoxyethanamine ; 2-Methoxy-Ethylamin
MF: C3H9NO
MW: 75.11
EINECS: 203-712-1
Density: 0.852 g/cm3
Melting Point: -82 °C
Flash Point: 9.4 °C
Boiling Point: 95 °C at 760 mmHg
Vapour Pressure: 46.3 mmHg at 25°C
Enthalpy of Vaporization: 33.47 kJ/mol
Refractive Index: n20/D 1.406(lit.)
Storage temp.: Flammables area
BRN: 741854
Following is the molecular structure of 2-Methoxyethylamine (CAS NO.109-85-3) is:
2-Methoxyethylamine (CAS NO.109-85-3) was used for synthetic intermediates.
Preparation Products is Bis(2-Methoxyethyl)Amine .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LDLo | oral | 1600mg/kg (1600mg/kg) | behavioral: tremor behavioral: muscle weakness behavioral: ataxia | National Technical Information Service. Vol. OTS0546426, |
rat | LDLo | oral | 1600mg/kg (1600mg/kg) | behavioral: muscle weakness lungs, thorax, or respiration: dyspnea lungs, thorax, or respiration: cyanosis | National Technical Information Service. Vol. OTS0546426, |
Reported in EPA TSCA Inventory.
Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Hazard Codes:
F
C
Risk Statements:
R11:Highly flammable.
R34:Causes burns.
Safety Statements:
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2733 3/PG 2
WGK Germany: 3
RTECS: KR8750000
HazardClass: 3
PackingGroup: II
By glycol monomethyl ether and ammonia in the nickel or alumina catalysts under high-temperature dehydration in, or methicillin-acetonitrile nickel to be catalytic hydrogenation.
2-Methoxyethylamine (CAS NO.109-85-3) is a clear colorles liquid. It combustible and can soluble in ethanol and ether.
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