3,4-Dimethoxybenzoyl chloride supplier

Name
3,4-Dimethoxybenzoyl chloride
EINECS 222-568-0
CAS No. 3535-37-3
Article Data127
CAS DataBase
Density 1.224 g/cm³
Solubility
Melting Point 70-73 °C(lit.)
Formula C₉H₉ClO₃
Boiling Point 298.2 °C at 760 mmHg
Molecular Weight 200.622
Flash Point 129.2 °C
Transport Information UN 3261 8/PG 2
Appearance off-white to grey crystals, flakes or chunks
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Veratroylchloride (7CI,8CI);3,4-Dimethoxy-1-benzenecarbonyl chloride;3,4-Dimethoxybenzoic acid chloride;Benzoylchloride, 3,4-dimethoxy-;3,4-Dimethoxyphenylcarbonyl chloride;Veratric acid chloride;
PSA 35.53000
LogP 2.08280

Synthetic route

: 93-07-2
Veratric acid

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
With pyridine; thionyl chloride In benzene	100%
With thionyl chloride In dichloromethane at 40℃; for 4h; Solvent;	100%
With thionyl chloride at 20℃; for 5h;	100%

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
Stage #1: 1-(3,4-dimethoxyphenyl)ethanone With pyridine; disulfur dichloride In chlorobenzene at 20℃; for 2h; Stage #2: With sulfuryl dichloride In chlorobenzene at 20 - 132℃; for 15.5h; Reagent/catalyst; Temperature;	77%
Stage #1: 1-(3,4-dimethoxyphenyl)ethanone With pyridine; sulfur monochloride In chlorobenzene at 20℃; Stage #2: With thionyl chloride In chlorobenzene at 20 - 132℃;	47%
With pyridine; disulfur dichloride at 70 - 136℃; for 22h;	79 %Spectr.

: 93342-78-0
1-(3,4-Dimethoxy-benzoyl)-3-methyl-3H-imidazol-1-ium; chloride

A: 616-47-7
1-methyl-1H-imidazole

B: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
In dichloromethane at 25℃; Rate constant; Equilibrium constant;

: 93-03-8
(3,4-dimethoxyphenyl)methanol

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
With phosphorus pentachloride In diethyl ether at 0℃;

: 7719-09-7
thionyl chloride

: 93-07-2
Veratric acid

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 93-07-2
Veratric acid

CS2: CS2

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

...Expand

: 121-34-6
3-methoxy-4-hydroxybenzoic acid

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KOH / ethanol; H2O / 25 h / Heating 2: SOCl2 / 3 h / Heating View Scheme

: 93-07-2
Veratric acid

: 69788-97-2
N-ethyl-N-(6-hydroxyhexyl)-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 2150-38-1
methyl 3,4-dimethoxybenzoate

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol; water / 2 h / Reflux 2: thionyl chloride / 2 h / Reflux View Scheme

: 79-37-8
oxalyl dichloride

: 93-07-2
Veratric acid

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;

: 5460-32-2
1-iodo-3,4-dimethoxybenzene

: 141-75-3
butyryl chloride

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium permanganate / acetone; water 2: thionyl chloride / 2 h / Reflux View Scheme

: 134-20-3
2-carbomethoxyaniline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 67836-52-6
methyl N-(3,4-dimethoxybenzoyl)anthranilate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.5h;	100%

: 108-18-9
diisopropylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 156300-76-4
3,4-dimethoxy-N,N-bis-(methylethyl)benzamide

Conditions

Conditions	Yield
In benzene for 3h; 0 deg C to RT;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 12h;	73%

: 78083-81-5
methyl-3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline-3-carboxylate

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 78083-82-6
methyl 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylene-2-veratroylisoquinoline-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In benzene for 3h; Heating;	100%

: 5020-41-7
2-(3-methoxyphenyl)-ethanol

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 3,4-dimethoxybenzoic acid 2-(3-methoxyphenyl)ethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0℃;	100%
With dmap; triethylamine In dichloromethane at 20℃; for 16h;

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 619329-87-2
(+/-)-3-amino-1-[3-(3,4-methylenedioxyphenoxy)propyl]-piperidine

: (+/-)-3,4-dimethoxy-N-{1-[3-(3,4-methylenedioxyphenoxy)propyl]-3-piperidyl}benzamide

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 14h;	100%

: 4651-81-4
Methyl 2-aminothiophene-3-carboxylate

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 773071-56-0
methyl 2-(3,4-dimethoxybenzamido)thiophene-3-carboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 12h;	100%
With triethylamine In dichloromethane at 20℃; Cooling with ice;	15%
With triethylamine In dichloromethane at 0 - 20℃;	15%

: 1342891-17-1
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)aniline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 1342891-18-2
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%
With triethylamine In dichloromethane at 20℃;	98%

: 108-59-8
malonic acid dimethyl ester

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: dimethyl 2-(3,4-dimethoxybenzoyl)malonate

Conditions

Conditions	Yield
Stage #1: malonic acid dimethyl ester With triethylamine; magnesium chloride In acetonitrile at 0℃; for 0.5h; Stage #2: 3,4-dimethoxybenzoic acid chloride In acetonitrile at 20℃; for 16h;	100%

: 40106-13-6
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid ethyl ester

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: ethyl 2-[(3,4-dimethoxybenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate

Conditions

Conditions	Yield
With pyridine at 20℃; for 1h;	100%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 102011-15-4
N-<2-(3,4-dimethoxyphenyl)ethyl>-3,4-dimethoxyphenylacetamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at 0℃; for 1.5h; Sealed tube;	99%
With calcium oxide; benzene
With sodium hydroxide In 1,4-dioxane

: 104-96-1
4-methylsulfanylaniline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 3,4-Dimethoxy-N-(4-methylsulfanyl-phenyl)-benzamide

Conditions

Conditions	Yield
With Amberlite IRA-68 In ethyl acetate Ambient temperature;	99%

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 100-51-6
benzyl alcohol

: benzyl 3,4-dimethoxybenzoate

Conditions

Conditions	Yield
With Amberlite IRA-68 In ethyl acetate Ambient temperature;	99%
With triethylamine In acetonitrile at 20℃; for 3h;	15%

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 204979-42-0
1-benzyl-3-[(2,2-dimethoxyethyl)amino]piperidine

: 204979-43-1
(+/-)-N-(1-benzyl-3-piperidyl)-N'-(2,2-dimethoxyethyl)-3.4-dimethoxybenzamide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h;	99%
With triethylamine In tetrahydrofuran at 20℃; for 3h;	2.11 g

: 91-59-8
naphthalen-2-ylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 331270-79-2
3,4-dimethoxy-N-(naphthalen-2-yl)benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	99%

: 64725-89-9
1-benzoyloxy-5-methoxy naphthalene

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 8-benzoyloxy-4-methoxy-1-veratroylnaphthalene

Conditions

Conditions	Yield
With aluminium trichloride In various solvent(s) at 0℃;	98%

: 75-64-9
tert-butylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 349107-92-2
N-(tert-butyl)-3,4-dimethoxybenzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 10h; Inert atmosphere;	98%
With triethylamine In dichloromethane at 0 - 25℃; for 5h;
With triethylamine In dichloromethane at 20℃; for 5h;
Stage #1: 3,4-dimethoxybenzoic acid chloride With triethylamine In diethyl ether at 0℃; for 0.25h; Stage #2: tert-butylamine In diethyl ether at 20℃; for 3h;	1.52 g

: tert-butyl (1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)carbamate

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: tert-butyl (4-(3,4-dimethoxybenzoyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)carbamate

Conditions

Conditions	Yield
With pyridine at 20℃;	98%

: 496-15-1
1-indoline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 128581-33-9
(3,4-dimethoxyphenyl)(indolin-1-yl)methanone

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	98%

: 6315-89-5
3,4-dimethoxyaniline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 59699-54-6
N-(3,4-dimethoxyphenyl)-3,4-dimethoxybenzamide

Conditions

Conditions	Yield
With pyridine In dichloromethane	97%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	88%
With diethyl ether; potassium carbonate
With triethylamine In dichloromethane

: 593-56-6
N-methoxylamine hydrochloride

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 25563-13-7
3,4-dimethoxy-N-methoxybenzamide

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate at 0 - 20℃;	97%
With potassium carbonate In water; ethyl acetate at 0 - 20℃;
Stage #1: N-methoxylamine hydrochloride With potassium carbonate In water; ethyl acetate Stage #2: 3,4-dimethoxybenzoic acid chloride In water; ethyl acetate at 0 - 20℃; for 5h;

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: N,N-dipropargylamine hydrochloride

: 1300021-71-9
3,4-dimethoxy-N,N-bis(prop-2-yn-1-yl)benzamide

Conditions

Conditions	Yield
Stage #1: N,N-dipropargylamine hydrochloride With dmap; triethylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 3,4-dimethoxybenzoic acid chloride In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;	97%
Stage #1: N,N-dipropargylamine hydrochloride With triethylamine; trifluoroacetic acid In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 3,4-dimethoxybenzoic acid chloride In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;

: 1062211-31-7
(S)-4-Benzyl-3-(2-methyleneamino-acetyl)-oxazolidin-2-one

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: (S)-4-Benzyl-3-[5-(3,4-dimethoxy-phenyl)-oxazole-4-carbonyl]-oxazolidin-2-one

Conditions

Conditions	Yield
With trimethyl-pro-azaphosphatrane In tetrahydrofuran 1.) 0 deg C, 20 min, 2.) room temperature, 30 min;	96%

: (R)-4-Benzyl-3-(2-methyleneamino-acetyl)-oxazolidin-2-one

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: (R)-4-Benzyl-3-[5-(3,4-dimethoxy-phenyl)-oxazole-4-carbonyl]-oxazolidin-2-one

Conditions

Conditions	Yield
With trimethyl-pro-azaphosphatrane In tetrahydrofuran 1.) 0 deg C, 20 min, 2.) room temperature, 30 min;	96%

: 881-70-9
3',4'-dimethoxyacetanilide

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 189001-13-6
2-acetylamino-3',4,4'-5-tetramethoxybenzophenone

Conditions

Conditions	Yield
With tin(IV) chloride; trichlorophosphate In dichloromethane Friedel-Crafts reaction; Heating;	96%

: 880550-62-9
7-bromo-6-methylamino-2,2-dimethyl-2-silatetralin

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 880550-63-0
N-(7-bromo-2,2-dimethyl-2-silatetralin-6-yl)-N-methylveratramide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; for 24h;	96%

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: ethyl 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Conditions

Conditions	Yield
With pyridine at 20℃; for 1h;	96%

: 110-91-8
morpholine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 22792-13-8
4-(3’,4’-dimethoxybenzoyl)morpholine

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 2h;	95%

: 2216-51-5
(-)-menthol

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3,4-dimethoxybenzoate

Conditions

Conditions	Yield
With pyridine In diethyl ether at 48℃; Acylation; Heating;	95%

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 212512-28-2
3,5-dimethoxy-2-(methoxyacetyl)aniline

: 1026457-04-4
N-(3,5-dimethoxy-2-(2-methoxyacetyl)phenyl)-3,4-dimethoxybenzamide

Conditions

Conditions	Yield
With pyridine for 18h; Acylation; Heating;	95%
With dmap; N-ethyl-N,N-diisopropylamine at 80℃; Sealed tube;	67%

3,4-Dimethoxybenzoyl chloride Chemical Properties

The molecular structure of 3,4-Dimethoxybenzoyl chloride (CAS NO.3535-37-3):

IUPAC Name: 3,4-Dimethoxybenzoyl chloride
Molecular Weight: 200.61896 g/mol
Molecular Formula: C₉H₉ClO₃
Density: 1.224 g/cm³
Melting Point: 70-73 °C(lit.)
Boiling Point: 298.2 °C at 760 mmHg
Flash Point: 129.2 °C
Index of Refraction: 1.52
Molar Refractivity: 49.85 cm³
Molar Volume: 163.8 cm³
Surface Tension: 37.1 dyne/cm
Enthalpy of Vaporization: 53.81 kJ/mol
Vapour Pressure: 0.00129 mmHg at 25 °C
Sensitive: moisture sensitive
XLogP3: 2.6
H-Bond Acceptor: 3
Rotatable Bond Count: 3
Exact Mass: 200.024022
MonoIsotopic Mass: 200.024022
Topological Polar Surface Area: 35.5
Heavy Atom Count: 13
Canonical SMILES: COC1=C(C=C(C=C1)C(=O)Cl)OC
InChI: InChI=1S/C9H9ClO3/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5H,1-2H3
InChIKey: VIOBGCWEHLRBEP-UHFFFAOYSA-N
EINECS: 222-568-0
Product Categories: Aromatic Halides (substituted)

3,4-Dimethoxybenzoyl chloride Uses

3,4-Dimethoxybenzoyl chloride (CAS NO.3535-37-3) is used as intermediates of medicine and pesticide.

3,4-Dimethoxybenzoyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II

3,4-Dimethoxybenzoyl chloride Specification

3,4-Dimethoxybenzoyl chloride (CAS NO.3535-37-3) is also named as 3,4-dimethoxybenzene-1-carbonyl chloride ; Benzoyl chloride, 3,4-dimethoxy- ; Veratroyl chloride . 3,4-Dimethoxybenzoyl chloride (CAS NO.3535-37-3) is off-white to grey crystals, flakes or chunks.

Product Name

3,4-Dimethoxybenzoyl chloride

Synthetic route

3,4-Dimethoxybenzoyl chloride Chemical Properties

3,4-Dimethoxybenzoyl chloride Uses

3,4-Dimethoxybenzoyl chloride Safety Profile

3,4-Dimethoxybenzoyl chloride Specification

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