Product Name

  • Name

    3-Amino-2,2-dimethylpropionamide

  • EINECS 1806241-263-5
  • CAS No. 324763-51-1
  • Article Data12
  • CAS DataBase
  • Density 1.004 g/cm3
  • Solubility
  • Melting Point 74-75 °C
  • Formula C5H12N2O
  • Boiling Point 270.7 °C at 760 mmHg
  • Molecular Weight 116.163
  • Flash Point 117.5 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 324763-51-1 (3-Amino-2,2-dimethylpropionamide)
  • Hazard Symbols
  • Synonyms 3-Amino-2,2-dimethylpropanamide;
  • PSA 69.11000
  • LogP 0.85720

Synthetic route

3-Chloropivaloyl chloride
4300-97-4

3-Chloropivaloyl chloride

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2: sodium methylate; ammonia / methanol / 50 h / 60 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube
2.2: 0.17 h / 0 - 20 °C
3.1: hydrogenchloride / 20 h / 20 °C
4.1: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
3-bromo-2,2-dimethylpropionic acid
2843-17-6

3-bromo-2,2-dimethylpropionic acid

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave
2: hydrogenchloride / 20 h / 20 °C
3: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

acetic acid (1S,2S,4S)-2-azido-1-[(S)-2-(2-carbamoyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexyl ester

acetic acid (1S,2S,4S)-2-azido-1-[(S)-2-(2-carbamoyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexyl ester

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 90℃; for 16h; After distillation of a part of Et3N over a period of 0.5 h further 8.5 h heating at 90 °ree;C;100%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one
1309922-72-2

(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
1607844-94-9

(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 110℃; for 2h;95%
tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate
866030-35-5

tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate

aminopivalinamide
324763-51-1

aminopivalinamide

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate
173338-07-3

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In n-heptane at 60℃; Reagent/catalyst; Temperature; Solvent; Time;94%
With 2-Ethylhexanoic acid In n-heptane at 60℃; for 40h; Solvent; Reagent/catalyst;93%
With 2-Ethylhexanoic acid In n-heptane at 70℃; for 8h; Inert atmosphere;92%
aminopivalinamide
324763-51-1

aminopivalinamide

1,1-dimethylethyl[(1S,3S)-3-[{4-methoxy-3-(3-methoxypropoxy)phenyl}methyl]-4-methyl-1-[tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate

1,1-dimethylethyl[(1S,3S)-3-[{4-methoxy-3-(3-methoxypropoxy)phenyl}methyl]-4-methyl-1-[tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate

C35H61N3O8

C35H61N3O8

Conditions
ConditionsYield
2-Ethylhexanoic acid In tetrahydrofuran at 100℃; for 6h; Product distribution / selectivity;93%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 120℃; for 1.5h;87%
aminopivalinamide
324763-51-1

aminopivalinamide

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester
1236549-00-0

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester
1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Solvent; Reagent/catalyst;86%
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Reagent/catalyst; Solvent;86%
With 2-hydroxypyridin; triethylamine In toluene for 16h; Reflux; Inert atmosphere;82%
aminopivalinamide
324763-51-1

aminopivalinamide

C30H49NO7

C30H49NO7

C35H61N3O8

C35H61N3O8

Conditions
ConditionsYield
With 2-Ethylhexanoic acid at 120℃; for 0.833333h;84%
2-hydroxypyridin
142-08-5

2-hydroxypyridin

aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
324763-47-5

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With triethylamine79%
...Expand
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5R)-5-[(1R,3S)-1-azido-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone

(3S,5R)-5-[(1R,3S)-1-azido-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone

(2S,4R,5R,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

(2S,4R,5R,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With triethylamine In toluene at 80 - 90℃; for 20h;78.5%
aminopivalinamide
324763-51-1

aminopivalinamide

N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide
1000047-42-6

N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

(2S,4S,5S)-6-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-4-hydroxy-2-isopropyl-5-(2-nitrobenzenesulfonylamino)hexanoic acid (2-carbamoyl-2-methylpropyl)amide
1000047-43-7

(2S,4S,5S)-6-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-4-hydroxy-2-isopropyl-5-(2-nitrobenzenesulfonylamino)hexanoic acid (2-carbamoyl-2-methylpropyl)amide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 15h;78%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
324763-47-5

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃;76%
With 2-hydroxypyridin; triethylamine59%
aminopivalinamide
324763-51-1

aminopivalinamide

N-{(1S)-2-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

N-{(1S)-2-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

(2S,4S,5S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-5-{[(2-nitrophenyl)sulfonyl]amino}hexanamide

(2S,4S,5S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-5-{[(2-nitrophenyl)sulfonyl]amino}hexanamide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 2h;73%
methyl 3-amino-2,2-dimethylpropionate
25307-82-8

methyl 3-amino-2,2-dimethylpropionate

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
With ammonia In methanol at 60℃; under 3750.38 Torr; for 48h; Autoclave;100%
2-cyano-2-methylpropanamide
7505-93-3

2-cyano-2-methylpropanamide

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Stage #1: 2-cyano-2-methylpropanamide With ammonia; Raney nickel In methanol at 25 - 35℃; Autoclave;
Stage #2: With hydrogen In methanol at 60 - 65℃; under 5149.01 - 5884.58 Torr; for 10h;		87.5%
With ammonia; hydrogen; Raney nickle In methanol at 60 - 70℃; under 3750.38 Torr; for 10h; Autoclave;78%
Multi-step reaction with 2 steps
1.1: LAH / tetrahydrofuran
1.2: Et3N
2.1: H2 / Pd()OH)2/C
View Scheme
With ammonia; hydrogen; raney nickel In methanol at 40 - 45℃; under 2942.29 Torr; for 14h;
With ammonium hydroxide; 5% rhodium on activated aluminium oxide; hydrogen In ethanol; water under 3102.97 Torr; for 72h;
(2-carbamoyl-2-methylpropyl)carbamic acid benzyl ester
666844-61-7

(2-carbamoyl-2-methylpropyl)carbamic acid benzyl ester

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
With hydrogen; palladium-carbon In ethanol at 20℃; for 2h;85%
With hydrogen; palladium hydroxide - carbon
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; for 2h;
chloro-pivalic acid amide
41461-75-0

chloro-pivalic acid amide

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
With ammonia; sodium methylate In methanol at 60℃; for 50h; Autoclave;62%
Multi-step reaction with 3 steps
1.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube
1.2: 0.17 h / 0 - 20 °C
2.1: hydrogenchloride / 20 h / 20 °C
3.1: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
α-(nitromethyl)isobutyronitrile
114583-17-4

α-(nitromethyl)isobutyronitrile

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
With methanol; Lindlar's catalyst Hydrogenation;
With nickel Hydrogenation;
With hydrogenchloride; iron
hydrogenchloride
7647-01-0

hydrogenchloride

α-(nitromethyl)isobutyronitrile
114583-17-4

α-(nitromethyl)isobutyronitrile

iron powder

iron powder

A

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide
859065-87-5

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B

2,2-Dimethyl-1,3-diaminopropane
7328-91-8

2,2-Dimethyl-1,3-diaminopropane

C

3-amino-2,2-dimethyl-propionitrile
67744-70-1

3-amino-2,2-dimethyl-propionitrile

D

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
at 60 - 70℃;
at 60 - 70℃;
...Expand
methanol
67-56-1

methanol

α-(nitromethyl)isobutyronitrile
114583-17-4

α-(nitromethyl)isobutyronitrile

palladium-CaCO3

palladium-CaCO3

A

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide
859065-87-5

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B

2,2-Dimethyl-1,3-diaminopropane
7328-91-8

2,2-Dimethyl-1,3-diaminopropane

C

3-amino-2,2-dimethyl-propionitrile
67744-70-1

3-amino-2,2-dimethyl-propionitrile

D

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Hydrogenation;
Hydrogenation;
...Expand
methanol
67-56-1

methanol

α-(nitromethyl)isobutyronitrile
114583-17-4

α-(nitromethyl)isobutyronitrile

Raney nickel

Raney nickel

A

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide
859065-87-5

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B

2,2-Dimethyl-1,3-diaminopropane
7328-91-8

2,2-Dimethyl-1,3-diaminopropane

C

3-amino-2,2-dimethyl-propionitrile
67744-70-1

3-amino-2,2-dimethyl-propionitrile

D

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Hydrogenation;
Hydrogenation;
...Expand
α-(nitromethyl)isobutyronitrile
114583-17-4

α-(nitromethyl)isobutyronitrile

Raney nickel

Raney nickel

methanolic NH3

methanolic NH3

A

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide
859065-87-5

2-(5,5-dimethyl-hexahydro-pyrimidin-2-yl)-2-methyl-propionic acid amide

B

2,2-Dimethyl-1,3-diaminopropane
7328-91-8

2,2-Dimethyl-1,3-diaminopropane

C

3-amino-2,2-dimethyl-propionitrile
67744-70-1

3-amino-2,2-dimethyl-propionitrile

D

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
at 100℃; Hydrogenation;
at 100℃; Hydrogenation;
...Expand
methyl 2,2-dimethyl-cyanoacetate
72291-30-6

methyl 2,2-dimethyl-cyanoacetate

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Stage #1: methyl 2,2-dimethyl-cyanoacetate With ammonia; hydrogen; nickel In 1-methyl-pyrrolidin-2-one; water at 80℃; under 3750.38 Torr; for 1.5h;
Stage #2: With ammonia; hydrogen; nickel In 1-methyl-pyrrolidin-2-one; water at 80℃; under 150015 Torr; Product distribution / selectivity;
Stage #1: methyl 2,2-dimethyl-cyanoacetate With ammonia; hydrogen; cobalt In water; butan-1-ol at 80℃; under 3750.38 Torr; for 1.5h;
Stage #2: With ammonia; hydrogen; cobalt In water; butan-1-ol at 80℃; under 48754.9 Torr; Product distribution / selectivity;
Stage #1: methyl 2,2-dimethyl-cyanoacetate With ammonia; hydrogen; cobalt In methanol; water at 80℃; under 3750.38 Torr; for 1.5h;
Stage #2: With ammonia; hydrogen; cobalt In methanol; water at 80℃; under 48754.9 Torr; Product distribution / selectivity;
Stage #1: methyl 2,2-dimethyl-cyanoacetate With ammonia; hydrogen; nickel In water; butan-1-ol at 80℃; under 3750.38 Torr; for 1.5h;
Stage #2: With ammonia; hydrogen; nickel In water; butan-1-ol at 80℃; under 48754.9 Torr; Product distribution / selectivity;
methyl 2,2-dimethyl-cyanoacetate
72291-30-6

methyl 2,2-dimethyl-cyanoacetate

A

aminopivalinamide
324763-51-1

aminopivalinamide

B

methyl 3-amino-2,2-dimethylpropionate
25307-82-8

methyl 3-amino-2,2-dimethylpropionate

Conditions
ConditionsYield
With ammonia; hydrogen; mixture of 28percent NiO, 28percent CoO, 13percent CuO, 31percent ZrO2; hydrogenated In methanol at 100℃; under 150015 Torr; Product distribution / selectivity;
With ammonia; hydrogen; mixture of 28percent NiO, 28percent CoO, 13percent CuO, 31percent ZrO2; hydrogenated In tetrahydrofuran at 100℃; under 150015 Torr; Product distribution / selectivity;
4,4-dimethylpyrazolidin-3-one
2941-18-6

4,4-dimethylpyrazolidin-3-one

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
With hydrogen; Raney-Nickel In 2-methyl-propan-1-ol at 55 - 65℃; under 750.075 Torr; Inert atmosphere; Sealed tube;
2-cyano-2-methyl-propionic acid ethyl ester
1572-98-1

2-cyano-2-methyl-propionic acid ethyl ester

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / methanol / 12 h / 25 - 30 °C
2: hydrogen; ammonia / raney nickel / methanol / 14 h / 40 - 45 °C / 2942.29 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: ammonia / methanol / 25 - 35 °C
2.1: ammonia / Raney nickel / methanol / 25 - 35 °C / Autoclave
2.2: 10 h / 60 - 65 °C / 5149.01 - 5884.58 Torr
View Scheme
Multi-step reaction with 2 steps
1: ammonia / methanol / 96 h / 35 °C / Sealed tube; Cooling with ice
2: hydrogen; ammonium hydroxide; 5% rhodium on activated aluminium oxide / ethanol; water / 72 h / 3102.97 Torr
View Scheme
3-Hydroxy-2,2-dimethylpropanoic acid
4835-90-9

3-Hydroxy-2,2-dimethylpropanoic acid

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen bromide / water / 19 h / 100 °C
2: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave
3: hydrogenchloride / 20 h / 20 °C
4: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
aminopivalic acid
19036-43-2

aminopivalic acid

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / 20 h / 20 °C
2: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
3-Chloropivaloyl chloride
4300-97-4

3-Chloropivaloyl chloride

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2: sodium methylate; ammonia / methanol / 50 h / 60 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice
2.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube
2.2: 0.17 h / 0 - 20 °C
3.1: hydrogenchloride / 20 h / 20 °C
4.1: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
3-bromo-2,2-dimethylpropionic acid
2843-17-6

3-bromo-2,2-dimethylpropionic acid

aminopivalinamide
324763-51-1

aminopivalinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave
2: hydrogenchloride / 20 h / 20 °C
3: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave
View Scheme
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

acetic acid (1S,2S,4S)-2-azido-1-[(S)-2-(2-carbamoyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexyl ester

acetic acid (1S,2S,4S)-2-azido-1-[(S)-2-(2-carbamoyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexyl ester

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 90℃; for 16h; After distillation of a part of Et3N over a period of 0.5 h further 8.5 h heating at 90 °ree;C;100%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one
1309922-72-2

(3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
1607844-94-9

(2S,4R,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 110℃; for 2h;95%
tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate
866030-35-5

tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate

aminopivalinamide
324763-51-1

aminopivalinamide

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate
173338-07-3

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In n-heptane at 60℃; Reagent/catalyst; Temperature; Solvent; Time;94%
With 2-Ethylhexanoic acid In n-heptane at 60℃; for 40h; Solvent; Reagent/catalyst;93%
With 2-Ethylhexanoic acid In n-heptane at 70℃; for 8h; Inert atmosphere;92%
aminopivalinamide
324763-51-1

aminopivalinamide

1,1-dimethylethyl[(1S,3S)-3-[{4-methoxy-3-(3-methoxypropoxy)phenyl}methyl]-4-methyl-1-[tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate

1,1-dimethylethyl[(1S,3S)-3-[{4-methoxy-3-(3-methoxypropoxy)phenyl}methyl]-4-methyl-1-[tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]pentyl]carbamate

C35H61N3O8

C35H61N3O8

Conditions
ConditionsYield
2-Ethylhexanoic acid In tetrahydrofuran at 100℃; for 6h; Product distribution / selectivity;93%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

Conditions
ConditionsYield
With propionic acid at 120℃; for 1.5h;87%
aminopivalinamide
324763-51-1

aminopivalinamide

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester
1236549-00-0

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester
1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

Conditions
ConditionsYield
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Solvent; Reagent/catalyst;86%
With 2-Ethylhexanoic acid In di-isopropyl ether at 60℃; Reagent/catalyst; Solvent;86%
With 2-hydroxypyridin; triethylamine In toluene for 16h; Reflux; Inert atmosphere;82%
aminopivalinamide
324763-51-1

aminopivalinamide

C30H49NO7

C30H49NO7

C35H61N3O8

C35H61N3O8

Conditions
ConditionsYield
With 2-Ethylhexanoic acid at 120℃; for 0.833333h;84%
2-hydroxypyridin
142-08-5

2-hydroxypyridin

aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
324763-47-5

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With triethylamine79%
...Expand
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5R)-5-[(1R,3S)-1-azido-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone

(3S,5R)-5-[(1R,3S)-1-azido-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone

(2S,4R,5R,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

(2S,4R,5R,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With triethylamine In toluene at 80 - 90℃; for 20h;78.5%
aminopivalinamide
324763-51-1

aminopivalinamide

N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide
1000047-42-6

N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

(2S,4S,5S)-6-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-4-hydroxy-2-isopropyl-5-(2-nitrobenzenesulfonylamino)hexanoic acid (2-carbamoyl-2-methylpropyl)amide
1000047-43-7

(2S,4S,5S)-6-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-4-hydroxy-2-isopropyl-5-(2-nitrobenzenesulfonylamino)hexanoic acid (2-carbamoyl-2-methylpropyl)amide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 15h;78%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide
324763-47-5

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃;76%
With 2-hydroxypyridin; triethylamine59%
aminopivalinamide
324763-51-1

aminopivalinamide

N-{(1S)-2-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

N-{(1S)-2-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

(2S,4S,5S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-5-{[(2-nitrophenyl)sulfonyl]amino}hexanamide

(2S,4S,5S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}-5-{[(2-nitrophenyl)sulfonyl]amino}hexanamide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 2h;73%
aminopivalinamide
324763-51-1

aminopivalinamide

triethoxymethylbenzene
1663-61-2

triethoxymethylbenzene

5,5-dimethyl-2-phenyl-5,6-dihydropyrimidin-4(3H)-one

5,5-dimethyl-2-phenyl-5,6-dihydropyrimidin-4(3H)-one

Conditions
ConditionsYield
With acetic acid In ethanol at 110℃; for 24h; Inert atmosphere;72%
aminopivalinamide
324763-51-1

aminopivalinamide

C29H49NO6S

C29H49NO6S

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
173334-57-1

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With 2-hydroxypyridin; hydrogenchloride; triethylamine In methanol at 80℃;68%
aminopivalinamide
324763-51-1

aminopivalinamide

tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate
1000046-88-7

tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

tert-butyl {(2S,3S,5S)-5-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-1-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-3-hydroxy-6-methylheptan-2-yl}carbamate
1000046-90-1

tert-butyl {(2S,3S,5S)-5-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-1-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-3-hydroxy-6-methylheptan-2-yl}carbamate

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 18h;66%
With 2-hydroxypyridin; triethylamine at 80℃; for 18h;66%
aminopivalinamide
324763-51-1

aminopivalinamide

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester
1236549-00-0

{(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester

A

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester
1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

B

C31H51N3O7

C31H51N3O7

Conditions
ConditionsYield
With 2-hydroxypyridin In tert-butyl methyl ether at 65℃;A 66%
B n/a
...Expand
tert-butyl (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-4-methylpentylcarbamate
953820-47-8

tert-butyl (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-4-methylpentylcarbamate

aminopivalinamide
324763-51-1

aminopivalinamide

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate
953820-48-9

tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-2,9-dimethyldecan-5-ylcarbamate

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃;65%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one
325740-70-3

(3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one

(2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
325154-31-2

(2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine59%
aminopivalinamide
324763-51-1

aminopivalinamide

(3S,5S)-5-{(1R,3S)-1-Benzylamino-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

(3S,5S)-5-{(1R,3S)-1-Benzylamino-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

(2S,4S,5R,7S)-5-Benzylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
361460-41-5

(2S,4S,5R,7S)-5-Benzylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 72h;53%
aminopivalinamide
324763-51-1

aminopivalinamide

{(S)-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]-2-[4-(2-methoxymethoxyphenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]ethyl}carbamic acid benzyl ester
1000047-28-8

{(S)-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]-2-[4-(2-methoxymethoxyphenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]ethyl}carbamic acid benzyl ester

{(1S,2S,4S)-4-(2-carbamoyl-2-methylpropylcarbamoyl)-2-hydroxy-1-[4-(2-methoxymethoxyphenyl)-2,2-dimethyl-5-oxopiperazin-1-ylmethyl]-5-methylhexyl}carbamic acid benzyl ester
1000047-29-9

{(1S,2S,4S)-4-(2-carbamoyl-2-methylpropylcarbamoyl)-2-hydroxy-1-[4-(2-methoxymethoxyphenyl)-2,2-dimethyl-5-oxopiperazin-1-ylmethyl]-5-methylhexyl}carbamic acid benzyl ester

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 80℃; for 11h;52%
aminopivalinamide
324763-51-1

aminopivalinamide

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

2,5,5-trimethyl-5,6-dihydropyrimidin-4(3H)-one

2,5,5-trimethyl-5,6-dihydropyrimidin-4(3H)-one

Conditions
ConditionsYield
With acetic acid In ethanol at 110℃; for 24h; Inert atmosphere;50%
aminopivalinamide
324763-51-1

aminopivalinamide

(2R,2'S,3S,4'S,5S)-3-isopropyl-5-(4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-2-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-pyrrolidine-1-sulfonic acid 2,2,2-trichloro-ethyl ester
1200341-46-3

(2R,2'S,3S,4'S,5S)-3-isopropyl-5-(4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-2-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-pyrrolidine-1-sulfonic acid 2,2,2-trichloro-ethyl ester

(2R,3S,5S)-2,2,2-trichloroethyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-sulfonate
1219468-79-7

(2R,3S,5S)-2,2,2-trichloroethyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-sulfonate

Conditions
ConditionsYield
With 2-hydroxypyridin; triethylamine at 85℃; Inert atmosphere;47%
With 2-hydroxypyridin; triethylamine at 85℃; for 72h; Inert atmosphere;
aminopivalinamide
324763-51-1

aminopivalinamide

Triethyl orthopropionate
115-80-0

Triethyl orthopropionate

2-ethyl-5,5-dimethyl-5,6-dihydropyrimidin-4(3H)-one

2-ethyl-5,5-dimethyl-5,6-dihydropyrimidin-4(3H)-one

Conditions
ConditionsYield
With acetic acid In ethanol at 110℃; for 24h; Inert atmosphere;44%
triethyl orthobutyrate
24964-76-9

triethyl orthobutyrate

aminopivalinamide
324763-51-1

aminopivalinamide

5,5-dimethyl-2-propyl-5,6-dihydropyrimidin-4(3H)-one

5,5-dimethyl-2-propyl-5,6-dihydropyrimidin-4(3H)-one

Conditions
ConditionsYield
With acetic acid In ethanol at 110℃; for 24h; Inert atmosphere;36%
aminopivalinamide
324763-51-1

aminopivalinamide

2-{[5-bromo-1-(2-chlorophenyl)-1H-1,2,4-triazol-3-yl]methyl}-5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

2-{[5-bromo-1-(2-chlorophenyl)-1H-1,2,4-triazol-3-yl]methyl}-5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

3-{[1-(2-chlorophenyl)-3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-5-yl]amino}-2,2-dimethylpropanamide

3-{[1-(2-chlorophenyl)-3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-5-yl]amino}-2,2-dimethylpropanamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 180℃; for 5h; Microwave irradiation;29%
aminopivalinamide
324763-51-1

aminopivalinamide

aminopivalic acid
19036-43-2

aminopivalic acid

Conditions
ConditionsYield
With sulfuric acid

3-Amino-2,2-dimethylpropionamide Chemical Properties

Product Name: 3-Amino-2,2-dimethylpropionamide (CAS NO.324763-51-1)

Molecular Formula: C5H12N2O
Molecular Weight: 116.16g/mol
Mol File: 324763-51-1.mol
Melting Point: 74-75 °C
Boiling point: 270.7 °C at 760 mmHg
Flash Point: 117.5 °C
Density: 1.004 g/cm3
Surface Tension: 39.2 dyne/cm
Enthalpy of Vaporization: 50.88 kJ/mol
Vapour Pressure: 0.00675 mmHg at 25°C 

3-Amino-2,2-dimethylpropionamide Specification

 3-Amino-2,2-dimethylpropionamide , its CAS NO. is 324763-51-1, the synonyms are 2-(Aminomethyl)-2-methylpropanamide ; 3-Amino-2,2-dimethylpropionic acid amide .

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