3-Chlorobenzyl Chloride supplier

Name
3-Chlorobenzyl chloride
EINECS 210-629-4
CAS No. 620-20-2
Article Data30
CAS DataBase
Density 1.247 g/cm³
Solubility
Melting Point 69-71oC
Formula C₇H₆Cl₂
Boiling Point 213.7 °C at 760 mmHg
Molecular Weight 161.031
Flash Point 98.9 °C
Transport Information UN 2235 6.1/PG 3
Appearance Colorless to light yellow liquid
Safety 26-36/37/39-45-61-14C
Risk Codes 34-51/53-43-36-20/21/22
Molecular Structure
Hazard Symbols C, N, Xn
Synonyms Toluene,m,a-dichloro- (8CI);1-Chloro-3-(chloromethyl)benzene;NSC 76577;m,a-Dichlorotoluene;m-Chlorobenzyl chloride;m-Chlorophenylmethyl chloride;a,3-Dichlorotoluene;a,m-Dichlorotoluene;
PSA 0.00000
LogP 3.07880

Synthetic route

: 873-63-2
m-chlorobenzyl alcohol

: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 0 - 15℃; for 12.5h;	31%
With thionyl chloride
With phosphorus pentachloride at 100℃;
With thionyl chloride In pyridine Ambient temperature;

: 108-41-8
1-chloro-3-methylbenzene

: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With hydrogenchloride; potassium chloride; tetrabutyl-ammonium chloride In water at 20℃; Irradiation; Green chemistry;	91%
With N-chloro-succinimide; N-hydroxyphthalimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 80℃; for 3h; Sealed tube; Inert atmosphere;	88%
With N-hydroxyphthalimide; carbon tetrabromide; trichloroisocyanuric acid; copper(II) acetate monohydrate In dichloromethane at 25℃; for 40h;	55%

: 873-63-2
m-chlorobenzyl alcohol

A: bis(3-chlorobenzyl) ether

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With thionyl chloride; benzene

: N,N-bis-(3-chloro-benzyl)-benzamide

: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With phosphorus pentachloride at 110℃;

: C8H6Cl2O

: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 25℃; Kinetics;

: N-(2-chloro-benzyl)-N-(3-chloro-benzyl)-benzamide

A: N-(2-chlorobenzyl) benzamide

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With phosphorus pentachloride at 110℃;

: N-(2-chloro-benzyl)-N-(4-chloro-benzyl)-benzamide

A: N-(2-chlorobenzyl) benzamide

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
With phosphorus pentachloride at 110℃; entsteht analog aus Benzoyl-<2.4'-dichlor-dibenzylamin>;

: 56-23-5
tetrachloromethane

: 123150-61-8
(Z)-hepta-1,2,4-trien-6-yne

A: 114980-29-9
1-(2,2,2-trichloroethyl)-3-chlorobenzene

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
at 100℃; Product distribution;

...Expand

: 7791-25-5
sulfuryl dichloride

: 591-17-3
meta-bromotoluene

: 94-36-0
dibenzoyl peroxide

A: 823-78-9
meta-bromobenzyl bromide

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

C: 932-77-4
3-bromobenzyl chloride

Conditions

Conditions	Yield
at 110℃;

...Expand

: 191402-55-8
1-(1-Chloro-2,2,2-trifluoro-ethyl)-3-methyl-benzene

: 65108-07-8
C7H6Cl(1+)

A C9H8F3(1+): C9H8F3(1+)

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

1-(1-Chloro-2,2,2-trifluoro-ethyl)-3,5-dimethyl-benzene: 1-(1-Chloro-2,2,2-trifluoro-ethyl)-3,5-dimethyl-benzene

: 65108-07-8
C7H6Cl(1+)

A: 128408-30-0
C10H10F3(1+)

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: N-(2-chloro-benzyl)-N-(3-chloro-benzyl)-benzamide

A: N-(2-chlorobenzyl) benzamide

B: 620-20-2
1-Chloro-3-chloromethyl-benzene

Conditions

Conditions	Yield
at 110℃;

...Expand

: 17356-08-0
thiourea

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 133067-71-7
S-(3-chloro)benzylisothiouronium chloride

Conditions

Conditions	Yield
In ethanol at 95℃; for 2h;	100%
In ethanol for 4h; Heating;	85%
In ethanol Heating;

: 73296-31-8
phenyltellurotrimethylsilane

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: m-chlorobenzyl phenyl telluride

Conditions

Conditions	Yield
at 20℃; for 0.5h;	100%
In acetonitrile at 20℃; for 0.5h;	100 % Spectr.

: (S)-2-(2-chloropyrimidin-4-yl)-6-methyl-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: (S)-7-(3-chlorobenzyl)-2-(2-chloropyrimidin-4-yl)-6-methyl-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one

Conditions

Conditions	Yield
Stage #1: (S)-2-(2-chloropyrimidin-4-yl)-6-methyl-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere; Stage #2: 1-Chloro-3-chloromethyl-benzene With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 18h;	100%

: 1252801-64-1
O7-demethyl glaziovianin A

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 7-((3-chlorobenzyl)oxy)-3-(4,7-dimethoxybenzo[d][1,3]dioxol-5-yl)-6-methoxy-4H-chromen-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 18h; Reflux;	100%

: 65-85-0
benzoic acid

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 38612-12-3
3-chlorobenzyl benzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	99%

: 32998-95-1
N-tert-butyl-3-methylpyridine-2-carboxamide

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 107285-30-3
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

Conditions

Conditions	Yield
Stage #1: N-tert-butyl-3-methylpyridine-2-carboxamide With n-butyllithium; sodium bromide In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-Chloro-3-chloromethyl-benzene In tetrahydrofuran; water for 2h; Inert atmosphere;	98.8%
With n-butyllithium; sodium bromide In tetrahydrofuran; hexane; water	92%
With n-butyllithium; sodium bromide In tetrahydrofuran; hexane; water	92%

: 5438-36-8
5-iodovaniline

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: (4-((3-chlorobenzyl)oxy)-3-iodo-5-methoxybenzaldehyde)

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	98.1%

: ethyl 7,8-dimethyl-1,4,5,7-tetrahydropyrrolo[3,4-g]indazole-6-carboxylate

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: ethyl 1-(3-chlorobenzyl)-7,8-dimethyl-1,4,5,7-tetrahydropyrrolo[3,4-g]indazole-6-carboxylate

Conditions

Conditions	Yield
Stage #1: ethyl 7,8-dimethyl-1,4,5,7-tetrahydropyrrolo[3,4-g]indazole-6-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 1h; Stage #2: 1-Chloro-3-chloromethyl-benzene In N,N-dimethyl-formamide at 0 - 20℃;	98%

: 536-74-3
phenylacetylene

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 126800-08-6
1‐(3‐chlorobenzyl)‐4‐phenyl‐1H‐1,2,3‐triazole

Conditions

Conditions	Yield
With sodium azide In water at 20℃; for 5h; Green chemistry;	98%
With sodium azide In water at 100℃; for 5h; Green chemistry; regioselective reaction;	90%
With sodium azide In water at 20℃; for 2.25h; Green chemistry;	89%

: 85732-81-6
4-(3,5-dimethylpyrazol-1-yl)imidazo<4,5-d>pyridazine-2-thiol

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 85732-92-9
4-(3,5-Dimethylpyrazol-1-yl)-2-(3-chlorobenzylthio)imidazo<4,5-d>pyridazine

Conditions

Conditions	Yield
With potassium hydroxide at 45℃; for 5h;	97%

: 75-15-0
carbon disulfide

: 107-11-9
1-amino-2-propene

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 1448156-36-2
3-chlorobenzyl N-allylcarbamodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 3h;	97%

...Expand

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 885432-92-8
2-(3-chlorobenzyl)-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
In acetonitrile at 20℃;	97%

: 471-53-4
enoxolone

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 3-(3-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;	97%

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 5-[(3-chlorobenzyl)oxy]-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 80℃; for 5.16667h;	97%

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 4-((3-chlorobenzyl)oxy)-3-ethoxybenzaldehyde

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; Inert atmosphere;	97%

: 19463-48-0
5-chlorovanillin

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 3-chloro-4-(3-chlorobenzyloxy)-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	96.5%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	96.5%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	96.5%

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 3-bromo-4-(3-chlorobenzyloxy)-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	96.5%

: 5798-75-4
Ethyl 4-bromobenzoate

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 1210054-79-7
ethyl 4-(3-chlorobenzyl)benzoate

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); zinc In water at 20℃; for 8h; Inert atmosphere;	96%

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 70450-41-8
1-chloro-3-(iodomethyl)benzene

Conditions

Conditions	Yield
With sodium iodide In acetone for 2h; Reflux;	96%
With sodium iodide In acetone for 2h; Reflux; Inert atmosphere;
With potassium iodide In acetone Reflux;

: 1849-01-0
1-methyl-2-benzimidazolone

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 860031-86-3
1-(3-chloro-benzyl)-3-methyl-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h;	95%

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 108-59-8
malonic acid dimethyl ester

: 670748-74-0
dimethyl 2-(3-chlorobenzyl)malonate

Conditions

Conditions	Yield
With sodium hydroxide In ISOPROPYLAMIDE at 20℃; for 6h;	95%
Stage #1: 1-Chloro-3-chloromethyl-benzene; malonic acid dimethyl ester With sodium hydroxide In ISOPROPYLAMIDE at 20℃; for 6h; Stage #2: With hydrogenchloride In ISOPROPYLAMIDE; water at 5℃; pH=3.5;	95%

: 292638-85-8
acrylic acid methyl ester

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 725705-34-0
C11H13ClO2S

Conditions

Conditions	Yield
Stage #1: 1-Chloro-3-chloromethyl-benzene With urea/choline chloride eutectic salt; thiourea at 60℃; Green chemistry; Stage #2: acrylic acid methyl ester With sodium hydroxide In water for 1.33333h; Heating; Green chemistry;	95%

: 615-43-0
2-iodophenylamine

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 22868-31-1
2-(3-chlorophenyl)benzothiazole

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; sodium carbonate; sulfur In dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; Inert atmosphere;	95%

: (Z)-5-benzylidene-3-butyl-4-propyl-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: (Z)-5-benzylidene-3-butyl-1-(3-chlorobenzyl)-4-propyl-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 3h; Sealed tube;	95%

poly(N-methyl-4-vinyl-pyridinium)thiocyanate: poly(N-methyl-4-vinyl-pyridinium)thiocyanate

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 64215-09-4
3-chlorobenzyl thiocyanate

Conditions

Conditions	Yield
In hexane at 20℃; for 72h;	93%

: 90591-48-3
tris-(4-ethoxy-phenyl)-bismuthine

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 1-chloro-3-(4-ethoxybenzyl)benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;	93%

: 8-(pyrrolidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-thione

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 3-(3-chlorobenzylthio)-8-(pyrrolidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 2h;	93%

N-(1,1-Dimethylethyl)-3-Methyl-2-Pyridine Carboximide: N-(1,1-Dimethylethyl)-3-Methyl-2-Pyridine Carboximide

: 32998-95-1
N-tert-butyl-3-methylpyridine-2-carboxamide

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 107285-30-3
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

Conditions

Conditions	Yield
With n-butyllithium; sodium bromide In tetrahydrofuran; hexane; water	92%

...Expand

: 16917-35-4
(E)-(1-bromoprop-1-en-2-yl)benzene

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 1310582-70-7
(E)-1-chloro-3-(3-phenylbut-2-en-1-yl)benzene

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); zinc In water at 20℃; for 6h; Inert atmosphere;	92%

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 1311146-73-2
1-(3-chlorobenzyl)-3,5-dimethyl-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 3,5-dimethyl-1H-pyrazole With potassium hydroxide In dimethyl sulfoxide at 20 - 80℃; for 1h; Inert atmosphere; Stage #2: 1-Chloro-3-chloromethyl-benzene In dimethyl sulfoxide at 20℃; for 2h; Inert atmosphere;	92%

3-Chlorobenzyl Chloride Chemical Properties

MF: C₇H₆Cl₂
MW: 161.03
EINECS: 210-629-4
3-Chlorobenzyl Chloride,it's bp is about 215-216 °C(lit.).density is 1.27 g/mL at 25 °C(lit.) Ihe appearance of 3-Chlorobenzyl Chloride is often colorless to light yellow liquid.the molecular structure is following:

3-Chlorobenzyl Chloride Safety Profile

Safety Information about 3-Chlorobenzyl Chloride:
Hazard Codes C,N,Xn
Risk Statements 34-51/53-43-36-20/21/22
Safety Statements 26-36/37/39-45-61-14C
RIDADR UN 2235 6.1/PG 3

3-Chlorobenzyl Chloride Specification

TRANSPORT INFORMATION:
UN Number : 2235
Land Transport
ADR/RIC Code/Class: 8 /Packing Group II
Maritime Transport IMDG Code/Class : 8 /Packing Group II
Air Transport IATA Code/Class : 8 /Packing Group II

Product Name

3-Chlorobenzyl chloride

Synthetic route

3-Chlorobenzyl Chloride Chemical Properties

3-Chlorobenzyl Chloride Safety Profile

3-Chlorobenzyl Chloride Specification

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