3-Pyridinecarboxaldehyde supplier

Name
3-Pyridinecarboxaldehyde
EINECS 207-900-4
CAS No. 500-22-1
Article Data173
CAS DataBase
Density 1.135 g/cm³
Solubility miscible with water
Melting Point 8 °C
Formula C₆H₅NO
Boiling Point 209.9 °C at 760 mmHg
Molecular Weight 107.112
Flash Point 60 °C
Transport Information UN 1989 3/PG 3
Appearance clear brown-yellow liquid (clear)
Safety 26-45-36/37/39-23
Risk Codes 10-42/43-41-34-22-36/37/38
Molecular Structure
Hazard Symbols Xi,C,Xn
Synonyms Nicotinaldehyde(8CI);3-Formylpyridine;3-Pyridinaldehyde;3-Pyridinealdehyde;3-Pyridylaldehyde;NSC 8952;Nicotinealdehyde;Nicotinic aldehyde;Pyridine-3-carbaldehyde;Rowalind;m-Formylpyridine;b-Formylpyridine;b-Pyridinecarbonaldehyde;
PSA 29.96000
LogP 0.89410

Synthetic route

: 100-55-0
3-hydroxymethylpyridin

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With 10% Ru/C; oxygen In toluene at 90℃; under 760.051 Torr; for 24h;	100%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide for 0.25h; Ambient temperature;	99%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; oxygen; copper(I) bromide dimethylsulfide complex In chlorobenzene at 80℃; for 8h;	99%

: 100-54-9
pyridine-3-carbonitrile

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With potassium carbonate In water; dimethyl sulfoxide at 60℃; for 8h; High pressure; Green chemistry;	99.9%
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;	96%
Stage #1: pyridine-3-carbonitrile With diisobutylaluminium hydride In toluene at 20℃; for 0.222222h; Flow reactor; Stage #2: With water; sodium L-tartrate In toluene at 0℃; chemoselective reaction;	52%

: 59-26-7
N,N-diethylnicotinamide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.25h;	99%
With diethyl ether; diisobutylaluminium hydride

: 51892-16-1
nicotinaldehyde oxime

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With titanium tetrachloride; sodium iodide In acetonitrile for 0.0833333h; Ambient temperature; other oximes, var. time;	97%

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol In tetrahydrofuran; hexane at 0℃;	97%
Multi-step reaction with 2 steps 1: diethyl ether; lithium alanate 2: lead (IV)-acetate; benzene View Scheme

: 20173-04-0
N-methyl-N-(3-pyridylmethyl)amine

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 12h; Reflux;	95%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 24h; Reflux;	93%

: pyridine-3-carboxaldehyde semicarbazone

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; silica gel In dichloromethane at 20℃; for 1.8h;	91%

: 100-55-0
3-hydroxymethylpyridin

A: 500-22-1
3-pyridinecarboxaldehyde

B: 59-67-6
nicotinic acid

Conditions

Conditions	Yield
With sodium hypochlorite; C8H18NPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;	A 90.1% B 3.4%
With sodium hypochlorite; C13H26N2OPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;	A 87.7% B 3.5%
With sodium hypochlorite; C16H28N2O5Pol; sodium hydrogencarbonate In water; 1,2-dichloro-ethane at 15 - 20℃; for 4.5h; Product distribution / selectivity;	A 85.3% B 5.3%

: 10400-19-8
3-pyridinecarbonyl chloride

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) In benzene for 0.166667h; Ambient temperature;	90%
With diethylene glycol dimethyl ether; lithium tri-t-butoxyaluminum hydride at -78℃;
With piperidine; diethyldihydroaluminate 1.) THF, RT, 30 min, 2.) THF, toluene, RT, 1 h; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: benzene; pyridine 2: lithium alanate; tetrahydrofuran / 0 °C View Scheme

: 1126-74-5
3-(pyridin-3-yl)acrylic acid

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With aluminum oxide; potassium permanganate In dichloromethane at 20℃;	90%

: 626-55-1
3-Bromopyridine

: 109-72-8, 29786-93-4
n-butyllithium

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
Stage #1: 3-Bromopyridine; n-butyllithium In toluene at -50℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -50 - -15℃;	90%

...Expand

: 1193-92-6
3-pyridinealdoxime

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With 2,6-dicarboxypyridinium fluorochromate for 0.333333h;	90%
With dihydrogen peroxide; phosphotungstic acid In various solvent(s) at 20℃; for 5h; Product distribution; Further Variations:; Catalysts;	76%
With oxygen; benzaldehyde In benzonitrile; toluene at 60℃; for 2.58333h; Green chemistry;

: 626-55-1
3-Bromopyridine

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 60℃; for 16h; Schlenk technique; Inert atmosphere;	90%

: 1120-90-7
3-iodopyridine

: 124-38-9
carbon dioxide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	89%
With rhodium(III) iodide; hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;	60%

: 108-99-6
3-Methylpyridine

: 2196-95-4, 17213-48-8
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A: 110-86-1
pyridine

B: 500-22-1
3-pyridinecarboxaldehyde

C: 59-67-6
nicotinic acid

D: 2415-33-0
2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions

Conditions	Yield
at 140℃; for 14h; Product distribution;	A 5% B 18% C 60% D 88%
at 140℃; for 14h; Further byproducts given;	A 5% B 18% C 60% D 88%

...Expand

: 2196-95-4, 17213-48-8
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A: 110-86-1
pyridine

B: 500-22-1
3-pyridinecarboxaldehyde

C: 59-67-6
nicotinic acid

D: 2415-33-0
2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions

Conditions	Yield
With 3-Methylpyridine at 140℃; for 14h; Further byproducts given;	A 5% B 18% C 60% D 88%

...Expand

: 3731-52-0
3-Aminomethylpyridine

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry;	88%
Multi-step reaction with 2 steps 1: 85 percent / CH2Cl2 / 12 h 2: 15 percent / NaOMe / methanol / 35 deg C -> 20 deg C, 2 h View Scheme

: 98-92-0
nicotinamide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.166667h;	86%
With lithium-tris(diethylamino)hydridoaluminate In tetrahydrofuran for 12h; Ambient temperature;	53%

: 108-99-6
3-Methylpyridine

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With N-hydroxyphthalimide; oxygen; nitric acid; acetic acid at 40℃; under 1520.1 Torr; for 5h; Temperature; Pressure; Reagent/catalyst; Autoclave; Sealed tube;	85%
With tert.-butylhydroperoxide at 120℃; for 5h; Sealed tube; Green chemistry;	80%
With oxygen; V-Mo oxide at 370 - 430℃; Mechanism;
With selenium(IV) oxide
With oxygen In water at 290℃; under 760.051 Torr; Reagent/catalyst;

: 95091-91-1
N-methoxy-N-methylpyridine-3-carboxamide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.25h;	85%
With lithium diisobutyl-tert-butoxyaluminum hydride In tetrahydrofuran; hexane at 0℃; Inert atmosphere; chemoselective reaction;	> 99 %Chromat.

: 69966-55-8
3-picolyl bromide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With oxygen; kieselguhr; copper(l) chloride In hexane for 2.5h; Oxidation; Heating;	84%

: 79-46-9
2-nitropropane

: 3-(bromomethyl)pyridine hydrobromide

A: 500-22-1
3-pyridinecarboxaldehyde

B: 36757-33-2
α-(1-methyl-1-nitroethyl)-3-pyridinemethanol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran Hass-Bender/Henry reaction;	A n/a B 84%

...Expand

: 6281-93-2
C13H13N3O3S

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With sodium carbonate In ethylene glycol for 0.025h; McFadyen-Stevens reaction; microwave irradiation;	82%

: 1120-90-7
3-iodopyridine

: 201230-82-2
carbon monoxide

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With sodium formate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 8h;	80%
With sodium formate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 10h;	79%
With palladium(II) acetylacetonate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-diphenylphosphinomethane In toluene at 100℃; under 7500.75 Torr; for 10h; Autoclave;	78%

: 626-55-1
3-Bromopyridine

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With carbon monoxide; triethylamine In benzene	80%

: 3-<(methylsulfinyl)(methylsulfanyl)methyl>pyridine

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With tetrafluoroboric acid In tetrahydrofuran; water for 192h; Ambient temperature;	78%

: 1120-90-7
3-iodopyridine

: 82102-37-2
9-methyl-9H-fluorene-9-carbonyl chloride

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 80℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;	78%

: 16837-38-0
nicotinic anhydride

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With P(p-CH3OC6H4)3; methylphenylsilane; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 20h; Schlenk technique; Inert atmosphere;	75%

: 1120-90-7
3-iodopyridine

: 64-18-6
formic acid

: 500-22-1
3-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	71%
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 2h; Sealed tube;	70%

: 500-22-1
3-pyridinecarboxaldehyde

: 613-94-5
benzoic acid hydrazide

: 1215-53-8
(E)-N'-(pyridin-3-ylmethylene)benzohydrazide

Conditions

Conditions	Yield
at 205℃; under 4350.44 Torr; for 0.0666667h; Microwave irradiation; neat (no solvent);	100%
In ethanol for 3h; Heating;	89%
With hydrogenchloride In ethanol at 20℃; for 0.5h; Condensation;	84%

: 500-22-1
3-pyridinecarboxaldehyde

: 51892-16-1
nicotinaldehyde oxime

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In ethanol	100%
With hydroxylamine hydrochloride; sodium acetate In methanol; water for 0.5h; Reflux;	58%
With hydroxylamine hydrochloride; sodium hydroxide In water at 20℃; for 0.5h;	47%

: 500-22-1
3-pyridinecarboxaldehyde

: 5344-90-1
2-Aminobenzyl alcohol

: 134778-04-4
2-Pyridin-3-yl-1,4-dihydro-2H-benzo[d][1,3]oxazine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 31523-22-5
3-hydrazino-5H-[1,2,4]triazino[5,6-b]indole

: 73718-28-2
3-(Pyridine-3-aldehyde)hydrazono-1,2,4-triazino<5,6-b>indole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Heating;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 932-30-9
2-Hydroxybenzylamine

: 134778-03-3
2-Pyridin-3-yl-3,4-dihydro-2H-benzo[e][1,3]oxazine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 14838-15-4
u-2-amino-1-phenylpropan-1-ol

: 134778-06-6, 134778-07-7, 134876-47-4, 134876-48-5
3-((4S,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature; Further byproducts given;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 37577-07-4
Norpseudoephedrine

: 134778-06-6, 134778-07-7, 134876-47-4, 134876-48-5
3-((4R,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature; Further byproducts given;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 151-50-8
potassium cyanide

: 17604-74-9
2-hydroxy-2-(pyridin-3-yl)acetonitrile

Conditions

Conditions	Yield
With water; acetic acid at 5 - 10℃; for 2h;	100%
With hydrogenchloride
With acetic acid In water for 18h; Ambient temperature;

: 500-22-1
3-pyridinecarboxaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 134778-05-5
3-(4,4-Dimethyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 63-74-1
sulfanilamide

: 74028-05-0
N4-(3-pyridylidene) sulfanilamide

Conditions

Conditions	Yield
at 150 - 155℃; for 0.0833333h;	100%
In ethanol for 3h; Heating;

: 500-22-1
3-pyridinecarboxaldehyde

: 292638-85-8
acrylic acid methyl ester

: 87102-11-2
methyl 2-[hydroxy(pyridin-3-yl)methyl]propenoate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; water at 20℃; for 8h; Baylis-Hillman reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 0.75h; Baylis-Hillman reaction; neat (no solvent);	100%
With uracil-Cu2+ nanoparticles immobilized on alpha-zirconium hydrogen phosphate In N,N-dimethyl-formamide at 20℃; for 8.5h; Morita-Baylis-Hillman Alkylation;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 2,3-dimethylquinolizinium perchlorate

: 3-Methyl-2-((E)-2-pyridin-3-yl-vinyl)-quinolizinylium; perchlorate

Conditions

Conditions	Yield
With piperidine In acetonitrile for 4h; Heating;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 156-87-6
propan-1-ol-3-amine

: 134778-02-2
2-Pyridin-3-yl-[1,3]oxazinane

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 94-09-7
p-aminoethylbenzoate

: 25927-67-7
ethyl p-(3-pyridylmethyleneamino)benzoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux;	100%
toluene-4-sulfonic acid In toluene for 12h; Reflux;	100%
In benzene for 6h; Heating;	98.5%

: 500-22-1
3-pyridinecarboxaldehyde

: 107-13-1
acrylonitrile

: 3-hydroxy-2-methylene-3-(3-pyridyl)propanenitrile

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 0.833333h; Morita-Baylis-Hillman reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 0℃; for 0.833333h; Catalytic behavior; Solvent; Temperature; Time; Morita-Baylis-Hillman Alkylation;	100%
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 0.2h; Baylis-Hillman reaction; neat (no solvent);	99%

: 500-22-1
3-pyridinecarboxaldehyde

: 6926-44-9
phenethyl azide

: phenethyl-pyridin-3-ylmethylene-amine

Conditions

Conditions	Yield
With triphenylphosphine-bound polystyrene In tetrahydrofuran at 20℃; for 24h; Staudinger/Aza-Wittig reaction;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 2101-87-3
p-methoxy-phenylazide

: N-(4-methoxyphenyl)-N-[(E)-1-(3-pyridyl)methylidene]amine

Conditions

Conditions	Yield
With triphenylphosphine-bound polystyrene In tetrahydrofuran at 20℃; for 24h; Staudinger/Aza-Wittig reaction;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 106-49-0
p-toluidine

: 110684-48-5
3-<(4-methylphenyl)iminomethyl>pyridine

Conditions

Conditions	Yield
at 120 - 130℃; for 2.5h;	100%
In ethanol Heating;
With sulfonic acid supported on hydroxyapatite-γ-Fe2O3 In ethanol

: 500-22-1
3-pyridinecarboxaldehyde

: 1193-92-6
3-pyridinealdoxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol for 0.416667h; Heating;	100%
With hydroxylamine hydrochloride	100%
With hydroxylamine hydrochloride; triethylamine In methanol at 80℃; Inert atmosphere;	92%

: 500-22-1
3-pyridinecarboxaldehyde

: 107-15-3
ethylenediamine

: N,N’-bis[1-pyridin-3-ylmeth-(E)-ylidene]ethane-1,2-diamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
With iron(III) chloride In methanol at 20℃; for 0.5h;	90%
In methanol for 3h; Heating;	85%
In methanol at 80℃; for 0.5h;	47%
In methanol for 0.166667h;

: 500-22-1
3-pyridinecarboxaldehyde

: 104-94-9
4-methoxy-aniline

: 41855-73-6
3-<(4-methoxyphenyl)iminomethyl>pyridine

Conditions

Conditions	Yield
In ethanol for 1h; Sonication;	100%
With acetic acid In ethanol at 85℃; for 12h;	50.3%
In tetrahydrofuran for 0.5h; Heating;

: 500-22-1
3-pyridinecarboxaldehyde

: 110-60-1
1,4-diaminobutane

: N,N-bis-(pyridin-3-ylmethylene)butane-1,4-diamine

Conditions

Conditions	Yield
In ethanol Heating;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 56613-80-0
(R)-Phenylglycinol

: C14H14N2O

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1000387-97-2
((R)-1-Phenyl-ethyl)-[1-pyridin-3-yl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%
In dichloromethane at 20℃; for 48h;

: 500-22-1
3-pyridinecarboxaldehyde

: 2393-23-9
4-methoxy-benzylamine

: C14H14N2O

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 64715-85-1, 91298-74-7, 127180-88-5
(R)-2-methoxy-1-phenylethylamine

: C15H16N2O

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 725229-81-2
4-[bromo-(piperidin-4-ylidene)methyl]-N,N-diethylbenzamide

: 725242-76-2
4-[bromo[1-(3-pyridinylmethyl)-4-piperidinylidene]methyl]-N,N-diethyl-benzamide

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 18h;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 154464-26-3
3-(cyclopentyloxy)-4-methoxybenzenamine

: 3-Cyclopentyl-4-methoxy-N-(pyridin-3-ylmethyl)aniline

Conditions

Conditions	Yield
Stage #1: 3-pyridinecarboxaldehyde; 3-(cyclopentyloxy)-4-methoxybenzenamine With toluene-4-sulfonic acid In methanol for 4h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 20h;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 286932-63-6
4-(2,4-difluorophenoxy)aniline

: 353235-61-7
N-(4-(2,4-difluorophenoxy)phenyl)pyrid-3-ylmethyleneamine

Conditions

Conditions	Yield
In methanol at 55℃; for 3h;	100%

3-Pyridinecarboxaldehyde Chemical Properties

IUPAC Name: Pyridine-3-carbaldehyde
Systematic of 3-Pyridinaldehyde (CAS NO.500-22-1): 3-Formylpyridine ; 3-Pyridenecarboxaldehyde ; 3-Pyridinealdehyde ; 3-Pyridylaldehyde ; 3-Pyridylcarboxaldehyde ; 5-21-07-00334 (Beilstein Handbook Reference) ; AI3-33231 ; BRN 0105343 ; EINECS 207-900-4 ; NSC 8952 ; Nicotinealdehyde ; Nicotinic aldehyde ; Pyridine-3-carbaldehyde ; Rowalind ; beta-Pyridinecarbonaldehyde
CAS NO: 500-22-1
Molecular Formula of 3-Pyridinaldehyde (CAS NO.500-22-1): C₆H₅NO
Molecular Weight: 107.11
Molecular Structure:

ProductCategories: Pyridine ; Heterocyclic Compounds
Melting Point: 8°C
Polar Surface Area: 29.96 Å²
Index of Refraction: 1.573
Molar Refractivity: 31.09 cm³
Molar Volume: 94.3 cm³
Surface Tension: 46.6 dyne/cm
Density of 3-Pyridinaldehyde (CAS NO.500-22-1): 1.135 g/cm³
Flash Point: 60 °C
Enthalpy of Vaporization: 44.62 kJ/mol
Boiling Point: 209.9 °C at 760 mmHg
Vapour Pressure: 0.198 mmHg at 25°C

3-Pyridinecarboxaldehyde Uses

Nicotinaldehyde(500-22-1) is mainly used as the intermediates of pymetrozine.

3-Pyridinecarboxaldehyde Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD25	intraperitoneal	720mg/kg (720mg/kg)		Journal of Pharmaceutical Sciences. Vol. 64, Pg. 528, 1975.

3-Pyridinecarboxaldehyde Consensus Reports

Reported in EPA TSCA Inventory.

3-Pyridinecarboxaldehyde Safety Profile

Hazard Codes: Irritant Xi, Corrosive C,Xn
Risk Statements: 10-42/43-41-34-22-36/37/38
R10: Flammable.
R42/43: May cause sensitization by inhalation and skin contact.
R41: Risk of serious damage to the eyes.
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-45-36/37/39-23
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S23: Do not breathe vapour.
RIDADR: UN 1989 3/PG 3
WGK Germany: 3
RTECS: QS2980000
F: 8-10-23
Hazard Note: Irritant/Keep Cold/Air Sensitive
HazardClass: 3.2
PackingGroup: III
HS Code: 29333999

Product Name

3-Pyridinecarboxaldehyde

Synthetic route

3-Pyridinecarboxaldehyde Chemical Properties

3-Pyridinecarboxaldehyde Uses

3-Pyridinecarboxaldehyde Toxicity Data With Reference

3-Pyridinecarboxaldehyde Consensus Reports

3-Pyridinecarboxaldehyde Safety Profile

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