4-Acetamidobenzenesulfonamide supplier

Name
4-Acetamidobenzenesulfonamide
EINECS 204-486-7
CAS No. 121-61-9
Article Data59
CAS DataBase
Density 1.414 g/cm³
Solubility slightly soluble in water
Melting Point 214-217 °C
Formula C₈H₁₀N₂O₃S
Boiling Point 418.91℃[at 101 325 Pa]
Molecular Weight 214.245
Flash Point
Transport Information
Appearance White to light beige crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Acetanilide,4'-sulfamoyl- (6CI,7CI,8CI);4-Acetylaminobenzenesulfonamide;4'-Sulfamoylacetanilide;A-319;Acetylsulfanilamide;Benzenesulfonamide, 4-(acetylamino)-;Erytrin;N-(4-Sulfamoylphenyl)acetamide;N-[4-(Aminosulfonyl)phenyl]acetamide;N4-Acetsulfanilamide;N4-Acetylsulfanilamide;NSC 217;NSC 406839;Neotherapol;N'-Acetylsulphanilamide;Sulfanilamide-N4-acetate;p-(Acetylamino)benzenesulfonamide;p-Acetamidobenzenesulfonamide;p-Sulfamoylacetanilide;p-Sulfamylacetanilide;
PSA 97.64000
LogP 2.14650

Synthetic route

: 108-24-7
acetic anhydride

: 63-74-1
sulfanilamide

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
at 20℃; for 1h;	100%
In ethanol at 20 - 70℃; for 0.0166667h; other time tested;

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With C64H104N2O29; ammonium chloride; zinc In water at 20℃; for 2h; Inert atmosphere;	100%
With Decaborane; palladium on activated charcoal In methanol at 20℃; for 0.333333h;	98%
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 2h;	98%

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With ammonia In dichloromethane at 20℃; for 0.166667h;	99%
With ammonia	88%
With ammonium hydroxide at 0℃;	82%

: 579479-65-5
ethyl o-vinylbenzoyl acetate

A: 579479-51-9
ethyl (o-vinylbenzoyl)diazoacetate

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 0 - 20℃; for 16h;	A 95.8% B n/a

: 91430-85-2
N-Isopropyl-p-acetamido-benzol-sulfonamid

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With chromium(III) acetate hydroxide; periodic acid In acetonitrile at 20℃; for 14h;	90%

: N-[4-({(E)-[methyl(phenyl)amino]methylidene}sulfamoyl)phenyl]acetamide

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; for 1.5h;	87%

: 63-74-1
sulfanilamide

: 75-36-5
acetyl chloride

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With potassium carbonate In acetone at 0 - 30℃; for 11h;	80.8%
With sodium hydroxide at 20℃;

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 108-18-9
diisopropylamine

: 198827-85-9
N-1-propargylthymine

A: 1422277-71-1
(E)-N1,N1-diisopropyl-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 25℃; for 24h;	A 78% B n/a

...Expand

: 120085-82-7
N-(acetoacetyl)-N-methyl-6-heptynamide

A: 120085-83-8
N-(diazoacetoacetyl)-N-methyl-6-heptynamide

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile for 24h; Ambient temperature;	A 70% B n/a

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 109-89-7
diethylamine

: 198827-85-9
N-1-propargylthymine

A: 1422277-72-2
N1,N1-diethyl-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 25℃; for 24h;	A 64% B n/a

...Expand

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 1003-03-8
Cyclopentamine

: 198827-85-9
N-1-propargylthymine

A: 1422277-74-4
N1-cyclopentyl-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 25℃; for 24h;	A 58% B n/a

...Expand

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 75-31-0
isopropylamine

: 198827-85-9
N-1-propargylthymine

A: 1422277-73-3
N1-isopropyl-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 25℃; for 24h;	A 54% B n/a

...Expand

: 580-15-4
6-aminoquinoline

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 198827-85-9
N-1-propargylthymine

A: 1422277-75-5
N1-(quinolin-6-yl)-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 25℃; for 24h;	A 54% B n/a

...Expand

: 120085-84-9
N-(acetoacetyl)-5-benzyloxy-N-methyl-6-heptynamide

A: 120085-85-0
N-(diazoacetoacetyl)-5-benzyloxy-N-methyl-6-heptynamide

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile for 24h; Ambient temperature;	A 47% B n/a

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 15996-76-6
4-cyanobenzylamine hydrochloride

: 198827-85-9
N-1-propargylthymine

A: 1422277-76-6
N1-(4-cyanobenzyl)-N2-(4-acetoamidobenzene-1-sulfonyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamidine

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
Stage #1: 4-cyanobenzylamine hydrochloride; N-1-propargylthymine With copper(l) iodide; triethylamine In dichloromethane Stage #2: 4-acetamidobenzenesulfonyl azide In dichloromethane at 25℃; for 24h;	A 45% B n/a

...Expand

: N-[4-({[(4-oxo-4H-1,3-benzoxazin-2-yl)methyl]amino}sulfonyl)phenyl]acetamide

: 100-63-0
phenylhydrazine

A: C23H21N5O4S

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With pyridine for 0.0833333h; Reflux; Microwave irradiation;	A 42% B n/a

...Expand

: N-[4-({[(4-oxo-4H-1,3-benzoxazin-2-yl)methyl]amino}sulfonyl)phenyl]acetamide

: 62-53-3
aniline

A: C23H20N4O4S

B: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With pyridine; acetic acid In N,N-dimethyl-formamide Heating;	A 19% B 34%

...Expand

: 108-24-7
acetic anhydride

: 64-19-7
acetic acid

: 63-74-1
sulfanilamide

: 121-61-9
p-acetylaminobenzenesulfonamide

...Expand

: 2828-63-9
4-acetylamino-N-carbamoyl-benzenesulfonamide

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With pyridine; quinoclamine

: 2158-14-7
4-acetamidobenzenesulfonyl azide

A: 121-61-9
p-acetylaminobenzenesulfonamide

B: 27491-70-9, 28447-24-7, 25411-73-8
dimethyl diazomethylphosphonate

Conditions

Conditions	Yield
With triethylamine; dimethyl (3,3,3-trifluoro-2,2-dihydroxypropyl)phosphonate In acetonitrile at 0 - 20℃;

: 153650-87-4
dimethyl (3,3,3-trifluoro-2,2-dihydroxypropyl)phosphonate

A: 121-61-9
p-acetylaminobenzenesulfonamide

B: 27491-70-9, 28447-24-7, 25411-73-8
dimethyl diazomethylphosphonate

Conditions

Conditions	Yield
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile at 0 - 20℃;	A n/a B 1.23 g

: 623-11-0
1-methyl-4-nitrosobenzene

: ammonium hydroxide

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

A: 185117-46-8
bis(acetylaminobenzenesulfon)imide

B: 121-61-9
p-acetylaminobenzenesulfonamide

...Expand

: 110-86-1
pyridine

: 2158-14-7
4-acetamidobenzenesulfonyl azide

A: 96748-88-8
N-<4-(acetylamino)benzenesulphonyliminol>pyridinium ylide

B: 181359-93-3
N-acetyl-sulfanilic acid-(4-acetylamino-anilide)

C: 121-61-9
p-acetylaminobenzenesulfonamide

D compound C13H15N3O3S: compound C13H15N3O3S

...Expand

: N-(N-acetyl-sulfanilyl)-2-(2-nitro-phenyl)-acetimidic acid ethyl ester

: 67-64-1
acetone

platinum: platinum

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 103-84-4
Acetanilid

A: 121-61-9
p-acetylaminobenzenesulfonamide

B (S)-2-phenyl-butyryl chloride: (S)-2-phenyl-butyryl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 97 percent / ClSO3H 2: 88 percent / ammonia View Scheme

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 395065-67-5
methyl (5S)-5-(3-fluorophenyl)-3-oxo-6-heptenoate

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In 1,2-dichloro-ethane

: 121-61-9
p-acetylaminobenzenesulfonamide

: 6101-31-1, 34612-79-8
sulfanilamide hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol for 2.5h; Reflux;	99.5%

: 3972-65-4
1-bromo-4-tert-butylbenzene

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-(4-(N-(4-(tert-butyl)phenyl)sulfamoyl)phenyl)acetamide

Conditions

Conditions	Yield
With (1,2-dimethoxyethane)dichloronickel(II); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; N,N,N',N'-tetramethylguanidine In acetonitrile at 55℃; for 48h; Temperature; Inert atmosphere; Irradiation; Sealed tube;	99%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 121-61-9
p-acetylaminobenzenesulfonamide

: 1344029-99-7
N-[4-({[(dimethylamino)methylidene]amino}sulfonyl)phenyl]acetamide

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; under 760.051 Torr; for 0.25h; Green chemistry;	97%

: 98-88-4
benzoyl chloride

: 121-61-9
p-acetylaminobenzenesulfonamide

: 5661-33-6
N-benzoyl-4-(acetamido)benzenesulfonamide

Conditions

Conditions	Yield
With magnetic composite Fe3O4 Diatomite earth In tetrahydrofuran at 50℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Solvent;	95%
With toluene
With pyridine

: 97942-31-9
2-Chloromethyl-5-(4-chloro-phenoxymethyl)-[1,3,4]oxadiazole

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-(4-{[5-(4-Chloro-phenoxymethyl)-[1,3,4]oxadiazol-2-ylmethyl]-sulfamoyl}-phenyl)-acetamide

Conditions

Conditions	Yield
With potassium carbonate In methanol at 250℃; for 5h;	95%

: 39650-82-3
2,2-dimethoxy-1-methylpyrrolidine

: 121-61-9
p-acetylaminobenzenesulfonamide

: 124869-79-0
N-{4-[1-Methyl-pyrrolidin-(2E)-ylidenesulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	95%

: 75256-21-2
1-Methyl-2,2-dimethoxypiperidine

: 121-61-9
p-acetylaminobenzenesulfonamide

: 93100-98-2
N-{4-[1-Methyl-piperidin-(2E)-ylidenesulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	95%

: 84859-26-7
1-Ethyl-2,2-dimethoxy-pyrrolidine

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-{4-[1-Ethyl-pyrrolidin-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	94%

: 108-24-7
acetic anhydride

: 121-61-9
p-acetylaminobenzenesulfonamide

: 5626-90-4
N-acetyl-4-(acetamido)benzenesulfonamide

Conditions

Conditions	Yield
With magnetic composite Fe3O4 Diatomite earth In tetrahydrofuran at 50℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Solvent;	93%

: 39650-81-2
1-Methyl-2,2-dimethoxyhexahydroazepine

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-{4-[1-Methyl-azepan-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	93%

: 2213-63-0
2,3-dichloroquinoxaline

: 121-61-9
p-acetylaminobenzenesulfonamide

: 4029-42-9
4-acetylamino-N-(3-chloro-quinoxalin-2-yl)-benzenesulfonamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 1h; Heating;	92%

: 121-61-9
p-acetylaminobenzenesulfonamide

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 128924-65-2
C16H14F3N3O4S

Conditions

Conditions	Yield
With sodium hydroxide In acetone	90%

: C4Br2F8O3S

: 121-61-9
p-acetylaminobenzenesulfonamide

: C12H9Br2F7N2O6S2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 90℃; for 120h; Inert atmosphere;	87.5%

: 1316755-26-6
N-ethyl-2,3-diaza-spiro[4.4]non-3-ene-2-carboximidothioic acid methyl ester

: 121-61-9
p-acetylaminobenzenesulfonamide

: 1316755-27-7
N-(4-{[(2,3-diaza-spiro[4.4]non-3-en-2-yl)-ethylamino-methylene]-sulfamoyl}-phenyl)-acetamide

Conditions

Conditions	Yield
In acetonitrile Reflux;	87%

: 2432-51-1
ethylthioacetic acid methyl ester

: 121-61-9
p-acetylaminobenzenesulfonamide

: 5661-36-9
4-(acetamido)-N-butyryl-benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: p-acetylaminobenzenesulfonamide With N-Bromosuccinimide; iron(II) chloride In acetonitrile at 20℃; for 0.0166667h; Stage #2: S-methyl ester butanethioic acid In acetonitrile at 45℃; for 12h;	86%

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 121-61-9
p-acetylaminobenzenesulfonamide

: 1344029-99-7
N-[4-({[(dimethylamino)methylidene]amino}sulfonyl)phenyl]acetamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; sodium iodide In water at 90℃; for 3h;	86%

: 626-67-5
N-methylcyclohexylamine

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-(4-(N-(piperidin-1-ylmethylene)sulfamoyl)phenyl)acetamide

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In ethanol at 20℃; for 12h; Electrochemical reaction; Inert atmosphere; regioselective reaction;	84%

: 4921-49-7
8-chlorocaffeine

: 121-61-9
p-acetylaminobenzenesulfonamide

: 155581-81-0
4-acetylamino-N-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonamide

Conditions

Conditions	Yield
With pyridine for 3h; Heating;	83%
With potassium carbonate

: 74255-10-0
1-Butyl-2,2-dimethoxy-pyrrolidine

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-{4-[1-Butyl-pyrrolidin-(2Z)-ylidenesulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	82%

: [5-(5-Chloromethyl-[1,3,4]oxadiazol-2-yl)-2-(3-chloro-phenyl)-4-methoxy-2H-pyrazol-3-yl]-(4-nitro-phenyl)-diazene

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-[4-({5-[1-(3-Chloro-phenyl)-4-methoxy-5-(4-nitro-phenylazo)-1H-pyrazol-3-yl]-[1,3,4]oxadiazol-2-ylmethyl}-sulfamoyl)-phenyl]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In methanol for 10h; Heating;	82%

: 110-82-7
cyclohexane

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-cyclohexyl 4-(acetamido)benzenesulfonamide

Conditions

Conditions	Yield
With di-tert-butyl peroxide; copper diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine In acetonitrile at 25℃; for 12h; Inert atmosphere; Irradiation; chemoselective reaction;	82%

: 113604-00-5
2-(chloromethyl)-5-(pyridin-4-yl)-1,3,4-oxadiazole

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-{4-[(5-Pyridin-4-yl-[1,3,4]oxadiazol-2-ylmethyl)-sulfamoyl]-phenyl}-acetamide

Conditions

Conditions	Yield
With potassium carbonate In methanol at 250℃; for 5h;	80%

: [5-(5-Chloromethyl-[1,3,4]oxadiazol-2-yl)-2-(3-chloro-phenyl)-4-methoxy-2H-pyrazol-3-yl]-phenyl-diazene

: 121-61-9
p-acetylaminobenzenesulfonamide

: N-[4-({5-[1-(3-Chloro-phenyl)-4-methoxy-5-phenylazo-1H-pyrazol-3-yl]-[1,3,4]oxadiazol-2-ylmethyl}-sulfamoyl)-phenyl]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In methanol for 10h; Heating;	80%

4-Acetamidobenzenesulfonamide Chemical Properties

Product Name: N4-Acetylsulfanilamide (CAS NO.121-61-9)

Molecular Formula: C₈H₁₀N₂O₃S
Molecular Weight: 214.24g/mol
Mol File: 121-61-9.mol
EINECS: 204-486-7
Melting Point: 214-217 °C
Density: 1.414 g/cm³
Water Solubility: slightly soluble
Surface Tension: 61.8 dyne/cm
XLogP3-AA: 0
H-Bond Donor: 2
H-Bond Acceptor: 4
Structure Descriptors of N4-Acetylsulfanilamide (CAS NO.121-61-9):
IUPAC Name: N-(4-sulfamoylphenyl)acetamide
Canonical SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N
InChI: InChI=1S/C8H10N2O3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
InChIKey: PKOFBDHYTMYVGJ-UHFFFAOYSA-N

4-Acetamidobenzenesulfonamide Safety Profile

Safety Information of N4-Acetylsulfanilamide (CAS NO.121-61-9):
Hazard Codes: Xi
Safety Statements: 24/25
24: Avoid contact with skin
25: Avoid contact with eyes
RTECS: AE7015000
Hazard Note: Irritant

4-Acetamidobenzenesulfonamide Specification

N4-Acetylsulfanilamide , its CAS NO. is 121-61-9, the synonyms are 4'-Sulfamoylacetanilide ; 4-14-00-02704 (Beilstein Handbook Reference) ; 4-Acetylaminobenzenesulfonamide ; A-319 ; AI3-08023 ; Acetylsulfanilamide ; BRN 0746675 ; Benzenesulfonamide, 4-(acetylamino)- ; Benzenesulfonamide, p-acetamido- ; CCRIS 6813 ; EINECS 204-486-7 ; Erytrin ; N'-Acetylsulphanilamide ; N(sup 4)-Acetylsulfanilamide ; N-(4-(Aminosulfonyl)phenyl)acetamide ; N-(4-Sulphamoylphenyl)acetamide ; N-4-Acetylsulfanilamide ; NSC 217 ; Neotherapol ; Sulfanilamide-N(sup 4)-acetate ; Sulfanilamide-N4-acetate ; p-(Acetylamino)benzenesulfonamide ; p-Acetamidobenzenesulfonamide ; p-Sulfamylacetanilide .

Product Name

4-Acetamidobenzenesulfonamide

Synthetic route

4-Acetamidobenzenesulfonamide Chemical Properties

4-Acetamidobenzenesulfonamide Safety Profile

4-Acetamidobenzenesulfonamide Specification

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