Product Name

  • Name

    4-PHENOXYBENZOIC ACID

  • EINECS 218-682-5
  • CAS No. 2215-77-2
  • Article Data69
  • CAS DataBase
  • Density 1.241 g/cm3
  • Solubility
  • Melting Point 163-165 °C(lit.)
  • Formula C13H10O3
  • Boiling Point 364.2 °C at 760 mmHg
  • Molecular Weight 214.221
  • Flash Point 141.7 °C
  • Transport Information
  • Appearance white to slightly yellow crystalline powder
  • Safety 26-37/39-36/37/39-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 2215-77-2 (4-PHENOXYBENZOIC ACID)
  • Hazard Symbols IrritantXi
  • Synonyms Benzoicacid, p-phenoxy- (6CI,7CI,8CI);4-Phenoxybenzoic acid;NSC 246039;p-Phenoxybenzoic acid;
  • PSA 46.53000
  • LogP 3.17710

Synthetic route

methyl 4-phenoxybenzoate
21218-94-0

methyl 4-phenoxybenzoate

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
Stage #1: methyl 4-phenoxybenzoate With water; sodium hydroxide In 1,4-dioxane at 20℃;
Stage #2: With hydrogenchloride In water
100%
With water; sodium hydroxide In ethanol at 20 - 70℃; for 1h;95%
With titanium(IV) oxide; dihydrogen peroxide; sodium hydroxide at 50℃; for 5h; Temperature;92%
4-phenoxybenzonitrile
3096-81-9

4-phenoxybenzonitrile

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide; potassium hydroxide In methanol; ethanol for 4.5h; Reflux;96%
With potassium phosphate buffer at 30℃; for 72h; Rhodococcus sp. AJ270 cells;59.3%
With potassium hydroxide
carbon monoxide
201230-82-2

carbon monoxide

4-phenoxyanilin
139-59-3

4-phenoxyanilin

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With tert.-butylnitrite; methanesulfonic acid; Ru(2,2'-bipyridine)3Cl2·6H2O; water In acetonitrile at 20℃; for 16h; Autoclave; Irradiation;95%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

phenol
108-95-2

phenol

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 12h;92%
Stage #1: phenol With sodium hydroxide In water at 60℃; for 2h;
Stage #2: para-chlorobenzoic acid In tetralin at 150℃; for 10h; Temperature;
89%
carbon monoxide
201230-82-2

carbon monoxide

4-phenoxybenzene-1-diazonium tetrafluoroborate

4-phenoxybenzene-1-diazonium tetrafluoroborate

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With Ru(2,2'-bipyridine)3Cl2·6H2O; water In acetonitrile at 20℃; under 7500.75 Torr; for 3h; Autoclave; Irradiation;91%
Ethyl 4-hydroxybenzoate
120-47-8

Ethyl 4-hydroxybenzoate

fluorobenzene
462-06-6

fluorobenzene

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
Stage #1: Ethyl 4-hydroxybenzoate; fluorobenzene With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;
Stage #2: With lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 0.5h;
90%
4-phenoxybenzoic acid ethyl ester
31994-68-0

4-phenoxybenzoic acid ethyl ester

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran; ethanol Reflux;89%
With water; sodium hydroxide In ethanol for 3h; Reflux;87%
With sodium hydroxide In ethanol; water for 3h; Reflux;75%
4-phenoxyphenylglyoxal
70-97-3

4-phenoxyphenylglyoxal

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With iodine; dimethyl sulfoxide at 180℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;88%
4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

carbon dioxide
124-38-9

carbon dioxide

A

diphenylether
101-84-8

diphenylether

B

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 10h; Ambient temperature; electrochemically;A 1 mmol
B 86%
1-(4-ethynylphenoxy)benzene
4200-06-0

1-(4-ethynylphenoxy)benzene

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry;83%
4-phenoxyacetophenone
5031-78-7

4-phenoxyacetophenone

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hypochlorite In ethanol; water80%
With potassium hypochlorite
With sodium hydroxide; water; bromine In ethanol at 40℃; for 3h;
2-chloro-1-(4-(phenoxy)phenyl)ethanone
13075-63-3

2-chloro-1-(4-(phenoxy)phenyl)ethanone

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite; trimethylbenzylammonium bromide; sodium hydroxide In dichloromethane at 0 - 20℃;76.7%
carbon dioxide
124-38-9

carbon dioxide

2-(4-phenoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

2-(4-phenoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-phenoxyphenyl)-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave;
Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;
75%
4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

carbon dioxide
124-38-9

carbon dioxide

potassium carbonate
584-08-7

potassium carbonate

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; 2.9-dimethyl-1,10-phenanthroline; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C60H36N2 In N,N-dimethyl-formamide at 20℃; for 24h; Molecular sieve; Irradiation;68%
1-(4-phenoxyphenyl)cyclohexan-1-ol

1-(4-phenoxyphenyl)cyclohexan-1-ol

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With iron(III) chloride; cerium(III) chloride; tetrabutyl-ammonium chloride; oxygen In acetonitrile at 20℃; under 760.051 Torr; for 24h; Schlenk technique; Irradiation;58%
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

diethyl ether
60-29-7

diethyl ether

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
at 26℃; anschliessende Behandlung mit festem CO2;
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

diethyl ether
60-29-7

diethyl ether

4-phenoxyiodobenzene
2974-94-9

4-phenoxyiodobenzene

A

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

B

5-iodo-2-phenoxy-benzoic acid
69199-91-3

5-iodo-2-phenoxy-benzoic acid

Conditions
ConditionsYield
at 20 - 35℃; anschliessende Behandlung mit festem CO2;
4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

diethyl ether
60-29-7

diethyl ether

propyllithium
2417-93-8

propyllithium

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
at 26℃; anschliessende Behandlung mit festem CO2;
4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With diethyl ether; propyllithium anschliessend mit festem Kohlendioxid behandeln;
With n-butyllithium; diethyl ether anschliessend mit festem Kohlendioxid behandeln;
4-phenoxy benzaldehyde
67-36-7

4-phenoxy benzaldehyde

A

(4-phenoxyphenyl)methanol
2215-78-3

(4-phenoxyphenyl)methanol

B

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With potassium hydroxide at 60℃;
4-phenoxy benzaldehyde
67-36-7

4-phenoxy benzaldehyde

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With silver(l) oxide
With potassium permanganate
With rat hepatic microsomal aldehyde dehydrogenase; NAD In phosphate buffer; N,N-dimethyl-formamide at 37℃; pH=7.4; Enzyme kinetics; Dehydrogenation;
With potassium permanganate Alkaline aq. solution;
With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water In tetrahydrofuran; tert-butyl alcohol Pinnick oxidation;
4-phenoxytoluene
1706-12-3

4-phenoxytoluene

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
With potassium permanganate; water
With sodium dichromate; sulfuric acid; acetic acid
4-phenoxybenzamide
29921-15-1

4-phenoxybenzamide

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

diethyl ether
60-29-7

diethyl ether

4-phenoxyiodobenzene
2974-94-9

4-phenoxyiodobenzene

phenyllithium
591-51-5

phenyllithium

A

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

B

5-iodo-2-phenoxy-benzoic acid
69199-91-3

5-iodo-2-phenoxy-benzoic acid

Conditions
ConditionsYield
at 20 - 35℃; anschliessende Behandlung mit festem CO2;
carbon dioxide
124-38-9

carbon dioxide

4-phenoxyiodobenzene
2974-94-9

4-phenoxyiodobenzene

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Conditions
ConditionsYield
(i) poly-4-lithium-styrene, Et2O, (ii) /BRN= 1900390/; Multistep reaction;
p-phenoxyphenyltellurium(IV) trichloride
36310-34-6

p-phenoxyphenyltellurium(IV) trichloride

A

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

B

4,4'-diphenoxy-1,1'-biphenyl
2519-16-6

4,4'-diphenoxy-1,1'-biphenyl

Conditions
ConditionsYield
With sodium hydroxide; lithium pentachloropalladate; carbon monoxide 1.) MeCN, 25 deg C, 20 h; 2.) H2O; Yield given. Multistep reaction;
4-phenoxy-phenyl magnesium bromide

4-phenoxy-phenyl magnesium bromide

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

phenol
108-95-2

phenol

1-carboxy-benzenediazonium sulfate-(4)

1-carboxy-benzenediazonium sulfate-(4)

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxybenzoyl chloride
1623-95-6

4-phenoxybenzoyl chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide at 70℃; for 3h;100%
With thionyl chloride In N,N-dimethyl-formamide at 70℃; for 3h;100%
With thionyl chloride at 90℃;99%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

(4-phenoxyphenyl)methanol
2215-78-3

(4-phenoxyphenyl)methanol

Conditions
ConditionsYield
Stage #1: 4-Phenoxybenzoic acid With sodium hydroxide; sodium tetrahydroborate; sulfuric acid In tetrahydrofuran; diethyl ether at 0 - 20℃; for 4h;
Stage #2: With methanol In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.5h;
100%
Stage #1: 4-Phenoxybenzoic acid With sodium tetrahydroborate; sulfuric acid In tetrahydrofuran; diethyl ether at 0 - 20℃; for 4h;
Stage #2: With methanol In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.5h;
100%
Stage #1: 4-Phenoxybenzoic acid With borane-THF In tetrahydrofuran at 20℃;
Stage #2: With hydrogenchloride In water
87%
benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate
299432-52-3

benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

benzyl (4S)-5-(2-methoxyethoxy)methoxy-4-[(4-phenoxybenzoyl)amino]pentanoate
911050-53-8

benzyl (4S)-5-(2-methoxyethoxy)methoxy-4-[(4-phenoxybenzoyl)amino]pentanoate

Conditions
ConditionsYield
Stage #1: benzyl (4S)-4-(tert-butoxycarbonyl)amino-5-[(2-methoxyethoxy)methoxy]pentanoate With trifluoroacetic acid In dichloromethane; water at 0℃; for 0.5h;
Stage #2: 4-Phenoxybenzoic acid With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0℃;
100%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-chlorodiphenyl ether
7005-72-3

4-chlorodiphenyl ether

Conditions
ConditionsYield
With dichloromethane extract derived from 6percent aqueous hypochlorite/tetra-n-butylammonium bisulfate solution with pH value to 8-9 In dichloromethane at 20℃;100%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C13H9O3(1-)*C4H12N(1+)

C13H9O3(1-)*C4H12N(1+)

Conditions
ConditionsYield
With water In ethanol at 0 - 20℃; for 0.0833333h;100%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

C20H18O3

C20H18O3

C33H26O5

C33H26O5

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;100%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester
883560-03-0

2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; diethyl dicarbonate In N,N-dimethyl-formamide99%
With N-ethyl-N,N-diisopropylamine; diethyl dicarbonate In N,N-dimethyl-formamide99%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxybenzoyl fluoride
370-12-7

4-phenoxybenzoyl fluoride

Conditions
ConditionsYield
With tetramethylammonium trifluoromethanethiolate In dichloromethane at 25℃; for 2h; Inert atmosphere;99%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In tetrahydrofuran at 20℃;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxybenzoic acid succinimide ester
437708-50-4

4-phenoxybenzoic acid succinimide ester

Conditions
ConditionsYield
With pyridine; thionyl chloride In acetonitrile at 0 - 20℃; for 1h;98.4%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

diethyl (3-aminobenzyl)phosphonate
104139-11-9

diethyl (3-aminobenzyl)phosphonate

diethyl 3-(4-phenoxybenzamido)benzylphosphonate
1456602-22-4

diethyl 3-(4-phenoxybenzamido)benzylphosphonate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h;98%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

C16H14O5

C16H14O5

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 4h;97%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

N,N-dimethyl-2-(4-phenoxybenzamido)ethylamine

N,N-dimethyl-2-(4-phenoxybenzamido)ethylamine

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;97%
4-tert-Butylaniline
769-92-6

4-tert-Butylaniline

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

N-(4-tert-butylphenyl)-4-phenoxybenzamide

N-(4-tert-butylphenyl)-4-phenoxybenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;97%
2-amino-4-ethoxycarbonyl-pyridine
13362-30-6

2-amino-4-ethoxycarbonyl-pyridine

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

ethyl 2-(4-phenoxybenzamido)isonicotinate

ethyl 2-(4-phenoxybenzamido)isonicotinate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 50℃; Inert atmosphere;97%
ethanol
64-17-5

ethanol

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxybenzoic acid ethyl ester
31994-68-0

4-phenoxybenzoic acid ethyl ester

Conditions
ConditionsYield
With acetyl chloride for 3h; Reflux; Inert atmosphere;96%
With sulfuric acid for 72h; Heating;50%
With sulfuric acid
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

malononitrile
109-77-3

malononitrile

2-[hydroxy-(4-phenoxy-phenyl)-methylene]-malononitrile
330792-68-2

2-[hydroxy-(4-phenoxy-phenyl)-methylene]-malononitrile

Conditions
ConditionsYield
Stage #1: 4-Phenoxybenzoic acid With thionyl chloride for 1h; Heating / reflux;
Stage #2: malononitrile With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; toluene at -10 - 20℃;
96%
Stage #1: 4-Phenoxybenzoic acid With thionyl chloride for 1h; Reflux;
Stage #2: malononitrile With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; toluene at -10 - 20℃;
96%
Stage #1: 4-Phenoxybenzoic acid With thionyl chloride In toluene for 1h; Reflux;
Stage #2: malononitrile With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; toluene at 0 - 20℃;
96%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

diethyl (4-aminobenzyl)phosphonate
20074-79-7

diethyl (4-aminobenzyl)phosphonate

diethyl 4-(4-phenoxybenzamido)benzylphosphonate
1456602-21-3

diethyl 4-(4-phenoxybenzamido)benzylphosphonate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h;96%
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0 - 20℃; for 16h;96%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

N-(3,4-dimethoxyphenethyl)-4-phenoxybenzamide
143576-84-5

N-(3,4-dimethoxyphenethyl)-4-phenoxybenzamide

Conditions
ConditionsYield
Stage #1: 4-Phenoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; for 0.166667h;
Stage #2: 2-(3,4-dimethoxyphenyl)-ethylamine With triethylamine at 20℃;
95%
With hydrogenchloride In dichloromethane
1,4-dioxane
123-91-1

1,4-dioxane

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

1,4-dioxan-2-yl 4-phenoxybenzoate
1597710-67-2

1,4-dioxan-2-yl 4-phenoxybenzoate

Conditions
ConditionsYield
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique;94%
3-(TRIFLUOROMETHYL)BENZYLAMINE
2740-83-2

3-(TRIFLUOROMETHYL)BENZYLAMINE

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxy-N-(3-trifluoromethyl-benzyl)-benzamide

4-phenoxy-N-(3-trifluoromethyl-benzyl)-benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In dichloromethane at 20℃; for 17.5h;93%
1,2,3,4-tetrahydronaphthalen-1-amine
2217-40-5

1,2,3,4-tetrahydronaphthalen-1-amine

4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

4-phenoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

4-phenoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;91%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

(3-aminophenyl)phosphonate de diethyle
89277-85-0

(3-aminophenyl)phosphonate de diethyle

diethyl 3-(4-phenoxybenzamido)phenylphosphonate
1456602-20-2

diethyl 3-(4-phenoxybenzamido)phenylphosphonate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;90%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;90%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

Cyclopentamine
1003-03-8

Cyclopentamine

N-cyclopentyl-4-phenoxybenzamide

N-cyclopentyl-4-phenoxybenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;90%
4-Phenoxybenzoic acid
2215-77-2

4-Phenoxybenzoic acid

aniline
62-53-3

aniline

4-phenoxy-N-phenylbenzamide
864175-69-9

4-phenoxy-N-phenylbenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;90%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;90%

4-Phenoxybenzoic acid Chemical Properties

The Molecular formula of p-PHENOXYBENZOIC ACID(2215-77-2):C13H10O3
The Molecular Weight of p-PHENOXYBENZOIC ACID(2215-77-2):214.22 
The Molecular Structure of p-PHENOXYBENZOIC ACID(2215-77-2) is:
Density:1.241 g/cm3
Melting point:163-165 °C(lit.)
Boiling point:364.2 °C at 760 mmHg
Flash point:141.7 °C   
Sensitive:Air Sensitive
BRN:2212463
Index of Refraction:1.607  
Molar Refractivity:59.62 cm3
Molar Volume:172.5 cm
Polarizability:23.63 10-24cm3 
Surface Tension:50.7 dyne/cm 
Enthalpy of Vaporization:64.4 kJ/mol  
Vapour Pressure:6.07E-06 mmHg at 25°C
IUPAC Name:4-phenoxybenzoic acid
Synonyms:4-phenoxy-benzoicaci;RARECHEM AL BO 0319;P-PHENOXYBENZOIC ACID;TIMTEC-BB SBB000542;4-PHENOXYBENZOIC ACID;LABOTEST-BB LT00454671;DIPHENYL ETHER 4-CARBOXYLIC ACID;Benzoic acid, p-phenoxy-
 

4-Phenoxybenzoic acid Toxicity Data With Reference

1.    

ivn-rat TDLo:10,711 µg/kg

    BIPBU*    Biological & pharmaceutical bulletin. 25 (2002),686.

4-Phenoxybenzoic acid Safety Profile

A poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes:Xi
Xi:Irritant
Risk Statements
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
WGK Germany:3
 

 

4-Phenoxybenzoic acid Specification

Chemical Stability: Not available 
Incompatibilities with Other Materials: Strong oxidizing agents, strong bases. 
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. 
Hazardous Polymerization: Has not been reported.
Conditions to Avoid: Incompatible materials, exposure to moist air or water

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