5-Chlorosalicylic acid supplier

Name
5-Chloro-2-hydroxybenzoic acid
EINECS 206-283-9
CAS No. 321-14-2
Article Data95
CAS DataBase
Density 1.536 g/cm³
Solubility water: 1 g/L (20 °C) in water
Melting Point 171-176 °C
Formula C₇H₅ClO₃
Boiling Point 320.5 °C at 760 mmHg
Molecular Weight 172.568
Flash Point 147.6 °C
Transport Information UN 2811 6.1/PG 3
Appearance white crystalline powder
Safety 26-36-37/39
Risk Codes 22-36/38-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Salicylicacid, 5-chloro- (6CI,7CI,8CI);2-Hydroxy-5-chlorobenzoic acid;5-Chloro-2-hydroxybenzoic acid;NSC 30111;
PSA 57.53000
LogP 1.74380

Synthetic route

: 124-38-9
carbon dioxide

: 106-48-9
4-chloro-phenol

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chloro-phenol With sodium hydroxide In water for 2h; Autoclave; Reflux; Stage #2: carbon dioxide In N,N-dimethyl-formamide at 80 - 145℃; under 2250.23 - 3750.38 Torr; for 15h; Autoclave; Stage #3: With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene pH=6.5;	97.65%
Stage #1: 4-chloro-phenol With Mesitol; sodium hydride In mineral oil at 100℃; for 0.0833333h; Glovebox; Stage #2: carbon dioxide In mineral oil at 185℃; under 760.051 Torr; for 2h;	85%
With potassium carbonate at 140℃; under 29420.3 Torr;

: 535-80-8
3-chlorobenzoate

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With oxygen; potassium acetate; palladium diacetate; p-benzoquinone In N,N-dimethyl acetamide at 115℃; under 3800.26 Torr; for 15h;	95%
With oxygen; potassium acetate; p-benzoquinone; palladium diacetate In ISOPROPYLAMIDE at 115℃; under 3800.26 Torr; for 15h; Product distribution / selectivity;	95%
Multi-step reaction with 2 steps 1: fuming nitric acid / Reduzieren des Nitrierungsprodukts mit Zinn und Salzsaeure 2: water; nitrous acid View Scheme

: 69-72-7
salicylic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: salicylic acid With sulfuric acid In acetonitrile at 20℃; for 0.0833333h; Stage #2: With N-chloro-succinimide In acetonitrile at 20℃; for 2.5h; regioselective reaction;	92%
With sodium periodate; sulfuric acid; sodium dodecyl-sulfate; acetic acid; sodium chloride In water at 25℃; for 2h;	85%
With hydrogenchloride; sodium percarbonate; dihydrogen peroxide In dichloromethane; water at 40 - 45℃; Reagent/catalyst; Solvent; Green chemistry;	82.5%

: 50-79-3
2,5-dichlorobenzoic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With pyridine; water; potassium carbonate; copper for 0.25h; sonication;	92%
With pyridine; copper; potassium carbonate In water for 2h; Heating;	84%
With sodium methylate at 150℃; Eintragen des Reaktionsgemisches in Wasser;
With copper(l) iodide; copper; potassium carbonate at 170℃; under 4413.05 Torr;

: 17201-44-4
sodium ethyl carbonate

: 106-48-9
4-chloro-phenol

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With carbon dioxide at 190℃; under 7600.51 Torr; for 6h; Time; Temperature; Pressure; Autoclave; regioselective reaction;	86.1%

: 21739-93-5
2-bromo-5-chlorobenzoic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 100℃; for 48h; Inert atmosphere;	81%

: 69693-00-1
6-chloro-2-methyl-4H-chromen-4-one

: furan-2,3,5(4H)-trione pyridine (1:1)

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 3260-85-3
2-methyl-4-chloroanisole

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With potassium permanganate beim Erwaermen mit Jodwasserstoffsaeure;

: 13589-72-5
5-chloro-2-hydroxybenzonitrile

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sulfuric acid; water at 200℃;

: 1820-99-1
5,5'-thio-bis(2-hydroxy-benzoic acid)

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sulfuryl dichloride; benzene

: 56-23-5
tetrachloromethane

: 106-48-9
4-chloro-phenol

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 106-48-9
4-chloro-phenol

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With tetrachloromethane; potassium hydroxide; ethanol at 140℃; im geschlossenen Rohr;
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: water; sodium hydrogencarbonate / N,N-dimethyl-formamide; diethyl ether / 0.5 h / 20 °C / Inert atmosphere 3.1: palladium diacetate; silver(I) acetate; N-tert-butoxycarbonyl-L-leucine; 2,2,2-trifluoroethanol / 1,2-dichloro-ethane / 0.08 h / 95 °C / Inert atmosphere 3.2: 18 h / 95 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere View Scheme
With oxygen; potassium acetate; palladium diacetate; p-benzoquinone In N,N-dimethyl acetamide at 115℃; for 15h; Schlenk technique; regioselective reaction;
With tetrachloromethane; sodium hydroxide; copper

: 635-21-2
5-chloroanthranilic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With water; cis-nitrous acid

: 473-34-7
N,N-dichloro-p-toluenesulfonamide

: 69-72-7
salicylic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With chloroform

: 69-72-7
salicylic acid

A: 321-14-2
5-chloro-2-hydroxybenzoic acid

B: 320-72-9
3,5-dichlorosalicylic acid

Conditions

Conditions	Yield
With ethanol; chlorine
With tert-butylhypochlorite In water
With ethanol beim Chlorieren; Trennung ueber die Bariumsalze;
With antimonypentachloride

: 69-72-7
salicylic acid

A: 321-14-2
5-chloro-2-hydroxybenzoic acid

B: 1829-32-9
3-Chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium carbonate bei der Chlorierung;
With sodium hydroxide; sodium hypochlorite at 20℃; for 2.5h; pH > 12; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With N-chlorotriethylammonium chloride In trifluoroacetic acid Ambient temperature; Yield given. Yields of byproduct given;

: 118-61-6
2-hydroxy-benzoic acid ethyl ester

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sulfuryl dichloride Behandeln mit Kalilauge;

: 1734-62-9
2-acetoxy-5-chloro-benzoic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; alpha cyclodextrin In water at 25℃; Rate constant; Ionic strength: 1.0 (NaCl); effect of pH, concentration of α-cyclodextrin;
With water at 25℃; Kinetics;

: 45866-17-9
4-chlorosalicylate

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
In ethanol; water at 25℃; Equilibrium constant;

: 69693-00-1
6-chloro-2-methyl-4H-chromen-4-one

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In methanol at 20℃; Oxidation;
Multi-step reaction with 2 steps 1: 59 percent / AcONa / 2 h / 260 - 270 °C 2: 10 percent aq. NaOH / ethanol / 4 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 88 percent / Na / diethyl ether 2: 10 percent aq. KOH View Scheme

: 144880-76-2
3-(6-chloro-4-oxo-4H-chromen-2-yl)-2-oxo-propionic acid ethyl ester

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With potassium hydroxide Hydrolysis;

: 144880-82-0
6-Chloro-2-(3-phthalidenemethylene)chromone

A: 321-14-2
5-chloro-2-hydroxybenzoic acid

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Hydrolysis; Heating;

: 99852-42-3
6-chloro-2,3-dimethyl-chromen-4-one

diluted alkali: diluted alkali

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 2051-59-4
6-Chloro-chromen-2-one

potassium hydroxide: potassium hydroxide

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
beim Schmelzen;

: 6-chloro-2,3-diphenyl-4H-chromen-4-one

KOH-solution: KOH-solution

A: 321-14-2
5-chloro-2-hydroxybenzoic acid

B: 65-85-0
benzoic acid

C 4-chloro-2-phenacetyl-phenol: 4-chloro-2-phenacetyl-phenol

...Expand

: 7732-18-5
water

: 7782-77-6
cis-nitrous acid

: 635-21-2
5-chloroanthranilic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

...Expand

: 7782-50-5
chlorine

: 98-95-3
nitrobenzene

: 69-72-7
salicylic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

...Expand

: 635-93-8
5-chlorosalicyclaldehyde

chromic acid: chromic acid

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 56-23-5
tetrachloromethane

: 106-48-9
4-chloro-phenol

: furan-2,3,5(4H)-trione pyridine (1:1)

copper: copper

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
bei Siedetemperatur;

...Expand

: 56-23-5
tetrachloromethane

: 64-17-5
ethanol

: 106-48-9
4-chloro-phenol

KOH: KOH

: 321-14-2
5-chloro-2-hydroxybenzoic acid

Conditions

Conditions	Yield
at 140℃;

...Expand

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 563-47-3
3-Chloro-2-methylpropene

: 2-methylallyl 5-chloro-2-(2-methylallyloxy)benzoate

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 65℃; for 0.0833333h; Inert atmosphere; Stage #2: 3-Chloro-2-methylpropene In N,N-dimethyl-formamide at 65℃; for 21h;	100%
With potassium carbonate In N-methyl-acetamide

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 16419-60-6
2-Methylphenylboronic acid

: 25205-15-6
4-hydroxy-2'-methylbiphenyl-3-carboxylic acid

Conditions

Conditions	Yield
With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; potassium carbonate In water at 20℃; for 12h; Suzuki-Miyaura coupling;	99%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 5330-38-1
4-chloro-2-hydroxymethylphenol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 0.75h; Heating;	97%
With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 4.5h;	96%
With borane-THF; boron trifluoride diethyl etherate In tetrahydrofuran at 20℃; for 18h;	85%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 108-24-7
acetic anhydride

: 1734-62-9
2-acetoxy-5-chloro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid for 3h; Heating / reflux;	97%
With sulfuric acid	93%
With sulfuric acid	93%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1461-22-9
tributyltin chloride

: C19H31ClO3Sn

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: tributyltin chloride In methanol for 5h;	97%

: 1291-32-3
zirconocene dichloride

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1192558-54-5
[Cp2Zr(μ2-O',O''C-C6H3(OH)Cl)2]

Conditions

Conditions	Yield
In hydrogenchloride; dichloromethane mixt. of zirconocene dichloride in 1 M aq. HCl and dichlorobenzoic acidin CH2Cl2 was stirred for 30 min at room temp.; organic layer was separated, dried over MgSO4, filtered, concd. in vac.,crystd. form CH2Cl2/Et2O/hexane, elem. anal.;	96.3%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 7195-78-0
5-chloro-2-hydroxy-3-nitrobenzoic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 20℃;	96%
With sulfuric acid; nitric acid at 0 - 20℃; for 5.66667h;	95%
With sulfuric acid; nitric acid for 6h; Ambient temperature;	90.5%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 4068-58-0
3-bromo-5-chloro-2-hydroxy benzoic acid

Conditions

Conditions	Yield
With bromine In chloroform	96%
With N-Bromosuccinimide In carbon disulfide at 25℃; for 14h;
With bromine; acetic acid at 80℃; for 8h;	204.6 g
With bromine; acetic acid at 80℃; for 8h;	204.6 g

: 75-09-2
dichloromethane

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 342411-03-4
6-chloro-4H-benzo[d][1,3]dioxin-4-one

Conditions

Conditions	Yield
With potassium phosphate tribasic trihydrate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 6h; Green chemistry;	96%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1416767-53-7
5,5-dibenzyl-2,3,4,5-tetrahydropyridine

: 6,6-dibenzyl-2-chloro-6,7,8,9-tetrahydro-5aH,11H-pyrido[2,1-b][1,3]benzoxazin-11-one

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 20h;	96%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 75-36-5
acetyl chloride

: 1734-62-9
2-acetoxy-5-chloro-benzoic acid

Conditions

Conditions	Yield
With pyridine; sulfuric acid In toluene	95.6%
With triethylamine In tetrahydrofuran at 20℃;	46.7%

: 111-19-3
sebacoyl chloride

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1,10-bis-4-chlorosalicyl-sebacate

Conditions

Conditions	Yield
Stage #1: sebacoyl chloride; 5-chloro-2-hydroxybenzoic acid With pyridine In tetrahydrofuran for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=2;	95%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 683-18-1
dibutyltin chloride

: 2C7H4ClO3(1-)*Sn(4+)*2C4H9(1-)

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: dibutyltin chloride In methanol for 5h;	95%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 144025-03-6
2,4-difluorophenylboronic acid

: 22494-42-4
2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

Conditions

Conditions	Yield
With bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); tetrabutylammomium bromide; potassium carbonate In ethanol; water for 8h; Concentration; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Reflux;	95%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 2-[(N,N-dimethylamino)methyl]ferrocenylmethylamine

: C21H23ClFeN2O2

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide at 80℃; for 2h; Microwave irradiation;	95%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

Conditions

Conditions	Yield
With sulfuric acid In methanol	94.8%
With thionyl chloride In methanol; ethyl acetate	74%
With thionyl chloride In methanol; ethyl acetate	74%

conc. H2 SO4: conc. H2 SO4

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

Conditions

Conditions	Yield
In methanol	94.8%

: 67-56-1
methanol

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

Conditions

Conditions	Yield
With thionyl chloride for 168h; Inert atmosphere; Reflux;	94%
With sulfuric acid for 120h; Inert atmosphere; Reflux;	91%
With sulfuric acid for 120h; Reflux;	91%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 639-58-7
triphenyltin chloride

: C25H19ClO3Sn

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: triphenyltin chloride In methanol for 5h;	94%

: 762-49-2
2-fluoroethyl bromide

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 334652-76-5
2-fluoroethyl 5-chloro-2-(2-fluoroethoxy)benzoate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 80℃; for 48h;	93.4%
With sodium hydride

: 58929-72-9
bis(3-bromopropyl) ether

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 521065-04-3
5-chloro-2-(2-methoxyethoxy)benzoic acid 2-methoxyethyl ester

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate; acetonitrile	93%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: copper dichloride

: 5-chloro-2-hydroxy benzoic acid copper (II) salt

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With sodium hydroxide In water Stage #2: copper dichloride In water for 24h;	93%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 126747-14-6
4-cyanophenylboronic acid

: 4'-cyano-4-hydroxybiphenyl-3-carboxylic acid

Conditions

Conditions	Yield
With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; potassium carbonate In water at 80℃; for 12h; Suzuki-Miyaura coupling;	92%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 683-18-1
dibutyltin chloride

: C15H22Cl2O3Sn

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: dibutyltin chloride In methanol for 5h;	92%

: 1271-19-8
bis(cyclopentadienyl)titanium dichloride

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 233600-03-8
Ti(η5-C5H5)2(C6H3Cl(O)(CO2))

Conditions

Conditions	Yield
With NaOH; catalyst: C2H5OH In ethanol; chloroform; water-d2 Kinetics; NaOH and C2H5OH added to mixt. of (C5H5)2TiCl2 and acid dissolved in CHCl3, stirred for 30 min at room temp.; dried (anhydrous MgSO4), filtered, filtrate concd. in vac., ppt. recrystd. from CH2Cl2/hexane; elem. anal.;	91.1%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1066-45-1
trimethyltin(IV)chloride

C10H13ClO3Sn: C10H13ClO3Sn

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxybenzoic acid With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: trimethyltin(IV)chloride In methanol for 5h;	91%

5-Chlorosalicylic acid Consensus Reports

Reported in EPA TSCA Inventory.

5-Chlorosalicylic acid Specification

The IUPAC name of 5-Chlorosalicylic acid is 5-chloro-2-hydroxybenzoic acid. With the CAS registry number 321-14-2, it is also named as 2-Hydroxy-5-chlorobenzoic acid. The product's categories are Fine Chemical & Intermediates; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Amino Acid Derivatives. It is white crystalline powder which is soluble in hot water, insoluble in cold water, easily soluble in alcohol, ether, benzene, chloroform and acetic acid.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.42; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.34; (4)ACD/LogD (pH 7.4): 0.27; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.44; (8)ACD/KOC (pH 7.4): 1.22; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.629; (13)Molar Refractivity: 39.95 cm³; (14)Molar Volume: 112.3 cm³; (15)Polarizability: 15.84×10^-24 cm³; (16)Surface Tension: 66 dyne/cm; (17)Enthalpy of Vaporization: 59.35 kJ/mol; (18)Vapour Pressure: 0.000132 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Tautomer Count: 4; (21)Exact Mass: 171.992722; (22)MonoIsotopic Mass: 171.992722; (23)Topological Polar Surface Area: 57.5; (24)Heavy Atom Count: 11; (25)Complexity: 160.

Preparation of 5-Chlorosalicylic acid: It can be obtained by salicylic acid and chlorine.

Uses of 5-Chlorosalicylic acid: It can be used as intermediate of pesticide, medicine and dyes. It also can react with methanol to get 5-chloro-2-hydroxy-benzoic acid methyl ester. This reaction needs reagent hydrogen chloride.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:Clc1cc(C(=O)O)c(O)cc1
2. InChI:InChI=1/C7H5ClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)
3. InChIKey:NKBASRXWGAGQDP-UHFFFAOYAL

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	250mg/kg (250mg/kg)		"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 792, 1955.
rat	LD50	oral	250mg/kg (250mg/kg)		Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.

Product Name

5-Chloro-2-hydroxybenzoic acid

Synthetic route

5-Chlorosalicylic acid Consensus Reports

5-Chlorosalicylic acid Specification

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