Conditions | Yield |
---|---|
Stage #1: 5-Hexen-1-ol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 1h; Swern oxidation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -78 - 0℃; Swern oxidation; Inert atmosphere; | 100% |
Stage #1: 5-Hexen-1-ol With oxalyl dichloride; dimethyl sulfoxide at -78℃; for 1h; Stage #2: With triethylamine | 100% |
With (NH4)4[CuMo6O18(OH)6]·5H2O; oxygen; sodium sulfite In water; acetonitrile at 60℃; under 760.051 Torr; for 6h; | 95% |
N,N-dimethylhexa-1,5-dien-3-amine
A
hex-5-en-1-al
B
(E)-N,N-Dimethyl-1,5-hexadien-1-amin
C
dimethyl amine
Conditions | Yield |
---|---|
at 223.5℃; for 12h; | A n/a B 95.8% C n/a |
at 160.2 - 200.1℃; Yield given. Yields of byproduct given; | |
With N,N-dimethyl-cyclohexanamine at 160.2 - 200.1℃; under 3 Torr; Kinetics; Thermodynamic data; Cope rearrengament, ΔH*, ΔG*, ΔS*, Ea; |
5-hexenal dimethylhydrazone
hex-5-en-1-al
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether for 4h; Ambient temperature; | 92% |
hex-5-enyl hydroperoxide
A
5-Hexen-1-ol
B
(+/-)-2-pentanol
C
hex-5-en-1-al
Conditions | Yield |
---|---|
In pentane for 48h; Irradiation; | A 60% B 10% C 30% |
hex-5-enyl hydroperoxide
A
5-Hexen-1-ol
B
hex-5-en-1-al
C
5-hexenyl acetate
Conditions | Yield |
---|---|
With titanium(III) chloride; acetic acid In water for 2h; | A 56% B 27% C 17% |
Conditions | Yield |
---|---|
With chromium(V) | A 32% B 52% |
hex-5-enyl hydroperoxide
A
5-Hexen-1-ol
B
hex-5-en-1-al
C
phenol
Conditions | Yield |
---|---|
In benzene for 48h; Irradiation; | A 44% B 43% C 13% |
cyclohexane
A
7-oxabicyclo(2.2.1)heptane
B
hex-5-en-1-al
C
cyclohexane-1,2-epoxide
D
cyclohexene
Conditions | Yield |
---|---|
With tetramethylbutane; oxygen at 753℃; under 15 Torr; for 0.00555556h; Product distribution; Kinetics; Further Variations:; Temperatures; | A 0.062% B 0.195% C 0.037% D 0.488% |
1,3-diaminocyclohexane
hex-5-en-1-al
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite |
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite |
oct-1-ene
cyclohexanone
A
cis-2-octene
B
trans-2-Octene
C
hex-5-en-1-al
D
2-octylcyclohexanone
Conditions | Yield |
---|---|
at 40℃; im UV-Licht.Irradiation; |
Conditions | Yield |
---|---|
Irradiation.mit UV-Licht; |
Conditions | Yield |
---|---|
at 410℃; |
Conditions | Yield |
---|---|
(hydrolysis); |
1-(4-dimethylamino-phenyl)-hex-5-en-1-ol
hex-5-en-1-al
Conditions | Yield |
---|---|
With 4-diazonio-benzenesulfonic acid betaine |
Conditions | Yield |
---|---|
(i) Mg, Et2O, (ii) /BRN= 605384/, (iii) aq. H2SO4; Multistep reaction; |
(2-hydroxy-cyclopentylmethyl)-trimethyl-ammonium; hydroxide
hex-5-en-1-al
Conditions | Yield |
---|---|
In water at 450℃; |
Conditions | Yield |
---|---|
under 5 Torr; Ambient temperature; Irradiation; | |
under 5 Torr; Thermodynamic data; Product distribution; Ambient temperature; Irradiation; energy absorb., var. pulses; |
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
5-hexenoyl chloride
hex-5-en-1-al
trans-(3-Trimethylsilyl)-cyclohexanol
hex-5-en-1-al
Conditions | Yield |
---|---|
With iodosylbenzene; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide In dichloromethane for 3h; Ambient temperature; | 18 % Chromat. |
Conditions | Yield |
---|---|
In benzene Quantum yield; Mechanism; Irradiation; λ=300 nm; |
Conditions | Yield |
---|---|
With sulphur hexafluoride Product distribution; Quantum yield; Mechanism; Irradiation; partial pressures varied; |
Conditions | Yield |
---|---|
With water-d2 at 19.9℃; for 0.5h; Product distribution; Irradiation; var. conditions; |
cyclohexanone
A
hex-5-en-1-al
B
cyclohexane-1,3-diol
C
hexanoic acid
Conditions | Yield |
---|---|
With water-d2 at 19.9℃; for 0.5h; Product distribution; Mechanism; Irradiation; var. temp., var. magnetic field intensity; | A 12 % Spectr. B 3 % Spectr. C 10 % Spectr. |
(1R,3R)-3-Tributylstannanyl-cyclohexanol
hex-5-en-1-al
Conditions | Yield |
---|---|
With iodosylbenzene; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide In dichloromethane for 1h; Ambient temperature; | 74 % Chromat. |
(1S,3R)-3-Tributylstannanyl-cyclohexanol
hex-5-en-1-al
Conditions | Yield |
---|---|
With iodosylbenzene; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide In dichloromethane for 1h; Ambient temperature; | 74 % Chromat. |
hex-5-enyl hydroperoxide
A
2-(chloromethyl)tetrahydropyran
B
2-vinyltetrahydrofuran
C
5-Hexen-1-ol
D
hex-5-en-1-al
E
5-hexenyl acetate
Conditions | Yield |
---|---|
With acetic acid; iron(II) chloride In water for 2h; Product distribution; Heating; other reagent:TiCl3/AcOH; |
hex-5-enyl hydroperoxide
A
5-Hexen-1-ol
B
(+/-)-2-pentanol
C
hex-5-en-1-al
D
phenol
Conditions | Yield |
---|---|
Product distribution; Irradiation; in different solvents and reaction time; |
hex-5-en-1-al
Conditions | Yield |
---|---|
Irradiation; |
Conditions | Yield |
---|---|
With magnesium sulfate In dichloromethane Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; Grignard reaction; | 99% |
In tetrahydrofuran at -80.15℃; Grignard reaction; | 68% |
In tetrahydrofuran at 0℃; Yield given; | |
In tetrahydrofuran at -78℃; for 0.75h; | 1.07 g |
In tetrahydrofuran |
Conditions | Yield |
---|---|
Stage #1: 2–(1H–pyrrol–1–yl)–5–methylaniline; hex-5-en-1-al In dichloromethane at -90℃; for 1h; Pictet-Spengler Synthesis; Inert atmosphere; Stage #2: With C80H60F6N4O6PS2(1-)*H(1+)*2CH4N2O In dichloromethane at -90℃; for 23h; Pictet-Spengler Synthesis; Inert atmosphere; enantioselective reaction; | 99% |
hex-5-en-1-al
(3R)-3-propionyl-4-benzyloxazolidin-2-one
4-benzyl-3-(3-hydroxy-2-methyl-oct-7-enoyl)-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (3R)-3-propionyl-4-benzyloxazolidin-2-one With di-n-butylboryl trifluoromethanesulfonate; triethylamine In dichloromethane at -78 - 0℃; for 0.5h; Aldol Addition; Inert atmosphere; Stage #2: hex-5-en-1-al In dichloromethane at -78 - 0℃; for 2h; Aldol Addition; Inert atmosphere; | 98% |
Stage #1: (3R)-3-propionyl-4-benzyloxazolidin-2-one With di-n-butylboryl trifluoromethanesulfonate; triethylamine In dichloromethane at 0 - 3℃; Stage #2: hex-5-en-1-al In dichloromethane at -78 - 0℃; | 73% |
hex-5-en-1-al
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; | 98% |
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
In diethyl ether at -78℃; | 96% |
hex-5-en-1-al
valeryl bromide
(3R,4R)-3-propyl-4-(4-penten-1-yl)oxetan-2-one
Conditions | Yield |
---|---|
With 2Br(1-)*C41H51AlN4O2(2+); N-ethyl-N,N-diisopropylamine In dichloromethane at -70℃; for 24h; Inert atmosphere; optical yield given as %ee; | 96% |
With 2Br(1-)*C41H51AlN4O2(2+); N-ethyl-N,N-diisopropylamine In dichloromethane at -70℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 96% |
hex-5-en-1-al
(5S)-5-phenylmorpholin-2-one
Conditions | Yield |
---|---|
With molecular sieve In benzene for 3h; Heating; other substrates, toluene as solvens, stereochemistry; | 95% |
With molecular sieve In benzene for 3h; Heating; | 95% |
hex-5-en-1-al
2-But-3-enyl-4-isopropyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-cyclopenta[b]pyrrol-6-one
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran at -60 - -45℃; | 95% |
hex-5-en-1-al
(R)-α-(hydroxymethyl)benzylhydroxylamine
B
(R)-2-(3aR,6aS)-Hexahydro-cyclopenta[c]isoxazol-1-yl-2-phenyl-ethanol
Conditions | Yield |
---|---|
With isopropyl alcohol; magnesium bromide In tetrahydrofuran at 65℃; for 48h; | A n/a B 95% |
Conditions | Yield |
---|---|
Stage #1: 1.3-propanedithiol; hex-5-en-1-al In chloroform at 20℃; for 1h; Stage #2: With boron trifluoride diethyl etherate In chloroform at 20℃; for 17h; Further stages.; | 94% |
With hydrogenchloride In chloroform at -3 - 0℃; for 5h; | 76.8% |
With boron trifluoride diethyl etherate In dichloromethane for 1h; Ambient temperature; Yield given; |
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In diethyl ether for 0.166667h; | 94% |
With boron trifluoride diethyl etherate In diethyl ether for 0.166667h; Ambient temperature; | 94% |
Conditions | Yield |
---|---|
at 20℃; | 94% |
at 20℃; for 21h; | 94% |
hex-5-en-1-al
1-(hepta-1,6-diene-1-sulfonyl)-4-nitro-benzene
Conditions | Yield |
---|---|
Stage #1: (4-nitro-benzenesulfonylmethyl)-phosphonic acid dimethyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Stage #2: hex-5-en-1-al In tetrahydrofuran; dichloromethane at -78 - 25℃; for 1h; | 93% |
hex-5-en-1-al
(2-nitroethenyl)benzene
(R)-2-((S)-2-nitro-1-phenylethyl)-hex-5-enal
Conditions | Yield |
---|---|
With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid In water at 0 - 20℃; Michael condensation; enantioselective reaction; | 93% |
3-bromo-2,3-dihydro-thiophene-1,1-dioxide
hex-5-en-1-al
4-(1-hydroxy-5-hexenyl)-2-sulfolene
Conditions | Yield |
---|---|
With silver; zinc In tetrahydrofuran for 5h; Ambient temperature; | 91.7% |
With silver; zinc In tetrahydrofuran for 5h; Ambient temperature; Irradiation; | 91.7% |
hex-5-en-1-al
Conditions | Yield |
---|---|
In pentane stirred (2 h, room temp.); filtration (Celite); | 91% |
In hexane addn. of the unsaturated ketone in hexane to the Ti compd. in hexane at room temp. and addn. of CDCl3 after 0.5 h; | 76% |
hex-5-en-1-al
trimethylsilylacetylene
(S)-1-(trimethylsilyl)oct-7-en-1-yn-3-ol
Conditions | Yield |
---|---|
Stage #1: trimethylsilylacetylene With (S)-3,3'-bis(5-tert-butyl-2-methoxyphenyl)-1,1'-binaphthyl-2,2'-diol; diethylzinc In diethyl ether at 20℃; for 16h; Inert atmosphere; Stage #2: With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #3: hex-5-en-1-al In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; optical yield given as %ee; | 91% |
Stage #1: trimethylsilylacetylene With (S)-3,3'-bis(5-tert-butyl-2-methoxyphenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol; diethylzinc In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; Stage #2: With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #3: hex-5-en-1-al In tetrahydrofuran at 20℃; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 68% |
Conditions | Yield |
---|---|
In tetrahydrofuran; tert-butyl alcohol at 0 - 20℃; | 90.2% |
With sodium hydroxide In ethanol for 96h; Ambient temperature; | 84% |
Conditions | Yield |
---|---|
In tetrahydrofuran | 90% |
hex-5-en-1-al
diethyl 2-oxo-2-((1S,2R)-N-camphor-10,2-sultam)-ethylphosphonate
Conditions | Yield |
---|---|
With sodium hydride In dichloromethane at 0℃; Horner-Emmons reaction; | 90% |
Conditions | Yield |
---|---|
With triphenylphosphine In benzene byproducts: OP(C6H5)3; | 90% |
hex-5-en-1-al
3-(3,4-methylenedioxyphenyl)-3-oxopropionic acid methyl ester
Conditions | Yield |
---|---|
With piperidine; acetic acid; lithium bromide In dichloromethane at 20 - 40℃; for 12h; Sealed tube; Inert atmosphere; Molecular sieve; | 90% |
hex-5-en-1-al
5-aminopenta-1,2-diene
N-(penta-3,4-dien-1-yl)hex-5-en-1-amine
Conditions | Yield |
---|---|
Stage #1: hex-5-en-1-al; 5-aminopenta-1,2-diene In ethanol at 20 - 25℃; for 2h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In ethanol at 0℃; for 4h; Inert atmosphere; | 88% |
hex-5-en-1-al
(3R)-3-propionyl-4-benzyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (3R)-3-propionyl-4-benzyloxazolidin-2-one With di-n-butylboryl trifluoromethanesulfonate; triethylamine In dichloromethane at -78℃; Stage #2: hex-5-en-1-al In dichloromethane at -78℃; | 87% |
Conditions | Yield |
---|---|
Stage #1: phenylacetylene With diethylzinc In toluene for 4h; Inert atmosphere; Reflux; Stage #2: With titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol In touene; diethyl ether at 20℃; for 1h; Inert atmosphere; Stage #3: hex-5-en-1-al In diethyl ether; toluene at 20℃; for 2h; Inert atmosphere; optical yield given as %ee; | 87% |
hex-5-en-1-al
1-(triisopropylsilyl)butadiyne
(R)-1-(triisopropylsilyl)deca-9-en-1,3-diyn-5-ol
Conditions | Yield |
---|---|
Stage #1: 1-(triisopropylsilyl)butadiyne With diethylzinc; (S)-[1,1']-binaphthalenyl-2,2'-diol; N-cyclohexyl-cyclohexanamine In diethyl ether at 20℃; for 16h; Inert atmosphere; Stage #2: hex-5-en-1-al With titanium(IV) isopropylate In diethyl ether for 3h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 87% |
The 5-Hexenal, with CAS registry number 764-59-0, has the systematic name of hex-5-enal. Its molecular weight is 98.143. And the chemical formula of this chemical is C6H10O. What's more, its EINECS is 212-127-0.
Physical properties of 5-Hexenal: (1)ACD/LogP: 1.58; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.58; (4)ACD/LogD (pH 7.4): 1.58; (5)ACD/BCF (pH 5.5): 9.35; (6)ACD/BCF (pH 7.4): 9.35; (7)ACD/KOC (pH 5.5): 172.37; (8)ACD/KOC (pH 7.4): 172.37; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 17.07 Å2; (13)Index of Refraction: 1.41; (14)Molar Refractivity: 29.75 cm3; (15)Molar Volume: 119.9 cm3; (16)Polarizability: 11.79×10-24cm3; (17)Surface Tension: 25.1 dyne/cm; (18)Density: 0.817 g/cm3; (19)Flash Point: 18.8 °C; (20)Enthalpy of Vaporization: 36.61 kJ/mol; (21)Boiling Point: 128.4 °C at 760 mmHg; (22)Vapour Pressure: 10.7 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=CCCC\C=C
(2)InChI: InChI=1/C6H10O/c1-2-3-4-5-6-7/h2,6H,1,3-5H2
(3)InChIKey: USLRUYZDOLMIRJ-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C6H10O/c1-2-3-4-5-6-7/h2,6H,1,3-5H2
(5)Std. InChIKey: USLRUYZDOLMIRJ-UHFFFAOYSA-N
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