5-Isopropyl-2-methylphenol supplier

Name
Carvacrol
EINECS 207-889-6
CAS No. 499-75-2
Article Data180
CAS DataBase
Density 0.974 g/cm³
Solubility Insoluble in water
Melting Point 3-4 °C(lit.)
Formula C₁₀H₁₄O
Boiling Point 237.2 °C at 760 mmHg
Molecular Weight 150.221
Flash Point 106.7 °C
Transport Information UN 3265 8/PG 3
Appearance liquid
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols
Synonyms Carvacrol;
PSA 20.23000
LogP 2.82400

Synthetic route

: 99-49-0, 22327-39-5
Carvone

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With montmorillonite In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 160℃; Temperature; Solvent; Autoclave; Green chemistry; Industrial scale;	99%
With 5 weight% palladium(0) nanoparticles supported on mesoporous natural phosphate In neat (no solvent) for 24h; Reflux;	94%
With toluene-4-sulfonic acid In 1,4-dioxane; chlorobenzene at 180℃; under 2475.2 Torr; for 0.583333h; Irradiation;	85%

: 7712-46-1
5-(1-Hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enone

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With Amberlyst-15 cation exchange resin In toluene at 120 - 150℃; Temperature; Solvent; Reagent/catalyst;	98%

: 2244-16-8, 6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 499-75-2
carvacrol

Conditions

Conditions	Yield
In water at 180 - 250℃; for 0.166667h;	95%
at 160 - 180℃;

: 6380-28-5
carvacryl acetate

: 499-75-2
carvacrol

Conditions

Conditions	Yield
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 18h;	94%

: (+)-(1S,4S,5R,6R)-1,5,6-trihydroxy-2-menthene

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With iodine In toluene for 5h; Reflux;	94%

: 99-48-9, 1197-06-4, 1197-07-5, 2102-58-1, 2102-59-2, 5157-78-8, 5503-11-7, 7632-16-8, 18383-51-2
(4R,6R)-carveol

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With palladium 10% on activated carbon at 135℃; for 1h; Temperature;	91%

: 99-48-9
5-Isopropenyl-2-methyl-cyclohex-2-enol

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With 5 weight% palladium(0) nanoparticles supported on mesoporous natural phosphate In neat (no solvent) for 24h; Reflux;	90%

: 6485-40-1, 2244-16-8
(R)-Carvone

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With tert-butyldimethylsilyl 2-methylpropane-2-sulfonate; platinum(IV) chloride In toluene at 80℃; for 2h; Inert atmosphere; regioselective reaction;	87%
With triethylsilyl chloride; triethylamine; sodium iodide In acetonitrile at 4℃;	67%
With chloro-trimethyl-silane; water for 3h; Ambient temperature;
In water Heating; Acidic conditions;
With aqueous acid Heating;

: 130912-76-4
(R)-1-(1-Hydroxy-1-methyl-ethyl)-4-methyl-bicyclo[3.1.0]hexan-3-one

A: 499-75-2
carvacrol

B: (5S,6S)-5-Bromo-3-isopropyl-6-methyl-cyclohex-2-enone

Conditions

Conditions	Yield
With hydrogen bromide In dichloromethane for 1.5h; Ambient temperature;	A 10% B 85%

: 6485-40-1, 2244-16-8
(R)-Carvone

A: 499-75-2
carvacrol

B: 85710-71-0
(5R)-5-(1-chloro-1-methylethyl)-2-methylcyclohex-2-enone

Conditions

Conditions	Yield
With hydrogenchloride; silica gel In water at 0 - 20℃; for 0.75h; Time;	A 11% B 83%

: 95-48-7
ortho-cresol

: 67-63-0
isopropyl alcohol

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With diatomaceous earth phosphoric acid at 135℃; for 6h; Temperature;	82.3%
With phosphorus pentoxide
With aluminum (III) chloride In dichloromethane at -5℃; for 4h; Solvent; Reagent/catalyst; Large scale;	75.6 kg

: 2-hydroxy-5-isopropenyl-2-methylcyclohexanone

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With phosphorus pentoxide In 1,4-dioxane at 98 - 108℃; for 2h; Solvent;	81%

: (+)-(4S,5R,6S)-5,6-dihydroxy-1(7),2-menthadiene

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 5h;	80%

: (+)-Δ5-dehydro-1-hydroxyisocarvomenthol

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With iodine In toluene for 5h; Reflux;	80%

: 23733-68-8
p-menth-3-en-2-one

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With Cu-C composite catalyst In 5,5-dimethyl-1,3-cyclohexadiene at 190 - 220℃; Solvent; Green chemistry;	78%
With copper in charcoal In 5,5-dimethyl-1,3-cyclohexadiene at 190 - 220℃; Concentration; Solvent;	77%
With copper in charcoal In 5,5-dimethyl-1,3-cyclohexadiene at 190 - 230℃; Reflux;	77%

: 6485-40-1, 2244-16-8
(R)-Carvone

: 107-14-2
chloroacetonitrile

A: 499-75-2
carvacrol

B: 128011-29-0
8-(chloroacetylamino)-p-menth-6-en-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 68%

...Expand

: (+)-Δ5-dehydro-1-hydroxyisocarvomenthol

A: 499-75-2
carvacrol

B: 499-71-8
carvotanacetone

Conditions

Conditions	Yield
With iodine In toluene for 3h; Reflux;	A 64% B 26%

: formic acid 5-isopropyl-2-methyl-phenyl ester

A: 499-75-2
carvacrol

B: 1665-99-2
2-hydroxy-6-isopropyl-3-methyl-benzaldehyde

Conditions

Conditions	Yield
With boron tribromide; iron(III) chloride In chlorobenzene at -15 - 12℃; for 3h; Fries rearrangement;	A n/a B 55%

: 628-20-6
4-Chlorobutyronitrile

: 6485-40-1, 2244-16-8
(R)-Carvone

A: 499-75-2
carvacrol

B: 8-(4-chlorobutyramido)-6-p-menthen-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 54%

...Expand

: 110-59-8
pentanonitrile

: 6485-40-1, 2244-16-8
(R)-Carvone

A: 499-75-2
carvacrol

B: 8-valeramido-6-p-menthen-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 53%

...Expand

: 6485-40-1, 2244-16-8
(R)-Carvone

: 100-47-0
benzonitrile

A: 499-75-2
carvacrol

B: 128011-32-5
8-benzoylamino-p-menth-6-en-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 48%

...Expand

: 130912-76-4
(R)-1-(1-Hydroxy-1-methyl-ethyl)-4-methyl-bicyclo[3.1.0]hexan-3-one

A: 499-75-2
carvacrol

B: (5S,6S)-5-Chloro-3-isopropyl-6-methyl-cyclohex-2-enone

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane for 1.5h; Ambient temperature;	A 40% B 45%

: 75-05-8
acetonitrile

/PRSGG643-3025/: /PRSGG643-3025/

A: 499-75-2
carvacrol

B: 128011-28-9
8-acetylamino-p-menth-6-en-2-one

C /PRSGG643-3027/: /PRSGG643-3027/

Conditions

Conditions	Yield
With sulfuric acid at 0 - 20℃;	A n/a B 44% C n/a

...Expand

: 78-82-0
Isobutyronitrile

/PRSGG643-3025/: /PRSGG643-3025/

A: 499-75-2
carvacrol

B: 128011-31-4
8-isobutyrylamino-p-menth-6-en-2-one

C /PRSGG643-3027/: /PRSGG643-3027/

Conditions

Conditions	Yield
With sulfuric acid at 0 - 20℃;	A n/a B 42% C n/a

...Expand

: 100-47-0
benzonitrile

/PRSGG643-3025/: /PRSGG643-3025/

A: 499-75-2
carvacrol

B: 128011-32-5
8-benzoylamino-p-menth-6-en-2-one

C /PRSGG643-3027/: /PRSGG643-3027/

Conditions

Conditions	Yield
With sulfuric acid In dibutyl ether at 0 - 20℃;	A n/a B 42% C n/a

...Expand

: 6485-40-1, 2244-16-8
(R)-Carvone

: 75-05-8
acetonitrile

A: 499-75-2
carvacrol

B: 128011-28-9
8-acetylamino-p-menth-6-en-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 38%

...Expand

: 6485-40-1, 2244-16-8
(R)-Carvone

: 107-12-0
propiononitrile

A: 499-75-2
carvacrol

B: 8-propioamido-6-p-menthen-2-one

Conditions

Conditions	Yield
With sulfuric acid at -25 - 20℃; Ritter reaction;	A n/a B 34%

...Expand

: 107-14-2
chloroacetonitrile

/PRSGG643-3025/: /PRSGG643-3025/

A: 499-75-2
carvacrol

B: 128011-29-0
8-(chloroacetylamino)-p-menth-6-en-2-one

C /PRSGG643-3027/: /PRSGG643-3027/

Conditions

Conditions	Yield
With sulfuric acid at 0 - 20℃;	A n/a B 33% C n/a

...Expand

: 65733-27-9
cis-piperitol

: 499-75-2
carvacrol

Conditions

Conditions	Yield
With selenium(IV) oxide; formic acid In 1,4-dioxane at 80℃; for 72h;	33%

: 499-75-2
carvacrol

: 74-88-4
methyl iodide

: 6379-73-3
carvacrol methyl ether

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide In tetrahydrofuran at 50℃; for 1h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 50℃; Inert atmosphere;	100%
Stage #1: carvacrol With sodium hydroxide In methanol at 20℃; for 0.25h; Williamson Ether Synthesis; Inert atmosphere; Alkaline conditions; Stage #2: methyl iodide In methanol at 65℃; for 1h; Reagent/catalyst; Williamson Ether Synthesis; Cooling; Inert atmosphere;	84%
With potassium carbonate In acetone at 60℃; for 2h;	81%
With methanol
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;

: 499-75-2
carvacrol

: 5665-94-1
2-methyl-5-isopropyl-4-chlorophenol

Conditions

Conditions	Yield
With oxygen; lithium chloride; copper dichloride In acetic acid at 80℃; for 6h; regioselective reaction;	99%
With sulfuryl dichloride In dichloromethane at 0 - 20℃;	82%
With sulfuryl dichloride In tetrachloromethane at 0 - 20℃; for 0.75h;	81%

: 499-75-2
carvacrol

: 106-95-6
allyl bromide

: 29652-98-0
2-(allyloxy)-4-isopropyl-1-methylbenzene

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydrogencarbonate In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: allyl bromide In dimethyl sulfoxide at 20℃; for 8h;	98%
With water; sodium hydroxide In acetone Williamson Ether Synthesis; Reflux;	76%
Stage #1: carvacrol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: allyl bromide In N,N-dimethyl-formamide Inert atmosphere;	70%
With potassium carbonate; acetone

: 499-75-2
carvacrol

: 3163-27-7
2-(bromomethyl)naphthalene

: 1-((5-isopropyl-2-methylphenoxy)methyl)naphthalene

Conditions

Conditions	Yield
Stage #1: carvacrol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2-(bromomethyl)naphthalene In N,N-dimethyl-formamide Inert atmosphere;	98%

: 499-75-2
carvacrol

: 32122-64-8
2-(4-chlorophenyl) malononitrile

: 2-(4-chlorophenyl)-2-(4-hydroxy-2-isopropyl-5-methylphenyl)malononitrile

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 18h; Inert atmosphere; Sealed tube;	98%

: 75-77-4
chloro-trimethyl-silane

: 499-75-2
carvacrol

: 66760-13-2
5-isopropyl-2-methylphenoxytrimethylsilane

Conditions

Conditions	Yield
With triethylamine In benzene	97%

: 75-79-6
Methyltrichlorosilane

: 499-75-2
carvacrol

: 66760-15-4
C31H42O3Si

Conditions

Conditions	Yield
With triethylamine In benzene	97%

: 358-23-6
trifluoromethylsulfonic anhydride

: 499-75-2
carvacrol

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 23℃; for 3h;	97%
With pyridine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;

: 499-75-2
carvacrol

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 2-methyl-5-isopropylphenyl 4-fluorobenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	97%

: 499-75-2
carvacrol

: 121-51-7
3-nitrobenzenesulphonyl chloride

: 2-methyl-5-isopropylphenyl 3-nitrobenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	97%

: 499-75-2
carvacrol

: 98-88-4
benzoyl chloride

: 100752-52-1
5-isopropyl-2-methylphenyl benzoate

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide; Amberlyst A26 Stage #2: benzoyl chloride In acetone at 20℃; for 0.25h; Further stages.;	96%
With aluminum oxide; sodium hydroxide microwave irradiation;	90%
With triethylamine In dichloromethane at 0 - 20℃; for 11h; Inert atmosphere;	82%
im Druckrohr;
With picoline In dichloromethane for 1h; Reflux;

: 499-75-2
carvacrol

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 2-methyl-5-isopropylphenyl 2-nitrobenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	96%

: 499-75-2
carvacrol

: 121665-99-4
2-methyl-5-isopropyl-4-bromophenol

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In chloroform for 0.0333333h;	95%
With tetra-N-butylammonium tribromide In methanol; dichloromethane at 20℃; for 0.166667h;	93%
With tetra-N-butylammonium tribromide In methanol; dichloromethane at 23℃; for 0.166667h;	93%

: 499-75-2
carvacrol

α-halo acetic acid: α-halo acetic acid

: 19728-20-2
2-(5-isopropyl-2-methylphenoxy)acetic acid

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide Stage #2: α-halo acetic acid In acetone for 0.333333h; Further stages.;	95%

: 499-75-2
carvacrol

: 503-60-6
3,3-dimethyl-allyl chloride

: 4-isopropyl-1-methyl-2-((3-methylbut-2-en-1-yl)oxy)benzene

Conditions

Conditions	Yield
Stage #1: carvacrol With potassium carbonate In acetone at 20℃; for 0.166667h; Stage #2: 3,3-dimethyl-allyl chloride In acetone at 80℃; for 4h;	95%

: 499-75-2
carvacrol

: 98-58-8
4-bromobenzenesulfonyl chloride

: 2-methyl-5-isopropylphenyl 4-bromobenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	95%

: 499-75-2
carvacrol

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 4-isopropyl-1-methyl-2-((4-nitrobenzyl)oxy)benzene

Conditions

Conditions	Yield
Stage #1: carvacrol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 1-bromomethyl-4-nitro-benzene In N,N-dimethyl-formamide Inert atmosphere;	95%

: 499-75-2
carvacrol

: 79-03-8
propionyl chloride

: 157252-17-0
3-(isopropyl)-6-methylphenyl propionate

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide; Amberlyst A26 Stage #2: propionyl chloride In acetone at 20℃; for 0.166667h; Further stages.;	94%
With aluminum oxide; sodium hydroxide microwave irradiation;	91%
With triethylamine In dichloromethane at 0 - 20℃; for 11h; Inert atmosphere;	75%

: 499-75-2
carvacrol

: 75-36-5
acetyl chloride

: 6380-28-5
carvacryl acetate

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide; Amberlyst A26 Stage #2: acetyl chloride In acetone at 20℃; for 0.166667h; Further stages.;	94%
With aluminum oxide; sodium hydroxide microwave irradiation;	94%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3.26667h;	86%

: 87-41-2
2-benzofuran-1(3H)-one

: 499-75-2
carvacrol

: 2-(5'-isopropyl-2'-methyl-phenoxymethyl)-benzoic acid

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium methylate In methanol salt formation; Stage #2: 2-benzofuran-1(3H)-one at 150 - 160℃; for 4h; Addition; ring cleavage;	94%

: 499-75-2
carvacrol

ethyl halide: ethyl halide

: 4732-13-2
2-ethoxy-4-isopropyl-1-methylbenzene

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide; Amberlite IRA 400 Stage #2: ethyl halide In acetone for 0.583333h; Further stages.;	94%

: 499-75-2
carvacrol

n-butyl halide: n-butyl halide

: 2-butoxy-4-isopropyl-1-methylbenzene

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide Stage #2: n-butyl halide In acetone for 0.583333h; Further stages.;	94%

: 499-75-2
carvacrol

n-propyl halide: n-propyl halide

: 5648-33-9
4-isopropyl-1-methyl-2-propoxybenzene

Conditions

Conditions	Yield
Stage #1: carvacrol With sodium hydroxide Stage #2: n-propyl halide In acetone for 0.5h; Further stages.;	94%

: 499-75-2
carvacrol

CH3CH2-Hal: CH3CH2-Hal

: 4732-13-2
2-ethoxy-4-isopropyl-1-methylbenzene

Conditions

Conditions	Yield
With aluminum oxide; sodium hydroxide microwave irradiation;	94%

: 499-75-2
carvacrol

: 959576-29-5
(Z)-4-(2-bromovinyl)benzoic acid

: 1202386-11-5
(Z)-5-isopropyl-2-methylphenyl-4-(2-bromovinyl)benzoate

Conditions

Conditions	Yield
Stage #1: carvacrol; (Z)-4-(2-bromovinyl)benzoic acid With dmap In N,N-dimethyl-formamide; benzene for 0.166667h; Stage #2: With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide; benzene at 20℃; for 24h; optical yield given as %de; stereoselective reaction;	94%

: 499-75-2
carvacrol

: 20149-84-2
2-chloro-N-(3,4-dichlorophenyl)acetamide

: 1228237-34-0
C18H19Cl2NO2

Conditions

Conditions	Yield
With sodium hydroxide In acetone for 0.0416667h; Microwave irradiation;	94%

5-Isopropyl-2-methylphenol Chemical Properties

Molecular structure of Carvacrol (CAS NO.499-75-2):

IUPAC Name: 2-Methyl-5-propan-2-ylphenol
Molecular Weight: 150.21756 g/mol
Molecular Formula: C₁₀H₁₄O
Density: 0.974 g/cm³
Melting Point: 3-4 °C(lit.)
Boiling Point: 237.2 °C at 760 mmHg
Flash Point: 106.7 °C
Index of Refraction: 1.523
Molar Refractivity: 47.14 cm³
Molar Volume: 154.2 cm³
Polarizability: 18.68×10^-24cm³
Surface Tension: 34.9 dyne/cm
Enthalpy of Vaporization: 49.32 kJ/mol
Vapour Pressure: 0.0296 mmHg at 25 °C
Water Solubility: insoluble
XLogP3: 3.1
H-Bond Donor: 1
H-Bond Acceptor: 1
Rotatable Bond Count: 1
Tautomer Count: 9
Exact Mass: 150.104465
MonoIsotopic Mass: 150.104465
Topological Polar Surface Area: 20.2
Heavy Atom Count: 11
Complexity: 120
Canonical SMILES: CC1=C(C=C(C=C1)C(C)C)O
InChI: InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
InChIKey: RECUKUPTGUEGMW-UHFFFAOYSA-N
EINECS: 207-889-6
Product Categories: Alcohols and Derivatives; Miscellaneous Natural Products

5-Isopropyl-2-methylphenol Uses

Carvacrol (CAS NO.499-75-2) is used for the preparation of spices, fungicides and disinfectants. It also is used as the spices in toothpaste, soap and other daily necessities. Carvacrol also can be used as food flavor.

5-Isopropyl-2-methylphenol Production

Carvacrol may be synthetically prepared by the action of nitrous acid on 1-methyl-2-amino-4-propyl benzene; by the fusion of cymol sulfonic acid with caustic potash; by prolonged heating of five parts of camphor with one part of iodine; or by heating carvol with glacial phosphoric acid or by performing a dehydrogenation of carvone with a Pd/C catalyst.

5-Isopropyl-2-methylphenol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	100mg/kg (100mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
dog	LDLo	intravenous	310mg/kg (310mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Therapie. Vol. 3, Pg. 109, 1948.
frog	LDLo	subcutaneous	75mg/kg (75mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
mouse	LD50	intraperitoneal	73300ug/kg (73.3mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Quarterly Journal of Crude Drug Research. Vol. 19, Pg. 1, 1981.
mouse	LD50	intravenous	80mg/kg (80mg/kg)	BEHAVIORAL: SLEEP	Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse	LD50	subcutaneous	680mg/kg (680mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 3, Pg. 73, 1952.
rabbit	LDLo	oral	100mg/kg (100mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 161, Pg. 196, 1931.
rabbit	LDLo	skin	2700mg/kg (2700mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
rat	LD50	oral	810mg/kg (810mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

5-Isopropyl-2-methylphenol Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 22-34
R22:Harmful if swallowed.
R34:Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 3
WGK Germany: 3
RTECS: FI1225000
HazardClass: 8
PackingGroup: III
Hazardous Substances Data: 499-75-2(Hazardous Substances Data)

5-Isopropyl-2-methylphenol Specification

Carvacrol (CAS NO.499-75-2) is also named as 1-Hydroxy-2-methyl-5-isopropylbenzene ; 1-Methyl-2-hydroxy-4-isopropylbenzene ; 2-Hydroxy-p-cymene ; 2-Methyl-5-(1-methylethyl)phenol ; 2-Methyl-5-isopropylphenol ; 2-p-Cymenol ; 3-Isopropyl-6-methylphenol ; 4-06-00-03331 (Beilstein Handbook Reference) ; 5-Isopropyl-2-methylphenol ; 5-Isopropyl-o-cresol ; 6-Methyl-3-isopropylphenol ; AI3-03438 ; Antioxine ; BRN 1860514 ; CCRIS 7450 ; Caswell No. 511 ; Cymene-2-ol, p- ; EPA Pesticide Chemical Code 022104 ; FEMA No. 2245 ; HSDB 906 ; Isopropyl-o-cresol ; Karvakrol ; NSC 6188 ; Phenol, 2-methyl-5-(1-methylethyl)- ; Phenol, 3-isopropyl-6-methyl- ; Phenol, 5-isopropyl-2-methyl- ; UNII-9B1J4V995Q ; o-Cresol, 5-isopropyl- ; o-Thymol ; p-Cymen-2-ol ; p-Cymene, 2-hydroxy- . Carvacrol (CAS NO.499-75-2) is colorless to pale yellow viscous oil with a bit thick. It is stable and combustible. It can be incompatible with strong bases, strong oxidizing agents. It is soluble in ethanol, ethyl ether, propylene glycol and alkali, insoluble in water. It also can miscible in oil.

Product Name

Carvacrol

Synthetic route

5-Isopropyl-2-methylphenol Chemical Properties

5-Isopropyl-2-methylphenol Uses

5-Isopropyl-2-methylphenol Production

5-Isopropyl-2-methylphenol Toxicity Data With Reference

5-Isopropyl-2-methylphenol Safety Profile

5-Isopropyl-2-methylphenol Specification

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