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Cas:78-82-0
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With ammonia; oxidized form SMS-4 Zn-Cr-O at 360℃; | 95.8% |
With ammonia; oxidized form SMS-4 Zn-Cr-O at 360℃; Product distribution; 1:4 molar ratio n-butyl alcohol/NH3, other temperature (300-420 deg C);; | 95.8% |
With ammonia; zinc(II) oxide at 19.9℃; Mechanism; |
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate; N,N-dimethyl-formamide at 100℃; | 91% |
Stage #1: isobutyraldehyde With hydroxylamine hydrochloride; sodium hydroxide In water at 70℃; Stage #2: With copper diacetate; hydrazine In acetonitrile at 90℃; for 0.5h; | 80% |
With ammonium hydroxide; periodic acid; potassium iodide at 60℃; for 65745h; Green chemistry; Sealed tube; | 78% |
Conditions | Yield |
---|---|
With ammonium bromide In methanol; water Electrochemical reaction; | 91% |
With perchloric acid; N,N-Dichlorobenzenesulfonamide In methanol; water at 29.9℃; Rate constant; Kinetics; Thermodynamic data; other amino acids; var. temp. and conditions; ΔH(excit.), ΔS(excit.), ΔG(excit.), Ea; equilibrium constant; | |
With perchloric acid; N,N-Dichlorobenzenesulfonamide; sodium perchlorate In water; acetic acid at 39.9℃; Rate constant; Kinetics; Thermodynamic data; var. temp. and conditions; Ea, ΔH(excit.), ΔS(excit.), ΔG(excit.); |
2,2'-azobis(isobutyronitrile)
4-methyl-benzaldehyde
A
Isobutyronitrile
B
2,2,3,3-tetramethylsuccinonitrile
Conditions | Yield |
---|---|
In 1,2-dichloro-ethane at 50℃; for 24h; Inert atmosphere; | A n/a B n/a C 88% |
Conditions | Yield |
---|---|
With S,S-dimethyl dithiocarbonate; triethylamine In 1,4-dioxane at 90℃; | 85% |
With ethyl cyanoformate; triethylamine In acetonitrile Ambient temperature; | 75% |
With phenylacetaldoxime dehydratase(Bacillus OxB-1 expres.E.coli) In water at 30℃; for 17h; pH=8.0; |
Conditions | Yield |
---|---|
With potassium hydroxide; p-t-butylcalix<6>arene derivative In dichloromethane at 40℃; for 4h; | 84% |
With 3 A molecular sieve at 90 - 500℃; under 0.01 Torr; for 0.25h; Pyrolysis; | 59% |
With phosphorus pentoxide durch Destillation; |
Conditions | Yield |
---|---|
With oxygen In para-xylene at 110℃; for 2h; | A 8% B 77% |
Conditions | Yield |
---|---|
A 75% B 15% |
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2,2'-azobis(isobutyronitrile)
4-chlorobenzaldehyde
A
Isobutyronitrile
B
2,2,6,6-tetramethylpiperidin-1-yl 4-chlorobenzoate
Conditions | Yield |
---|---|
With S-(trifluoromethyl) benzenesulfonothioate In 1,2-dichloro-ethane at 80℃; for 16h; Irradiation; | A 73% B n/a |
isobutyraldehyde dimethylhydrazone
Isobutyronitrile
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 5h; | 65% |
Conditions | Yield |
---|---|
With pyridine; trichloroisocyanuric acid In water | 58.4% |
2,2'-azobis(isobutyronitrile)
A
Isobutyronitrile
B
dimethyl N-(2-cyano-2-propyl)ketenimine
C
2,2,3,3-tetramethylsuccinonitrile
D
N-(1-cyano-1-methylethyl)-2-methylpropanamide
Conditions | Yield |
---|---|
With silica gel at 10℃; Product distribution; Irradiation; further in benzene, D-labelled, var. conditions of irradiation; | A 5% B 16% C 53% D 31% |
isobutyraldehyde
A
diisobutylamine
B
Isobutyronitrile
C
triisobutylamine
D
N-isobutylideneisobutylamine
E
isobutylamine
Conditions | Yield |
---|---|
With ammonia; hydrogen; palladium on activated charcoal at 180℃; under 760 Torr; Product distribution; Mechanism; other catalyst, temperature;; | A 47.1% B 3% C 5.7% D 6.1% E 19.9% |
N-tosyl dimethylketenimine
A
4-toluenesulfonyl azide
B
Isobutyronitrile
C
N-[1-Amino-2-methyl-prop-2-en-(Z)-ylidene]-4-methyl-benzenesulfonamide
D
C22H28N2O5S2
Conditions | Yield |
---|---|
With tris-(2-chloro-ethyl)-amine In diethyl ether Product distribution; | A n/a B n/a C 14% D 3% |
With tris-(2-chloro-ethyl)-amine In diethyl ether | A n/a B n/a C 14% D 3% |
methacrylonitrile
A
Isobutyronitrile
B
2,2,3,3-tetramethylsuccinonitrile
C
2-amino-2-cyanopropane
Conditions | Yield |
---|---|
With ammonia for 3h; Irradiation; | A 3% B 14% C 8% |
With ammonia for 3h; Irradiation; | A 3% B 14% C 8% |
With ammonia for 3h; Irradiation; | A 3% B 14% C 8% |
Conditions | Yield |
---|---|
With aluminum oxide; ammonia; copper at 400 - 430℃; | |
With silica-alumina; ammonia; silver at 400 - 430℃; | |
With chromium(III) oxide; ammonia at 350 - 500℃; | |
With molybdenum(IV) oxide; kieselguhr; ammonia at 350 - 500℃; |
Conditions | Yield |
---|---|
With aluminum oxide at 500℃; |
Conditions | Yield |
---|---|
With mercury tetracarbonylcobaltate (1-) | |
With dicobalt octacarbonyl; triphenylphosphine | |
With aluminum oxide; hydrogen at 430 - 505℃; |
Conditions | Yield |
---|---|
With hydrogen; nickel at 320 - 330℃; |
Conditions | Yield |
---|---|
With aluminum oxide at 350 - 360℃; | |
With thorium dioxide at 350 - 360℃; |
Conditions | Yield |
---|---|
With diethyl ether; phenylmagnesium bromide Zersetzung mit kalter verd.HCl; |
Conditions | Yield |
---|---|
With nickel at 430℃; |
Conditions | Yield |
---|---|
With copper-zinc catalyst; ammonia at 350℃; |
O-isopropyl methylphosphonofluoridate
3-isonitroso-4-methyl-2-pentanone
A
Isobutyronitrile
B
acetic acid
Conditions | Yield |
---|---|
at 25℃; Rate constant; |
Conditions | Yield |
---|---|
bei rascher Destillation; |
Conditions | Yield |
---|---|
With hydrogen; nickel at 180 - 190℃; |
Conditions | Yield |
---|---|
With copper at 400 - 420℃; | |
With nickel at 320 - 330℃; | |
With Ru2Cl4(4'-azulenyl-2,2':6',2''-terpyridine)2; oxygen In methanol at 60℃; under 19001.3 Torr; for 24h; Autoclave; |
Isobutyronitrile
1,3-chlorobromopropane
5-chloro-2,2-dimethylpentanenitrile
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane at 70℃; for 16h; | 100% |
With lithium hexamethyldisilazane at 70℃; for 16h; | 100% |
With lithium hexamethyldisilazane at 70℃; for 16h; | 100% |
Isobutyronitrile
Bromoacetaldehyde diethyl acetal
2,2-dimethyl-4,4-diethoxybutyronitrile
Conditions | Yield |
---|---|
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -68℃; for 1.66667h; Stage #2: Isobutyronitrile In tetrahydrofuran; hexane at -70℃; for 2h; Stage #3: Bromoacetaldehyde diethyl acetal With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone more than 3 stages; | 100% |
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Stage #2: Bromoacetaldehyde diethyl acetal In tetrahydrofuran at -20 - 20℃; Reflux; | 89% |
With lithium diisopropyl amide In N,N,N,N,N,N-hexamethylphosphoric triamide | 88% |
Isobutyronitrile
(4,5-dimethoxy-2-iodophenyl)methyl bromide
3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: (4,5-dimethoxy-2-iodophenyl)methyl bromide In tetrahydrofuran; hexane at -78 - 20℃; Further stages.; | 100% |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 19h; | 100% |
Isobutyronitrile
Cinnamyl bromide
(4E)-2,2-dimethyl-5-phenylpent-4-enenitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 0.5h; Stage #2: Cinnamyl bromide In tetrahydrofuran at -78 - 20℃; for 2h; | 100% |
Stage #1: Isobutyronitrile With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1h; Stage #2: Cinnamyl bromide In tetrahydrofuran at -78 - 20℃; | 91% |
Stage #1: Isobutyronitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: Cinnamyl bromide In tetrahydrofuran; mineral oil at -78 - 20℃; for 1h; Inert atmosphere; | 84% |
Isobutyronitrile
Conditions | Yield |
---|---|
In acetonitrile Ar-atmosphere; stirring (-30°C, 1 h); filtering, washing (MeCN, pentane, -30°C), drying (vac.); elem. anal.; | 100% |
In further solvent(s) reaction of Me2PN(t-Bu3C6H2)ZrCp2Cl with (i-Pr)CN under Ar; |
Isobutyronitrile
meta-bromobenzyl bromide
3-(3-bromophenyl)-2,2-dimethylpropanenitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 0.75h; Stage #2: meta-bromobenzyl bromide In tetrahydrofuran; n-heptane; ethylbenzene for 2h; | 100% |
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 0.75h; Stage #2: meta-bromobenzyl bromide In tetrahydrofuran; n-heptane; ethylbenzene at -78℃; for 2h; |
6-fluoro-3,4-dihydro-2H-isoquinolin-1-one
Isobutyronitrile
2-methyl-2-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-propionitrile
Conditions | Yield |
---|---|
With potassium hexamethylsilazane In tetrahydrofuran; toluene at 70℃; for 12h; | 100% |
Isobutyronitrile
2-Fluorobenzaldehyde
3-(2-fluoro-phenyl)-3-hydroxy-2,2-dimethyl-propionitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -70 - -10℃; for 0.166667h; Inert atmosphere; Stage #2: 2-Fluorobenzaldehyde In tetrahydrofuran; hexane at -10 - 20℃; for 1h; | 100% |
Isobutyronitrile
3,6-bis(1-methylethyl)-1,2,4,5-tetrazine
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With hydrazine hydrate; zinc(II) iodide at 60℃; Inert atmosphere; Stage #2: With hydrogenchloride; sodium nitrite In water; N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 100% |
Stage #1: Isobutyronitrile With hydrazine hydrate; zinc(II) iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere; Stage #2: With sodium nitrite In water; N,N-dimethyl-formamide at 20℃; Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide pH=2; | 100% |
Stage #1: Isobutyronitrile With hydrazine hydrate; zinc(II) iodide at 60℃; Inert atmosphere; Stage #2: With hydrogenchloride; sodium nitrite In water; N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 100% |
Stage #1: Isobutyronitrile With hydrazine hydrate; zinc(II) iodide In N,N-dimethyl-formamide at 60℃; Inert atmosphere; Stage #2: With hydrogenchloride; sodium nitrite In water; N,N-dimethyl-formamide at 20℃; pH=2; | 100% |
Stage #1: Isobutyronitrile With zinc trifluoromethanesulfonate; hydrazine at 60℃; for 24h; Inert atmosphere; Stage #2: With sodium nitrite In water; N,N-dimethyl-formamide Inert atmosphere; Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide pH=3; Inert atmosphere; | 72% |
Conditions | Yield |
---|---|
With C25H38NiOP2; water In isopropyl alcohol at 80℃; for 3h; Reagent/catalyst; Sealed tube; | 99% |
With water; tricyclohexylphosphine; {Rh(OMe)(cod)}2 In isopropyl alcohol at 25℃; for 24h; | 93% |
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; water; 1-benzyl-1-azonia-3,5-diaza-7-phosphaadamantyl chloride for 1h; Catalytic behavior; Reagent/catalyst; Schlenk technique; Reflux; Green chemistry; | 92% |
Conditions | Yield |
---|---|
With lithium diethylamide In diethyl ether at 20℃; | 99% |
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: allyl bromide In tetrahydrofuran; hexane at 0 - 20℃; for 16h; Inert atmosphere; | 99% |
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.75h; Stage #2: allyl bromide In tetrahydrofuran at -78 - 20℃; Further stages.; | 65% |
Isobutyronitrile
ethyl 2-bromomethyl-2-propenoate
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran for 2h; Heating; | 99% |
Isobutyronitrile
(2R,3S)-5-iodo-1,2-(isopropylidenedioxy)-3-(methoxymethoxy)pentane
(5S,6R)-6,7-(isopropylidenedioxy)-5-(methoxymethoxy)-2,2-dimethyl-1-heptanenitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: (2R,3S)-5-iodo-1,2-(isopropylidenedioxy)-3-(methoxymethoxy)pentane In tetrahydrofuran; hexane at -18℃; for 0.5h; | 99% |
Isobutyronitrile
4-bromobenzenecarbonitrile
4-(1-cyano-1-methyl-ethyl)-benzonitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With sodium hexamethyldisilazane In toluene at 25℃; for 0.166667h; Stage #2: 4-bromobenzenecarbonitrile With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene at 100℃; for 1h; Further stages.; | 99% |
With P(i-BuNCH2CH2)3N; sodium hexamethyldisilazane; palladium diacetate In toluene at 100℃; for 2h; | 98% |
With sodium hexamethyldisilazane In toluene at 100℃; for 1h; | 42% |
Isobutyronitrile
cis-bis(isobutyronitrile)dichloroplatinum(II)
Conditions | Yield |
---|---|
In not given excess nitrile; | 99% |
Isobutyronitrile
1-Bromo-2-bromomethyl-benzene
3-(2-bromophenyl)-2,2-dimethylpropanenitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: 1-Bromo-2-bromomethyl-benzene In tetrahydrofuran at 20℃; for 3h; | 99% |
Stage #1: Isobutyronitrile With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: 1-Bromo-2-bromomethyl-benzene In tetrahydrofuran at 20℃; for 3h; | 99% |
Stage #1: Isobutyronitrile With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: 1-Bromo-2-bromomethyl-benzene In tetrahydrofuran at 20℃; for 3h; | 99% |
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: 1-Bromo-2-bromomethyl-benzene In tetrahydrofuran at -78 - 20℃; Inert atmosphere; | 68% |
With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃; for 12h; Inert atmosphere; |
Isobutyronitrile
2-(glycidyloxy)-1-naphthonitrile-N-oxide
C18H18N2O3
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 90℃; for 4h; | 99% |
Isobutyronitrile
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
Conditions | Yield |
---|---|
With C52H70Mg2N4 In benzene-d6 at 60℃; for 5h; Glovebox; | 99% |
With manganese(II) triflate bis-acetonitrile solvate; potassium tert-butylate In benzene-d6 at 20℃; for 3h; Inert atmosphere; Glovebox; | 98% |
With C37H59AlN2 In neat (no solvent) at 60℃; for 1h; Inert atmosphere; | 97% |
Isobutyronitrile
cyclopropyl(4-fluorophenyl)methanone
A
2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile
Conditions | Yield |
---|---|
With potassium hexamethylsilazane In toluene at 60 - 62℃; for 0.166667h; Reagent/catalyst; Temperature; | A 99% B n/a |
Conditions | Yield |
---|---|
With hydrogenchloride In Petroleum ether at 0℃; for 60h; | 98% |
With hydrogenchloride In hexane at 0℃; for 3h; | 98% |
With hydrogenchloride 1.) 0 deg C, 2.) 5 deg C, 1-2 d; | 95% |
Isobutyronitrile
1-[(1-chloro-1-methylethyl)azo]-2,4,6-trichlorobenzene
Conditions | Yield |
---|---|
With antimonypentachloride In dichloromethane at -60 - 23℃; | 98% |
Isobutyronitrile
isobutyramide oxime
Conditions | Yield |
---|---|
With hydroxylamine In ethanol; water for 5h; Heating / reflux; | 98% |
With hydroxylamine hydrochloride; potassium hydroxide In methanol for 24h; Reflux; | 88% |
With hydroxylamine hydrochloride; potassium hydroxide In methanol for 24h; Reflux; | 85% |
Isobutyronitrile
methyl trifluoromethanesulfonate
N-methylisobutyronitrilium trifluoromethanesulfonate
Conditions | Yield |
---|---|
for 48h; Ambient temperature; | 98% |
95% |
Isobutyronitrile
chloromethyl methyl ether
3-methoxy-2,2-dimethylpropionitrile
Conditions | Yield |
---|---|
Stage #1: Isobutyronitrile With lithium diisopropyl amide In tetrahydrofuran at -70℃; for 1.16667h; Stage #2: chloromethyl methyl ether In tetrahydrofuran at 20℃; for 1h; Stage #3: With water; ammonium chloride In tetrahydrofuran | 98% |
With lithium diisopropyl amide In diethyl ether at -78℃; for 1h; | 62% |
Isobutyronitrile
1-chloroisoquinoline
1-(1-cyano-1-methylethyl)isoquinoline
Conditions | Yield |
---|---|
With sodium hexamethyldisilazane In tetrahydrofuran; toluene at 0 - 20℃; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2,3-dichloropyrazine With lithium hexamethyldisilazane In toluene Stage #2: Isobutyronitrile In toluene at 20℃; for 24h; | 98% |
Isobutyronitrile
N-hydroxyisobutyramidine
Conditions | Yield |
---|---|
With hydroxylamine In ethanol; water for 5h; Heating / reflux; | 98% |
With hydroxylamine In ethanol; water for 5h; Heating / reflux; | 98% |
With hydroxylamine In ethanol; water for 3h; Product distribution / selectivity; Reflux; | 98% |
Isobutyronitrile
tricarbonyl(η(6)-1,2,3-trimethoxybenzene)chromium
2-(3,4-dimethoxy-phenyl)-2-methylpropiononitrile tricarbonylchromium
Conditions | Yield |
---|---|
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane N2-atmosphere, in dark; addn. of i-Pr2NH to BuLi (in hexane) at -78°C, nitrile addn. (after 10 min), stirring (-78°C, 15 min), addn. of Cr-complex, 1 h at -78°C, addn. to acid, stirring -78°C, 30 min, warming to room temp.; partitioning between Et2O/aq. KOH, washing of org. layer (water, brine),filtration over MgSO4, evapn. (reduced pressure), chromy. (SiO2, AcOEt/ petroleum ether); elem. anal.; | 98% |
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