7-Chloro-2-methylquinoline supplier

Name
7-Chloro-2-methylquinoline
EINECS 440-600-3
CAS No. 4965-33-7
Article Data33
CAS DataBase
Density 1.225 g/cm³
Solubility
Melting Point 74-78 °C(lit.)
Formula C₁₀H₈ClN
Boiling Point 278.177 °C at 760 mmHg
Molecular Weight 177.633
Flash Point 148.736 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 7-Chloro-2-methylquinoline(7-Chloroquinaldine);Quinoline, 7-chloro-2-methyl-;7-chloro-2-methyl-quinoline;7-chlorquinaldine;7-Chloroquinaldine;
PSA 12.89000
LogP 3.19660

Synthetic route

: 123-42-2
4-Hydroxy-4-methyl-2-pentanone

: 59236-37-2
2-amino-4-chlorobenzaldehyde

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate In toluene at 70℃; Inert atmosphere; Schlenk technique; chemoselective reaction;	90%

: 123-73-9
trans-Crotonaldehyde

: 108-42-9
3-chloro-aniline

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With phospho-tungstic acid; phosphotungstic acid; silica gel for 0.2h; Doebner-Miller reaction; microwave irradiation;	86%
With hydrogenchloride; chloranil In tetrahydrofuran; methanol; iso-butanol

: 7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With tetrasodium cobalt(II) 4,4',4'',4'''-tetrasulphophthalocyanine In water; ethyl acetate at 20℃; for 18h; Irradiation; Green chemistry;	85%
With rose bengal; oxygen In N,N-dimethyl acetamide at 20℃; for 24h; Irradiation;	73%
With rose bengal In N,N-dimethyl acetamide at 20℃; for 28h; Irradiation;	73%
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; Co(dmgH)2(4-MeCO2Py)Cl In water at 28℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;	73%
With 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; oxygen; nickel dibromide In tert-Amyl alcohol at 95℃; for 48h;	42%

: 109-92-2
ethyl vinyl ether

: 108-42-9
3-chloro-aniline

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With magnetite-palladium-graphene nanocomposite In acetonitrile at 80℃; for 12h;	72%

: 64-17-5
ethanol

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate In tetrachloromethane at 140℃; for 4h; Autoclave; Inert atmosphere; Sealed tube;	A 11% B 67%

...Expand

: 108-42-9
3-chloro-aniline

: 123-73-9
crotonaldehyde

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
Stage #1: 3-chloro-aniline; crotonaldehyde With hydrogenchloride In water; toluene at 110℃; for 1.5h; Stage #2: With zinc(II) chloride In tetrahydrofuran; water; acetone; toluene at 60℃; for 1h; Cooling with ice;	30%
With hydrogenchloride In water; toluene for 2h; Doebner-Miller Quinoline Synthesis; Reflux;
With hydrogenchloride; 1-methyl-2-nitrobenzene In water at 100℃; for 9h; Reagent/catalyst; Skraup Quinoline Synthesis; Reflux;

: 10138-89-3
1,1,3-trimethoxybutane

: 141-85-5
3-chloroaniline hydrochloride

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With ethanol; iron(III) chloride; zinc(II) chloride

: 75-07-0
acetaldehyde

: 108-42-9
3-chloro-aniline

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
With hydrogenchloride

: 75-07-0
acetaldehyde

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With di-μ-chlorobis(norbornadiene)dirhodium(I); 3-Nitrochlorobenzene In ethanol at 180℃; for 4h; Yield given. Yields of byproduct given;

...Expand

: 106237-28-9
β-(m-chloroanilino)crotonaldehyde

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With sulfuric acid at 25℃; Rate constant;

: 50-00-0
formaldehyd

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With sulfuric acid; sodium 3-nitrobenzenesulfonate at 120 - 130℃; for 1.83333h;	A 8.64 g B 0.28 g
With sulfuric acid; sodium 3-nitrobenzenesulfonate at 120 - 130℃; for 1.83333h;	A 8.64 g B 0.79 g

...Expand

: 123-73-9
trans-Crotonaldehyde

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With hydrogenchloride; chloranil In various solvent(s) for 0.333333h; Heating;

...Expand

: 108-42-9
3-chloro-aniline

m-nitro-benzenesulfonate sodium: m-nitro-benzenesulfonate sodium

A: 4965-33-7
2-methyl-7-chloroquinoline

B 5-chloro-quinaldine: 5-chloro-quinaldine

Conditions

Conditions	Yield
at 120 - 130℃; Behandeln mit Paraldehyd; Trennung der Isomeren ueber die Pikrate;

...Expand

: 123-73-9
trans-Crotonaldehyde

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

C: 15258-44-3
N-ethyl-3-chloroaniline

D: 75813-68-2
Butyl-(3-chloro-phenyl)-amine

E: C10H12ClN

F: C10H12ClN

G 7-chlorotetrahydroquinaldine: 7-chlorotetrahydroquinaldine

Conditions

Conditions	Yield
With hydrogenchloride; chloranil In ethanol; water Product distribution; Heating; other substituted anilines; var. solvents, var. oxidants and acids, var. temperatures;

...Expand

: 106237-20-1
1-(m-chlorophenylamino)-3-(m-chlorophenylimino)-1-butene hydrochloride

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.29 g / NaOH / H2O; ethanol / 2 h / 80 °C 2: 8.64 g / sodium m-nitrobenzenesulfonate, 72.2 percent H2SO4 / 1.83 h / 120 - 130 °C View Scheme

aqueous crotonaldehyde: aqueous crotonaldehyde

: 60-29-7
diethyl ether

: 108-42-9
3-chloro-aniline

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
zinc(II) chloride In hydrogenchloride; water

...Expand

: 109-92-2
ethyl vinyl ether

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 15258-44-3
N-ethyl-3-chloroaniline

Conditions

Conditions	Yield
With palladium on activated charcoal; palladium dichloride In acetonitrile at 80℃; for 24h;	A 68 %Chromat. B 23 %Chromat.

...Expand

: 4784-77-4, 39616-19-8, 29576-14-5
(E)-1-Bromo-2-butene

: 15426-14-9, 106131-20-8, 106131-24-2
3,3'-dichloroazobenzene

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With copper(l) iodide In 1,2-dichloro-ethane at 120℃; for 12h; Inert atmosphere; Sealed tube; Overall yield = 44 %; Overall yield = 15.6 mg;

...Expand

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper(I) bromide; pyridine / toluene / 20 h / 60 °C 2: copper(l) iodide / 1,2-dichloro-ethane / 12 h / 120 °C / Inert atmosphere; Sealed tube View Scheme

: 107-21-1
ethylene glycol

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

Conditions

Conditions	Yield
With tetrachloromethane; iron(III) chloride hexahydrate at 150℃; for 8h; Inert atmosphere; Sealed tube; Autoclave; Overall yield = 56 %;

...Expand

: 18826-95-4, 107-88-0
1.3-butanediol

: 108-42-9
3-chloro-aniline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: 4964-69-6
2-methyl-5-chloroquinoline

C: 40941-53-5
7-chloro-4-methyl-quinoline

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate In tetrachloromethane at 150℃; for 8h; Inert atmosphere; Overall yield = 79 %;

...Expand

: 37585-16-3
(2-amino-4-chlorophenyl)methanol

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: manganese(IV) oxide / dichloromethane / Inert atmosphere 2: chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate / toluene / 70 °C / Inert atmosphere; Schlenk technique View Scheme

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere 2: manganese(IV) oxide / dichloromethane / Inert atmosphere 3: chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate / toluene / 70 °C / Inert atmosphere; Schlenk technique View Scheme

: 7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

A: 4965-33-7
2-methyl-7-chloroquinoline

B: (R)-7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

Conditions

Conditions	Yield
With monoamine oxidase from Pseudomonas monteilii ZMU-T01 In aq. buffer at 37℃; pH=7.5; Resolution of racemate; enantioselective reaction;	A n/a B n/a

: 3-(3-chloroanilino)butyraldehyde

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloromethane / 5 h / 40 °C / Acidic conditions 2: sulfuric acid / toluene; water / 100 °C 3: water / 70 °C View Scheme

: C10H10ClN

: 4965-33-7
2-methyl-7-chloroquinoline

Conditions

Conditions	Yield
In water at 70℃; Temperature; Reagent/catalyst;

: 4965-33-7
2-methyl-7-chloroquinoline

: 7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

Conditions

Conditions	Yield
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate at -10℃; Green chemistry; enantioselective reaction;	99%

: 108-85-0
1-bromocyclohexane

: 4965-33-7
2-methyl-7-chloroquinoline

: 7-chloro-4-cyclohexyl-2-methylquinoline

Conditions

Conditions	Yield
With {Au(dppm)}2Cl2; trifluoroacetic acid In methanol Inert atmosphere; UV-irradiation;	99%

: 4965-33-7
2-methyl-7-chloroquinoline

: 7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

Conditions

Conditions	Yield
With hydrogen In toluene at 100℃; under 37503.8 Torr; for 24h; chemoselective reaction;	99%
With C46H49CoN3P4(2+)*2BF4(1-); hydrogen; potassium hydroxide In toluene; acetonitrile at 100℃; under 22801.5 Torr; for 48h; Autoclave; Glovebox; chemoselective reaction;	87%
With sodium tetrahydroborate; hydrogen; cobalt(II) chloride In water at 150℃; under 30003 Torr; for 17h; Green chemistry; chemoselective reaction;	67%
With sodium cyanoborohydride; acetic acid at 20℃; Sealed tube;

: 4965-33-7
2-methyl-7-chloroquinoline

: 1260753-86-3
(-)-7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

Conditions

Conditions	Yield
With bromopentacarbonylmanganese(I); potassium tert-butylate; hydrogen; E-1-(1H-benzo[d]imidazol-2-yl)-N-((SC,RFC)-1-(2-diphenylphosphino)ferrocenyl)methanimine In 1,4-dioxane at 80℃; under 45004.5 Torr; for 16h; Autoclave; enantioselective reaction;	98%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C73H100O2P2; hydrogen; iodine In toluene at 20℃; under 15201 Torr; for 24h; optical yield given as %ee; enantioselective reaction;

: 4965-33-7
2-methyl-7-chloroquinoline

: 108-95-2
phenol

: C16H13NO

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; N1-benzyl-N2-(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere;	98%

: 504-29-0
2-aminopyridine

: 4965-33-7
2-methyl-7-chloroquinoline

: C15H13N3

Conditions

Conditions	Yield
With C51H57ClNiO2P2; sodium t-butanolate at 25℃;	98%

: 4965-33-7
2-methyl-7-chloroquinoline

: 626-19-7
Isophthalaldehyde

: 120578-03-2
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde

Conditions

Conditions	Yield
With lanthanum pentafluorobenzoate In toluene at 120℃; for 24h;	97%
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry;	93%
With acetic anhydride In toluene at 100 - 105℃; for 12 - 15h;	75.15%

: 4965-33-7
2-methyl-7-chloroquinoline

: 758640-21-0
N-Benzylaniline

: 70382-84-2
(E)-7-chloro-2-styrylquinoline

Conditions

Conditions	Yield
Stage #1: N-Benzylaniline With 2,3-dicyano-5,6-dichloro-p-benzoquinone In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-methyl-7-chloroquinoline In N,N-dimethyl-formamide at 70℃; for 24h; Inert atmosphere; diastereoselective reaction;	97%

: 4965-33-7
2-methyl-7-chloroquinoline

: 100-46-9
benzylamine

: 70382-84-2
(E)-7-chloro-2-styrylquinoline

Conditions

Conditions	Yield
With lanthanum pentafluorobenzoate In toluene at 120℃; for 24h;	97%
With tert.-butylhydroperoxide; N-Bromosuccinimide In water; acetonitrile at 100℃; for 48h; Schlenk technique; Darkness; Green chemistry;	95%
With 1,10-phenanthroline-5,6-dione; trifluorormethanesulfonic acid; oxygen In chlorobenzene at 80℃; under 760.051 Torr; for 24h;	86%
With tert.-butylhydroperoxide; water; sodium chloride at 100℃;	75%

: 4965-33-7
2-methyl-7-chloroquinoline

: 7-chloro-2-(d3)methylquinoline

Conditions

Conditions	Yield
With water-d2; benzoic acid at 80℃; for 4h;	97%
With water-d2; benzoic acid at 90℃; for 8h; Inert atmosphere; Schlenk technique;

: 4965-33-7
2-methyl-7-chloroquinoline

: 75-64-9
tert-butylamine

: N-(tert-butyl)-2-methylquinolin-7-amine

Conditions

Conditions	Yield
With (PhPAd-DalPhos)NiCl(o-tol); sodium t-butanolate In toluene at 25℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;	97%

: 4965-33-7
2-methyl-7-chloroquinoline

: 79-31-2
isobutyric Acid

: 7-chloro-4-isopropyl-2-methylquinoline

Conditions

Conditions	Yield
With 2-Picolinic acid; ferrous(II) sulfate heptahydrate; sodium bromate In water; dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Irradiation;	97%

: 4965-33-7
2-methyl-7-chloroquinoline

: 71-36-3
butan-1-ol

: 7-butoxy-2-methylquinoline

Conditions

Conditions	Yield
With (4,4′-di-tert-butyl-2,2′-dipyridyl)Ni(o-tolyl)(Br); 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 80℃; for 12h; Inert atmosphere; Sealed tube; UV-irradiation;	97%

: 4965-33-7
2-methyl-7-chloroquinoline

: 753-90-2
trifluoroethylamine

: 2-methyl-N-(2,2,2-trifluoroethyl)quinolin-7-amine

Conditions

Conditions	Yield
With C33H43ClNiO6P2; sodium t-butanolate In toluene at 25℃; for 18h; Inert atmosphere; Sealed tube;	97%

: 4965-33-7
2-methyl-7-chloroquinoline

: 100-52-7
benzaldehyde

: 70382-84-2
(E)-7-chloro-2-styrylquinoline

Conditions

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry;	96%
With cobalt(II) chloride In water at 120℃; for 24h;	93%
With 1,3-dimethylbarbituric acid; acetic acid In 1,4-dioxane; water at 60℃; for 24h;	93%

: 4965-33-7
2-methyl-7-chloroquinoline

: 64334-96-9
2-methylquinolin-7-amine

Conditions

Conditions	Yield
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;	96%
With bis(1,5-cyclooctadiene)nickel (0); (R)-1-[(Sp)-2-(dicyclohexylphosphanyl)ferrocenyl]ethyldicyclohexylphosphane; ammonia; sodium t-butanolate In 1,4-dioxane; toluene at 105℃; under 5895.64 - 7757.43 Torr; for 18h; Sealed tube;	92%

: 4965-33-7
2-methyl-7-chloroquinoline

: 5764-82-9
bromo(2-ethoxy-2-oxoethyl)zinc

: ethyl 2-(2-methyl-7-quinolyl)acetate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); N,N,N,N,-tetramethylethylenediamine; C38H62P2 In tetrahydrofuran at 20℃; for 16h; Negishi Coupling; Inert atmosphere;	96%

: 13331-23-2
fur-2-ylboronic acid

: 4965-33-7
2-methyl-7-chloroquinoline

: 1445086-33-8
C14H11NO

Conditions

Conditions	Yield
With potassium phosphate; ((2-dicyclohexylphosphino-2',4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate) In tetrahydrofuran at 20℃; for 0.5h; Suzuki-Miyaura Coupling;	95%
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;	95%

: 500-22-1
3-pyridinecarboxaldehyde

: 4965-33-7
2-methyl-7-chloroquinoline

: C16H11ClN2

Conditions

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry;	95%

: 4965-33-7
2-methyl-7-chloroquinoline

: 50-00-0
formaldehyd

: 177748-00-4
7-chloro-2-ethenylquinoline

Conditions

Conditions	Yield
With diethyl amine hydrochloride; triethylamine In 1,4-dioxane at 100℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;	95%

: 4965-33-7
2-methyl-7-chloroquinoline

: 95-54-5
1,2-diamino-benzene

: 2-(1H-benzo[d]imidazol-2-yl)-7-chloroquinoline

Conditions

Conditions	Yield
With iodine; oxygen In dimethyl sulfoxide at 110℃;	95%

: 4965-33-7
2-methyl-7-chloroquinoline

: 75264-92-5
tetramethylammonium trifluoromethylselenate(0)

: 2-methyl-7-((trifluoromethyl)selanyl)quinoline

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)nickel (0) In toluene at 50℃; for 12h; Inert atmosphere;	95%

: 4965-33-7
2-methyl-7-chloroquinoline

: 555-16-8
4-nitrobenzaldehdye

: C17H11ClN2O2

Conditions

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry;	94%

: 4965-33-7
2-methyl-7-chloroquinoline

: C12H13OS(1-)*Na(1+)

: 7-(1-naphthyl)-2-methylquinoline

Conditions

Conditions	Yield
With η3-1-tert-butylindenyl palladium chloride dimer In toluene at 70℃; for 4h; Hiyama Coupling; Inert atmosphere; Glovebox; Sealed tube;	94%

: 67-56-1
methanol

: 4965-33-7
2-methyl-7-chloroquinoline

: 19069-95-5
7-chloro-4-(hydroxymethyl)-2-methylquinoline

Conditions

Conditions	Yield
With silver nitrate; Selectfluor In water at 80℃; for 4h; Sealed tube;	94%
With sodium persulfate In water at 80℃; for 4h; Reagent/catalyst; Inert atmosphere;	85%
With ferrous(II) sulfate heptahydrate; sulfuric acid; hydroxylamine-O-sulfonic acid In water for 3h;	78%

: 4965-33-7
2-methyl-7-chloroquinoline

: (R)-7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; iodine; (((1R,3S,3'S)-3,3'-diethyl-3H,3'H-1,1'-spirobi[isobenzofuran]-7,7'-diyl)bis(oxy))bis(diphenylphosphane) In tetrahydrofuran at 20℃; under 18100.7 Torr; for 10h; Inert atmosphere; enantioselective reaction;	94%

: 4965-33-7
2-methyl-7-chloroquinoline

: 949155-92-4
methyl 2-(3-(3-formylphenyl)-3-oxopropyl)benzoate

: 149968-11-6
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate

Conditions

Conditions	Yield
With acetic anhydride at 140℃; for 8h;	93%

: 4965-33-7
2-methyl-7-chloroquinoline

: 104-88-1
4-chlorobenzaldehyde

: C17H11Cl2N

Conditions

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry;	93%

: 4965-33-7
2-methyl-7-chloroquinoline

: 124-63-0
methanesulfonyl chloride

: 7-chloro-2-((methylsulfonyl)methyl)quinoline

Conditions

Conditions	Yield
With benzophenone In acetone at 20℃; for 4h; Microwave irradiation;	93%

: 4965-33-7
2-methyl-7-chloroquinoline

: 59394-27-3
7-chloro-quinoline-2-carbaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 60℃; Inert atmosphere;	92%
With selenium(IV) oxide In 1,4-dioxane for 2.5h; Oxidation; Heating;	84%
With selenium(IV) oxide; water In tetrahydrofuran at 25℃; for 6h;	78%

7-Chloro-2-methylquinoline Chemical Properties

Molecular Structure:

Molecular Formula: C₁₀H₈ClN
Molecular Weight: 177.6302
IUPAC Name: 7-Chloro-2-methylquinoline
Synonyms of 7-Chloroquinaldine (CAS NO.4965-33-7): Quinoline, 7-chloro-2-methyl-
CAS NO: 4965-33-7
Product Categories: Quinolines, Quinazolines and derivatives ; Halides ; Quinolines, Isoquinolines & Quinoxalines ; Quinoline&Isoquinoline ; API ; Alkylquinolines ; Haloquinolines ; Quinolines ; Quinolines, Isoquinolines & Quinoxalines
Melting point: 74-78 °C
Polar Surface Area: 12.89 Å²
Index of Refraction: 1.634
Molar Refractivity: 51.9 cm³
Molar Volume: 144.9 cm³
Surface Tension: 46.5 dyne/cm
Density: 1.225 g/cm³
Flash Point: 148.7 °C
Enthalpy of Vaporization: 49.6 kJ/mol
Boiling Point: 278.2 °C at 760 mmHg
Vapour Pressure: 0.00732 mmHg at 25°C

7-Chloro-2-methylquinoline Uses

7-Chloroquinaldine (CAS NO.4965-33-7) is used as a Pharmaceutical intermediates.

7-Chloro-2-methylquinoline Safety Profile

Safety Information of 7-Chloroquinaldine (CAS NO.4965-33-7):
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3

Product Name

7-Chloro-2-methylquinoline

Synthetic route

7-Chloro-2-methylquinoline Chemical Properties

7-Chloro-2-methylquinoline Uses

7-Chloro-2-methylquinoline Safety Profile

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