7-Methylindole supplier | CasNO.933-67-5

Name
7-Methylindole
EINECS 213-270-1
CAS No. 933-67-5
Article Data56
CAS DataBase
Density 1.0202
Solubility negligible
Melting Point 80-84 °C(lit.)
Formula C₉H₉N
Boiling Point 266 °C(lit.)
Molecular Weight 131.177
Flash Point 266°C
Transport Information
Appearance white to slightly beige shiny flakes
Safety 26-36-36/37/39
Risk Codes 36/37/38-36-21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 1H-Indole, 7-methyl- (9CI);Indole, 7-methyl- (8CI);7-methyl-1H-indole;7-Methylindol;Indole, 7-methyl-;1H-indole, 7-methyl-;7-Metylindole;
PSA 15.79000
LogP 2.47630

Synthetic route

: 65673-86-1
2,3-dihydro-7-methylindole

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With 6C44H32N6O4Ru(2+)12Hf(2+)8O(2-)14HO(1-)6C16H22ClCoN5O6(1-) In 2,2,2-trifluoroethanol; acetonitrile at 20℃; for 12h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Irradiation;	99%
With H8O20P8Pt2(4-)*4C34H72N(1+) In methanol Inert atmosphere; Irradiation;	97%
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; chloropyridinecobaloxime(III) In ethanol at 30℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;	89%

: 7-methyl-1-pivaloylindole

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; hexane at 40 - 45℃; for 40h;	93%
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexanes at -78 - 45℃; for 40h; Inert atmosphere;	93%

: 7-methyl-1-tosylindoline

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 7-methyl-1-tosylindoline In tetrahydrofuran at -78℃; for 2h; Stage #2: With oxygen In tetrahydrofuran at 20℃;	84%

: 210536-43-9
6-methyl-2-vinylaniline

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With p-benzoquinone; lithium chloride; dichloro bis(acetonitrile) palladium(II) In tetrahydrofuran for 10h; Heating;	82%

: 637-39-8
triethanolamine hydrochloride

: 95-53-4
o-toluidine

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With triphenylphosphine; tin(ll) chloride; ruthenium trichloride In 1,4-dioxane; water at 180℃; for 20h; Cyclization;	80%
With tin(ll) chloride; ruthenium trichloride; triphenylphosphine In 1,4-dioxane; water at 180℃; for 20h;	80%

: 1428257-94-6
C9H8N2O4

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With indium; acetic acid In benzene at 80℃; for 5h; Inert atmosphere;	76%

: 130103-44-5
7-methyl-1-(phenylsulfonyl)-1H-indole

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With potassium hydroxide In methanol; 1,2-dimethoxyethane for 24h; Heating;	75%

: 548775-76-4
7-methyl-2-trimethylsilanyl-indole-1-carboxylic acid diethylamide

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 12h; Heating;	75%

: 88-72-2
1-methyl-2-nitrobenzene

: 1826-67-1
vinyl magnesium bromide

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
In tetrahydrofuran at -45 - -40℃; Cyclization; Bartoli reaction;	71%
In tetrahydrofuran at -40℃; for 0.333333h;	67%
In tetrahydrofuran at -40℃; for 1h; Inert atmosphere;	34%

: 109532-22-1
1-(2-amino-3-methylphenyl)-2-chloroethan-1-one

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With sodium tetrahydroborate In 1,4-dioxane; water for 2h; Heating;	71%

: 127-17-3
2-oxo-propionic acid

: 529-27-1
2-methylphenylhydrazine

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With phosphorus pentachloride; zinc(II) chloride for 0.0666667h; microwave irradiation;	71%

: 88-72-2
1-methyl-2-nitrobenzene

: 1826-67-1
vinyl magnesium bromide

A: 933-67-5
7-methyl-1H-indole

B: 75-07-0
acetaldehyde

C: 584-90-7
2,2'-dimethylazobenzene

D: 95-53-4
o-toluidine

E: 956-31-0, 51284-68-5, 116723-89-8
N,N'-Di-o-tolyl-diazene N-oxide

Conditions

Conditions	Yield
In tetrahydrofuran at -40℃; for 0.333333h; other nitroarenes and vinyl Grignard reagents;	A 67% B n/a C n/a D 5% E n/a

...Expand

: (E)-1-(3-methyl-2-nitrostyryl)pyrrolidine

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
Stage #1: (E)-1-(3-methyl-2-nitrostyryl)pyrrolidine With iron(III) chloride; pyrographite In methanol for 0.166667h; Heating; Stage #2: With hydrazine hydrate In methanol for 3h; Heating; Further stages.;	67%

: 102-71-6
triethanolamine

: 95-53-4
o-toluidine

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With tin(ll) chloride; ruthenium trichloride; triphenylphosphine In 1,4-dioxane at 180℃; for 20h;	66%

: 136-80-1
2-(2-tolylamino)ethan-1-ol

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With o-toluidine In acetonitrile	64.3%

: (2,6-Dimethyl-phenyl)-[2-(phenyl-hydrazono)-prop-(Z)-ylidene]-amine

A: 933-67-5
7-methyl-1H-indole

B: 26941-20-8
2,5-dimethylquinoxaline

C: {(R)-4-[1-Cyano-meth-(Z)-ylidene]-2,2-dimethyl-thietan-3-yl}-carbamic acid benzyl ester

D: 81576-25-2
2,8-dimethylquinoxaline

Conditions

Conditions	Yield
at 650℃; under 0.01 Torr;	A 62% B 7% C n/a D 11%

...Expand

: (2,6-Dimethyl-phenyl)-[2-(phenyl-hydrazono)-prop-(Z)-ylidene]-amine

A: 933-67-5
7-methyl-1H-indole

B: 5621-13-6
2,7-dimethyl-1H-indole

C: 26941-20-8
2,5-dimethylquinoxaline

D: 81576-25-2
2,8-dimethylquinoxaline

Conditions

Conditions	Yield
at 650℃; under 0.01 Torr;	A 62% B 3% C 7% D 11%

...Expand

: 51417-51-7
7-bromo-1H-indole

: 80-48-8
methyl p-toluene sulfonate

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With nickel(II) iodide; 4,4'-dimethyl-2,2'-bipyridines; tetra-(n-butyl)ammonium iodide; magnesium chloride; zinc In N,N-dimethyl acetamide at 20℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;	60%

: 88-72-2
1-methyl-2-nitrobenzene

: 3536-96-7
vinylmagnesium chloride

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
In tetrahydrofuran at -45 - -40℃; Cyclization; Bartoli reaction;	58%

: 1127-59-9
7-methyl-1H-indole-2,3-dione

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With dimethylsulfide borane complex In tetrahydrofuran BH3*THF or LAH;	55%

: 2-[(Z)-2,6-Dimethyl-phenylimino]-propionaldehyde O-methyl-oxime

A: 933-67-5
7-methyl-1H-indole

B: 5621-13-6
2,7-dimethyl-1H-indole

C: 26941-20-8
2,5-dimethylquinoxaline

D: 81576-25-2
2,8-dimethylquinoxaline

Conditions

Conditions	Yield
at 650℃; under 0.01 Torr;	A 55% B 5% C 4% D 17%

...Expand

: 81-20-9
2,6-dimethylnitrobenzene

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 2,6-dimethylnitrobenzene; N,N-dimethyl-formamide dimethyl acetal With pyrrolidine In 1,4-dioxane at 102℃; for 22h; Leimgruber-Batcho Indole Synthesis; Reflux; Inert atmosphere; Stage #2: With hydrazine hydrate In 1,4-dioxane at 45℃; for 1h; Leimgruber-Batcho Indole Synthesis;	53%

: 180624-00-4
7-methyl-1H-indole-5-carboxylic acid

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With copper(I) oxide In quinoline at 230℃; for 4h; Decarboxylation;	50%

: 1,1-dimethylethyl (3S,4S)-3,4-dihydroxy-4-(7-methyl-1H-indol-3-yl)-1-piperidinecarboxylate

A: 933-67-5
7-methyl-1H-indole

B: 1143455-52-0
1-dimethylethyl (3R)-3-hydroxy-4-(7-methyl-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 70℃;	A 48% B 36%

: (2,6-Dimethyl-phenyl)-[2-(phenyl-hydrazono)-eth-(Z)-ylidene]-amine

A: 933-67-5
7-methyl-1H-indole

B: 13708-12-8
5-methylquinoxaline

Conditions

Conditions	Yield
at 650℃; under 0.01 Torr;	A 32% B 40%
at 650℃; under 0.01 Torr; Product distribution; Mechanism; also 15N labelled;

: 107-21-1
ethylene glycol

: 95-53-4
o-toluidine

A: 933-67-5
7-methyl-1H-indole

B: 136-80-1
2-(2-tolylamino)ethan-1-ol

C: 94-92-8
1,2-bis[(2-methylphenyl)amino]ethane

D: 3367-47-3
1,4-di-o-tolyl-piperazine

Conditions

Conditions	Yield
With palladium on activated charcoal; zinc(II) oxide In water at 150℃; for 24h; Sealed tube;	A 20% B 28% C n/a D n/a

...Expand

: 3-acetoxy-1-acetyl-7-methyl-indole

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With calcium hydroxide; kieselguhr; water; nickel at 30 - 40℃; under 132391 Torr; Hydrogenation;

: 7,7'-Dimethyl-2,3-dihydro-1H,1'H-[2,3']biindolyl

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
at 225 - 240℃; Vakuum;

: 119072-54-7, 2769-71-3
2,6-dimethylphenyl isonitrile

: 933-67-5
7-methyl-1H-indole

Conditions

Conditions	Yield
With n-butyllithium; diisopropylamine Yield given. Multistep reaction;
Ru(H)2(1,2-bis(dimethylphosphino)ethane)2 In benzene-d6 at 140℃; for 25h; in a sealed tube;	98 % Spectr.

: 933-67-5
7-methyl-1H-indole

: 74-88-4
methyl iodide

: 5621-16-9
1,7-dimethyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 7-methyl-1H-indole With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.25h; Stage #2: methyl iodide In DMF (N,N-dimethyl-formamide) at 30℃; for 1h;	100%
With sodium hydroxide In dimethyl sulfoxide at 20℃;	99%
Stage #1: 7-methyl-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;	97%

: 933-67-5
7-methyl-1H-indole

: 65673-86-1
2,3-dihydro-7-methylindole

Conditions

Conditions	Yield
Stage #1: 7-methyl-1H-indole With sodium cyanoborohydride; acetic acid In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With water; sodium hydroxide In N,N-dimethyl-formamide	99%
With tetrahydroxydiboron; palladium on activated carbon In 2,2,2-trifluoroethanol; water at 40℃; for 24h; Schlenk technique;	99%
With sodium cyanoborohydride In acetic acid; ethyl acetate	94%

: 933-67-5
7-methyl-1H-indole

: 434-45-7
1,1,1-trifluoroacetophenone

: 1160936-85-5
(R)-2,2,2-trifluoro-1-(7-methyl-1H-indol-3-yl)-1-phenylethanol

Conditions

Conditions	Yield
With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate In dichloromethane at 25℃; for 48h; optical yield given as %ee; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 924-44-7
glyoxylic acid ethyl ester

: hydroxy-(7-methyl-1H-indol-3-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With cupreidine 9-O-(4-(perfluoro-n-octyl)benzyl) ether In 1,1,1,3,3-pentafluorobutane; toluene at 20℃; for 1h; Friedel-Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%
Stage #1: 7-methyl-1H-indole With C43H64N4O4; scandium tris(trifluoromethanesulfonate); ortho-chlorobenzoic acid In dichloromethane at 30℃; for 1h; Inert atmosphere; Stage #2: glyoxylic acid ethyl ester In dichloromethane at -20℃; for 12h; Friedel Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	90%

: 933-67-5
7-methyl-1H-indole

: 107969-78-8, 6395-86-4
methyl 4-phenyl-2-oxo-3-butenoate

: 4-(7-methylindol-3-yl)-2-oxo-4-phenylbutyric acid methyl ester

Conditions

Conditions	Yield
With C35H48N4O4; samarium(III) trifluoromethanesulfonate In dichloromethane at -20℃; for 27h; asymmetric Friedel-Crafts alkylation; Inert atmosphere; optical yield given as %ee;	99%

: 933-67-5
7-methyl-1H-indole

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 1262999-81-4
3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 7-methyl-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h; Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;	99%
With (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; copper(II) bis(trifluoromethanesulfonate) at 0℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; stereoselective reaction;	97.6%

: 933-67-5
7-methyl-1H-indole

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 1179934-54-3
3,3,3-trifluoro-2-hydroxy-2-(7-methyl-1H-indol-3-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
In 1,1,1,3,3-pentafluorobutane at 20℃; for 0.5h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 0℃; Friedel Crafts alkylation;
With copper(II) bis(trifluoromethanesulfonate) In chloroform at 25℃; for 16h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique;

: 933-67-5
7-methyl-1H-indole

: 924-44-7
glyoxylic acid ethyl ester

: hydroxy-(7-methyl-1H-indol-3-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With cupreine 9-O-(4-(perfluoro-n-octyl)benzyl) ether In 1,1,1,3,3-pentafluorobutane; toluene at 20℃; for 1h; Friedel-Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 170564-83-7
dimethyl 2-(2,2,2-trifluoroethylidene)malonate

: 1275518-06-3
dimethyl (R)-2-(2,2,2-trifluoro-1-(7-methyl-1H-indol-3-yl)ethyl)malonate

Conditions

Conditions	Yield
Stage #1: dimethyl 2-(2,2,2-trifluoroethylidene)malonate With copper(II) bis(trifluoromethanesulfonate); 2,2-bis[(4S)-4-isopropyloxazolin-2-yl]propane In diethyl ether at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 7-methyl-1H-indole In diethyl ether at -35℃; for 10h; Friedel-Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 107-30-2
chloromethyl methyl ether

: 1322763-47-2
1-methoxymethyl-7-methylindole

Conditions

Conditions	Yield
Stage #1: 7-methyl-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; mineral oil for 1h; Inert atmosphere;	99%

: 933-67-5
7-methyl-1H-indole

: 5292-53-5
diethyl benzalmalonate

: 668463-75-0
(S)-ethyl 2-ethoxycarbonyl-3-[3-(7-methylindolyl)]-3-phenylpropanoate

Conditions

Conditions	Yield
Stage #1: diethyl benzalmalonate With 1,1-bis[(S)-4-benzyloxazolin-2-yl]-2,2-diphenylethene; copper(II) bis(trifluoromethanesulfonate) In ethanol at 20℃; for 0.5h; Friedel-Crafts alkylation; Inert atmosphere; Stage #2: 7-methyl-1H-indole In ethanol at 20℃; for 24h; Friedel-Crafts alkylation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 1436859-42-5
C11H10N2O4

: 5-methoxy-1-methyl-3-(7-methyl-1H-indol-3-yl)-3-(nitromethyl)indolin-2-one

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; 6-bromo-2-(((((4S,5S)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazol-2-yl)methyl)((S)-1-phenylethyl)amino)methyl)-4-nitrophenol; copper(I) triflate In toluene at 20℃; for 7h; Friedel-Crafts Alkylation; Inert atmosphere; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 1436859-40-3
C11H10N2O3

: 1,5-dimethyl-3-(7-methyl-1H-indol-3-yl)-3-(nitromethyl)indolin-2-one

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; 6-bromo-2-(((((4S,5S)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazol-2-yl)methyl)((S)-1-phenylethyl)amino)methyl)-4-nitrophenol; copper(I) triflate In toluene at 20℃; for 1h; Friedel-Crafts Alkylation; Inert atmosphere; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 1533443-74-1
ethyl 5-methyl-2-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate

: 1533444-40-4
ethyl (R)-5-methyl-3-(7-methyl-1H-indol-3-yl)-2-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate

Conditions

Conditions	Yield
With C38H33O4P In toluene at -78℃; for 5h; enantioselective reaction;	99%

: 123-75-1
pyrrolidine

: 933-67-5
7-methyl-1H-indole

: 105-07-7
4-cyanobenzaldehyde

: 1634687-10-7
4-((7-methyl-1H-indol-3-yl)(pyrrolidin-1-yl)methyl)benzonitrile

Conditions

Conditions	Yield
In methanol at 30℃; for 72h;	99%

...Expand

: 933-67-5
7-methyl-1H-indole

: 34157-83-0
celastrol

: (2R,4aS,6aS,12bR,14aS,14bR)-10,11-dihydroxy-2,4a,6a,9,12b,14a-hexamethyl-8-(7-methyl-1H-indol-3-yl)-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

Conditions

Conditions	Yield
With aluminium(III) chloride hexahydrate In dichloromethane at 20℃; for 3h; Friedel-Crafts Alkylation; Sealed tube;	99%
With scandium tris(trifluoromethanesulfonate) In dichloromethane at 20℃; for 24h; Friedel-Crafts Alkylation;

: 933-67-5
7-methyl-1H-indole

: 102-96-5
(2-nitroethenyl)benzene

: 1455513-15-1
7-methyl-3-(2-nitro-1-phenylethyl)-1H-indole

Conditions

Conditions	Yield
With 2,6-bis(2,2-dimethylpropionylamino)benzoic acid In chloroform at 40℃; for 24h; Friedel-Crafts Alkylation;	99%

: 933-67-5
7-methyl-1H-indole

: 1147550-11-5
ammonium thiocyanate

: 1112908-23-2
7-methyl-3-thiocyanato-1H-indole

Conditions

Conditions	Yield
With oxygen In tetrahydrofuran at 25℃; under 750.075 Torr; for 7h; Irradiation;	99%
With copper(II) choride dihydrate; oxygen In ethanol at 20℃; for 24h; Irradiation;	93%
With TiO2/MoS2 In acetonitrile at 20℃; for 16h; Irradiation;	90%

: 933-67-5
7-methyl-1H-indole

: 257-07-8
dibenz[b,f][1,4]oxazepine

: 2-(2-(bis(7-methyl-1H-indol-3-yl)methyl)phenoxy)aniline

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 3h; Friedel-Crafts Alkylation;	99%

: 933-67-5
7-methyl-1H-indole

: methyl 5-methylbenzo[d]isothiazole-3-carboxylate 1,1-dioxide

: (S)-3-methoxycarbonyl-3-(7-methyl-3-indolyl)-5-methyl-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

Conditions

Conditions	Yield
With (R)-2,6-bis(naphthalen-2-yl)-4-oxo-3,5-dioxa-4λ5-phosphacyclohepta[2,1-a;3,4-a']dinapthalen-4-ol In 1,2-dichloro-ethane at 20℃; for 16h; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: methyl benzo[d]isothiazole-3-carboxylate 1,1-dioxide

: (S)-3-methoxycarbonyl-3-(7-methyl-3-indolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

Conditions

Conditions	Yield
With (R)-2,6-bis(naphthalen-2-yl)-4-oxo-3,5-dioxa-4λ5-phosphacyclohepta[2,1-a;3,4-a']dinapthalen-4-ol In 1,2-dichloro-ethane at 20℃; for 16h; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 1666-13-3
diphenyl diselenide

: 7-methyl-3-(phenylselanyl)-1H-indole

Conditions

Conditions	Yield
With oxygen In tetrahydrofuran at 20℃; under 760.051 Torr; Irradiation;	99%
With iridium(III) bis[2-(4,6-difluorophenyl)pyridinato]picolinate In acetonitrile at 25℃; Irradiation; Green chemistry;	90%
With iridium(III) bis[2-(4,6-difluorophenyl)pyridinato]picolinate In acetonitrile at 20℃; Irradiation; Green chemistry;	90%
With 3-chloro-benzenecarboperoxoic acid; sodium bromide In acetonitrile at 20℃; for 24h; regioselective reaction;	61%

: 933-67-5
7-methyl-1H-indole

: 16090-33-8
2-nitrohydroquinone

: C15H10N2O4

Conditions

Conditions	Yield
With cerium(III) chloride; silver(l) oxide In 1,2-dichloro-ethane at 20℃; Darkness;	99%

: 933-67-5
7-methyl-1H-indole

: 213908-78-2
ethyl 3,3,3-trifluoro-2-iminopropionate

: 1014691-30-5
ethyl (S)-2-amino-3,3,3-trifluoro-2-(7-methyl-1H-indol-3-yl)propanoate

Conditions

Conditions	Yield
With (S)-3-(anthracen-9-yl)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate In chloroform at -60℃; for 1h; Inert atmosphere; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 36176-90-6
N-(4-bromobenzylidene)-4-methylbenzenesulfonamide

: (S)-N-((4-bromophenyl)(7-methyl-1H-indol-3-yl)methyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With (Rp)-4,12-di(4-(3',5'-bis(trifluoromethyl))-phenyl-3-yl)-[2.2]paracyclophane-hydrogenphosphate In toluene at -20℃; for 12h; Molecular sieve; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: tert-butyl (1,3-dioxo-2-phenyl-2,3-dihydroisoquinolin-4(1H)-ylidene)carbamate

: (S)-tert-butyl (4-(7-methyl-1H-indol-3-yl)-1,3-dioxo-2-phenyl-1,2,3,4-tetrahydroisoquinolin-4-yl)carbamate

Conditions

Conditions	Yield
With (11aR)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In toluene at 60℃; for 3h; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: C17H14N2O3

: benzyl (R)-(1-methyl-3-(7-methyl-1H-indol-3-yl)-2-oxoindolin-3-yl)carbamate

Conditions

Conditions	Yield
With C55H51F3N4O3PdS In toluene at 40℃; Inert atmosphere; Alkaline conditions; enantioselective reaction;	99%

: 933-67-5
7-methyl-1H-indole

: 25603-67-2
9-phenyl-fluoren-9-ol

: 7-methyl-3-(9-phenyl-9H-fluoren-9-yl)-1H-indole

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In dichloromethane at 60℃; for 4h; Sealed tube;	99%

: 933-67-5
7-methyl-1H-indole

: 2-((trifluoromethyl)sulfonyl)benzo[d]thiazole

: 7-methyl-3-((trifluoromethyl)sulfinyl)-1H-indole

Conditions

Conditions	Yield
With Diphenylphosphinic chloride In acetonitrile at 60℃; for 1h; Schlenk technique; Inert atmosphere;	99%

7-Methylindole Chemical Properties

7-Methylindole's Molecular formula: C₉H₉N
7-Methylindole's Molar mass: 131.17
EINECS: 213-270-1
Flash Point: 266°C
Melting point: 80-84 °C(lit.)
Boiling point: 266 °C(lit.)
Water Solubility: negligible
Sensitive: Light Sensitive
Synonyms: 7-Methylindol;Indole, 7-methyl-;7-METHYINDOLE;1H-Indole, 7-methyl-;7-METHYLINDOLE;7-METHYL-1H-INDOLE;7-Methylindole,98%;7-Metlylindole
7-Methylindole is a mildly toxic off-white crystalline organic compound with chemical formula C₉H₉N.

7-Methylindole Uses

7-Methylindole is used in the production of agricultural chemicals and pharmaceuticals.
7-Methylindole is used for organic synthetic reagent.

7-Methylindole Safety Profile

F 13
Hazard Codes Xi,Xn
WGK Germany 3
Risk Statements 36/37/38-36-21/22
Safety Statements 26-36-36/37/39
Hazard Note Light Sensitive/Irritant

Product Name

7-Methylindole

Synthetic route

7-Methylindole Chemical Properties

7-Methylindole Uses

7-Methylindole Safety Profile

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