Acetic acid,2-(diethoxyphosphinyl)- supplier

Name
DIETHYLPHOSPHONOACETIC ACID
EINECS 608-560-3
CAS No. 3095-95-2
Article Data42
CAS DataBase
Density 1.167 g/cm³
Solubility
Melting Point
Formula C₆H₁₃O₅P
Boiling Point 315.9 °C at 760 mmHg
Molecular Weight 196.14
Flash Point 144.9 °C
Transport Information
Appearance clear colorless to yellow viscous liquid
Safety 37/39-26
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Aceticacid, (diethoxyphosphinyl)- (9CI);Acetic acid, phosphono-, P,P-diethyl ester(7CI,8CI);(Diethoxyphosphinyl)acetic acid;(Diethylphosphono)acetic acid;Diethoxyphosphorylacetic acid;Diethyl carboxymethanephosphonate;Diethylcarboxymethylphosphonate;NSC 272281;
PSA 82.64000
LogP 1.33710

Synthetic route

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 20℃;	100%
With water; sodium hydroxide In ethanol at 20℃; Inert atmosphere;	97%
With hydrogenchloride; potassium hydroxide 1.) aq. EtOH, 20 h;	95%

: 7396-44-3
benzyl diethylphosphonoacetate

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With 1% Pd/C; hydrogen In ethyl acetate	99%
With hydrogen; palladium on activated charcoal
With hydrogen; palladium on activated charcoal In ethanol

: 79-11-8
chloroacetic acid

: 122-52-1
triethyl phosphite

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
In toluene Michaelis-Arbuzov Synthesis; Reflux;	68%

: 115124-53-3
C12H27O5PSi

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With hydrogen fluoride In acetonitrile	62%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With phosphate buffer; immobilized enzyme preparation from Rhodococcus sp for 168h; Ambient temperature; pH 7.0;	41%

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

A: 3095-95-2
diethylphosphonoacetic acid

B: 4408-78-0
phosphonoacetic acid

C: 35752-46-6
phosphonoacetic acid ethyl ester

Conditions

Conditions	Yield
With potassium hydroxide In water Product distribution; various reagents;

...Expand

: 683-08-9
Diethyl methylphosphonate

: 124-38-9
carbon dioxide

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With n-butyllithium 1.) ether, THF, -65 deg C, 30 min, 2.) ether, -65 deg C, 5 min; -65 deg C to room temp., 2 h; Yield given. Multistep reaction;
With n-butyllithium 1.) THF, hexane, -78 deg C to -20 deg C, 30 min, 2.) THF, -78 deg C to -10 deg C, 2 h; Multistep reaction;
With n-butyllithium at -78℃;

: 124-38-9
carbon dioxide

: 110625-05-3
diethyl-1-magnesium chloride methanephosphonate

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With water 1.) ether, -70 deg. C.; 2.) ether, room. temp.; Yield given. Multistep reaction;

: 1067-74-9
Methyl diethylphosphonoacetate

A: 3095-95-2
diethylphosphonoacetic acid

B: 40882-15-3
diethylphosphinylacethydroxamic acid

C: disodium ethylphosphonoacetohydroxamate

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride In water at 20℃; for 18h; pH=12; Title compound not separated from byproducts;

...Expand

: 1067-74-9
Methyl diethylphosphonoacetate

A: 3095-95-2
diethylphosphonoacetic acid

B: disodium ethylphosphonoacetohydroxamate

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride In water at 20℃; for 72h; pH=12; Title compound not separated from byproducts;

: 10419-77-9
diethyl iodomethanephosphonate

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / -70 °C 2: 2.) H2O / 1.) ether, -70 deg. C.; 2.) ether, room. temp. View Scheme

: 762-04-9, 123-22-8
Diethyl phosphonate

: 79-08-3
bromoacetic acid

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol; water

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 3095-95-2
diethylphosphonoacetic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water

: 3095-95-2
diethylphosphonoacetic acid

: 2216-51-5
(-)-menthol

: 141540-20-7
(diethoxy-phosphoryl)-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; Inert atmosphere;	100%
With triethylamine; 2-chloropyridinium iodide

: 3095-95-2
diethylphosphonoacetic acid

: 34170-81-5
diethyl (2-chloro-2-oxoethyl)phosphonate

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In benzene for 1h;	100%
With thionyl chloride at 20℃; for 2h; Inert atmosphere;	92%
With thionyl chloride at 20℃; for 2h; Inert atmosphere;	92%

: 3095-95-2
diethylphosphonoacetic acid

: 75-65-0
tert-butyl alcohol

: 27784-76-5
tert-butyl diethylphosphonoacetate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 0.25h;	100%
With dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 0.25h; Product distribution; Further Variations:; Reaction partners; Reagents; Solvents;	100%
With sulfuric acid In various solvent(s) for 12h;	90%
With dicyclohexyl-carbodiimide In acetonitrile at 25℃; for 1h;

: 3095-95-2
diethylphosphonoacetic acid

: 107-18-6
allyl alcohol

: 113187-28-3
allyl diethylphosphonoacetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Esterification;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 6-{6-[6-(6-{6-[2-(tert-butyl-dimethyl-silanyloxy)-5-iodo-1-methyl-pent-4-enyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2,4-dimethyl-hex-5-en-3-ol

: 375827-09-1
C53H96IO14PSi

Conditions

Conditions	Yield
With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In dichloromethane at 20℃; for 48h;	100%
With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In dichloromethane	99%

: 3095-95-2
diethylphosphonoacetic acid

: 3529-10-0
4-(Dimethylamino)butylamine

: 643763-06-8
[(4-dimethylamino-butylcarbamoyl)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With N'-methyl polystyrene; N-cyclohexylcarbodimide; benzotriazol-1-ol; tris(2-amimoethyl)amine polystyrene In dichloromethane; N,N-dimethyl acetamide at 20℃; for 24h;	100%

: (4E,2R)-5-((2R,6R)-6-{(6Z,2E)-8-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-4-[(4-methoxyphenyl)methyl]-6-methylocta-2,6-dienyl}-4-methylene(2,3,5,6-tetrahydropyran-2-yl))-1-[(4-methoxyphenyl)methoxy]-4-methylpent-4-en-2-ol

: 3095-95-2
diethylphosphonoacetic acid

: (Diethoxy-phosphoryl)-acetic acid (E)-(R)-4-{(2R,6R)-6-[(2E,6Z)-8-(tert-butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-6-methyl-octa-2,6-dienyl]-4-methylene-tetrahydro-pyran-2-yl}-1-(4-methoxy-benzyloxymethyl)-3-methyl-but-3-enyl ester

Conditions

Conditions	Yield
With dmap; PS-carbodiimide; 4-(dimethylamino)pyridine hydrochloride In chloroform for 0.5h;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 106-41-2
4-bromo-phenol

: 254114-95-9
(para-bromophenyl)diethylphosphonoacetate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide; dmap In dichloromethane at 0 - 20℃; for 10h; Addition;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 66-25-1
hexanal

: 1871-67-6
(E)-oct-2-enoic acid

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; zinc trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 25℃; for 12h; Horner-Wadsworth-Emmons reaction;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 108-93-0
cyclohexanol

: 65717-27-3
cyclohexyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With dicyclohexyl-carbodiimide In dichloromethane for 0.25h;

: 3095-95-2
diethylphosphonoacetic acid

: (3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-amine dihydrochloride

: 671207-11-7
diethyl[2-({(3E)-1-[(6-fluoro-2-naphthyl)methyl]-pyrrolidin-3-yl}amino)-2-oxoethyl]phosphonate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 3.5h;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 2516-47-4
cyclopropanemethylamine

: 1246448-96-3
diethyl {[(cyclopropylmethyl)carbamoyl]methyl}phosphonate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; water for 12h;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 1369406-43-8
(2-(2-(2-(4-(1-aminobutyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid bis(tert-butyl) ester

: 1369406-47-2
(2-(2-(2-(4-(1-(2-(diethoxyphosphoryl)acetamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid bis(tert-butyl) ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 1421359-27-4
(2R,3S,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-ol

: 1421359-38-7
(2R,3S,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 1421359-26-3
(2S,3S,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-ol

: 1421359-35-4
(2S,3S,6S)-7-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-methyleneheptan-3-yl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 60-12-8
2-phenylethanol

: 941582-78-1
phenethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 702-23-8
2-(4-Methoxyphenyl)ethanol

: 1607455-43-5
4-methoxyphenethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 6006-82-2
3,4-methylenedioxyphenethyl alcohol

: 1607455-48-0
2-(1,3-benzodioxol-5-yl)ethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 1123-85-9
(RS)-2-phenyl-1-propanol

: 1607455-49-1
2-phenylpropyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 111-70-6
n-heptan1ol

: 147318-09-0
heptyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 2917-47-7
3-trimethylsilyl-1-propanol

: 1607455-53-7
3-(trimethylsilyl)propyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 3637-61-4
1-amino-cyclopentanemethanol

: 1607455-54-8
cyclopentylmethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;

: 3095-95-2
diethylphosphonoacetic acid

: 2968-93-6
2-(4-trifluoromethylphenyl)ethanol

: 4-trifluoromethylphenethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 50438-75-0
2-(4-dimethylaminophenyl)ethyl alcohol

: 4-(dimethylamino)phenethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 123-51-3
i-Amyl alcohol

: 3-methylbutyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 78-83-1
2-methyl-propan-1-ol

: 75412-64-5
diethyl <(iso-butoxycarbonyl)methyl>phosphonate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In toluene at 20℃; for 4h; Inert atmosphere;	95%

: 3095-95-2
diethylphosphonoacetic acid

: (1RS,4aSR,8aSR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-ol

: (1RS,4aSR,8aSR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; toluene at 20℃; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 70-55-3
toluene-4-sulfonamide

: 2-(diethoxyphosphoryl)-N-(p-toluenesulfonyl)ethanamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 71h; Inert atmosphere;	100%

: 3095-95-2
diethylphosphonoacetic acid

: 3929-47-3
3-(3,4-dimethoxyphenyl)-1-propanol

: 3-(3,4-dimethoxyphenyl)propyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; Inert atmosphere;	100%

Acetic acid,2-(diethoxyphosphinyl)- Specification

The Acetic acid,2-(diethoxyphosphinyl)-, with the CAS registry number 3095-95-2, is also known as Diethylphosphonoacetic acid. It belongs to the product categories of C-C Bond Formation; Horner-Wadsworth-Emmons Reagents; Olefination. This chemical's molecular formula is C₆H₁₃O₅P and molecular weight is 196.138181. Its IUPAC name is called 2-diethoxyphosphorylacetic acid. The product should be sealed and stored in cool, dry place.

Physical properties of Acetic acid,2-(diethoxyphosphinyl)-: (1)ACD/LogP: -0.08; (2)ACD/LogD (pH 5.5): -2.09; (3)ACD/LogD (pH 7.4): -3.6; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.438; (12)Molar Refractivity: 41.77 cm³; (13)Molar Volume: 159 cm³; (14)Surface Tension: 41.6 dyne/cm; (15)Density: 1.233 g/cm³; (16)Flash Point: 144.9 °C; (17)Enthalpy of Vaporization: 61.27 kJ/mol; (18)Boiling Point: 315.9 °C at 760 mmHg; (19)Vapour Pressure: 9.07E-05 mmHg at 25°C.

Preparation: this chemical can be prepared by diethoxyphosphoryl-acetic acid ethyl ester. This reaction will need reagent potassium hydroxide and solvent ethanol, H₂O. The reaction time is 15 hours with reaction temperature of 20 °C. The yield is about 69%.

Uses of Acetic acid,2-(diethoxyphosphinyl)-: it can be used to produce (1-pyrrolidin-1-ylmethyl-vinyl)-phosphonic acid diethyl ester by heating. This reaction will need solvent benzene with reaction time of 6 hours. The yield is about 80%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful if swallowed. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCOP(=O)(CC(=O)O)OCC
(2)InChI: InChI=1S/C6H13O5P/c1-3-10-12(9,11-4-2)5-6(7)8/h3-5H2,1-2H3,(H,7,8)
(3)InChIKey: DVQMPWOLBFKUMM-UHFFFAOYSA-N

Product Name

DIETHYLPHOSPHONOACETIC ACID

Synthetic route

Acetic acid,2-(diethoxyphosphinyl)- Specification

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