Bromoacetyl bromide supplier

Name
Bromoacetyl bromide
EINECS 209-923-5
CAS No. 598-21-0
Article Data25
CAS DataBase
Density 2.373 g/cm³
Solubility REACTS
Melting Point 148.5°C (estimate)
Formula C₂H₂Br₂O
Boiling Point 148.5 °C at 760 mmHg
Molecular Weight 201.845
Flash Point 72 °C
Transport Information UN 2513 8/PG 2
Appearance COA
Safety 26-36/37/39-45-8-30-25
Risk Codes 34-14
Molecular Structure
Hazard Symbols C
Synonyms Acetyl bromide, bromo-;2-Bromoacetyl bromide;
PSA 17.07000
LogP 1.30280

Synthetic route

: 506-96-7
Acetyl bromide

: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
With bromine

: 593-92-0
vinylidene dibromide

: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
With oxygen

: 64-19-7
acetic acid

: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
With phosphorus; bromine; acetic anhydride
With phosphorus; bromine
With bromine; phosphorus tribromide at 20 - 75℃; Bromination; Hell-Vollhard-Zelinskii reaction;
With phosphorus; bromine; sodium hydroxide at 110℃; Hell-Vollard-Zelinsky halogenation; regioselective reaction;

: 79-08-3
bromoacetic acid

: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
With phosphorus tribromide

: 75-36-5
acetyl chloride

: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
With bromine at 100 - 140℃;
With bromine

: 7726-95-6
bromine

: 64-19-7
acetic acid

red phosphorus: red phosphorus

: 598-21-0
2-Bromoacetyl bromide

...Expand

: 7726-95-6
bromine

: 64-19-7
acetic acid

red phosphorus: red phosphorus

A: 79-08-3
bromoacetic acid

B: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
at 100 - 105℃;

...Expand

: 7726-95-6
bromine

: 64-19-7
acetic acid

phosphorus: phosphorus

A: 506-96-7
Acetyl bromide

B: 79-08-3
bromoacetic acid

C: 598-21-0
2-Bromoacetyl bromide

...Expand

: 593-92-0
vinylidene dibromide

air: air

: 598-21-0
2-Bromoacetyl bromide

: 593-92-0
vinylidene dibromide

oxygen: oxygen

: 598-21-0
2-Bromoacetyl bromide

: 593-92-0
vinylidene dibromide

hypobromous acid: hypobromous acid

A: 598-21-0
2-Bromoacetyl bromide

B 1.1.1.4.4.4-hexabromobutanone: 1.1.1.4.4.4-hexabromobutanone

...Expand

: 540-49-8
cis+trans-dibromoethylene

: 10028-15-6
ozone

A: 631-64-1
dibromoacetic acid

B: 3039-13-2
dibromoacetaldehyde

C: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
bei der Oxydation;

...Expand

: 540-49-8
cis+trans-dibromoethylene

nitrogen dioxide: nitrogen dioxide

A: 463-51-4
Ketene

B: 78957-22-9
bromoketene

C: 598-21-0
2-Bromoacetyl bromide

Conditions

Conditions	Yield
at -259.15℃; Kinetics; Photolysis;

...Expand

: 110-58-7
1-pentanamine

: 598-21-0
2-Bromoacetyl bromide

: 89520-10-5
2-bromo-N-pentylacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;	100%
With 1,2-dichloro-ethane at -10℃;
at -77℃;

: 111-92-2
dibutylamine

: 598-21-0
2-Bromoacetyl bromide

: 40124-27-4
N,N-dibutylbromoacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;	100%
In 1,2-dichloro-ethane at -20 - 20℃; for 0.833333h;	95%
In dichloromethane at 0 - 20℃; for 1h;	92%

: 109-73-9
N-butylamine

: 598-21-0
2-Bromoacetyl bromide

: 67056-04-6
2-bromo-N-butylacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;	100%
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	96%
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 12.5h;	95%

: 108-18-9
diisopropylamine

: 598-21-0
2-Bromoacetyl bromide

: 51321-61-0
2-bromo-N,N-diisopropylacetamide

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	100%
In dichloromethane at -60 - 20℃; for 1h;	98%
In dichloromethane at 0 - 20℃; for 1h;	88%

: 107-10-8
propylamine

: 598-21-0
2-Bromoacetyl bromide

: 5395-67-5
2‐bromo‐N‐propylacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 12.5h;	100%
With potassium carbonate In dichloromethane; water at 5 - 25℃; for 12.5h;	100%
With sodium carbonate In water pH=9 - 10;	99%

: 111-26-2
hexan-1-amine

: 598-21-0
2-Bromoacetyl bromide

: 5439-32-7
2-bromo-N-hexylethanamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 4h;	100%
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 4.5h;	100%
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;	100%

: 111-68-2
1-Heptylamine

: 598-21-0
2-Bromoacetyl bromide

: 5463-16-1
2-bromo-N-heptylacetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;	100%
In tetrahydrofuran; water	99%
In tetrahydrofuran; water	99%
In tetrahydrofuran; water	99%
With 1,2-dichloro-ethane at -10℃;

: 2016-57-1
1-aminodecane

: 598-21-0
2-Bromoacetyl bromide

: 5345-68-6
2-bromo-N-decyl-acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 4.5h;	100%
With 1,2-dichloro-ethane at -10℃;
With triethylamine In dichloromethane at -15℃;
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 12.5h;
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 12h;

: 2216-51-5
(-)-menthol

: 598-21-0
2-Bromoacetyl bromide

: 16832-20-5, 32815-12-6, 55284-67-8
(1R,2S,5R)-menthol bromoacetate

Conditions

Conditions	Yield
With pyridine In dichloromethane at -78℃; Inert atmosphere;	100%
With potassium carbonate In dichloromethane at 0 - 20℃; Inert atmosphere;	95%
With N,N-dimethyl-aniline In diethyl ether 1.) 0 deg C, 3 h, 2.) reflux, 3 h;	77%

: 598-21-0
2-Bromoacetyl bromide

: 62-53-3
aniline

: 5326-87-4
N-(phenyl)bromoacetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0℃; for 1.25h; Inert atmosphere;	99%
With sodium carbonate In water pH=9 - 10;	99%

: 598-21-0
2-Bromoacetyl bromide

: 95-53-4
o-toluidine

: 5332-69-4
2-bromo-N-(2'-methylphenyl)acetamide

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 24h;	100%
With sodium carbonate In water pH=9 - 10;	99%
With potassium carbonate In dichloromethane; water at 0℃; for 1h;	98%

: 598-21-0
2-Bromoacetyl bromide

: 100-61-8
N-methylaniline

: 29182-97-6
N-methyl-2-bromoacetanilide

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 0 - 25℃; for 0.5h;	100%
In dichloromethane at 0 - 20℃; for 1h;	98%
With triethylamine In dichloromethane at 20℃; for 16h;	88%

: 598-21-0
2-Bromoacetyl bromide

: 100-46-9
benzylamine

: 2945-03-1
N-benzyl-2-bromoacetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 2h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h;	99%
In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;	98%

: 186581-53-3, 908094-01-9
diazomethane

: 598-21-0
2-Bromoacetyl bromide

: 39755-31-2
1-bromo-3-diazopropan-2-one

Conditions

Conditions	Yield
With calcium oxide In diethyl ether at 0℃; for 3.08333h; Arndt-Eistert synthesis;	100%
In diethyl ether at 0℃;	88%

: 98-16-8
3-trifluoromethylaniline

: 598-21-0
2-Bromoacetyl bromide

: 25625-57-4
2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide

Conditions

Conditions	Yield
In dichloromethane at 10 - 20℃; for 1.58333h;	100%
Stage #1: 3-trifluoromethylaniline; 2-Bromoacetyl bromide In dichloromethane at 10 - 20℃; for 1.58333h; Stage #2: With sodium hydrogencarbonate In dichloromethane for 0.666667h;	100%
Stage #1: 3-trifluoromethylaniline; 2-Bromoacetyl bromide In dichloromethane at 10 - 20℃; for 1.58333h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water for 0.833333h;	100%

: 598-21-0
2-Bromoacetyl bromide

: 108-44-1
1-amino-3-methylbenzene

: 5439-17-8
2-bromo-N-(3-methylphenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With sodium carbonate In water pH=9 - 10;	99%
With triethylamine In dichloromethane at 0℃; for 1h;	93%

: 34820-01-4
methyl 2,3,6-tri-O-benzoyl-β-D-galactopyranoside

: 598-21-0
2-Bromoacetyl bromide

: 114682-52-9
methyl 2,3,6-tri-benzoyl-4-O-(bromoacetyl)-β-D-galactopyranoside

Conditions

Conditions	Yield
With tetramethylurea In 1,2-dimethoxyethane for 24h; Ambient temperature;	100%

: 110-91-8
morpholine

: 598-21-0
2-Bromoacetyl bromide

: 40299-87-4
N-(bromoacetyl)morpholine

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;	91%
With potassium phosphate In dichloromethane for 3h; Inert atmosphere;	89%

: 928-96-1
(Z)-3-Hexen-1-ol

: 598-21-0
2-Bromoacetyl bromide

: 90448-99-0
(Z)-3-hexenyl bromoacetate

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃;

: 85695-96-1
(1R,2S,3R,4S)-2-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>heptan-3-ol

: 598-21-0
2-Bromoacetyl bromide

: 88948-24-7
(1S,2R,3S)-3-(2,2-dimethylpropoxy)-4,7,7-trimethylbicyclo<2.2.1>hept-2-yl bromoacetate

Conditions

Conditions	Yield
With silver cyanide In benzene for 0.333333h; Heating;	100%
With silver cyanide In benzene at 80℃; for 0.333333h;

: 130533-09-4
2-[(4-methoxybenzyl)amino]-2-phenylacetonitrile

: 598-21-0
2-Bromoacetyl bromide

: 130533-00-5
N-(4-methoxybenzyl)-N-(1-cyanobenzyl)-2-bromoacetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 130533-04-9
(3R)-2-(4-methoxybenzylamino)-3-benzyloxymethylbutyronitrile

: 598-21-0
2-Bromoacetyl bromide

: 130533-05-0
N-(4-methoxybenzyl)-N-<(2R)-2-benzyloxymethyl-1-cyanopropyl>-2-bromoacetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 53518-15-3
Coumarin 151

: 598-21-0
2-Bromoacetyl bromide

: 78277-40-4
7-(bromoacetamido)-4-(trifluoromethyl)coumarin

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h; Ambient temperature;	100%
With triethylamine In dichloromethane at 0℃; for 3h;

: 82082-32-4
<5-chloro-2-<(phenylmethyl)amino>phenyl>(2,6-dichlorophenyl)methanone

: 598-21-0
2-Bromoacetyl bromide

: 82082-41-5
2-bromo-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-(phenylmethyl)acetamide

Conditions

Conditions	Yield
With pyridine In diethyl ether for 0.333333h; Ambient temperature;	100%

: 598-21-0
2-Bromoacetyl bromide

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 14439-71-5
2'-benzoyl-2-bromo-acetanilide

Conditions

Conditions	Yield
	100%
With potassium carbonate In acetonitrile at 20℃; for 1h;	98%
With potassium carbonate In acetonitrile at 20℃; for 1h;	98%

: 598-21-0
2-Bromoacetyl bromide

: 589-08-2
N-Methyl-N-phenethylamine

: 73391-97-6
N-methyl-N-2-phenylethyl-2-bromoacetamide

Conditions

Conditions	Yield
In dichloromethane at -25 - 20℃;	100%
With potassium carbonate In dichloromethane at 0 - 20℃; for 3h;

: 17061-62-0
N,N-bis(p-methoxybenzyl)amine

: 598-21-0
2-Bromoacetyl bromide

: 180747-36-8
2-Bromo-N,N-bis-(4-methoxy-benzyl)-acetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 0.25h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Schlenk technique; Inert atmosphere;
With potassium carbonate In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 598-21-0
2-Bromoacetyl bromide

: 129549-13-9
4S-3-(2-bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone

Conditions

Conditions	Yield
With n-butyllithium at -78 - 20℃; for 0.5h;	100%
Stage #1: (S)-4-Benzyl-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: 2-Bromoacetyl bromide In tetrahydrofuran; hexane at -78 - 20℃; for 16.5h; Inert atmosphere;	92%
Stage #1: (S)-4-Benzyl-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78 - -60℃; for 0.5h; Stage #2: 2-Bromoacetyl bromide In tetrahydrofuran; hexane at -78℃; for 1h;	87%

: 598-21-0
2-Bromoacetyl bromide

: 611-21-2
N,2-dimethylaniline

: 13508-79-7
N-methyl-N-(2-methylphenyl)-2-bromoacetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane for 1h; Ambient temperature;	100%

: 115196-83-3
methyl 4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

: 598-21-0
2-Bromoacetyl bromide

: methyl 4-azido-3-O-benzyl-2-O-bromoacetyl-4,6-dideoxy-α-D-mannopyranoside

Conditions

Conditions	Yield
With tetramethylurea In dichloromethane Ambient temperature;	100%

Bromoacetyl bromide Specification

The CAS registry number of Bromoacetyl bromide is 598-21-0. The IUPAC name is 2-bromoacetyl bromide. Its EINECS registry number is 209-923-5. In addition, the molecular formula is C₂H₂Br₂O and the molecular weight is 201.84. It is a kind of dark brown-yellow liquid and belongs to the classes of Pharmaceutical Intermediates; Organics; Acid Halides; Carbonyl Compounds; Organic Building Blocks.

Physical properties about this chemical are: (1)ACD/LogP: 1.32; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.32; (4)ACD/LogD (pH 7.4): 1.32; (5)ACD/BCF (pH 5.5): 5.93; (6)ACD/BCF (pH 7.4): 5.93; (7)ACD/KOC (pH 5.5): 124.42; (8)ACD/KOC (pH 7.4): 124.42; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.543; (14)Molar Refractivity: 26.8 cm³; (15)Molar Volume: 85 cm³; (16)Polarizability: 10.62 ×10^-24cm³; (17)Surface Tension: 45.6 dyne/cm ; (18)Density: 2.373 g/cm³; (19)Flash Point: 72 °C; (20)Enthalpy of Vaporization: 38.54 kJ/mol; (21)Boiling Point: 148.5 °C at 760 mmHg; (22)Vapour Pressure: 4.21 mmHg at 25°C.

Preparation of Bromoacetyl bromide: It can be prepared from acetic acid and bromine in the presence of phosphorus. Firstly, dry the red phosphorus for 2 hours. Then mix it with glacial acetic acid. Next, add the bromine with stirring. when add half of the bromine, you should heat it immediately. After adding the bromine, heat it to 140 °C for reaction 2 hours. By means of cooling and distilling you can get the product.

Uses of Bromoacetyl bromide: it is mainly used in medicine intermediates. And it can react with 10H-phenothiazine to get 10-bromoacetyl-10H-phenothiazine. This reaction will need reagent pyridine and solvent toluene. The reaction time is 12 hours at reaction ambient temperature. In addition, the yield is about 45%.

Bromoacetyl bromide can react with 10H-phenothiazine to get 10-bromoacetyl-10H-phenothiazine

When you are using this chemical, please be cautious about it as the following:
This chemical can react violently with water and cause burns. So you should never add water to this product.During using it, wear suitable protective clothing, gloves and eye/face protection and avoid contact with eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.). What's more, you should keep container dry.

You can still convert the following datas into molecular structure:
(1)SMILES: BrC(=O)CBr
(2)InChI: InChI=1/C2H2Br2O/c3-1-2(4)5/h1H2
(3)InChIKey: LSTRKXWIZZZYAS-UHFFFAOYAE

Product Name

Bromoacetyl bromide

Synthetic route

Bromoacetyl bromide Specification

Related Products

Hot Products